WO2003080567A3 - Intermediates for the synthesis of discodermolide and related analogues and methods for their preparation - Google Patents

Intermediates for the synthesis of discodermolide and related analogues and methods for their preparation Download PDF

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Publication number
WO2003080567A3
WO2003080567A3 PCT/EP2003/003152 EP0303152W WO03080567A3 WO 2003080567 A3 WO2003080567 A3 WO 2003080567A3 EP 0303152 W EP0303152 W EP 0303152W WO 03080567 A3 WO03080567 A3 WO 03080567A3
Authority
WO
WIPO (PCT)
Prior art keywords
discodermolide
synthesis
intermediates
preparation
methods
Prior art date
Application number
PCT/EP2003/003152
Other languages
French (fr)
Other versions
WO2003080567A2 (en
Inventor
Weichun Chen
Charles Francavilla
Christopher Turchik Jagoe
Frederick Ray Kinder Jr
Original Assignee
Novartis Ag
Novartis Pharma Gmbh
Weichun Chen
Charles Francavilla
Christopher Turchik Jagoe
Frederick Ray Kinder Jr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Novartis Pharma Gmbh, Weichun Chen, Charles Francavilla, Christopher Turchik Jagoe, Frederick Ray Kinder Jr filed Critical Novartis Ag
Priority to AU2003226717A priority Critical patent/AU2003226717A1/en
Publication of WO2003080567A2 publication Critical patent/WO2003080567A2/en
Publication of WO2003080567A3 publication Critical patent/WO2003080567A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/09—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis
    • C07C29/10—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of ethers, including cyclic ethers, e.g. oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/02—Acyclic alcohols with carbon-to-carbon double bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/21—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/188—Preparation; Treatments not provided for in C07F7/20 by reactions involving the formation of Si-O linkages

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

The invention relates to processes for preparing intermediates utilized in the synthesis of discodermolide and analogues thereof, to novel compounds utilized in the processes and to novel compounds prepared by the processes.
PCT/EP2003/003152 2002-03-27 2003-03-26 Intermediates for the synthesis of discodermolide and related analogues and methods for their preparation WO2003080567A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003226717A AU2003226717A1 (en) 2002-03-27 2003-03-26 Intermediates for the synthesis of discodermolide and related analogues and methods for their preparation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36781802P 2002-03-27 2002-03-27
US60/367,818 2002-03-27

Publications (2)

Publication Number Publication Date
WO2003080567A2 WO2003080567A2 (en) 2003-10-02
WO2003080567A3 true WO2003080567A3 (en) 2004-04-15

Family

ID=28454854

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/003152 WO2003080567A2 (en) 2002-03-27 2003-03-26 Intermediates for the synthesis of discodermolide and related analogues and methods for their preparation

Country Status (2)

Country Link
AU (1) AU2003226717A1 (en)
WO (1) WO2003080567A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7348436B2 (en) 2004-03-02 2008-03-25 Kosan Biosciences Incorporated Compounds useful for the synthesis of (+)-discodermolide and methods thereof
US7214708B2 (en) 2004-11-18 2007-05-08 Kosan Biosciences Incorporated Synthetic discodermolide analogs

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991001982A1 (en) * 1989-08-11 1991-02-21 Harbor Branch Oceanographic Institution, Inc. Discodermolide compounds, compositions containing same and methods of preparation and use
WO1998048791A1 (en) * 1997-04-30 1998-11-05 The Regents Of The University Of California Synthesis of discodermolide and analogs
US6031133A (en) * 1996-12-03 2000-02-29 The Trustees Of The University Of Pennsylvania Synthetic techniques and intermediates for polyhydroxy, dienyl lactones and mimics thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991001982A1 (en) * 1989-08-11 1991-02-21 Harbor Branch Oceanographic Institution, Inc. Discodermolide compounds, compositions containing same and methods of preparation and use
US6031133A (en) * 1996-12-03 2000-02-29 The Trustees Of The University Of Pennsylvania Synthetic techniques and intermediates for polyhydroxy, dienyl lactones and mimics thereof
WO1998048791A1 (en) * 1997-04-30 1998-11-05 The Regents Of The University Of California Synthesis of discodermolide and analogs

Also Published As

Publication number Publication date
WO2003080567A2 (en) 2003-10-02
AU2003226717A1 (en) 2003-10-08
AU2003226717A8 (en) 2003-10-08

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