WO2004010942A3 - Substituted heterocyclic compounds as modulators of the ccr5 receptor - Google Patents
Substituted heterocyclic compounds as modulators of the ccr5 receptor Download PDFInfo
- Publication number
- WO2004010942A3 WO2004010942A3 PCT/US2003/023523 US0323523W WO2004010942A3 WO 2004010942 A3 WO2004010942 A3 WO 2004010942A3 US 0323523 W US0323523 W US 0323523W WO 2004010942 A3 WO2004010942 A3 WO 2004010942A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ccr5
- receptor
- modulators
- substituted heterocyclic
- heterocyclic compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003256922A AU2003256922A1 (en) | 2002-07-31 | 2003-07-28 | Substituted heterocyclic compounds as modulators of the ccr5 receptor |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40025602P | 2002-07-31 | 2002-07-31 | |
US60/400,256 | 2002-07-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004010942A2 WO2004010942A2 (en) | 2004-02-05 |
WO2004010942A3 true WO2004010942A3 (en) | 2004-07-08 |
Family
ID=31188673
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/023523 WO2004010942A2 (en) | 2002-07-31 | 2003-07-28 | Substituted heterocyclic compounds as modulators of the ccr5 receptor |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU2003256922A1 (en) |
WO (1) | WO2004010942A2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8889690B2 (en) | 2007-04-27 | 2014-11-18 | Purdue Pharma L.P. | TRPV1 antagonists including dihydroxy substituent and uses thereof |
US9273043B2 (en) | 2011-06-22 | 2016-03-01 | Purdue Pharma L.P. | TRPV1 antagonists including dihydroxy substituent and uses thereof |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7479496B2 (en) | 2004-02-19 | 2009-01-20 | Bristol-Myers Squibb Company | Substituted spiro azabicyclics as modulators of chemokine receptor activity |
US7230022B2 (en) | 2004-02-19 | 2007-06-12 | Bristol-Myers Squibb Company | Substituted fused bicyclic amines as modulators of chemokine receptor activity |
US7288563B2 (en) | 2004-02-19 | 2007-10-30 | Bristol-Myers Squibb Company | Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity |
US7381738B2 (en) | 2004-02-19 | 2008-06-03 | Bristol-Myers Squibb Company | Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity |
JP2008501031A (en) | 2004-05-28 | 2008-01-17 | バーテックス ファーマシューティカルズ インコーポレイテッド | Muscarinic receptor modulators |
JP2008510728A (en) | 2004-08-19 | 2008-04-10 | バーテックス ファーマシューティカルズ インコーポレイテッド | Muscarinic receptor modulators |
US7786141B2 (en) | 2004-08-19 | 2010-08-31 | Vertex Pharmaceuticals Incorporated | Dihydrospiroindene modulators of muscarinic receptors |
WO2006058303A2 (en) | 2004-11-29 | 2006-06-01 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
KR20080094964A (en) | 2006-02-22 | 2008-10-27 | 버텍스 파마슈티칼스 인코포레이티드 | Modulators of muscarinic receptors |
JP2009542670A (en) | 2006-06-29 | 2009-12-03 | バーテックス ファーマシューティカルズ インコーポレイテッド | Modulator of muscarinic receptor |
AU2011261375B2 (en) | 2010-06-04 | 2016-09-22 | Albany Molecular Research, Inc. | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
US8980924B2 (en) | 2010-11-24 | 2015-03-17 | The Trustees Of Columbia University In The City Of New York | Non-retinoid RBP4 antagonist for treatment of age-related macular degeneration and stargardt disease |
US9333202B2 (en) | 2012-05-01 | 2016-05-10 | The Trustees Of Columbia University In The City Of New York | Non-retinoid antagonists for treatment of age-related macular degeneration and stargardt disease |
AU2013277154A1 (en) | 2012-06-20 | 2014-12-18 | Jonathan E. Grob | Complement pathway modulators and uses thereof |
US9944644B2 (en) | 2013-03-14 | 2018-04-17 | The Trustees Of Columbia University In The City Of New York | Octahydropyrrolopyrroles their preparation and use |
US10273243B2 (en) | 2013-03-14 | 2019-04-30 | The Trustees Of Columbia University In The City Of New York | 4-phenylpiperidines, their preparation and use |
ES2700541T3 (en) | 2013-03-14 | 2019-02-18 | Univ Columbia | Octahidrociclopentapirroles, its preparation and use |
US9938291B2 (en) | 2013-03-14 | 2018-04-10 | The Trustess Of Columbia University In The City Of New York | N-alkyl-2-phenoxyethanamines, their preparation and use |
WO2015168286A1 (en) | 2014-04-30 | 2015-11-05 | The Trustees Of Columbia University In The City Of New York | Substituted 4-phenylpiperidines, their preparaiton and use |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002005819A1 (en) * | 2000-07-15 | 2002-01-24 | Smithkline Beecham Corporation | Compounds and methods |
WO2002016351A1 (en) * | 2000-08-18 | 2002-02-28 | Cor Therapeutics, Inc. | Quinazoline derivatives as kinase inhibitors |
-
2003
- 2003-07-28 WO PCT/US2003/023523 patent/WO2004010942A2/en not_active Application Discontinuation
- 2003-07-28 AU AU2003256922A patent/AU2003256922A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002005819A1 (en) * | 2000-07-15 | 2002-01-24 | Smithkline Beecham Corporation | Compounds and methods |
WO2002016351A1 (en) * | 2000-08-18 | 2002-02-28 | Cor Therapeutics, Inc. | Quinazoline derivatives as kinase inhibitors |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8889690B2 (en) | 2007-04-27 | 2014-11-18 | Purdue Pharma L.P. | TRPV1 antagonists including dihydroxy substituent and uses thereof |
US9365563B2 (en) | 2007-04-27 | 2016-06-14 | Purdue Pharma L.P. | TRPV1 antagonists including dihydroxy substituent and uses thereof |
US9273043B2 (en) | 2011-06-22 | 2016-03-01 | Purdue Pharma L.P. | TRPV1 antagonists including dihydroxy substituent and uses thereof |
Also Published As
Publication number | Publication date |
---|---|
WO2004010942A2 (en) | 2004-02-05 |
AU2003256922A1 (en) | 2004-02-16 |
AU2003256922A8 (en) | 2004-02-16 |
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