WO2003070910A3 - INHIBITION OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) AND VEGF RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) - Google Patents
INHIBITION OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) AND VEGF RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) Download PDFInfo
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- WO2003070910A3 WO2003070910A3 PCT/US2003/005022 US0305022W WO03070910A3 WO 2003070910 A3 WO2003070910 A3 WO 2003070910A3 US 0305022 W US0305022 W US 0305022W WO 03070910 A3 WO03070910 A3 WO 03070910A3
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- vegf
- nucleic acid
- growth factor
- gene expression
- vascular endothelial
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Abstract
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03742833A EP1521768A4 (en) | 2002-02-20 | 2003-02-20 | RNA INTERFERENCE MEDIATED INHIBITION OF VASCULAR ENDOTHELIAL GROWTH FACTOR AND VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
CA002456444A CA2456444A1 (en) | 2002-02-20 | 2003-02-20 | Rna interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (sina) |
GB0404898A GB2396864B (en) | 2002-02-20 | 2003-02-20 | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression |
JP2003569803A JP2005517436A (en) | 2002-02-20 | 2003-02-20 | RNA interference-mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acids (siNA) |
AU2003216323A AU2003216323B2 (en) | 2002-02-20 | 2003-02-20 | Inhibition of vascular endothelial growth factor (vegf) and vegf receptor gene expression using short interfereing nucleic acid (sina) |
US10/665,951 US20040138163A1 (en) | 2002-05-29 | 2003-09-18 | RNA interference mediated inhibition of vascular edothelial growth factor and vascular edothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
US10/664,668 US20070203333A1 (en) | 2001-11-30 | 2003-09-18 | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
US10/670,011 US20040209832A1 (en) | 2001-11-30 | 2003-09-23 | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
US10/683,990 US20040198682A1 (en) | 2001-11-30 | 2003-10-10 | RNA interference mediated inhibition of placental growth factor gene expression using short interfering nucleic acid (siNA) |
US10/758,155 US20050075304A1 (en) | 2001-11-30 | 2004-01-12 | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
US10/764,957 US20050054596A1 (en) | 2001-11-30 | 2004-01-26 | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
US10/831,620 US20050148530A1 (en) | 2002-02-20 | 2004-04-23 | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
US10/844,076 US7176304B2 (en) | 2002-02-20 | 2004-05-11 | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
US10/922,761 US20050267058A1 (en) | 2001-05-18 | 2004-08-20 | RNA interference mediated inhibition of placental growth factor gene expression using short interfering nucleic acid (sINA) |
US10/944,611 US20050233998A1 (en) | 2001-05-18 | 2004-09-16 | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
US10/962,898 US20050222066A1 (en) | 2001-05-18 | 2004-10-12 | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
US11/299,391 US7517864B2 (en) | 2001-05-18 | 2005-12-09 | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
US12/171,111 US7928219B2 (en) | 2002-02-20 | 2008-07-10 | RNA interference mediated inhibition of placental growth factor gene expression using short interfering nucleic acid (SINA) |
Applications Claiming Priority (24)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35858002P | 2002-02-20 | 2002-02-20 | |
US60/358,580 | 2002-02-20 | ||
US36312402P | 2002-03-11 | 2002-03-11 | |
US60/363,124 | 2002-03-11 | ||
USPCT/US02/17674 | 2002-05-29 | ||
PCT/US2002/017674 WO2002096927A2 (en) | 2001-05-29 | 2002-05-29 | Ribozyme based treatment of female reproductive diseases |
US38678202P | 2002-06-06 | 2002-06-06 | |
US60/386,782 | 2002-06-06 | ||
US39379602P | 2002-07-03 | 2002-07-03 | |
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US10/683,990 Continuation-In-Part US20040198682A1 (en) | 2001-05-18 | 2003-10-10 | RNA interference mediated inhibition of placental growth factor gene expression using short interfering nucleic acid (siNA) |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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WO2017099238A1 (en) * | 2015-12-10 | 2017-06-15 | 東レ株式会社 | Pharmaceutical composition for treating and/or preventing cancer |
JP7461886B2 (en) | 2017-11-13 | 2024-04-04 | サイレンス・セラピューティクス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Nucleic acids containing phosphorodithioate bonds for suppressing expression of target genes |
US20220387475A1 (en) * | 2019-10-22 | 2022-12-08 | Aim Immunotech Inc. | Methods and compositions for treating endometriosis |
WO2023156652A1 (en) * | 2022-02-21 | 2023-08-24 | F. Hoffmann-La Roche Ag | Antisense oligonucleotide |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6346398B1 (en) * | 1995-10-26 | 2002-02-12 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for the treatment of diseases or conditions related to levels of vascular endothelial growth factor receptor |
-
2003
- 2003-02-20 WO PCT/US2003/005022 patent/WO2003070910A2/en active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6346398B1 (en) * | 1995-10-26 | 2002-02-12 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for the treatment of diseases or conditions related to levels of vascular endothelial growth factor receptor |
Non-Patent Citations (2)
Title |
---|
See also references of EP1521768A4 * |
TUSCHL T.: "RNA interference and small interfering RNAs", CHEMBIOCHEM, vol. 2, 2001, pages 239 - 245, XP002961590 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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