WO2004000094A3 - Predictive markers in cancer therapy - Google Patents

Predictive markers in cancer therapy Download PDF

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Publication number
WO2004000094A3
WO2004000094A3 PCT/US2003/012739 US0312739W WO2004000094A3 WO 2004000094 A3 WO2004000094 A3 WO 2004000094A3 US 0312739 W US0312739 W US 0312739W WO 2004000094 A3 WO2004000094 A3 WO 2004000094A3
Authority
WO
WIPO (PCT)
Prior art keywords
cancer therapy
predictive markers
markers
egf
responding
Prior art date
Application number
PCT/US2003/012739
Other languages
French (fr)
Other versions
WO2004000094A2 (en
WO2004000094A8 (en
Inventor
Sarah S Bacus
Myra R Herrle
L Edward Kirk
Neil L Spector
Michael T Stocum
Wenle Xia
Original Assignee
Smithkline Beecham Corp
Sarah S Bacus
Myra R Herrle
L Edward Kirk
Neil L Spector
Michael T Stocum
Wenle Xia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp, Sarah S Bacus, Myra R Herrle, L Edward Kirk, Neil L Spector, Michael T Stocum, Wenle Xia filed Critical Smithkline Beecham Corp
Priority to EP03724213A priority Critical patent/EP1810034A4/en
Priority to AU2003235470A priority patent/AU2003235470A1/en
Priority to US10/529,922 priority patent/US20060094068A1/en
Publication of WO2004000094A2 publication Critical patent/WO2004000094A2/en
Publication of WO2004000094A8 publication Critical patent/WO2004000094A8/en
Publication of WO2004000094A3 publication Critical patent/WO2004000094A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases

Abstract

Molecular markers useful in medicine response tests are provided, as an aid in determining whether an individual subject s tumor is responding to treatment with EGF and/or erbB2 inhibitors. Markers include phosphorylated ERK protein.
PCT/US2003/012739 2002-06-19 2003-04-24 Predictive markers in cancer therapy WO2004000094A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP03724213A EP1810034A4 (en) 2002-06-19 2003-04-24 Predictive markers in cancer therapy
AU2003235470A AU2003235470A1 (en) 2002-06-19 2003-04-24 Predictive markers in cancer therapy
US10/529,922 US20060094068A1 (en) 2002-06-19 2003-04-24 Predictive markers in cancer therapy

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US38979502P 2002-06-19 2002-06-19
US60/389,795 2002-06-19
US43281102P 2002-12-11 2002-12-11
US43294302P 2002-12-11 2002-12-11
US60/432,943 2002-12-11
US60/432,811 2002-12-11
US45197803P 2003-03-05 2003-03-05
US60/451,978 2003-03-05

Publications (3)

Publication Number Publication Date
WO2004000094A2 WO2004000094A2 (en) 2003-12-31
WO2004000094A8 WO2004000094A8 (en) 2007-04-12
WO2004000094A3 true WO2004000094A3 (en) 2007-06-14

Family

ID=30003983

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/012739 WO2004000094A2 (en) 2002-06-19 2003-04-24 Predictive markers in cancer therapy

Country Status (4)

Country Link
US (1) US20060094068A1 (en)
EP (1) EP1810034A4 (en)
AU (1) AU2003235470A1 (en)
WO (1) WO2004000094A2 (en)

Families Citing this family (33)

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Publication number Priority date Publication date Assignee Title
EP3115470B1 (en) 2002-03-13 2018-07-18 Genomic Health, Inc. Gene expression profiling in biopsied tumor tissues
US20040248151A1 (en) * 2002-04-05 2004-12-09 Ventana Medical Systems, Inc. Method for predicting the response to HER2-directed therapy
US20090111127A1 (en) * 2002-05-21 2009-04-30 Monogram Biosciences Inc. Surface Receptor Complexes as Biomarkers
JP4606879B2 (en) 2002-11-15 2011-01-05 ジェノミック ヘルス， インコーポレイテッド Gene expression profiling of EGFR positive cancer
WO2005011607A2 (en) * 2003-08-01 2005-02-10 Smithkline Beecham Corporation Treatment of cancers expressing p95 erbb2
EP1664716A4 (en) * 2003-08-15 2008-08-13 Smithkline Beecham Corp Biomarkers in cancer
WO2005094332A2 (en) * 2004-03-26 2005-10-13 Bristol-Myers Squibb Company Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators in non-small cell lung cancer
AU2005251722B2 (en) * 2004-06-03 2009-11-12 Smithkline Beecham (Cork) Limited Cancer treatment method
WO2005121380A1 (en) * 2004-06-04 2005-12-22 Smithkline Beecham Corporation Predictive biomarkers in cancer therapy
WO2006045991A1 (en) * 2004-10-25 2006-05-04 Astrazeneca Ab Method to predict whether a tumor will react to a chemotherapeutic treatment
US20060127935A1 (en) * 2004-12-15 2006-06-15 Nsabp Foundation, Inc. Identification and use of prognostic and predictive markers in cancer treatment
US7449184B2 (en) 2005-01-21 2008-11-11 Genentech, Inc. Fixed dosing of HER antibodies
PT1850874E (en) 2005-02-23 2013-12-02 Genentech Inc Extending time to disease progression or survival in ovarian cancer patients using pertuzumab
TW200716204A (en) 2005-04-19 2007-05-01 Smithkline Beecham Cork Ltd Pharmaceutical composition
US20060246536A1 (en) * 2005-04-29 2006-11-02 Margaret Hardy Xenograft tissue control for histology
AU2007248424B2 (en) 2006-05-05 2013-04-18 Historx, Inc. Immunohistochemical methods for determining signal transduction activity in tumors
US20080050757A1 (en) * 2006-08-23 2008-02-28 Sarah Bacus Rapid method for detecting mutated genes
DK2081950T3 (en) * 2006-09-21 2013-06-03 Nuclea Biomarkers Llc Expression profiles associated with irinotecan treatment
CA2675370A1 (en) * 2007-01-18 2008-07-24 University Of Southern California Gene polymorphisms as sex-specific predictors in cancer therapy
WO2008088861A2 (en) * 2007-01-18 2008-07-24 University Of Southern California Gene polymorphisms predictive for dual tki therapy
PE20090681A1 (en) 2007-03-02 2009-06-10 Genentech Inc PREDICTION OF RESPONSE TO A HER INHIBITOR
CA2690334C (en) 2007-06-08 2017-02-14 Genentech, Inc. Gene expression markers of tumor resistance to her2 inhibitor treatment
US9551033B2 (en) 2007-06-08 2017-01-24 Genentech, Inc. Gene expression markers of tumor resistance to HER2 inhibitor treatment
BRPI0812682A2 (en) 2008-06-16 2010-06-22 Genentech Inc metastatic breast cancer treatment
WO2010091198A1 (en) 2009-02-06 2010-08-12 University Of Southern California Therapeutic compositions comprising monoterpenes
US8568968B2 (en) * 2009-04-13 2013-10-29 University Of Southern California EGFR polymorphisms predict gender-related treatment
JP5705836B2 (en) 2009-05-29 2015-04-22 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Modulators for HER2 signaling in gastric cancer patients expressing HER2
EP2438443A4 (en) * 2009-06-02 2012-07-25 Targeted Molecular Diagnostics Llc Methods for the detection and quantitation of the p95 component of her2/neu (erbb2)
WO2011146568A1 (en) 2010-05-19 2011-11-24 Genentech, Inc. Predicting response to a her inhibitor
US9376715B2 (en) 2011-12-09 2016-06-28 Roche Molecular Systems, Inc Methods for detecting mutations in the catalytic subunit of the phosphoinositol-3 kinase (PIK3CA) gene
US8809026B2 (en) 2011-12-27 2014-08-19 Commonwealth Scientific And Industrial Research Organisation Processes for producing lipids
BR112015012644A2 (en) 2012-11-30 2017-12-19 Hoffmann La Roche method for determining a cancer patient's need, cancer treatment method, pharmaceutical composition, use of a nucleic acid or antibody and kit;
CN107091930B (en) * 2017-03-07 2020-09-15 杭州百凌生物科技有限公司 Method for rapidly predicting and improving sensitivity of non-small cell lung cancer cells to epidermal growth factor receptor inhibitor

Citations (2)

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Publication number Priority date Publication date Assignee Title
US20050004008A1 (en) * 2002-03-01 2005-01-06 Frackelton A. Raymond SHC proteins as therapeutic targets in proliferative diseases
US20060040338A1 (en) * 2004-08-18 2006-02-23 Odyssey Thera, Inc. Pharmacological profiling of drugs with cell-based assays

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US7541141B2 (en) * 1997-02-27 2009-06-02 Wisconsin Alumni Research Foundation Method of using estrogen-related receptor alpha (ERRα) status to determine prognosis, treatment strategy and predisposition to breast cancer, and method of using ERRα as a therapeutic target for the treatment of breast cancer
US20040127470A1 (en) * 1998-12-23 2004-07-01 Pharmacia Corporation Methods and compositions for the prevention or treatment of neoplasia comprising a Cox-2 inhibitor in combination with an epidermal growth factor receptor antagonist
US20030124130A1 (en) * 2002-01-02 2003-07-03 Brown Robert E. Proteomic analysis of tumors for development of consultative report of therapeutic options

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050004008A1 (en) * 2002-03-01 2005-01-06 Frackelton A. Raymond SHC proteins as therapeutic targets in proliferative diseases
US20060040338A1 (en) * 2004-08-18 2006-02-23 Odyssey Thera, Inc. Pharmacological profiling of drugs with cell-based assays

Non-Patent Citations (3)

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Title
NG S.S.W. ET AL.: "Effects of the Epidermal Growth Factor Receptor Inhibitor OSI-774, Tarceva, on Downstream Signaling Pathways and Apoptosis in Human Pancreatic Adenocarcinoma", MOLECULAR CANCER THERAPEUTICS, vol. 1, August 2002 (2002-08-01), pages 777 - 783, XP009056210 *
See also references of EP1810034A4 *
SUAREZ C. ET AL.: "Angiotensin II phosphorylation of extracellular signal-regulated kinases in rat anterior pituitary cells", AMERICAN JOURNAL OF PHYSIOLOGICAL ENDOCRINOLOGICAL METABOLISM, vol. 285, May 2003 (2003-05-01), pages E645 - E653, XP003013757 *

Also Published As

Publication number Publication date
EP1810034A2 (en) 2007-07-25
US20060094068A1 (en) 2006-05-04
WO2004000094A2 (en) 2003-12-31
EP1810034A4 (en) 2008-06-25
AU2003235470A1 (en) 2004-01-06
WO2004000094A8 (en) 2007-04-12
AU2003235470A8 (en) 2004-01-06

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