WO2003100469A3 - Dispositif de detection biochimique interne - Google Patents

Dispositif de detection biochimique interne Download PDF

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Publication number
WO2003100469A3
WO2003100469A3 PCT/US2002/031447 US0231447W WO03100469A3 WO 2003100469 A3 WO2003100469 A3 WO 2003100469A3 US 0231447 W US0231447 W US 0231447W WO 03100469 A3 WO03100469 A3 WO 03100469A3
Authority
WO
WIPO (PCT)
Prior art keywords
biosensing
optical fiber
analytes
information analyzer
biosensing element
Prior art date
Application number
PCT/US2002/031447
Other languages
English (en)
Other versions
WO2003100469A2 (fr
WO2003100469A9 (fr
Inventor
Gerald E M D Loeb
Thomas George
Original Assignee
Alfred E Mann Inst Biomed Eng
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfred E Mann Inst Biomed Eng filed Critical Alfred E Mann Inst Biomed Eng
Priority to AU2002367906A priority Critical patent/AU2002367906A1/en
Priority to EP02807474A priority patent/EP1519678A2/fr
Publication of WO2003100469A2 publication Critical patent/WO2003100469A2/fr
Publication of WO2003100469A9 publication Critical patent/WO2003100469A9/fr
Publication of WO2003100469A3 publication Critical patent/WO2003100469A3/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6432—Quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N2021/7706—Reagent provision
    • G01N2021/772—Tip coated light guide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N2021/7706—Reagent provision
    • G01N2021/7723—Swelling part, also for adsorption sensor, i.e. without chemical reaction

Abstract

La présente invention concerne un dispositif de biodétection destiné à la détection d'analytes biologiques, et des procédés d'utilisation et de réalisation. Le dispositif comprend un élément de biodétection qui peut rester implanté pendant des durées importantes. L'élément de biodétection est connecté à une fibre optique qui se termine à l'extérieur du corps. La fibre optique est également connectée à un dispositif d'analyse informations. Le dispositif d'analyse informations émet de la lumière par la fibre optique vers l'élément de biodétection. La lumière excite des fluorophores résultant d'une réaction chimique entre des analytes et de la matière de biodétection à l'intérieur de l'élément de biodétection. La lumière fluorescente émise est redirigée par la fibre optique vers le dispositif d'analyse informations. Des réseaux optiques disposés dans l'élément filtrant du dispositif d'analyse informations, dévient de façon sélective les émissions fluorescentes vers une gaine. Des détecteurs fixés à la gaine détectent les émissions fluorescentes déviées et, en fonction de leur longueur d'onde déterminée, reportent la présence d'analytes spécifiques ou la quantité de ceux-ci, chez le patient, sur un affichage externe.
PCT/US2002/031447 2001-10-02 2002-10-02 Dispositif de detection biochimique interne WO2003100469A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002367906A AU2002367906A1 (en) 2001-10-02 2002-10-02 Internal biochemical sensing device
EP02807474A EP1519678A2 (fr) 2001-10-02 2002-10-02 Dispositif de detection biochimique interne

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32690801P 2001-10-02 2001-10-02
US60/326,908 2001-10-02

Publications (3)

Publication Number Publication Date
WO2003100469A2 WO2003100469A2 (fr) 2003-12-04
WO2003100469A9 WO2003100469A9 (fr) 2004-09-16
WO2003100469A3 true WO2003100469A3 (fr) 2004-11-11

Family

ID=29584239

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/031447 WO2003100469A2 (fr) 2001-10-02 2002-10-02 Dispositif de detection biochimique interne

Country Status (4)

Country Link
US (1) US7096053B2 (fr)
EP (1) EP1519678A2 (fr)
AU (1) AU2002367906A1 (fr)
WO (1) WO2003100469A2 (fr)

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EP1519678A2 (fr) 2005-04-06
US7096053B2 (en) 2006-08-22
US20030171666A1 (en) 2003-09-11
WO2003100469A9 (fr) 2004-09-16
AU2002367906A8 (en) 2003-12-12
AU2002367906A1 (en) 2003-12-12

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