WO2004022542A3 - Substituted 1,2,3,4-tetrahydroquinoline derivatives - Google Patents

Substituted 1,2,3,4-tetrahydroquinoline derivatives Download PDF

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Publication number
WO2004022542A3
WO2004022542A3 PCT/EP2003/008889 EP0308889W WO2004022542A3 WO 2004022542 A3 WO2004022542 A3 WO 2004022542A3 EP 0308889 W EP0308889 W EP 0308889W WO 2004022542 A3 WO2004022542 A3 WO 2004022542A3
Authority
WO
WIPO (PCT)
Prior art keywords
substituted
tetrahydroquinoline derivatives
tetrahydroquinoline
derivatives
medicaments
Prior art date
Application number
PCT/EP2003/008889
Other languages
German (de)
French (fr)
Other versions
WO2004022542A2 (en
Inventor
Hagen-Heinrich Hennies
Corinna Sundermann
Michael Przewosny
Bernd Sundermann
Original Assignee
Gruenenthal Gmbh
Hagen-Heinrich Hennies
Corinna Sundermann
Michael Przewosny
Bernd Sundermann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh, Hagen-Heinrich Hennies, Corinna Sundermann, Michael Przewosny, Bernd Sundermann filed Critical Gruenenthal Gmbh
Priority to AU2003258598A priority Critical patent/AU2003258598A1/en
Publication of WO2004022542A2 publication Critical patent/WO2004022542A2/en
Publication of WO2004022542A3 publication Critical patent/WO2004022542A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/06—Peri-condensed systems

Abstract

The invention relates to substituted 1,2,3,4-tetrahydroquinoline derivatives, to methods for the production thereof, to their use for producing medicaments, and to medicaments containing these compounds.
PCT/EP2003/008889 2002-08-12 2003-08-11 Substituted 1,2,3,4-tetrahydroquinoline derivatives WO2004022542A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003258598A AU2003258598A1 (en) 2002-08-12 2003-08-11 Substituted 1,2,3,4-tetrahydroquinoline derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10236910.0 2002-08-12
DE2002136910 DE10236910A1 (en) 2002-08-12 2002-08-12 Substituted 1,2,3,4-tetrahydroquinoline derivatives

Publications (2)

Publication Number Publication Date
WO2004022542A2 WO2004022542A2 (en) 2004-03-18
WO2004022542A3 true WO2004022542A3 (en) 2004-06-03

Family

ID=31501737

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/008889 WO2004022542A2 (en) 2002-08-12 2003-08-11 Substituted 1,2,3,4-tetrahydroquinoline derivatives

Country Status (3)

Country Link
AU (1) AU2003258598A1 (en)
DE (1) DE10236910A1 (en)
WO (1) WO2004022542A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE413393T1 (en) * 2003-12-20 2008-11-15 Merck Patent Gmbh 2-(HETERO-)ARYL SUBSTITUTED TETRAHYDROCINOLINE DERIVATIVES
DE102004020908A1 (en) * 2004-04-28 2005-11-17 Grünenthal GmbH Substituted 5,6,7,8-tetrahydropyrido [4,3-d] pyrimidin-2-yl and 5,6,7,8-tetrahydroquinazolin-2-yl compounds
DE102005027169A1 (en) 2005-06-13 2006-12-14 Merck Patent Gmbh tetrahydroquinoline
WO2008109007A1 (en) * 2007-03-02 2008-09-12 Cara Therapeutics, Inc. Bridged phenanthridines
US8546427B2 (en) * 2010-10-20 2013-10-01 Hoffmann-La Roche Inc. Tetrahydroquinoline derivatives
US9751838B2 (en) 2012-10-02 2017-09-05 Institut National De La Sante Et De La Recherche Medicale (Inserm) Tetrahydroquinoline derivatives and their use as Epac inhibitors
CN110372589B (en) * 2019-08-13 2020-12-25 聊城大学 Preparation method of 4- (4-tert-butylphenyl) -2-phenyl-1, 2,3, 4-tetrahydroquinoline-8-methyl formate
TW202241852A (en) 2020-12-25 2022-11-01 日商東麗股份有限公司 Tetrahydroquinoline derivatives and medical use thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5017584A (en) * 1984-12-20 1991-05-21 Sterling Drug Inc. Antidepressant 2-(4,5-dihydro-1H-imidazolyl)-dihydro-1H-indoles, -1,2,3,4-tetrahydroquinolines and -1H-indoles, and methods of use thereas
US5461063A (en) * 1992-08-10 1995-10-24 Merck Sharp & Dohme Limited Azabicyclic compounds
WO1998027093A1 (en) * 1996-12-18 1998-06-25 Eli Lilly And Company Combinatorial process for preparing hydrofuroquinoline libraries
WO1998034111A1 (en) * 1997-02-04 1998-08-06 Trega Biosciences, Inc. Tricyclic tetrahydroquinoline derivatives and tricyclic tetrahydroquinoline combinatorial libraries
WO1998034115A1 (en) * 1997-02-04 1998-08-06 Trega Biosciences, Inc. 4-substituted-quinoline derivatives and 4-substitute-quinoline combinatorial libraries
WO2001058875A2 (en) * 2000-02-07 2001-08-16 Grünenthal GmbH Substituted 1,2,3,4- tetrahydroquinoline-2-carboxylic acid derivatives
WO2003015715A2 (en) * 2001-08-20 2003-02-27 Bristol-Myers Squibb Company Tetrahydroquinoline derivatives as antithrombotic agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4125270A1 (en) * 1991-07-31 1993-02-04 Bayer Ag QUINOLINE-2-YL-METHOXYBENZYLHYDROXYHARNSTOFFE
BR9610733A (en) * 1995-09-29 1999-07-13 Glaxo Wellcome Spa Compound processes for the preparation of it and for the treatment of a mammal pharmaceutical composition and use of a compound

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5017584A (en) * 1984-12-20 1991-05-21 Sterling Drug Inc. Antidepressant 2-(4,5-dihydro-1H-imidazolyl)-dihydro-1H-indoles, -1,2,3,4-tetrahydroquinolines and -1H-indoles, and methods of use thereas
US5461063A (en) * 1992-08-10 1995-10-24 Merck Sharp & Dohme Limited Azabicyclic compounds
WO1998027093A1 (en) * 1996-12-18 1998-06-25 Eli Lilly And Company Combinatorial process for preparing hydrofuroquinoline libraries
WO1998034111A1 (en) * 1997-02-04 1998-08-06 Trega Biosciences, Inc. Tricyclic tetrahydroquinoline derivatives and tricyclic tetrahydroquinoline combinatorial libraries
WO1998034115A1 (en) * 1997-02-04 1998-08-06 Trega Biosciences, Inc. 4-substituted-quinoline derivatives and 4-substitute-quinoline combinatorial libraries
WO2001058875A2 (en) * 2000-02-07 2001-08-16 Grünenthal GmbH Substituted 1,2,3,4- tetrahydroquinoline-2-carboxylic acid derivatives
WO2003015715A2 (en) * 2001-08-20 2003-02-27 Bristol-Myers Squibb Company Tetrahydroquinoline derivatives as antithrombotic agents

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HOEMANN, MICHAEL Z. ET AL: "Potent In vitro methicillin-resistant Staphylococcus aureus activity of 2-(1H-indol-3-yl)tetrahydroquinoline derivatives", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2002), 12(2), 129-132, XP002265033 *
KOBAYASHI S ET AL: "A CONVENIENT METHOD FOR LIBRARY CONSTRUCTION: PARALLEL SYNTHESIS OF BETA-AMINO ESTER AND QUINOLINE DERIVATIVES IN LIQUID PHASE USING LN(OTF)3-CATALYZED THREE-COMPONENT REACTIONS", BIOTECHNOLOGY AND BIOENGINEERING - COMBINATORIAL CHEMISTRY, WILEY, NEW YORK, NY, US, vol. 61, no. 1, 1998, pages 23 - 31, XP002145305, ISSN: 0006-3592 *
KOBAYASHI S ET AL: "LANTHANIDE TRIFLATE CATALYZED IMINO DIELS-ALDER REACTIONS;CONVENIENT SYNTHESES OF PYRIDINE AND QUINOLINE DERIVATIVES", SYNTHESIS, GEORG THIEME VERLAG. STUTTGART, DE, vol. 9, September 1995 (1995-09-01), pages 1195 - 1202, XP002941298, ISSN: 0039-7881 *
LEARDINI, R.; ET AL., J. ORG. CHEM., vol. 57, 1992, pages 1842 - 1848, XP002274144 *

Also Published As

Publication number Publication date
DE10236910A1 (en) 2004-03-11
WO2004022542A2 (en) 2004-03-18
AU2003258598A1 (en) 2004-03-29

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