WO2004020595A3 - Novel human polypeptides encoded by polynucleotides - Google Patents

Novel human polypeptides encoded by polynucleotides Download PDF

Info

Publication number
WO2004020595A3
WO2004020595A3 PCT/US2003/027107 US0327107W WO2004020595A3 WO 2004020595 A3 WO2004020595 A3 WO 2004020595A3 US 0327107 W US0327107 W US 0327107W WO 2004020595 A3 WO2004020595 A3 WO 2004020595A3
Authority
WO
WIPO (PCT)
Prior art keywords
polynucleotides
polypeptides encoded
novel human
human polypeptides
modulators
Prior art date
Application number
PCT/US2003/027107
Other languages
French (fr)
Other versions
WO2004020595A8 (en
WO2004020595A2 (en
Inventor
Lewis T Williams
Keting Chu
Ernestine Lee
Kevin Hestir
Original Assignee
Five Prime Therapeutics Inc
Riken The Inst Of Physical And
Dnaform Kk
Williams Lews T
Keting Chu
Ernestine Lee
Kevin Hestir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Five Prime Therapeutics Inc, Riken The Inst Of Physical And, Dnaform Kk, Williams Lews T, Keting Chu, Ernestine Lee, Kevin Hestir filed Critical Five Prime Therapeutics Inc
Priority to AU2003274935A priority Critical patent/AU2003274935A1/en
Publication of WO2004020595A2 publication Critical patent/WO2004020595A2/en
Publication of WO2004020595A8 publication Critical patent/WO2004020595A8/en
Publication of WO2004020595A3 publication Critical patent/WO2004020595A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention provides novel polynucleotides, related polypeptides, related nucleic acid and polypeptide compositions, and related modulators, such as antibodies and small molecule modulators. The compositions of the invention are useful' in treating proliferative disorders, e.g., cancers, and inflammatory, immune, bacterial, and viral disorders.
PCT/US2003/027107 2002-08-29 2003-08-28 Novel human polypeptides encoded by polynucleotides WO2004020595A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003274935A AU2003274935A1 (en) 2002-08-29 2003-08-28 Novel human polypeptides encoded by polynucleotides

Applications Claiming Priority (68)

Application Number Priority Date Filing Date Title
US40665502P 2002-08-29 2002-08-29
US40666602P 2002-08-29 2002-08-29
US40661602P 2002-08-29 2002-08-29
US40657602P 2002-08-29 2002-08-29
US40661202P 2002-08-29 2002-08-29
US40664002P 2002-08-29 2002-08-29
US40661102P 2002-08-29 2002-08-29
US60/406,655 2002-08-29
US60/406,576 2002-08-29
US60/406,616 2002-08-29
US60/406,666 2002-08-29
US60/406,640 2002-08-29
US60/406,611 2002-08-29
US60/406,612 2002-08-29
US41105202P 2002-09-17 2002-09-17
US41095102P 2002-09-17 2002-09-17
US41102402P 2002-09-17 2002-09-17
US41108202P 2002-09-17 2002-09-17
US41102202P 2002-09-17 2002-09-17
US41096002P 2002-09-17 2002-09-17
US41095702P 2002-09-17 2002-09-17
US41095302P 2002-09-17 2002-09-17
US41111102P 2002-09-17 2002-09-17
US41094602P 2002-09-17 2002-09-17
US41096202P 2002-09-17 2002-09-17
US41104602P 2002-09-17 2002-09-17
US41101902P 2002-09-17 2002-09-17
US41103702P 2002-09-17 2002-09-17
US60/411,111 2002-09-17
US60/410,951 2002-09-17
US60/410,946 2002-09-17
US60/411,024 2002-09-17
US60/410,960 2002-09-17
US60/411,046 2002-09-17
US60/410,953 2002-09-17
US60/411,022 2002-09-17
US60/411,082 2002-09-17
US60/411,019 2002-09-17
US60/410,962 2002-09-17
US60/410,957 2002-09-17
US60/411,052 2002-09-17
US60/411,037 2002-09-17
US46373203P 2003-04-18 2003-04-18
US46370003P 2003-04-18 2003-04-18
US60/463,732 2003-04-18
US60/463,700 2003-04-18
US46723003P 2003-05-02 2003-05-02
US46720303P 2003-05-02 2003-05-02
US60/467,203 2003-05-02
US60/467,230 2003-05-02
US47130603P 2003-05-19 2003-05-19
US60,471,306 2003-05-19
US47242003P 2003-05-22 2003-05-22
US60/472,420 2003-05-22
US47660903P 2003-06-09 2003-06-09
US60/476,609 2003-06-09
US48532503P 2003-07-08 2003-07-08
US48522303P 2003-07-08 2003-07-08
US60/485,223 2003-07-08
US60/485,325 2003-07-08
US48648003P 2003-07-14 2003-07-14
US60/486,480 2003-07-14
US48696003P 2003-07-15 2003-07-15
US60/486,960 2003-07-15
US49357303P 2003-08-08 2003-08-08
US49337003P 2003-08-08 2003-08-08
US60/493,370 2003-08-08
US60/493,573 2003-08-08

Publications (3)

Publication Number Publication Date
WO2004020595A2 WO2004020595A2 (en) 2004-03-11
WO2004020595A8 WO2004020595A8 (en) 2004-07-15
WO2004020595A3 true WO2004020595A3 (en) 2006-05-04

Family

ID=32686486

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/027107 WO2004020595A2 (en) 2002-08-29 2003-08-28 Novel human polypeptides encoded by polynucleotides

Country Status (1)

Country Link
WO (1) WO2004020595A2 (en)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101520209B1 (en) 2003-11-06 2015-05-13 시애틀 지네틱스, 인크. Monomethylvaline compounds capable of conjugation to ligands
BRPI0510883B8 (en) 2004-06-01 2021-05-25 Genentech Inc drug-antibody conjugate compound, pharmaceutical composition, method of manufacturing a drug-antibody conjugate compound, and uses of a formulation, a drug-antibody conjugate and a chemotherapeutic agent, and a combination
ES2579805T3 (en) 2004-09-23 2016-08-16 Genentech, Inc. Antibodies and conjugates engineered with cysteine
US20100111856A1 (en) 2004-09-23 2010-05-06 Herman Gill Zirconium-radiolabeled, cysteine engineered antibody conjugates
CA2650267A1 (en) * 2006-05-05 2007-11-15 Universiteit Maastricht / Carim Peptides for use in diagnosing the presence of ruptured atherosclerotic lesions in an individual
EP2414836B1 (en) * 2009-03-30 2014-05-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Biomarkers, methods and kits for the diagnosis of rheumatoid arthritis
CA2809819A1 (en) 2009-09-09 2011-03-17 Centrose, Llc Extracellular targeted drug conjugates
ES2430567T3 (en) 2010-04-15 2013-11-21 Spirogen Sàrl Pyrrolobenzodiazepines and conjugates thereof
EP2579897A1 (en) 2010-06-08 2013-04-17 Genentech, Inc. Cysteine engineered antibodies and conjugates
JP5889912B2 (en) 2010-11-17 2016-03-22 ジェネンテック， インコーポレイテッド Alaninyl maytansinol antibody conjugate
US8679767B2 (en) 2011-05-12 2014-03-25 Genentech, Inc. Multiple reaction monitoring LC-MS/MS method to detect therapeutic antibodies in animal samples using framework signature peptides
PT2750713E (en) 2011-10-14 2016-01-20 Genentech Inc Pyrrolobenzodiazepines and conjugates thereof
WO2013130093A1 (en) 2012-03-02 2013-09-06 Genentech, Inc. Biomarkers for treatment with anti-tubulin chemotherapeutic compounds
AU2013328623B8 (en) 2012-10-12 2017-06-15 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
ES2680153T3 (en) 2012-10-12 2018-09-04 Adc Therapeutics Sa Anti-PSMA-pyrrolobenzodiazepine antibody conjugates
NZ707543A (en) 2012-10-12 2018-09-28 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
SI2906253T1 (en) 2012-10-12 2018-11-30 Adc Therapeutics Sa Pyrrolobenzodiazepine - anti-psma antibody conjugates
ES2649990T3 (en) 2012-10-12 2018-01-16 Medimmune Limited Anti-CD22-pyrrolobenzodiazepine antibody conjugates
ES2530968T3 (en) 2012-10-12 2015-03-09 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
US10695433B2 (en) 2012-10-12 2020-06-30 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
CA2894961C (en) 2012-12-21 2020-09-15 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
US9567340B2 (en) 2012-12-21 2017-02-14 Medimmune Limited Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases
CN105209077B (en) 2013-03-13 2019-06-11 麦迪穆有限责任公司 Pyrrolobenzodiazepines Zhuo and its conjugate
CA2901941C (en) 2013-03-13 2020-04-07 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
AU2014229529B2 (en) 2013-03-13 2018-02-15 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
EP3033111B1 (en) 2013-08-12 2019-03-13 Genentech, Inc. 1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment
WO2015052534A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
WO2015052532A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
WO2015052535A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
CN107106700B (en) 2013-12-16 2020-10-30 基因泰克公司 Peptidomimetic compounds and antibody-drug conjugates thereof
MX2016007578A (en) 2013-12-16 2016-10-03 Genentech Inc 1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment.
RU2689388C1 (en) 2013-12-16 2019-05-28 Дженентек, Инк. Peptidomimetic compounds and their conjugates of antibodies with drugs
CN106687141A (en) 2014-09-10 2017-05-17 麦迪穆有限责任公司 Pyrrolobenzodiazepines and conjugates thereof
CN106714844B (en) 2014-09-12 2022-08-05 基因泰克公司 Anthracycline disulfide intermediates, antibody-drug conjugates and methods
AR101844A1 (en) 2014-09-12 2017-01-18 Genentech Inc ANTIBODIES AND GENETICALLY MODIFIED CONJUGATES WITH CYSTEINE
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
EP3194400A1 (en) 2014-09-17 2017-07-26 Genentech, Inc. Pyrrolobenzodiazepines and antibody disulfide conjugates thereof
CA2968447A1 (en) 2014-11-25 2016-06-02 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates and their use to treat neoplasms
WO2016090050A1 (en) 2014-12-03 2016-06-09 Genentech, Inc. Quaternary amine compounds and antibody-drug conjugates thereof
GB201506402D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
MA43345A (en) 2015-10-02 2018-08-08 Hoffmann La Roche PYRROLOBENZODIAZEPINE ANTIBODY-DRUG CONJUGATES AND METHODS OF USE
MA43354A (en) 2015-10-16 2018-08-22 Genentech Inc CONJUGATE DRUG CONJUGATES WITH CLOUDY DISULPHIDE
MA45326A (en) 2015-10-20 2018-08-29 Genentech Inc CALICHEAMICIN-ANTIBODY-DRUG CONJUGATES AND METHODS OF USE
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
EP4273551A3 (en) 2016-03-25 2024-01-17 F. Hoffmann-La Roche AG Multiplexed total antibody and antibody-conjugated drug quantification assay
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
WO2017201449A1 (en) 2016-05-20 2017-11-23 Genentech, Inc. Protac antibody conjugates and methods of use
JP7022080B2 (en) 2016-05-27 2022-02-17 ジェネンテック， インコーポレイテッド Biochemical analytical methods for the characterization of site-specific antibody-drug conjugates
JP7043425B2 (en) 2016-06-06 2022-03-29 ジェネンテック， インコーポレイテッド Silvestrol Antibodies-Drug Conjugates and Usage
JP7093767B2 (en) 2016-08-11 2022-06-30 ジェネンテック， インコーポレイテッド Pyrrolobenzodiazepine prodrug and its antibody conjugate
JP7050770B2 (en) 2016-10-05 2022-04-08 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Method for preparing antibody drug conjugate
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
AU2018217926B2 (en) 2017-02-08 2019-10-03 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
JP2020517609A (en) 2017-04-18 2020-06-18 メディミューン リミテッド Pyrrolobenzodiazepine complex
EP3612234B1 (en) 2017-04-20 2024-03-13 ADC Therapeutics SA Combination therapy with an anti-axl antibody-drug conjugate
US11318211B2 (en) 2017-06-14 2022-05-03 Adc Therapeutics Sa Dosage regimes for the administration of an anti-CD19 ADC
SI3668874T1 (en) 2017-08-18 2022-04-29 Medimmune Limited Pyrrolobenzodiazepine conjugates
US20200216463A1 (en) 2017-09-20 2020-07-09 Ph Pharma Co., Ltd. Thailanstatin analogs
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
GB201814281D0 (en) 2018-09-03 2018-10-17 Femtogenix Ltd Cytotoxic agents
WO2020086858A1 (en) 2018-10-24 2020-04-30 Genentech, Inc. Conjugated chemical inducers of degradation and methods of use
CN113227119A (en) 2018-12-10 2021-08-06 基因泰克公司 Photocrosslinked peptides for site-specific conjugation to Fc-containing proteins
KR102351041B1 (en) * 2018-12-19 2022-01-13 한국화학연구원 Cell penetrating Domain derived from human LRRC24 protein
GB201901197D0 (en) 2019-01-29 2019-03-20 Femtogenix Ltd G-A Crosslinking cytotoxic agents
CN111259667A (en) * 2020-01-16 2020-06-09 上海国民集团健康科技有限公司 Chinese medicine word segmentation algorithm
GB2597532A (en) 2020-07-28 2022-02-02 Femtogenix Ltd Cytotoxic compounds
WO2024138128A2 (en) 2022-12-23 2024-06-27 Genentech, Inc. Cereblon degrader conjugates, and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6365344B1 (en) * 1996-01-23 2002-04-02 The Board Of Trustees Of The Leland Stanford Junior University Methods for screening for transdominant effector peptides and RNA molecules
US6426186B1 (en) * 2000-01-18 2002-07-30 Incyte Genomics, Inc Bone remodeling genes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6365344B1 (en) * 1996-01-23 2002-04-02 The Board Of Trustees Of The Leland Stanford Junior University Methods for screening for transdominant effector peptides and RNA molecules
US6426186B1 (en) * 2000-01-18 2002-07-30 Incyte Genomics, Inc Bone remodeling genes

Also Published As

Publication number Publication date
WO2004020595A8 (en) 2004-07-15
WO2004020595A2 (en) 2004-03-11

Similar Documents

Publication Publication Date Title
WO2004020595A3 (en) Novel human polypeptides encoded by polynucleotides
WO2004035732A3 (en) Human polypeptides encoded by polynucleotides and methods of their use
IL161016A (en) Polypeptides capable of binding to ang-2
WO2002024909A3 (en) Receptor nucleic acids and polypeptides
EP1005540A4 (en) Ikk-beta proteins, nucleic acids and methods
HK1120556A1 (en) Neurotrophic factors
WO2003020932A1 (en) Novel secretory proteins and dna thereof
WO2003018758A3 (en) Reagents and methods for smooth muscle therapies
WO2004093804A3 (en) Human polypeptides encoded by polynucleotides and methods of their use
WO2007087053A3 (en) Bmp-7 variant compositions, methods and uses
WO2004087874A3 (en) Novel nucleic acids and polypeptides
WO2004099388A3 (en) Cbl-b polypeptides, complexes and related methods
MXPA03006218A (en) Type 2 ctokine receptor and nucleic acids encoding same.
WO2005085280A3 (en) HUMAN cDNA CLONES COMPRISING POLYNUCLEOTIDES ENCODING POLYPEPTIDES AND METHODS OF THEIR USE
WO2004094651A3 (en) Novel human polypeptides encoded by polynucleotides
WO2004020591A3 (en) Methods of use for novel human polypeptides encoded by polynucleotides
WO2004038003A3 (en) Human polypeptides encoded by polynucleotides and methods of their use
WO2005037236A3 (en) Novel heat shock protein 20-related polypeptides and uses therefor
WO2003055980A3 (en) Il-17 like molecules and uses thereof
WO2004039952A8 (en) Methods of use for novel human polypeptides encoded by polynucleotides
WO2004039319A3 (en) Novel human polypeptides encoded by polynucleotides
WO2004046310A3 (en) Novel mouse polypeptides encoded by polynucleotides and methods of their use
WO2004078130A3 (en) Posh interacting proteins and related methods
WO2004089302A3 (en) Posh polypeptides, complexes and related methods
WO2002072632A3 (en) Nucleic acids of the human abcc11 gene, vectors containing such nucleic acids and uses thereof.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i

Free format text: IN PCT GAZETTE 11/2004 UNDER (30) ADD "60/463,732 18 APRIL 2003 (18.04.2003) US; 60/463,700 18 APRIL 2003 (18.04.2003) US; 60/467,230 02 MAY 2003 (02.05.2003) US; 60/467,203 02 MAY 2003 (02.05.2003) US; 60/471,306 19 MAY 2003 (19.05.2003) US; 60/472,420 22 MAY 2003 (22.05.2003) US; 60/476,609 09 JUNE 2003 (09.06.2003) US; 60/485,223 08 JULY 2003 (08.07.2003) US; 60/485,325 08 JULY 2003 (08.07.2003) US; 60/486,480 14 JULY 203 (14.07.2003) US; 60/486,960 15 JULY 2003 (15.07.2003) US; 60/493,573 08 AUGUST 2003 (08.08.2003) US; 60/493,370 08 AUGUST 2003 (08.08.2003) US"

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP