WO2003089668A3 - Differentially expressed genes in conjunctivial pterygium - Google Patents

Differentially expressed genes in conjunctivial pterygium Download PDF

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Publication number
WO2003089668A3
WO2003089668A3 PCT/GB2003/001710 GB0301710W WO03089668A3 WO 2003089668 A3 WO2003089668 A3 WO 2003089668A3 GB 0301710 W GB0301710 W GB 0301710W WO 03089668 A3 WO03089668 A3 WO 03089668A3
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WO
WIPO (PCT)
Prior art keywords
pterygium
conjunctivial
differentially expressed
expressed genes
methods
Prior art date
Application number
PCT/GB2003/001710
Other languages
French (fr)
Other versions
WO2003089668A2 (en
Inventor
Donald Tan
Roger Beuerman
Original Assignee
Singapore Eye Res Inst
Brasnett Adrian H
Donald Tan
Roger Beuerman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Singapore Eye Res Inst, Brasnett Adrian H, Donald Tan, Roger Beuerman filed Critical Singapore Eye Res Inst
Priority to AU2003226557A priority Critical patent/AU2003226557A1/en
Publication of WO2003089668A2 publication Critical patent/WO2003089668A2/en
Publication of WO2003089668A3 publication Critical patent/WO2003089668A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Methods for monitoring and diagnosing a disease or condition associated with pterygium are described. Comparing gene expression levels between normal and pterygial tissue has provided an insight into factors that may drive the growth of pterygium. Assay methods and the products thereof for use in the treatment of pterygium are provided.
PCT/GB2003/001710 2002-04-19 2003-04-17 Differentially expressed genes in conjunctivial pterygium WO2003089668A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003226557A AU2003226557A1 (en) 2002-04-19 2003-04-17 Differentially expressed genes in conjunctivial pterygium

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0209040.5 2002-04-19
GBGB0209040.5A GB0209040D0 (en) 2002-04-19 2002-04-19 Improvements in diagnostics

Publications (2)

Publication Number Publication Date
WO2003089668A2 WO2003089668A2 (en) 2003-10-30
WO2003089668A3 true WO2003089668A3 (en) 2004-03-11

Family

ID=9935187

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2003/001710 WO2003089668A2 (en) 2002-04-19 2003-04-17 Differentially expressed genes in conjunctivial pterygium

Country Status (3)

Country Link
AU (1) AU2003226557A1 (en)
GB (1) GB0209040D0 (en)
WO (1) WO2003089668A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007339334A1 (en) * 2006-12-19 2008-07-10 Source Precision Medicine, Inc. Gene expression profiling for identification, monitoring, and treatment of ocular disease

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998053103A1 (en) * 1997-05-21 1998-11-26 Clontech Laboratories, Inc. Nucleic acid arrays
WO2001070720A2 (en) * 2000-03-21 2001-09-27 The Procter & Gamble Company Carbocyclic side chain containing, n-substituted metalloprotease inhibitors
EP1191107A2 (en) * 2000-09-25 2002-03-27 Schering Aktiengesellschaft Method for the in vitro diagnosis of endometriosis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998053103A1 (en) * 1997-05-21 1998-11-26 Clontech Laboratories, Inc. Nucleic acid arrays
WO2001070720A2 (en) * 2000-03-21 2001-09-27 The Procter & Gamble Company Carbocyclic side chain containing, n-substituted metalloprotease inhibitors
EP1191107A2 (en) * 2000-09-25 2002-03-27 Schering Aktiengesellschaft Method for the in vitro diagnosis of endometriosis

Non-Patent Citations (21)

* Cited by examiner, † Cited by third party
Title
BEUERMAN R W ET AL: "DNA Array Studies of Pterygium.", ARVO ANNUAL MEETING ABSTRACT SEARCH AND PROGRAM PLANNER, vol. 2002, 2002, Annual Meeting of the Association For Research in Vision and Ophthalmology;Fort Lauderdale, Florida, USA; May 05-10, 2002, pages Abstract No. 128, XP009015734 *
BEUERMAN: "Searching for genes that are responsible for eye diseases", ASIA PACIFIC BIOTECH NEWS, vol. 6, no. 2, January 2002 (2002-01-01), pages 39 - 40, XP002255485 *
BOEUF STEPHANE ET AL: "Differential gene expression in white and brown preadipocytes.", PHYSIOLOGICAL GENOMICS, vol. 7, January 2002 (2002-01-01), January, 2002, pages 15 - 25, XP002252657, ISSN: 1094-8341 *
BREIPOHL ET AL: "Pterygium tissue proteins as identified by immunhisto-chemistry and in-situ hybridzation", DOG JAHRESTAGUNG 26. - 29.9.02, 12 September 2002 (2002-09-12), Berlin, pages P130, XP002255487, Retrieved from the Internet <URL:http://www.dog.org/2002/abstracts/371_e.html> [retrieved on 20030917] *
CORTESE J. D.: "The Array of Today", THE SCIENTIST, vol. 14, no. 17, 4 September 2000 (2000-09-04), pages 25 - 30, XP002254748, Retrieved from the Internet <URL:http://www.the-scientist.com/yr2000/sep/profile_000904.html> [retrieved on 20030916] *
DATABASE GEO [online] 11 April 2002 (2002-04-11), "Affimetrix GeneChip Human Genome U133 Array Set HG-U133A", XP002254749, retrieved from NCBI Database accession no. GPL96 *
DATABASE OMIM [online] 19 February 2001 (2001-02-19), "Microseminoprotein", XP002263041, retrieved from NCBI Database accession no. 157145 *
DATABASE OMIM [online] 6 April 1986 (1986-04-06), "Fibronectin 1", XP002254750, retrieved from NCBI Database accession no. 135600 *
DI GIROLAMO NICK ET AL: "Differential expression of matrix metalloproteinases and their tissue inhibitors at the advancing pterygium head.", IOVS, vol. 41, no. 13, December 2000 (2000-12-01), pages 4142 - 4149, XP009017668 *
ELKINS DAVID A ET AL: "Identification of genes underexpressed in prostate cancer using a cDNA microarray", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, vol. 43, March 2002 (2002-03-01), 93rd Annual Meeting of the American Association for Cancer Research;San Francisco, California, USA; April 06-10, 2002, March, 2002, pages 458, XP001156277, ISSN: 0197-016X *
GIROLAMO DI N ET AL: "EXPRESSION OF MMPS AND TIMPS IN HUMAN PTERYGIA AND CULTURED PTERYGIUM EPITHELIAL CELLS", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOCIATION FOR RESEARCH IN VISION AND, US, vol. 41, no. 3, March 2000 (2000-03-01), pages 671 - 679, XP009015871, ISSN: 0146-0404 *
JOUSSEN A M ET AL: "[Possibilities of broad spectrum analysis of gene expression patterns with cDNA arrays]", DER OPHTHALMOLOGE: ZEITSCHRIFT DER DEUTSCHEN OPHTHALMOLOGISCHEN GESELLSCHAFT. GERMANY JUN 2001, vol. 98, no. 6, June 2001 (2001-06-01), pages 568 - 573, XP002255486, ISSN: 0941-293X *
LAFONTAINE P O ET AL: "ASSESSMENT OF TFF GENE EXPRESSION IN PTERYGIUM", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOCIATION FOR RESEARCH IN VISION AND, US, vol. 42, no. 4, 15 March 2001 (2001-03-15), pages S488, XP009015848, ISSN: 0146-0404 *
LI DE-QUAN ET AL: "Overexpression of collagenase (MMP-1) and stromelysin (MMP-3) by pterygium head fibroblasts.", ARCHIVES OF OPHTHALMOLOGY, vol. 119, no. 1, January 2001 (2001-01-01), pages 71 - 80, XP009015856, ISSN: 0003-9950 *
LIN N ET AL: "CHROMOSOME ABNORMALITY P53 ALLELIC DELETION AND OVER EXPRESSION OF VEGF, VEGF R1, IGF-I AND IGF-I R IN PTERYGIUM", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOCIATION FOR RESEARCH IN VISION AND, US, vol. 42, no. 4, 15 March 2001 (2001-03-15), pages S488, XP009015847, ISSN: 0146-0404 *
MERRITT J J ET AL: "Overexpression of IGF-BP2, IGF-BP3 and IGF2 in cultured primary pterygium fibroblasts.", IOVS, vol. 42, no. 4, 15 March 2001 (2001-03-15), Annual Meeting of the Association for Research in Vision and Ophthalmology;Fort Lauderdale, Florida, USA; April 29-May 04, 2001, pages S772, XP009016475 *
REYNOLDS M A: "MICROARRAY TECHNOLOGY GEM MICROARRAY AND DRUG DISCOVERY", JOURNAL OF INDUSTRIAL MICROBIOLOGY AND BIOTECHNOLOGY, BASINGSTOKE, GB, vol. 28, no. 3, March 2002 (2002-03-01), pages 180 - 185, XP009016572, ISSN: 1367-5435 *
SAKAI HIDEKI ET AL: "Prognostic significance of beta-microseminoprotein mRNA expression in prostate cancer", PROSTATE, vol. 38, no. 4, March 1999 (1999-03-01), pages 278 - 284, XP009021540, ISSN: 0270-4137 *
SOLOMON A ET AL: "OVEREXPRESSION OF INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-2 IN PTERYGIUM BODY FIBROBLASTS", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOCIATION FOR RESEARCH IN VISION AND, US, vol. 44, no. 2, February 2003 (2003-02-01), pages 573 - 580, XP009015855, ISSN: 0146-0404 *
SOLOMON A ET AL: "Regulation of collagenase, stromelysin, and urokinase-type plasminogen activator in primary pterygium body fibroblasts by inflammatory cytokines.", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. UNITED STATES JUL 2000, vol. 41, no. 8, July 2000 (2000-07-01), pages 2154 - 2163, XP009015870, ISSN: 0146-0404 *
TAN DONALD T H ET AL: "Apoptosis and apoptosis related gene expression in normal conjunctiva and pterygium.", BRITISH JOURNAL OF OPHTHALMOLOGY, vol. 84, no. 2, February 2000 (2000-02-01), pages 212 - 216, XP002254747, ISSN: 0007-1161 *

Also Published As

Publication number Publication date
WO2003089668A2 (en) 2003-10-30
AU2003226557A8 (en) 2003-11-03
GB0209040D0 (en) 2002-05-29
AU2003226557A1 (en) 2003-11-03

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