WO2003087159A3 - Modulators of the notch signalling pathway and uses thereof in medical treatment - Google Patents

Modulators of the notch signalling pathway and uses thereof in medical treatment Download PDF

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Publication number
WO2003087159A3
WO2003087159A3 PCT/GB2003/001525 GB0301525W WO03087159A3 WO 2003087159 A3 WO2003087159 A3 WO 2003087159A3 GB 0301525 W GB0301525 W GB 0301525W WO 03087159 A3 WO03087159 A3 WO 03087159A3
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WO
WIPO (PCT)
Prior art keywords
modulators
notch signalling
medical treatment
signalling pathway
notch
Prior art date
Application number
PCT/GB2003/001525
Other languages
French (fr)
Other versions
WO2003087159A8 (en
WO2003087159A2 (en
Inventor
Mark William Bodmer
Emmanuel Cyrille Pascal Briend
Brian Robert Champion
Andrew Christopher Lennard
Grahame James Mckenzie
Tamara Tugal
George Albert Ward
Lesley Lynn Young
Original Assignee
Lorantis Ltd
Mark William Bodmer
Emmanuel Cyrille Pascal Briend
Brian Robert Champion
Andrew Christopher Lennard
Grahame James Mckenzie
Tamara Tugal
George Albert Ward
Lesley Lynn Young
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0207930A external-priority patent/GB0207930D0/en
Priority claimed from GB0207929A external-priority patent/GB0207929D0/en
Priority claimed from GB0212283A external-priority patent/GB0212283D0/en
Priority claimed from GB0212282A external-priority patent/GB0212282D0/en
Priority claimed from PCT/GB2002/003426 external-priority patent/WO2003011317A1/en
Priority claimed from GB0220912A external-priority patent/GB0220912D0/en
Priority claimed from GB0220913A external-priority patent/GB0220913D0/en
Priority claimed from GB0300234A external-priority patent/GB0300234D0/en
Priority to EP03746366A priority Critical patent/EP1492816A2/en
Priority to JP2003584114A priority patent/JP2006506322A/en
Priority to AU2003226537A priority patent/AU2003226537A1/en
Application filed by Lorantis Ltd, Mark William Bodmer, Emmanuel Cyrille Pascal Briend, Brian Robert Champion, Andrew Christopher Lennard, Grahame James Mckenzie, Tamara Tugal, George Albert Ward, Lesley Lynn Young filed Critical Lorantis Ltd
Priority to JP2005506075A priority patent/JP2006513260A/en
Priority to PCT/GB2003/003285 priority patent/WO2004013179A1/en
Priority to AU2003255735A priority patent/AU2003255735A1/en
Priority to EP03766445A priority patent/EP1525221A1/en
Priority to PCT/GB2003/003908 priority patent/WO2004024764A1/en
Priority to AU2003267563A priority patent/AU2003267563A1/en
Priority to CA002497226A priority patent/CA2497226A1/en
Priority to EP03748255A priority patent/EP1537145A1/en
Priority to JP2004571915A priority patent/JP2006515177A/en
Publication of WO2003087159A2 publication Critical patent/WO2003087159A2/en
Priority to PCT/GB2004/000046 priority patent/WO2004060262A2/en
Priority to EP04704657A priority patent/EP1585543A1/en
Priority to JP2006500232A priority patent/JP2006517533A/en
Priority to PCT/GB2004/000263 priority patent/WO2004064863A1/en
Publication of WO2003087159A3 publication Critical patent/WO2003087159A3/en
Priority to EP04722319A priority patent/EP1646400B1/en
Priority to AT04722319T priority patent/ATE474593T1/en
Priority to PCT/GB2004/001252 priority patent/WO2004082710A1/en
Priority to US10/958,784 priority patent/US20050220886A1/en
Priority to US11/050,346 priority patent/US20060002924A1/en
Priority to US11/078,735 priority patent/US20050261477A1/en
Publication of WO2003087159A8 publication Critical patent/WO2003087159A8/en
Priority to US11/188,417 priority patent/US20060204508A1/en
Priority to US11/231,494 priority patent/US20060205823A1/en
Priority to US12/766,738 priority patent/US20100303867A1/en

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Abstract

A method is disclosed for therapeutic modulation of Notch signalling by administering a construct comprising a multiplicity of bound, linked or immobilised modulators of Notch signalling.
PCT/GB2003/001525 2002-04-05 2003-04-04 Modulators of the notch signalling pathway and uses thereof in medical treatment WO2003087159A2 (en)

Priority Applications (25)

Application Number Priority Date Filing Date Title
EP03746366A EP1492816A2 (en) 2002-04-05 2003-04-04 Modulators of the notch signalling pathway and uses thereof in medical treatment
JP2003584114A JP2006506322A (en) 2002-04-05 2003-04-04 Internal medicine
AU2003226537A AU2003226537A1 (en) 2002-04-05 2003-04-04 Modulators of the notch signalling pathway and uses thereof in medical treatment
AU2003255735A AU2003255735A1 (en) 2002-08-03 2003-08-01 Conjugate of notch signalling pathway modulators and their use in medical treatment
EP03766445A EP1525221A1 (en) 2002-08-03 2003-08-01 Conjugate of notch signalling pathway modulators and their use in medical treatment
JP2005506075A JP2006513260A (en) 2002-08-03 2003-08-01 Complexes of Notch signaling pathway regulators and their use in drug therapy
PCT/GB2003/003285 WO2004013179A1 (en) 2002-08-03 2003-08-01 Conjugate of notch signalling pathway modulators and their use in medical treatment
JP2004571915A JP2006515177A (en) 2002-09-10 2003-09-09 Pharmaceutical composition comprising Notch ligand protein and medical treatment
EP03748255A EP1537145A1 (en) 2002-09-10 2003-09-09 Pharmaceutical compositions and medical treatments comprising notch ligand proteins
PCT/GB2003/003908 WO2004024764A1 (en) 2002-09-10 2003-09-09 Pharmaceutical composition and medical treatments comprising notch ligand proteins
CA002497226A CA2497226A1 (en) 2002-09-10 2003-09-09 Pharmaceutical compositions and medical treatments comprising notch ligand proteins
AU2003267563A AU2003267563A1 (en) 2002-09-10 2003-09-09 Pharmaceutical composition and medical treatments comprising notch ligand proteins
PCT/GB2004/000046 WO2004060262A2 (en) 2003-01-07 2004-01-07 Modulators of notch signalling for use in immunotherpapy
PCT/GB2004/000263 WO2004064863A1 (en) 2003-01-23 2004-01-23 Treatment of autoimmune diseases using an activator for the notch signaling pathway
JP2006500232A JP2006517533A (en) 2003-01-23 2004-01-23 Treatment of autoimmune diseases using activators of the Notch signaling pathway
EP04704657A EP1585543A1 (en) 2003-01-23 2004-01-23 Treatment of autoimmune diseases using an activator for the notch signaling pathway
PCT/GB2004/001252 WO2004082710A1 (en) 2003-03-21 2004-03-22 Treatment of allergic diseases using a modulator of the notch signaling pathway
AT04722319T ATE474593T1 (en) 2003-03-21 2004-03-22 TREATMENT OF ALLERGIC DISEASES USING A MODULATOR OF THE NOTCH SIGNALING PATHWAY
EP04722319A EP1646400B1 (en) 2003-03-21 2004-03-22 Treatment of allergic diseases using a modulator of the notch signaling pathway
US10/958,784 US20050220886A1 (en) 2002-04-05 2004-10-05 Modulators of the Notch signalling pathway and uses thereof in medical treatment
US11/050,346 US20060002924A1 (en) 2002-08-03 2005-02-03 Conjugate of notch signalling pathway modulators and their use in medical treatment
US11/078,735 US20050261477A1 (en) 2002-09-10 2005-03-10 Pharmaceutical compositions and medical treatments comprising notch ligand proteins
US11/188,417 US20060204508A1 (en) 2003-01-23 2005-07-25 Treatment of autoimmune diseases using an activator for the notch signalling pathway
US11/231,494 US20060205823A1 (en) 2003-03-21 2005-09-21 Treatment of allergic diseases using a modulator of the Notch signaling pathway
US12/766,738 US20100303867A1 (en) 2003-03-21 2010-04-23 a composition comprising a notch ligand and an allergenb or allergen bystander antigen

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GB0207930A GB0207930D0 (en) 2002-04-05 2002-04-05 A method
GB0207930.9 2002-04-05
GB0207929A GB0207929D0 (en) 2002-04-05 2002-04-05 A method
GB0207929.1 2002-04-05
GB0212283A GB0212283D0 (en) 2002-05-28 2002-05-28 A method
GB0212283.6 2002-05-28
GB0212282A GB0212282D0 (en) 2002-05-28 2002-05-28 A method
GB0212282.8 2002-05-28
GBPCT/GB02/03397 2002-07-25
PCT/GB2002/003426 WO2003011317A1 (en) 2001-07-25 2002-07-25 Modulators of notch signalling for use in immunotherapy
GBPCT/GB02/03426 2002-07-25
PCT/GB2002/003397 WO2003012441A1 (en) 2001-07-25 2002-07-25 Method for detecting modulators of notch signalling
GB0220912A GB0220912D0 (en) 2002-09-10 2002-09-10 Medical treatment
GB0220913.8 2002-09-10
GB0220913A GB0220913D0 (en) 2002-09-10 2002-09-10 Medical treatment
GB0220912.0 2002-09-10
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GB0300234A GB0300234D0 (en) 2003-01-07 2003-01-07 Medical treatment

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WO2004060262A2 (en) * 2003-01-07 2004-07-22 Lorantis Limited Modulators of notch signalling for use in immunotherpapy
GB0300428D0 (en) * 2003-01-09 2003-02-05 Lorantis Ltd Medical treatment
JP2006517533A (en) * 2003-01-23 2006-07-27 ロランティス リミテッド Treatment of autoimmune diseases using activators of the Notch signaling pathway
WO2004083372A2 (en) * 2003-03-21 2004-09-30 Lorantis Limited Modulators of the notch signaling pathway immobilized on particles for modifying immune responses
GB0307472D0 (en) * 2003-04-01 2003-05-07 Lorantis Ltd Medical treatment
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JP2007512348A (en) * 2003-11-26 2007-05-17 ヘルス　リサーチ　インコーポレイテッド Use of Notch pathway interference agents for the treatment of plasma cells
WO2005111072A2 (en) 2004-04-29 2005-11-24 The Trustees Of Columbia University In The City Of New York Notch-based fusion proteins and uses thereof
WO2007027226A2 (en) * 2005-04-28 2007-03-08 Board Of Regents, The University Of Texas System Systems and methods for the production of differentiated cells
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US9127085B2 (en) * 2007-08-23 2015-09-08 The Trustees Of Columbia University In The City Of New York Compositions of humanized notch fusion proteins and methods of treatment
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