WO2003080086A1 - A composition for treating gastric ulcer and a process for preparing the same - Google Patents
A composition for treating gastric ulcer and a process for preparing the same Download PDFInfo
- Publication number
- WO2003080086A1 WO2003080086A1 PCT/IB2002/001122 IB0201122W WO03080086A1 WO 2003080086 A1 WO2003080086 A1 WO 2003080086A1 IB 0201122 W IB0201122 W IB 0201122W WO 03080086 A1 WO03080086 A1 WO 03080086A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- extract
- composition
- plant part
- piper
- ziniber
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/58—Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Definitions
- the present invention relates to a novel synergistic herbal composition for the treatment of gastric ulcer. More particularly, the present invention relates to a novel synergistic herbal composition which is effective against pyloric ligation induced ulcer model and histamine induced ulcer model. The present invention also relates to a method for the preparation of the composition. The present invention further relates to a process for the treatment of gastric ulcer using the composition.
- composition of the present invention should not be treated as an obvious one as none of the citations are able to provide all the advantages of the present invention. .
- the main object of the present invention is to provide a novel synergistic herbal composition for the treatment of gastric ulcer.
- Yet another object of the present invention is to provide a process for the preparation of the composition.
- Still another object of the present invention is to provide a method for the treatment of gastric ulcer using the composition.
- the present invention provides a novel synergistic herbal composition for the treatment of gastric ulcer. More particularly, the present invention relates to a novel synergistic herbal composition which is effective against pyloric ligation induced ulcer model and histamine induced ulcer model. Also, the present invention provides a process for the preparation of the composition. The present invention further provides a method for the treatment of gastric ulcer using said composition. Detailed Description of the present Invention
- a novel synergistic herbal composition for the treatment of gastric ulcer comprises an extract essentially obtained from one or more parts of Aegle marmelos and Withania somnifra and optionally from one or more parts of Blechnum orintale, Vitis vinifera, Feronia elephantum, Punica grantum, Ziniber of ⁇ cnale, Piper nigrum, Piper longum and Azadirachta indica along with one or more pharmaceutically acceptable additives/carriers .
- the present invention provides a novel synergistic herbal composition for the treatment of gastric ulcer, said composition essentially comprises 4-10% by wt. of an extract from Aegle marmelos and 4-11% by wt. of an extract from Withania somnifra and optionally comprises 5-8 % by wt. of an extract from Blechnum orintale, 5-11% by wt. of an extract from Vitis vinifera, 5-9% by wt. of an extract from Feronia elephantum, 8-
- the extract is an aqueous extract.
- the plant part of Aegle marmelos, Withania somnifra and Blechnum orintale is root.
- the plant part of Punica grantum is fruit rind.
- the plant part of Ziniber officnale is rhizome.
- the plant part of Azadirachta indica is bark.
- said process extract is obtained by grinding 4- 10% by wt. of an extract from Aegle marmelos and 4-11% by wt. of an extract from Withania somnifra and optionally 5-8 %> by wt. of an extract from Blechnum orintale, 5- 11%) by wt. of an extract from Vitis vinifera, 5-9% by wt.
- the extract is an aqueous extract.
- the plant part of Aegle marmelos, Withania somnifra and Blechnum orintale is root.
- the plant part of Vitis vinifera, Feronia elephantum, Piper nigrum and Piper longum is fruit.
- the plant part of Punica grantum is fruit rind.
- the plant part of Ziniber officnale is rhizome.
- the plant part of Azadirachta indica is bark.
- a method of treating gastric ulcer in a subject comprises administering an effective amount of the synergistic herbal composition essentially comprises 4-10%o by wt. of an extract from Aegle marmelos and 4-11% by wt. of an extract from Withania somnifra and optionally comprises 5-8 %> by wt. of an extract from Blechnum orintale, 5-11% by wt. of an extract from Vitis vinifera, 5-9% by wt. of an extract from Feronia elephantum, 8-11%> by wt.
- the subject is a mammal including human being.
- 50 to lOOmg of the composition is administered per Kg of body weight to the subject.
- the composition can be in the form of tablets, capsules, syrup or by any other form known in the art.
- the composition is administered orally, intra-muscularly, and by any other conventional methods.
- the composition may be used for therapeutic as well as prophylactic treatment of gastric ulcer.
- the subject may be administered a single bolus dose or a multiple dose.
- Table 1 represents the effect of Omeprazole (a standard drug) and the new herbal composition (HF) against Cold Restraint Ulcer (CRU) Model.
- Table 2 compares the percentage protection of Omeprazole and the Herbal composition
- Table 4 gives the percentage protection of Omeprazole and the Herbal composition (HF) against aspirin induced ulcer model.
- Table 5 gives the effect of Omeprazole and the Herbal composition (HF) against histamine induced duodenal ulcer in Guinea pig.
- Table 6 gives the percentage protection of Omeprazole and the Herbal composition (HF) against histamine induced duodenal ulcer in Guinea pigs.
- Table 7 gives the effect of Omeprazole and the Herbal composition (HF) against Ethanol
- Table 8 gives the percentage protection of Omeprazole and the Herbal composition (HF) against Alcohol induced Ulcer Model.
- Table 9 gives the effect of Omeprazole and the Herbal composition (HF) against pyloric ligation induced Ulcer.
- Table 10 gives the percentage protection of Omeprazole and the Herbal composition (HF) against pyloric ligation induced Ulcer.
- Table 11 gives the composition of the Herbal composition (HF) of the present invention.
- EXPERIMENT 1 EFFECT ON COLD RESTRAINT ULCERS (CRU) MODEL METHOD: Adult rats of either sex, weighing 150-175 grams are fasted for 24 hours in metallic cages with raised mesh bottoms to prevent coprophagia and were allowed free access to water. The test drugs were administered 45 minutes before immobilizing the animals. The rats were immobilized in the restraint cage and kept at 4°C in BOD incubator for 2 hours (According to the method of Senay and Levine 1967). The animals were sacrificed immediately after the restraint period. The abdomen was cut opened; stomach was taken out and incised along the greater curvature to observe the gastric lesions with the help of Magnascope (5X magnification)
- ulcer index is the mean score of gastric lesions of all the rats in a group.
- Ulcer Index is defined as:
- the percentage protection is calculated as follows:
- Percentage protection (C-T/C) x 100.
- the effect of the herbal composition of the present invention hereafter referred to as "HF” against Cold Restraint Ulcer Model (CRU) is given in Table 1.
- the effect of the standard drug "Omeprazole” is also given in Table 1 given at the end of the description.
- Percentage protection of the herbal composition of the present invention (HF) and Omeprazole against CRU model are tabulated in Table 2 given at the end of the description.
- composition of the present invention is significantly effective in CRU model.
- EXPERIMENT 2 EFFECT ON ASPIRIN INDUCED GASTRIC ULCER MODEL Method: Gastric ulceration was induced by aspirin according to the method of
- the herbal composition of the present invention is effective against Aspirin induced gastric ulcer model.
- Histamine was administered in a dose of 0.25 mg/Kg, i.m. at 30 minutes interval for 7 times and it induced 100 % duodenal ulceration in guinea pig (According to the method of Watt and Eagleton 1964).
- RATS Method 1. Adult rats of either sex were taken; weighing 150 - 175 grams were fasted for 24 hours with free access to water.
- test drugs were administered (p.o.) 45 minutes before alcohol administration.
- the ulcers are examined under the 5X magnification with the help of magnascope. • Absolute ethanol lesions appears as blackish lesions grouped in patches of varying size, usually parallel to the major axis of the stomach. 5. The lengths of the lesions are measured and summated to give a total lesion score, then calculated and expressed in percentage.
- EXPERIMENT 5 EFFECT ON PYLORIC LIGATION INDUCED ULCER MODEL Method:
- Herbal composition shows high anti ulcer activity.
- the anti ulcer activity of the herbal composition is higher than that of Omeprazole.
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02716987A EP1490079A1 (en) | 2002-03-25 | 2002-03-25 | A composition for treating gastric ulcer and a process for preparing the same |
JP2003577912A JP2005526791A (en) | 2002-03-25 | 2002-03-25 | Composition for treating gastric ulcer and method for producing the same |
CNA028290011A CN1627953A (en) | 2002-03-25 | 2002-03-25 | Compsn. for treating gastric ulcer and process for preparing same |
AU2002247908A AU2002247908A1 (en) | 2002-03-25 | 2002-03-25 | A composition for treating gastric ulcer and a process for preparing the same |
CA2480223A CA2480223C (en) | 2002-03-25 | 2002-03-25 | A composition for treating gastric ulcer and a process for preparing the same |
PCT/IB2002/001122 WO2003080086A1 (en) | 2002-03-25 | 2002-03-25 | A composition for treating gastric ulcer and a process for preparing the same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB2002/001122 WO2003080086A1 (en) | 2002-03-25 | 2002-03-25 | A composition for treating gastric ulcer and a process for preparing the same |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003080086A1 true WO2003080086A1 (en) | 2003-10-02 |
Family
ID=28053158
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2002/001122 WO2003080086A1 (en) | 2002-03-25 | 2002-03-25 | A composition for treating gastric ulcer and a process for preparing the same |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1490079A1 (en) |
JP (1) | JP2005526791A (en) |
CN (1) | CN1627953A (en) |
AU (1) | AU2002247908A1 (en) |
CA (1) | CA2480223C (en) |
WO (1) | WO2003080086A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6713092B1 (en) * | 2002-12-03 | 2004-03-30 | Natreon Inc. | Withania Somnifera composition, method for obtaining same and pharmaceutical, nutritional and personal care formulations thereof |
JPWO2014010658A1 (en) * | 2012-07-11 | 2016-06-23 | 興和株式会社 | Hihitsu formulation |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08295632A (en) * | 1995-03-02 | 1996-11-12 | Takeda Chem Ind Ltd | Antibacterial agent |
US5730986A (en) * | 1995-06-14 | 1998-03-24 | Council Of Scientific & Industrial Research | Process for the isolation of an active principle from azadirachta indica useful for controlling gastric hyperacidity and gastric ulceration |
FR2775686A1 (en) * | 1998-03-09 | 1999-09-10 | Pascal Commenil | Production of neutral lipids useful in cosmetic, dermatological or pharmaceutical compositions |
US6291517B1 (en) * | 1999-11-19 | 2001-09-18 | Dry Creek Nutrition, Inc | Method for preventing or reducing stress-induced gastric injury using grape seed proanthocyanidin extract |
-
2002
- 2002-03-25 CA CA2480223A patent/CA2480223C/en not_active Expired - Fee Related
- 2002-03-25 EP EP02716987A patent/EP1490079A1/en not_active Withdrawn
- 2002-03-25 JP JP2003577912A patent/JP2005526791A/en active Pending
- 2002-03-25 WO PCT/IB2002/001122 patent/WO2003080086A1/en active Application Filing
- 2002-03-25 AU AU2002247908A patent/AU2002247908A1/en not_active Abandoned
- 2002-03-25 CN CNA028290011A patent/CN1627953A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08295632A (en) * | 1995-03-02 | 1996-11-12 | Takeda Chem Ind Ltd | Antibacterial agent |
US5730986A (en) * | 1995-06-14 | 1998-03-24 | Council Of Scientific & Industrial Research | Process for the isolation of an active principle from azadirachta indica useful for controlling gastric hyperacidity and gastric ulceration |
FR2775686A1 (en) * | 1998-03-09 | 1999-09-10 | Pascal Commenil | Production of neutral lipids useful in cosmetic, dermatological or pharmaceutical compositions |
US6291517B1 (en) * | 1999-11-19 | 2001-09-18 | Dry Creek Nutrition, Inc | Method for preventing or reducing stress-induced gastric injury using grape seed proanthocyanidin extract |
Non-Patent Citations (11)
Title |
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AGRAWAL A K ET AL: "Effect of Piper longum Linn, Zingiber officianalis Linn and Ferula species on gastric ulceration and secretion in rats.", INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY, vol. 38, no. 10, October 2000 (2000-10-01), pages 994 - 998, XP009001799, ISSN: 0019-5189 * |
ALKOFAHI A., ATTA A.H.: "Pharmacological screening of the anti-ulcerogenic effects of some Jordanian medicinal plants in rats", JOURNAL OF ETHNOPHARMACOLOGY, vol. 67, no. 3, 1999, pages 341 - 345, XP001120796 * |
DAS S ET AL: "The gastric antiulcer effects of Azadirachta indica (Neem) leaves in albino rats.", INDIAN JOURNAL OF PHARMACOLOGY, vol. 33, no. 4, August 2001 (2001-08-01), XXXIII Annual Conference of the Indian Pharmacological Society;Gandhinagar, India; December 28-30, 2000, pages 299, XP001120856, ISSN: 0253-7613 * |
GARG G P ET AL: "THE GASTRIC ANTIULCER EFFECTS OF THE LEAVES OF THE NEEM TREE", PLANTA MEDICA, THIEME, STUTTGART, DE, vol. 59, 1993, pages 215 - 217, XP000195725, ISSN: 0032-0943 * |
GOEL R K ET AL: "Antiulcer activity of naturally occurring pyrano- coumarin and isocoumarins and their effect on prostanoid synthesis using human colonic mucosa.", INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY, vol. 35, no. 10, October 1997 (1997-10-01), pages 1080 - 1083, XP009001798, ISSN: 0019-5189 * |
MITRA S K ET AL: "Protective effect of UL-409, a herbal formulation against physical and chemical factor induced gastric and duodenal ulcers in experimental animals.", JOURNAL OF ETHNOPHARMACOLOGY, vol. 52, no. 3, 1996, pages 165 - 169, XP001119018, ISSN: 0378-8741 * |
PATENT ABSTRACTS OF JAPAN vol. 1997, no. 03 31 March 1997 (1997-03-31) * |
SAHNI Y P ET AL: "Protective activity of some indigenous medicinal plants on gastric ulceration in albino rats.", JOURNAL OF MEDICINAL AND AROMATIC PLANT SCIENCES, vol. 22-23, no. 4A-1A, October 2000 (2000-10-01), pages 89 - 90, XP001119912 * |
SAIMA Y ET AL.: "An antitumor pectic polysaccharide from Feronia limonia", INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, vol. 27, no. 5, 2000, pages 333 - 335, XP001120795 * |
SATO A: "STUDIES ON ANTI-TUMOR ACTIVITY OF CRUDE DRUGS. I. THE EFFECTS OF AQUEOUS EXTRACTS OF SOME CRUDE DRUGS IN SHORTTERM SCREENING TEST", PHARMACEUTICAL SOCIETY OF JAPAN. JOURNAL - YAKUGAKU ZASSHI, PHARMACEUTICAL SOCIETY OF JAPAN, TOKYO, JP, vol. 109, no. 6, 1989, pages 407 - 423, XP001068600, ISSN: 0031-6903 * |
SINGH B ET AL: "Adaptogenic activity of a novel, withanolide-free aqueous fraction from the roots of Withania somnifera Dun.", PHYTOTHERAPY RESEARCH: PTR. ENGLAND JUN 2001, vol. 15, no. 4, June 2001 (2001-06-01), pages 311 - 318, XP009001795, ISSN: 0951-418X * |
Also Published As
Publication number | Publication date |
---|---|
EP1490079A1 (en) | 2004-12-29 |
JP2005526791A (en) | 2005-09-08 |
CA2480223A1 (en) | 2003-10-02 |
CA2480223C (en) | 2011-06-21 |
AU2002247908A1 (en) | 2003-10-08 |
CN1627953A (en) | 2005-06-15 |
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