WO2004013340A3 - Process for the production of l-lysine using coryneform bacteria - Google Patents

Process for the production of l-lysine using coryneform bacteria Download PDF

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Publication number
WO2004013340A3
WO2004013340A3 PCT/EP2003/007475 EP0307475W WO2004013340A3 WO 2004013340 A3 WO2004013340 A3 WO 2004013340A3 EP 0307475 W EP0307475 W EP 0307475W WO 2004013340 A3 WO2004013340 A3 WO 2004013340A3
Authority
WO
WIPO (PCT)
Prior art keywords
lysine
bacteria
production
coryneform bacteria
optionally
Prior art date
Application number
PCT/EP2003/007475
Other languages
French (fr)
Other versions
WO2004013340A2 (en
Inventor
Brigitte Bathe
Caroline Reynen
Walter Pfefferle
Original Assignee
Degussa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa filed Critical Degussa
Priority to MXPA05001106A priority Critical patent/MXPA05001106A/en
Priority to AU2003250933A priority patent/AU2003250933A1/en
Priority to EP03766148A priority patent/EP1525322A2/en
Publication of WO2004013340A2 publication Critical patent/WO2004013340A2/en
Publication of WO2004013340A3 publication Critical patent/WO2004013340A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/12—Animal feeding-stuffs obtained by microbiological or biochemical processes by fermentation of natural products, e.g. of vegetable material, animal waste material or biomass
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Husbandry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Sustainable Development (AREA)
  • Physiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Fodder In General (AREA)

Abstract

The invention relates to a process for the production of L-lysine, in which the following steps are carried out a) fermentation of the L-lysine producing coryneform bacteria that are at least sensitive to diaminopimelic acid analogues, in particular 4-hydroxydiaminopimelic acid; b) enrichment of the L-lysine in the medium or in the bacterial cells; and optionally c) isolation of the L-lysine or L-lysine-containing feedstuffs additive from the fermentation broth, so that ≥ 0 to 100% of the constituents from the fermentation broth and/or from the biomass are present, and optionally bacteria are used in which in addition further genes of the biosynthesis pathway of L-lysine are enhanced, or bacteria are used in which the metabolic pathways that reduce the formation of L-lysine are at least partially switched off.
PCT/EP2003/007475 2002-07-31 2003-07-10 Process for the production of l-lysine using coryneform bacteria WO2004013340A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
MXPA05001106A MXPA05001106A (en) 2002-07-31 2003-07-10 Process for the production of l-lysine using coryneform bacteria.
AU2003250933A AU2003250933A1 (en) 2002-07-31 2003-07-10 Process for the production of l-lysine using coryneform bacteria
EP03766148A EP1525322A2 (en) 2002-07-31 2003-07-10 Process for the production of l-lysine using coryneform bacteria

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10235029.9 2002-07-31
DE10235029A DE10235029A1 (en) 2002-07-31 2002-07-31 Process for the production of L-lysine using coryneform bacteria

Publications (2)

Publication Number Publication Date
WO2004013340A2 WO2004013340A2 (en) 2004-02-12
WO2004013340A3 true WO2004013340A3 (en) 2004-03-25

Family

ID=30469287

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/007475 WO2004013340A2 (en) 2002-07-31 2003-07-10 Process for the production of l-lysine using coryneform bacteria

Country Status (8)

Country Link
EP (1) EP1525322A2 (en)
KR (1) KR20050026037A (en)
CN (1) CN1671853A (en)
AU (1) AU2003250933A1 (en)
DE (1) DE10235029A1 (en)
MX (1) MXPA05001106A (en)
PL (1) PL374942A1 (en)
WO (1) WO2004013340A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0510319A2 (en) * 1991-04-25 1992-10-28 Degussa Aktiengesellschaft Process for increasing the performance of L-lysine secreting coryneform microorganisms

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0510319A2 (en) * 1991-04-25 1992-10-28 Degussa Aktiengesellschaft Process for increasing the performance of L-lysine secreting coryneform microorganisms

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
COMPTES RENDUS DES SEANCES DE L'ACADEMIE DES SCIENCES, SERIE D: SCIENCES NATURELLES (1973), 277(13), 1245-8 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; COUDERT, MICHELE ET AL: "Obtainment of regulation mutants for the lysine biosynthetic pathway in a Corynebacterium strain resistant to lysine analogs", XP002267565, retrieved from STN Database accession no. 80:105697 *
SAHM H ET AL: "CONSTRUCTION OF L-LYSINE, L-THREONINE-, OR L-ISOLEUCINE-OVERPRODUCING STRAINS OF CORYNEBACTERIUM GLUTAMICUM", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, NEW YORK ACADEMY OF SCIENCES, NEW YORK, NY, US, vol. 782, 1996, pages 25 - 39, XP000943151, ISSN: 0077-8923 *
SIMMONDS D H: "ANALOGS OF DIAMINOPIMELIC ACID AS INHIBITORS OF BACTERIAL GRWOTH", BIOCHEMICAL JOURNAL, PORTLAND PRESS, LONDON, GB, vol. 58, 1954, pages 520 - 523, XP008025012, ISSN: 0264-6021 *

Also Published As

Publication number Publication date
MXPA05001106A (en) 2005-04-28
KR20050026037A (en) 2005-03-14
AU2003250933A8 (en) 2004-02-23
AU2003250933A1 (en) 2004-02-23
WO2004013340A2 (en) 2004-02-12
DE10235029A1 (en) 2004-02-19
CN1671853A (en) 2005-09-21
EP1525322A2 (en) 2005-04-27
PL374942A1 (en) 2005-11-14

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