WO2003097800A3 - Cancer-linked gene as target for chemotherapy - Google Patents

Cancer-linked gene as target for chemotherapy Download PDF

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Publication number
WO2003097800A3
WO2003097800A3 PCT/US2003/015282 US0315282W WO03097800A3 WO 2003097800 A3 WO2003097800 A3 WO 2003097800A3 US 0315282 W US0315282 W US 0315282W WO 03097800 A3 WO03097800 A3 WO 03097800A3
Authority
WO
WIPO (PCT)
Prior art keywords
cancer
target
disclosed
chemotherapy
linked gene
Prior art date
Application number
PCT/US2003/015282
Other languages
French (fr)
Other versions
WO2003097800A2 (en
Inventor
Zoe Weaver
Reinhard Ebner
Original Assignee
Avalon Pharmaceuticals
Zoe Weaver
Reinhard Ebner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avalon Pharmaceuticals, Zoe Weaver, Reinhard Ebner filed Critical Avalon Pharmaceuticals
Priority to AU2003241455A priority Critical patent/AU2003241455A1/en
Publication of WO2003097800A2 publication Critical patent/WO2003097800A2/en
Publication of WO2003097800A3 publication Critical patent/WO2003097800A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Cancer-linked gene sequences, and derived amino acid sequences, are disclosed along with processes for assaying potential antitumor agents based on their modulation of the expression of these cancer-linked genes. Also disclosed are antibodies that react with the disclosed polypeptides and methods of using the antibodies to treat cancerous conditions, such as by using the antibody to target cancerous cells in vivo for purposes of delivering therapeutic agents thereto. Also described are methods of diagnosing using the gene sequences.
PCT/US2003/015282 2002-05-16 2003-05-16 Cancer-linked gene as target for chemotherapy WO2003097800A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003241455A AU2003241455A1 (en) 2002-05-16 2003-05-16 Cancer-linked gene as target for chemotherapy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38088702P 2002-05-16 2002-05-16
US60/380,887 2002-05-16

Publications (2)

Publication Number Publication Date
WO2003097800A2 WO2003097800A2 (en) 2003-11-27
WO2003097800A3 true WO2003097800A3 (en) 2006-10-12

Family

ID=29550033

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/015282 WO2003097800A2 (en) 2002-05-16 2003-05-16 Cancer-linked gene as target for chemotherapy

Country Status (2)

Country Link
AU (1) AU2003241455A1 (en)
WO (1) WO2003097800A2 (en)

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HUANG ET AL.: "Gene expression predictors of breast cancer outcomes", THE LANCET, vol. 361, 10 May 2003 (2003-05-10), pages 1590 - 1596, XP004782813, DOI: doi:10.1016/S0140-6736(03)13308-9 *
TOUCHER A.W.: "Novel Compounds in the Therapy of Breast cancer: Opportunities for Integration with Docetaxel", THE ONCOLOGIST, no. 6, SUPPLEMENT 3, 2001, pages 40 - 44 *
VAN 'T VEER ET AL.: "Gene expression profiling predicts clinical outcome of breast cancer", NATURE, vol. 415, 31 January 2002 (2002-01-31), pages 530 - 536, XP008138701, DOI: doi:10.1038/415530a *

Also Published As

Publication number Publication date
AU2003241455A8 (en) 2003-12-02
WO2003097800A2 (en) 2003-11-27
AU2003241455A1 (en) 2003-12-02

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