WO2003063799A3 - Compositions and methods for systemic inhibition of cartilage degradation - Google Patents
Compositions and methods for systemic inhibition of cartilage degradation Download PDFInfo
- Publication number
- WO2003063799A3 WO2003063799A3 PCT/US2003/003175 US0303175W WO03063799A3 WO 2003063799 A3 WO2003063799 A3 WO 2003063799A3 US 0303175 W US0303175 W US 0303175W WO 03063799 A3 WO03063799 A3 WO 03063799A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compositions
- methods
- cartilage degradation
- cartilage
- agent
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
- A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
- A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
- A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
- A61K47/6935—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being obtained otherwise than by reactions involving carbon to carbon unsaturated bonds, e.g. polyesters, polyamides or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
- A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
- A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
- A61K47/6935—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being obtained otherwise than by reactions involving carbon to carbon unsaturated bonds, e.g. polyesters, polyamides or polyglycerol
- A61K47/6937—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being obtained otherwise than by reactions involving carbon to carbon unsaturated bonds, e.g. polyesters, polyamides or polyglycerol the polymer being PLGA, PLA or polyglycolic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2004-7011603A KR20040094413A (en) | 2002-02-01 | 2003-01-31 | Compositions and methods for systemic inhibition of cartilage degradation |
MXPA04007124A MXPA04007124A (en) | 2002-02-01 | 2003-01-31 | Compositions and methods for systemic inhibition of cartilage degradation. |
EP03708941A EP1496835A4 (en) | 2002-02-01 | 2003-01-31 | Compositions and methods for systemic inhibition of cartilage degradation |
AU2003212898A AU2003212898B2 (en) | 2002-02-01 | 2003-01-31 | Compositions and methods for systemic inhibition of cartilage degradation |
CA2474645A CA2474645C (en) | 2002-02-01 | 2003-01-31 | Compositions and methods for systemic inhibition of cartilage degradation |
JP2003563495A JP2005519917A (en) | 2002-02-01 | 2003-01-31 | Compositions and methods for systemic inhibition of cartilage degradation |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35355202P | 2002-02-01 | 2002-02-01 | |
US60/353,552 | 2002-02-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003063799A2 WO2003063799A2 (en) | 2003-08-07 |
WO2003063799A3 true WO2003063799A3 (en) | 2004-11-04 |
Family
ID=27663221
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/003175 WO2003063799A2 (en) | 2002-02-01 | 2003-01-31 | Compositions and methods for systemic inhibition of cartilage degradation |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1496835A4 (en) |
JP (1) | JP2005519917A (en) |
KR (1) | KR20040094413A (en) |
CN (1) | CN1697647A (en) |
AU (1) | AU2003212898B2 (en) |
CA (1) | CA2474645C (en) |
MX (1) | MXPA04007124A (en) |
WO (1) | WO2003063799A2 (en) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7083786B2 (en) | 1997-04-03 | 2006-08-01 | Jensenius Jens Chr | MASP-2, a complement-fixing enzyme, and uses for it |
US20040225077A1 (en) | 2002-12-30 | 2004-11-11 | Angiotech International Ag | Drug delivery from rapid gelling polymer composition |
DE10304994A1 (en) * | 2003-02-07 | 2004-09-02 | Aventis Pharma Deutschland Gmbh | The use of antagonists of the bradykinin B2 receptor for the treatment of osteoarthrosis |
SI1625166T1 (en) | 2003-05-12 | 2015-08-31 | Helion Biotech Aps | Antibodies to masp-2 |
TW200538148A (en) * | 2004-01-13 | 2005-12-01 | Vasogenix Pharmaceuticals Inc | Methods for treating acute myocardial infarction by administering calcitonin gene related peptide and compositions containing the same |
WO2005067890A2 (en) * | 2004-01-13 | 2005-07-28 | Vasogenix Pharmaceuticals, Inc. | Controlled release cgrp delivery composition for cardiovascular and renal indications |
EP2298335B1 (en) * | 2004-05-25 | 2014-09-03 | Stryker Corporation | Use of OP-1 for treating cartilage defects |
AU2011265308B2 (en) * | 2004-05-25 | 2014-06-26 | Stryker Corporation | Use of Morphogenic Proteins for Treating Cartilage Defects |
US7919094B2 (en) | 2004-06-10 | 2011-04-05 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
US8840893B2 (en) | 2004-06-10 | 2014-09-23 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
LT1753456T (en) | 2004-06-10 | 2016-11-10 | Omeros Corporation | Methods for treating conditions associated with masp-2 dependent complement activation |
EP1879552B1 (en) * | 2005-03-14 | 2016-02-17 | Biotegra, Inc. | Drug delivery compositions comprising a polyelectrolyte complex within a polymeric matrix |
EP3332807B1 (en) | 2005-10-26 | 2023-02-22 | Novartis AG | Use of anti il-1beta antibodies |
EP3199635B1 (en) | 2007-05-11 | 2019-02-06 | Adynxx, Inc. | Gene expression and pain |
WO2009108890A1 (en) | 2008-02-27 | 2009-09-03 | Biomet Biologics, Llc | Methods and compositions for delivering interleukin-1 receptor antagonist |
US8753690B2 (en) | 2008-02-27 | 2014-06-17 | Biomet Biologics, Llc | Methods and compositions for delivering interleukin-1 receptor antagonist |
CN102573790B (en) | 2009-08-27 | 2017-03-22 | 拜欧米特生物制剂有限责任公司 | Implantable device for production of interleukin-1 receptor antagonist |
JP5911804B2 (en) | 2009-10-16 | 2016-04-27 | オメロス コーポレーション | Method for treating disseminated intravascular coagulation by inhibiting MASP-2-dependent complement activation |
KR20220044616A (en) | 2011-04-08 | 2022-04-08 | 유니버시티 오브 레스터 | Methods for treating conditions associated with masp-2 dependent complement activation |
US9644035B2 (en) | 2011-04-08 | 2017-05-09 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
EP2704743B1 (en) | 2011-05-04 | 2020-03-11 | Omeros Corporation | Compositions for inhibiting masp-2 dependent complement acitivation |
EP2846839B1 (en) | 2012-05-10 | 2019-02-20 | Adynxx, Inc. | Formulations for the delivery of active ingredients |
US9895418B2 (en) | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
US10143725B2 (en) | 2013-03-15 | 2018-12-04 | Biomet Biologics, Llc | Treatment of pain using protein solutions |
US9758806B2 (en) | 2013-03-15 | 2017-09-12 | Biomet Biologics, Llc | Acellular compositions for treating inflammatory disorders |
US9878011B2 (en) | 2013-03-15 | 2018-01-30 | Biomet Biologics, Llc | Treatment of inflammatory respiratory disease using biological solutions |
US10208095B2 (en) | 2013-03-15 | 2019-02-19 | Biomet Manufacturing, Llc | Methods for making cytokine compositions from tissues using non-centrifugal methods |
US20140271589A1 (en) | 2013-03-15 | 2014-09-18 | Biomet Biologics, Llc | Treatment of collagen defects using protein solutions |
US9950035B2 (en) | 2013-03-15 | 2018-04-24 | Biomet Biologics, Llc | Methods and non-immunogenic compositions for treating inflammatory disorders |
KR20150134417A (en) * | 2013-03-29 | 2015-12-01 | 메리맥 파마슈티컬즈, 인크. | Cartilage-binding fusion proteins |
CN111588855A (en) | 2013-10-17 | 2020-08-28 | 奥默罗斯公司 | Methods for treating conditions associated with MASP-2 dependent complement activation |
EP3074507B1 (en) | 2013-11-26 | 2022-01-05 | Biomet Biologics, LLC | Methods of mediating macrophage phenotypes |
JP6705807B2 (en) | 2014-08-15 | 2020-06-03 | エーダイニクス インコーポレイテッド | Oligonucleotide decoys for treating pain |
US10441635B2 (en) | 2014-11-10 | 2019-10-15 | Biomet Biologics, Llc | Methods of treating pain using protein solutions |
JP6508670B2 (en) * | 2014-12-26 | 2019-05-08 | 国立大学法人広島大学 | Cartilage degeneration inhibitor |
US9763800B2 (en) | 2015-03-18 | 2017-09-19 | Biomet C. V. | Implant configured for hammertoe and small bone fixation |
JP6814802B2 (en) | 2015-11-09 | 2021-01-20 | オメロス コーポレーション | Methods for treating conditions associated with MASP-2 dependent complement activation |
CN106390099A (en) * | 2016-11-07 | 2017-02-15 | 广州赛莱拉干细胞科技股份有限公司 | Dental pulp stem cell composition and application thereof |
TWI818919B (en) | 2017-08-15 | 2023-10-21 | 美商歐米諾斯公司 | Methods for treating and/or preventing graft-versus-host disease and/or diffuse alveolar hemorrhage and/or veno-occlusive disease associated with hematopoietic stem cell transplant |
CN112274646B (en) * | 2019-07-12 | 2023-06-02 | 北京茵诺医药科技有限公司 | Amphiphilic protein-macromolecule conjugate delivery system for targeted activation of CD44 molecules, preparation method and application thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5206023A (en) * | 1991-01-31 | 1993-04-27 | Robert F. Shaw | Method and compositions for the treatment and repair of defects or lesions in cartilage |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990004417A1 (en) * | 1988-10-24 | 1990-05-03 | Bruce Caterson | Methods of and compositions for diagnosing, monitoring and treating the early stages of osteoarthritis |
DE69937070D1 (en) * | 1998-11-05 | 2007-10-18 | Omeros Corp | RINSE SOLUTION AND METHOD FOR PAIN LIFTING AND INFLAMMATION INHIBITION |
ES2308985T3 (en) * | 1999-07-21 | 2008-12-16 | Omeros Corporation | DISSOLUTIONS AND PROCEDURES FOR THE INHIBITION OF PAIN, INFLAMMATION AND DEGRADATION OF CARTILAGO. |
EP1401818A2 (en) * | 2001-05-30 | 2004-03-31 | Targesome, Inc. | Targeted multivalent macromolecules |
US6998019B2 (en) * | 2002-09-10 | 2006-02-14 | Fibermark, Inc. | Glazed paper webs |
-
2003
- 2003-01-31 CA CA2474645A patent/CA2474645C/en not_active Expired - Fee Related
- 2003-01-31 CN CNA038031361A patent/CN1697647A/en active Pending
- 2003-01-31 WO PCT/US2003/003175 patent/WO2003063799A2/en active Search and Examination
- 2003-01-31 AU AU2003212898A patent/AU2003212898B2/en not_active Ceased
- 2003-01-31 JP JP2003563495A patent/JP2005519917A/en not_active Withdrawn
- 2003-01-31 KR KR10-2004-7011603A patent/KR20040094413A/en not_active Application Discontinuation
- 2003-01-31 EP EP03708941A patent/EP1496835A4/en not_active Withdrawn
- 2003-01-31 MX MXPA04007124A patent/MXPA04007124A/en active IP Right Grant
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5206023A (en) * | 1991-01-31 | 1993-04-27 | Robert F. Shaw | Method and compositions for the treatment and repair of defects or lesions in cartilage |
Non-Patent Citations (1)
Title |
---|
See also references of EP1496835A4 * |
Also Published As
Publication number | Publication date |
---|---|
CN1697647A (en) | 2005-11-16 |
CA2474645C (en) | 2011-08-09 |
MXPA04007124A (en) | 2004-10-29 |
WO2003063799A2 (en) | 2003-08-07 |
AU2003212898B2 (en) | 2008-10-02 |
EP1496835A4 (en) | 2006-10-18 |
JP2005519917A (en) | 2005-07-07 |
CA2474645A1 (en) | 2003-08-07 |
KR20040094413A (en) | 2004-11-09 |
EP1496835A2 (en) | 2005-01-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2003063799A3 (en) | Compositions and methods for systemic inhibition of cartilage degradation | |
IL267381A (en) | Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders | |
WO2003068171A3 (en) | Method and composition for treatment of inflammation and aids-associated neurological disorders | |
WO2004018419A3 (en) | Benzimidazole quinolinones and uses thereof | |
WO2004002999A3 (en) | Modified 2' and 3' -nucleoside produgs for treating flaviridae infections | |
EP1426375A3 (en) | Analgesic spiroindole derivatives | |
IL148127A0 (en) | Use of inhibitors of the renin-angiotensin system in the prevention of cardiovascular events | |
WO2001062272A3 (en) | Soluble tumor necrosis factor receptor and il-4 inhibitor for the treatment of medical disorders | |
WO2005047244A3 (en) | Inhibition of fgfr3 and treatment of multiple myeloma | |
NZ524138A (en) | Cyanophenoxy carboxylic acid compounds and compositions for delivering active agents | |
EP2295063A3 (en) | Compositions and the use thereof the treatment of mitochondrial diseases | |
WO1999062510A3 (en) | Compositions comprising anti-microtubule agents for treating or preventing inflammatory diseases | |
JP2002516262A5 (en) | ||
WO2007062093A3 (en) | Combination therapy for the treatment of cancer comprising a metalloprotease inhibitor | |
WO2001030802A3 (en) | Therapeutic treatments comprising administration of certain steroids for blood cell deficiencies | |
WO2005037323A3 (en) | Use of gro to treat or prevent inflammation | |
WO2001068125A3 (en) | Methods and compositions for the treatment and prevention of erectile dysfunction | |
WO2001001972A3 (en) | SELECTIVE iGluR5 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF MIGRAINE | |
EP1348466A3 (en) | Method for treating pain with adenosine-tetraphosphates | |
PL368971A1 (en) | Compositions for the treatment and prevention of pain and inflammation with a cyclooxygenase-2 selective inhibitor and chondroitin sulfate | |
MY126321A (en) | Use of (alpha)-adrenoreceptor antagonists in the prevention and treatment of cancer. | |
WO2006014507A3 (en) | Method for inhibiting lipid peroxidation | |
WO2002076393A3 (en) | Antiagionecic, antitumor, chemopreventative agents | |
WO2005035500A3 (en) | Therapeutic agents useful for treating pain | |
RS20050603A (en) | New combinations and new application of pharmaceutically active compounds |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SC SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 953/KOLNP/2004 Country of ref document: IN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2003212898 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: PA/a/2004/007124 Country of ref document: MX |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2474645 Country of ref document: CA Ref document number: 1020047011603 Country of ref document: KR |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2003563495 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 20038031361 Country of ref document: CN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2003708941 Country of ref document: EP |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWP | Wipo information: published in national office |
Ref document number: 2003708941 Country of ref document: EP |