WO2003053960A3 - Composes chimiques - Google Patents

Composes chimiques Download PDF

Info

Publication number
WO2003053960A3
WO2003053960A3 PCT/GB2002/005518 GB0205518W WO03053960A3 WO 2003053960 A3 WO2003053960 A3 WO 2003053960A3 GB 0205518 W GB0205518 W GB 0205518W WO 03053960 A3 WO03053960 A3 WO 03053960A3
Authority
WO
WIPO (PCT)
Prior art keywords
quinline
derivates
mek inhibitors
containment
medicament
Prior art date
Application number
PCT/GB2002/005518
Other languages
English (en)
Other versions
WO2003053960A2 (fr
Inventor
Laurent Francois And Hennequin
Keith Hopkinson Gibson
Kevin Michael Foote
Original Assignee
Astrazeneca Ab
Astrazeneca Uk Ltd
Laurent Francois And Hennequin
Keith Hopkinson Gibson
Kevin Michael Foote
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab, Astrazeneca Uk Ltd, Laurent Francois And Hennequin, Keith Hopkinson Gibson, Kevin Michael Foote filed Critical Astrazeneca Ab
Priority to AU2002356276A priority Critical patent/AU2002356276A1/en
Publication of WO2003053960A2 publication Critical patent/WO2003053960A2/fr
Publication of WO2003053960A3 publication Critical patent/WO2003053960A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des dérivés de quinoléine de formule générale (I), dans laquelle Z, m, R1, n et R3, X, Y et W ont la signification indiquée dans la description; leurs procédés de préparation; des compositions pharmaceutiques les contenant ainsi que leur utilisation dans la production d'un médicament destiné à être utilisé en tant qu'agent antiprolifératif dans le confinement et/ou le traitement de maladies à tumeur solide.
PCT/GB2002/005518 2001-12-05 2002-12-05 Composes chimiques WO2003053960A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002356276A AU2002356276A1 (en) 2001-12-05 2002-12-05 Quinline derivates and their use as mek inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0129099.8 2001-12-05
GBGB0129099.8A GB0129099D0 (en) 2001-12-05 2001-12-05 Chemical compounds

Publications (2)

Publication Number Publication Date
WO2003053960A2 WO2003053960A2 (fr) 2003-07-03
WO2003053960A3 true WO2003053960A3 (fr) 2003-09-12

Family

ID=9927037

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2002/005518 WO2003053960A2 (fr) 2001-12-05 2002-12-05 Composes chimiques

Country Status (3)

Country Link
AU (1) AU2002356276A1 (fr)
GB (1) GB0129099D0 (fr)
WO (1) WO2003053960A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8877776B2 (en) 2009-01-16 2014-11-04 Exelixis, Inc. (L)-malate salt of N-(4-{[6,7-bis(methyloxy) quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
US9359332B2 (en) 2002-07-15 2016-06-07 Symphony Evolution, Inc. Processes for the preparation of substituted quinazolines

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60215178T2 (de) 2001-07-16 2007-08-23 Astrazeneca Ab Quinolin-derivate und ihre verwendung als inhibitoren der tyrosine kinase
GB0215823D0 (en) 2002-07-09 2002-08-14 Astrazeneca Ab Quinazoline derivatives
GB0225579D0 (en) 2002-11-02 2002-12-11 Astrazeneca Ab Chemical compounds
ES2371383T3 (es) 2003-09-26 2011-12-30 Exelixis, Inc. N-[3-fluoro-4-({6-(metiloxi)-7-[(3-morfolin-4-ilpropil)oxi]quinolin-4-il}oxi)fenil]-n'-(4-fluorofenil)ciclopropan-1,1-dicarboxamida para el tratamiento del cáncer.
DE102007024470A1 (de) 2007-05-24 2008-11-27 Bayer Schering Pharma Aktiengesellschaft Neue Sulfoximin-substituierte Chinolin- bzw. Chinazolinderivate als Kinase-Inhibitoren
EP2072502A1 (fr) 2007-12-20 2009-06-24 Bayer Schering Pharma Aktiengesellschaft Dérivés de chinoline substitués par du sulfoximide et dérivés de chinazoline en tant qu'inhibiteurs de kinase
UA108618C2 (uk) 2009-08-07 2015-05-25 Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку
JP6431770B2 (ja) 2012-03-14 2018-11-28 ルピン・リミテッド Ｍｅｋインヒビターとしてのヘテロシクリル化合物
WO2016009306A1 (fr) 2014-07-15 2016-01-21 Lupin Limited Composés hétérocyclyles utilisés comme inhibiteurs de mek
WO2016035008A1 (fr) 2014-09-04 2016-03-10 Lupin Limited Dérivés de pyridopyrimidine utilisés comme inhibiteurs de mek
JP6740354B2 (ja) 2015-10-05 2020-08-12 ザ トラスティーズ オブ コロンビア ユニバーシティー イン ザ シティー オブ ニューヨーク オートファジーの流れ及びホスホリパーゼｄ及びタウを含むタンパク質凝集体のクリアランスの活性化剤ならびにタンパク質症の治療方法
CN113620874B (zh) * 2021-08-10 2024-02-06 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 2-三氟甲基-4-氨基-喹啉衍生物及其用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998043960A1 (fr) * 1997-04-03 1998-10-08 American Cyanamid Company 3-cyano quinolines substituees
WO2000018761A1 (fr) * 1998-09-29 2000-04-06 American Cyanamid Company Inhibiteurs de proteines de type tyrosine kinases a base de 3-cyanoquinolines substituees

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998043960A1 (fr) * 1997-04-03 1998-10-08 American Cyanamid Company 3-cyano quinolines substituees
WO2000018761A1 (fr) * 1998-09-29 2000-04-06 American Cyanamid Company Inhibiteurs de proteines de type tyrosine kinases a base de 3-cyanoquinolines substituees

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9359332B2 (en) 2002-07-15 2016-06-07 Symphony Evolution, Inc. Processes for the preparation of substituted quinazolines
US8877776B2 (en) 2009-01-16 2014-11-04 Exelixis, Inc. (L)-malate salt of N-(4-{[6,7-bis(methyloxy) quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Also Published As

Publication number Publication date
WO2003053960A2 (fr) 2003-07-03
AU2002356276A1 (en) 2003-07-09
GB0129099D0 (en) 2002-01-23
AU2002356276A8 (en) 2003-07-09

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