WO2003090679A3 - 11-deoxy azalide antibacterials - Google Patents

11-deoxy azalide antibacterials Download PDF

Info

Publication number
WO2003090679A3
WO2003090679A3 PCT/US2003/012590 US0312590W WO03090679A3 WO 2003090679 A3 WO2003090679 A3 WO 2003090679A3 US 0312590 W US0312590 W US 0312590W WO 03090679 A3 WO03090679 A3 WO 03090679A3
Authority
WO
WIPO (PCT)
Prior art keywords
azalide
antibacterials
deoxy
compounds
prodrugs
Prior art date
Application number
PCT/US2003/012590
Other languages
French (fr)
Other versions
WO2003090679A2 (en
Inventor
Richard Clark
Stevan Djuric
Zhenkun Ma
Sanyi Wang
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Priority to EP03733878A priority Critical patent/EP1501847A2/en
Priority to MXPA04010557A priority patent/MXPA04010557A/en
Priority to JP2003587318A priority patent/JP2005529884A/en
Priority to CA002483281A priority patent/CA2483281A1/en
Publication of WO2003090679A2 publication Critical patent/WO2003090679A2/en
Publication of WO2003090679A3 publication Critical patent/WO2003090679A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Antibacterial compounds having formula (I) and formula (II), and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods for prophylaxis or treatment of bacterial infections using the compounds are disclosed.
PCT/US2003/012590 2002-04-25 2003-04-24 11-deoxy azalide antibacterials WO2003090679A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP03733878A EP1501847A2 (en) 2002-04-25 2003-04-24 11-deoxy azalide antibacterials
MXPA04010557A MXPA04010557A (en) 2002-04-25 2003-04-24 11-deoxy azalide antibacterials.
JP2003587318A JP2005529884A (en) 2002-04-25 2003-04-24 11-deoxyazalide antibacterial drug
CA002483281A CA2483281A1 (en) 2002-04-25 2003-04-24 11-deoxy azalide antibacterials

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US13203602A 2002-04-25 2002-04-25
US10/132,036 2002-04-25
US42109103A 2003-04-23 2003-04-23
US10/421,091 2003-04-23

Publications (2)

Publication Number Publication Date
WO2003090679A2 WO2003090679A2 (en) 2003-11-06
WO2003090679A3 true WO2003090679A3 (en) 2004-03-11

Family

ID=29272618

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/012590 WO2003090679A2 (en) 2002-04-25 2003-04-24 11-deoxy azalide antibacterials

Country Status (5)

Country Link
EP (1) EP1501847A2 (en)
JP (1) JP2005529884A (en)
CA (1) CA2483281A1 (en)
MX (1) MXPA04010557A (en)
WO (1) WO2003090679A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7407941B2 (en) * 2003-08-26 2008-08-05 Pfizer, Inc. N-desmethyl-N-substituted-11-deoxyerythromycin compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
A.BRIAN JONES ET AL.: "Assessment of the biological value of the 11-hydroxy group of the azalides.", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 3, no. 10, 1993, pages 1999 - 2004, XP008023252 *

Also Published As

Publication number Publication date
MXPA04010557A (en) 2005-02-17
EP1501847A2 (en) 2005-02-02
JP2005529884A (en) 2005-10-06
CA2483281A1 (en) 2003-11-06
WO2003090679A2 (en) 2003-11-06

Similar Documents

Publication Publication Date Title
HUP0400446A2 (en) Crystal forms of azithromycin
WO2006120563A3 (en) Antibacterial agents
MXPA05008126A (en) Gyrase inhibitors and uses thereof.
WO2004062601A3 (en) Antibacterial agents
TW200734344A (en) Antibacterial agents
BRPI0412763A (en) anhydrous, hydrated or solvated forms of a compound, crystalline form, pharmaceutical composition, and method for the treatment or prophylaxis of disorders
WO2007067559A3 (en) Antibacterial agents
WO2003077828A3 (en) Novel florfenicol-type antibiotics
MXPA03003168A (en) Topical antibiotic composition for treatment of eye infection.
MXPA05009352A (en) Methods and compositions for the treatment and prevention of staphylococcus and other bacterial infections.
AU3196900A (en) Preventives/remedies for interstitial pneumonia and pulmonary fibrosis
EP1594444A3 (en) Methods and compositions for the treatment and prevention of staphylococcus and other bacterial infections
WO2004080391A3 (en) Novel antibacterial agents
AP2003002942A0 (en) New derivatives of oxazolidinones as bacterial agents
MXPA05009688A (en) Naphthyridine derivatives as antibacterial agents.
WO2004011477A3 (en) 6,11-4-carbon bridged ketolides
UA84879C2 (en) Isothiazoloquinolones and related compounds as anti-infective agents
WO2004096822A3 (en) Pyridyl substituted ketolide antibiotics
ATE260928T1 (en) KETOLIDE ANTIBIOTICS
MXPA05011785A (en) Positive modulators of nicotinic acetylcholine receptors.
EP1114826A3 (en) Novel antibacterial and prokinetic macrolides
WO2002072581A3 (en) Pyrazolopyriadine derivatives
WO2003090679A3 (en) 11-deoxy azalide antibacterials
WO2002018353A3 (en) Oxazolidinone chemotherapeutic agents
WO2004078115A3 (en) Benzothiazole compounds, compositions and methods for treatment and prophylaxis of rotavirus infections and associated diseases

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): CA JP MX

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2483281

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2003587318

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: PA/a/2004/010557

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 2003733878

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2003733878

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 2003733878

Country of ref document: EP