WO2003053331A3 - Inhibiteurs de la protease - Google Patents

Inhibiteurs de la protease Download PDF

Info

Publication number
WO2003053331A3
WO2003053331A3 PCT/US2001/051647 US0151647W WO03053331A3 WO 2003053331 A3 WO2003053331 A3 WO 2003053331A3 US 0151647 W US0151647 W US 0151647W WO 03053331 A3 WO03053331 A3 WO 03053331A3
Authority
WO
WIPO (PCT)
Prior art keywords
disease
amino
compounds
cartilage
protease inhibitors
Prior art date
Application number
PCT/US2001/051647
Other languages
English (en)
Other versions
WO2003053331A2 (fr
Inventor
Robert W Marquis Jr
Daniel F Veber
Dennis S Yamashita
Original Assignee
Smithkline Beecham Corp
Robert W Marquis Jr
Daniel F Veber
Dennis S Yamashita
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp, Robert W Marquis Jr, Daniel F Veber, Dennis S Yamashita filed Critical Smithkline Beecham Corp
Priority to MXPA03004542A priority Critical patent/MXPA03004542A/es
Priority to BR0115473-7A priority patent/BR0115473A/pt
Priority to EP01275089A priority patent/EP1392657A4/fr
Priority to PL01366232A priority patent/PL366232A1/xx
Priority to IL15599701A priority patent/IL155997A0/xx
Priority to AU2001298052A priority patent/AU2001298052A1/en
Priority to CA002436850A priority patent/CA2436850A1/fr
Priority to KR10-2003-7006807A priority patent/KR20040004445A/ko
Priority to HU0301964A priority patent/HUP0301964A3/hu
Priority to JP2003554091A priority patent/JP2005513083A/ja
Priority to NO20032328A priority patent/NO20032328L/no
Publication of WO2003053331A2 publication Critical patent/WO2003053331A2/fr
Publication of WO2003053331A3 publication Critical patent/WO2003053331A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

L'invention concerne: des inhibiteurs de la C3-6 1-amino-1-acyle cycloalcane-substitué 4-amino-azepan-3-one protéase, et des sels, hydrates et solvates pharmaceutiquement acceptables de ceux-ci, qui inhibent les protéases, notamment la cathépsine K; des compositions pharmaceutiques desdits composés; ainsi que des nouveaux produits intermédiaires desdits composés. L'invention concerne également des méthodes de traitement de maladies entraînant une perte osseuse ou une dégradation de cartilage ou de matrice excessives, notamment l'ostéoporose; de maladies gingivales, notamment la gingivite et la parodontite; de l'arthrite, plus particulièrement l'arthrose et la polyarthrite rhumatoïde, de la maladie de Paget, de l'hypercalcémie maligne, et de maladies osseuses métaboliques, qui consistent à inhiber ladite perte osseuse ou ladite dégradation de cartilage et de matrice excessives par administration à un patient nécessitant ce traitement d'un composé de l'invention.
PCT/US2001/051647 2000-11-22 2001-11-19 Inhibiteurs de la protease WO2003053331A2 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
MXPA03004542A MXPA03004542A (es) 2000-11-22 2001-11-19 Inhibidores de proteasa.
BR0115473-7A BR0115473A (pt) 2000-11-22 2001-11-19 Inibidores de protease
EP01275089A EP1392657A4 (fr) 2000-11-22 2001-11-19 Inhibiteurs de la protease
PL01366232A PL366232A1 (en) 2000-11-22 2001-11-19 Protease inhibitors
IL15599701A IL155997A0 (en) 2000-11-22 2001-11-19 Protease inhibitors
AU2001298052A AU2001298052A1 (en) 2000-11-22 2001-11-19 Protease inhibitors
CA002436850A CA2436850A1 (fr) 2000-11-22 2001-11-19 Inhibiteurs de la protease
KR10-2003-7006807A KR20040004445A (ko) 2000-11-22 2001-11-19 프로테아제 억제제
HU0301964A HUP0301964A3 (en) 2000-11-22 2001-11-19 Protease inhibitors
JP2003554091A JP2005513083A (ja) 2000-11-22 2001-11-19 プロテアーゼ阻害剤
NO20032328A NO20032328L (no) 2000-11-22 2003-05-22 Proteaseinhibitorer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25250800P 2000-11-22 2000-11-22
US60/252,508 2000-11-22

Publications (2)

Publication Number Publication Date
WO2003053331A2 WO2003053331A2 (fr) 2003-07-03
WO2003053331A3 true WO2003053331A3 (fr) 2003-11-13

Family

ID=22956303

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/051647 WO2003053331A2 (fr) 2000-11-22 2001-11-19 Inhibiteurs de la protease

Country Status (17)

Country Link
EP (1) EP1392657A4 (fr)
JP (1) JP2005513083A (fr)
KR (1) KR20040004445A (fr)
CN (1) CN1635903A (fr)
AR (1) AR034278A1 (fr)
AU (1) AU2001298052A1 (fr)
BR (1) BR0115473A (fr)
CA (1) CA2436850A1 (fr)
CZ (1) CZ20031403A3 (fr)
HU (1) HUP0301964A3 (fr)
IL (1) IL155997A0 (fr)
MX (1) MXPA03004542A (fr)
NO (1) NO20032328L (fr)
PL (1) PL366232A1 (fr)
UY (1) UY27032A1 (fr)
WO (1) WO2003053331A2 (fr)
ZA (1) ZA200303848B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030144175A1 (en) 1998-12-23 2003-07-31 Smithkline Beecham Corporation Protease inhibitors
CN1416346A (zh) 2000-03-21 2003-05-07 史密丝克莱恩比彻姆公司 蛋白酶抑制剂
AU2001268407A1 (en) * 2000-06-14 2001-12-24 Smithkline Beecham Corporation Protease inhibitors
CN101970007A (zh) 2007-06-08 2011-02-09 日本化学医药株式会社 脑动脉瘤的治疗或预防药
JPWO2009054454A1 (ja) 2007-10-24 2011-03-03 国立大学法人 東京医科歯科大学 カテプシン阻害剤を有効成分として含有するＴｏｌｌ様受容体のシグナル伝達の調整剤

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001070232A1 (fr) * 2000-03-21 2001-09-27 Smithkline Beecham Corporation Inhibiteur de proteinase

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ511710A (en) * 1998-12-23 2003-12-19 Smithkline Beecham Corp 4-Amino-azepan-3-one derivatives useful as protease inhibitors
AU2001268407A1 (en) * 2000-06-14 2001-12-24 Smithkline Beecham Corporation Protease inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001070232A1 (fr) * 2000-03-21 2001-09-27 Smithkline Beecham Corporation Inhibiteur de proteinase

Also Published As

Publication number Publication date
CZ20031403A3 (cs) 2003-10-15
UY27032A1 (es) 2002-07-31
MXPA03004542A (es) 2003-09-10
JP2005513083A (ja) 2005-05-12
PL366232A1 (en) 2005-01-24
EP1392657A2 (fr) 2004-03-03
WO2003053331A2 (fr) 2003-07-03
HUP0301964A2 (en) 2007-02-28
CN1635903A (zh) 2005-07-06
EP1392657A4 (fr) 2004-03-10
NO20032328L (no) 2003-07-02
KR20040004445A (ko) 2004-01-13
AU2001298052A1 (en) 2003-07-09
IL155997A0 (en) 2003-12-23
CA2436850A1 (fr) 2003-07-03
NO20032328D0 (no) 2003-05-22
BR0115473A (pt) 2004-09-28
ZA200303848B (en) 2004-06-28
AR034278A1 (es) 2004-02-18
HUP0301964A3 (en) 2007-09-28

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