WO2003049594A2 - Traitement du cancer du sein avec effraction minimale - Google Patents

Traitement du cancer du sein avec effraction minimale Download PDF

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Publication number
WO2003049594A2
WO2003049594A2 PCT/US2002/037890 US0237890W WO03049594A2 WO 2003049594 A2 WO2003049594 A2 WO 2003049594A2 US 0237890 W US0237890 W US 0237890W WO 03049594 A2 WO03049594 A2 WO 03049594A2
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WO
WIPO (PCT)
Prior art keywords
tumor
breast
tissue
minimally invasive
treatment
Prior art date
Application number
PCT/US2002/037890
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English (en)
Other versions
WO2003049594A3 (fr
Inventor
Suzanne V. Klimberg
Soheila Korourian
Steven Harms
Original Assignee
The Board Of Trustees Of The University Of Arkansas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Board Of Trustees Of The University Of Arkansas filed Critical The Board Of Trustees Of The University Of Arkansas
Priority to AU2002366635A priority Critical patent/AU2002366635A1/en
Publication of WO2003049594A2 publication Critical patent/WO2003049594A2/fr
Publication of WO2003049594A3 publication Critical patent/WO2003049594A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0233—Pointed or sharp biopsy instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0041—Detection of breast cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0233—Pointed or sharp biopsy instruments
    • A61B10/0283—Pointed or sharp biopsy instruments with vacuum aspiration, e.g. caused by retractable plunger or by connected syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00796—Breast surgery
    • A61B2017/008—Removal of tumors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B2018/2005—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser with beam delivery through an interstitially insertable device, e.g. needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/374—NMR or MRI

Definitions

  • the present invention relates generally to the field of cancer treatment. More specifically, the present invention relates to a method of same day diagnosis and treatment for cancer such as breast cancer.
  • Biopsy requests stem from a screening process generally performed via a physical examination (palpable) and/or mammogram (non-palpable). A biopsy is indicated if suspicious tissue is detected. Five out of six biopsies performed return benign indications.
  • Biopsy may be an open or percutaneous technique. Open biopsy removes the entire mass (excisional biopsy) or a p art of the mass (incisional biopsy). Percutaneous biopsy on the other hand is usually done with a needle-like instrument and may b e either a fine needle aspiration (FNA) or a core biopsy. In fine needle aspiration biopsy, very small needles are used to obtain individual cells or clusters of cells for cytologic examination. The cells may be prepared such as in a Papanicolaou (Pap) smear. I n core biopsy, as the term suggests, a core or fragment of tissue is obtained for histologic examination, which may be done via a frozen section or paraffin section.
  • FNA fine needle aspiration
  • core biopsy very small needles are used to obtain individual cells or clusters of cells for cytologic examination. The cells may be prepared such as in a Papanicolaou (Pap) smear.
  • I n core biopsy as the term suggests, a core or fragment of tissue is obtained for histologic
  • the chief difference between fine needle aspiration and core biopsy is the size of the actual tissue core taken.
  • An imaging system having spectroscopic capabilities such as the stereotactic guidance system described in U.S. Pat. No. 5,240,011 is employed to guide the extraction instrument to the lesion.
  • th e suspicious lesion may be partially or completely removed. Visibility of the lesion by the imaging system may be hampered because of the distortion created by the extraction process itself as well as associated bleeding in the surrounding tissues. Although the lesion is removed and all fluids are continuously aspirated from the extraction site, it is likely that the process will "cloud" the lesion, thus impairing exact recognition of its margins . This makes it difficult to ensure that the entire lesion will b e removed.
  • the lesion is merely a calcification derived from dead abnormal tissue which may be cancerous or precancerous, and it is desirable to remove only a sample of the lesion rather than the entire lesion. This is because such a lesion actually serves to mark or define the location of adjacent abnormal tissue, so the physician does not wish to remove the entire lesion an d thereby lose a critical means for later relocating the affected tissue.
  • One of the benefits to the patient from core biopsy is that the mass of the tissue taken is small. However, oftentimes, either inadvertently or because the lesion is too small, the entire lesion is removed for evaluation, even though it is desirable to remove only a portion.
  • location wire guides such as that described in U.S. Patent No. 5,221 ,269 are well known for locating lesions, particularly in the breast.
  • the device comprises a tubular introducer needle and an attached wire guide which has at its distal end a helical coil configuration for locking into position about the targeted lesion.
  • the needle is introduced onto the breast and guided to the lesion site using an imaging system of a known type, for example, x-ray, ultrasound or magnetic resonance imaging (MRI), at which time the helical coil at the distal end is deployed about the lesion.
  • an imaging system of a known type, for example, x-ray, ultrasound or magnetic resonance imaging (MRI), at which time the helical coil at the distal end is deployed about the lesion.
  • MRI magnetic resonance imaging
  • the needle may then be removed from the wire guide which remains in a locked position distally about the lesion for guiding a surgeon down the wire to the lesion site during subsequent surgery. While such a location system is effective, it is obviously intended and designed to be only temporary, and is removed once th e surgery or other procedure has been completed.
  • U.S. Patent No. 5, 192,270 to Carswell, Jr. discloses a syringe which dispenses a colorant to give a visual indication on the surface of the point at which an injection has or will be given.
  • U.S. Patent No. 5,147,307 to Gluck discloses a device which has patterning elements for impressing a temporary mark in a patients skin for guiding the location of a n injection or the like. It is also known to tape or otherwise adhere a small metallic marker, e.g. a 3 millimeter diameter lead sphere, on the skin of a human breast in order to delineate the location of skin calcifications.
  • a small metallic marker e.g. a 3 millimeter diameter lead sphere
  • a method of identifying and treating abnormal neoplastic tissue or pathogens within the body is described in U.S. Patent No. 4,649, 151 to Doughety et al.
  • a tumor- selective photosensitizing drug is introduced into a patient's body, where it is cleared from normal tissue faster than it is cleared from abnormal tissue.
  • the abnormal neoplastic tissue may be located by the luminescence of the drug within the abnormal tissue. The fluorescence may be observed with low intensity light, some of which is within the drug's absorbency spectrum. Once detected, the tissue may be destroyed by further application of higher intensity light having a frequency within the absorbency spectrum of the drug.
  • this method also is only a temporary means for marking the abnormal tissue. Additionally, once the abnormal tissue has been destroyed during treatment, the marker is destroyed as well. It is also known to employ biocompatible dyes or stains to mark breast lesions. First, a syringe containing th e colorant is guided to a detected lesion by an imaging system. Later, during the extraction procedure, the surgeon harvests a tissue sample from the stained tissue. However, while such staining techniques can be effective, it is difficult to precisely localize the stain. Also, the stains are difficult to detect flouoroscopically and may not always be permanent.
  • the prior art is deficient in a treatment system for breast cancer that remove the tumor and ablate the margin of the tumor.
  • the present invention fulfills this long-standing need and desire in the art.
  • the present invention provides a minimally invasive, comprehensive same-day diagnosis and treatment system for patients with small ( ⁇ 1.5 cm in diameter) breast lesions.
  • the system provides improved cosmetic results, reduced recovery time and requires less waiting time for diagnosis and treatment.
  • the treatment method uses imaging techniques such as MRI or ultrasound to predict the extent of the disease and guide th e removal of the tumor.
  • the procedure further uses touch preparation cytology for diagnosis and any known ablation techniques for the establishment of margins.
  • Figure 1 shows a schema for the minimally invasive, comprehensive same-day diagnosis and treatment method for breast cancer.
  • the present invention is directed to a comprehensive same-day diagnosis and treatment system for patients with small
  • An object of the present invention is not to simply ablate tumor but to ablate margins as well.
  • th e treatment method uses the Mammotome ® Breast Biopsy System to remove abnormal tissue.
  • Other percutaneous devices known to one of skill in the art can also be used. Imaging systems such as MRI or ultrasound are used to predict the extent of the disease, guide the removal of the tumor and document ablation zone, whereas diagnosis is provided by touch preparation cytology.
  • the Mammotome ® Breast Biopsy System is a minimally invasive, image guided procedure (stereotactic or ultrasound) that helps physicians locate breast abnormalities and obtain tissue samples for diagnosis. In stereotactic procedures, the patient lies face down on a special table with the breast protruding through a hole in the table. The breast is lightly compressed to immobilize it.
  • This table is also a mammogram table that allows the physician to get a clear mammographic image of the area to be sampled.
  • the table is connected to a computer that processes digital images. Placement of the sampling device is guided by a computerized system using x-rays.
  • the Mammotome ® Breast Biopsy System procedure can be performed through a 1/8" skin incision in less than one hour under a local anesthetic.
  • the Mammotome ® is capable of sampling a variety of breast abnormalities, such as microcalcifications, asymmetric densities, solid masses or nodules. It can obtain multiple tissue samples with one insertion, whereas other methods require multiple insertions.
  • the tissue samples are sent to a laboratory for pathologic analysis.
  • a procedure which requires no sutures, the Mammotome ® is a valuable tool that helps physicians accurately diagnose breast cancer in its earliest stages.
  • the Mammotome ® Breast Biopsy System is a well- established diagnostic tool that allows more accurate diagnosis and permits removal of larger specimens than is possible with core biopsy.
  • Core needle biopsy limits the amount of tissue available to pathologists for establishing the histologic diagnosis and biochemical markers.
  • a core biopsy may show ductal carcinoma in situ, but the final pathology of the lumpectomy specimen may demonstrate focal areas of infiltrating carcinoma.
  • the Mammotome ® System uses single-insertion technology with vacuum assistance for removal of an imaged abnormality via a sutureless incision.
  • the present invention uses the Mammotome ® System as a treatment tool to remove small lesions ( ⁇ 1.5 cm in diameter) followed by tissue ablation to establish margins.
  • Other percutaneous devices known to one of skill in the art can also be used, and this treatment paradigm is potentially more accurate than surgery.
  • pre-procedure fine needle cytology or intra-procedure touch preparation cytology can be used for immediate diagnosis of lesions.
  • the touch-prep method which involves touching th e specimen to a glass slide to which tumor cells will adhere, allows simple, quick (2-3 minutes), safe (no loss of diagnostic material), and accurate diagnosis at the time of surgery.
  • Imaging techniques such as MRI can be used as the imaging modality for the present invention.
  • MRI of the breast using the RoDEO (Rotating Delivery of Excitation Off-resonance) pulse sequence has recently been developed to diagnose and determine the extent of local breast cancer.
  • Validation studies comparing breast Rotating Delivery of Excitation Off-resonance MRI to serially sectioned mastectomy specimens showed a high degree of correlation in the ability of Rotating Delivery of Excitation Off-resonance MRI to predict disease extent and lesion margins.
  • the present invention can employ a number of ablation techniques known to one skilled in the art.
  • IDP interstitial laser photocoagulation
  • Preliminary results of MRI-directed interstitial laser photocoagulation in 30 patients with breast cancer indicated that the procedure was well-tolerated and side effects were similar to those of routine stereotaxic needle biopsy.
  • Each patient has between one and five ablation zones for a total of 68 treatment zones.
  • the pathology correlation determined effective cell death in all cases.
  • the histologic determination of treatment zones by proliferating cell nuclear antigen (PCNA) staining within the tumor matched the MRI estimates of zone size in all cases.
  • PCNA proliferating cell nuclear antigen
  • ablation of tumor tissue can be accomplished by cryotherapy, radiofrequency, or ultracision with the harmonic scapel.
  • Major benefits of the same-day treatment system disclosed herein include improved cosmetic result, reduced recovery time, and less stress for the patient as no waiting for a diagnosis or treatment decision is involved.
  • a s ame- day diagnosis and treatment system also means lowered cost du e to reduced hospital or same-day surgery time.
  • the treatment method disclosed herein is also applicable to other cancers besides breast cancer.
  • a minimally invasive method for diagnosing, removing and ablating margins of a tumor in a breast of an individual as a same day treatment comprising the steps of imaging the breast of the individual to locate a potential tumor or to determine th e extent of an existing tumor within the breast or a combination thereof; obtaining a cell specimen from the tumor pre-procedure or intra-procedure; preparing cytology samples from the specimen for diagnosis; excising the tumor from the breast under imaging guidance; and ablating the tumor margins in the breast where performing the method steps on the same day results in a minimally invasive treatment of the individual.
  • the breast is imaged by MRI.
  • the cytology samples may be prepared by touch preparation cytology or fine needle cytology.
  • the excision of th e tumor is directed by ultrasound or MRI and the ablation of th e tumor margin is by interstitial laser photocoagulation, cryotherapy, radiofrequency, or ultracision with a harmonic scalpel.
  • a representative example of a breast tumor is one having a diameter of about 1.5 cm or less.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne une méthode complète de traitement et de diagnostic pouvant être pratiquée en un seul jour, permettant l'élimination de la tumeur et l'ablation des bords tumoraux chez les patientes présentant un cancer du sein. Cette méthode comprend un diagnostic par IRM et par examen cytologique du tissu fixé sur lame, suivi de l'extraction de la tumeur et de l'ablation des bords tumoraux.
PCT/US2002/037890 2001-12-10 2002-11-27 Traitement du cancer du sein avec effraction minimale WO2003049594A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002366635A AU2002366635A1 (en) 2001-12-10 2002-11-27 Minimally invasive treatment for breast cancer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33762601P 2001-12-10 2001-12-10
US60/337,626 2001-12-10

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WO2003049594A2 true WO2003049594A2 (fr) 2003-06-19
WO2003049594A3 WO2003049594A3 (fr) 2003-12-11

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AU (1) AU2002366635A1 (fr)
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Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6424969B1 (en) * 1999-07-20 2002-07-23 Inmentia, Inc. System and method for organizing data
US6944619B2 (en) * 2001-04-12 2005-09-13 Primentia, Inc. System and method for organizing data
US7942873B2 (en) * 2005-03-25 2011-05-17 Angiodynamics, Inc. Cavity ablation apparatus and method
DE102005031125A1 (de) * 2005-07-04 2007-01-11 Siemens Ag Verfahren und Lithotripsieanlage zur Zerstörung eines Konkrements in einem Patienten
DE102005033474A1 (de) * 2005-07-18 2007-01-25 Heywang-Köbrunner, Sylvia, Prof. Dr. Verfahren zur Untersuchung von Gewebeproben, Vorrichtung dafür und neue Verwendung von Fluoreszenzmarkern
US9517240B2 (en) 2006-09-26 2016-12-13 The Regents Of The University Of California Methods and compositions for cancer prevention and treatment
US20100160275A1 (en) * 2006-09-26 2010-06-24 Lee Eva Y H P Methods and compositions for cancer prevention and treatment
WO2015142674A1 (fr) 2014-03-15 2015-09-24 Rioux Robert F Système et procédé d'ablation tissulaire marginale
US10368938B2 (en) 2014-10-07 2019-08-06 City Of Hope Margin extension device and method
WO2016176567A1 (fr) 2015-04-29 2016-11-03 Innoblative Designs, Inc. Ablation d'un tissu cavitaire
EP3367945B1 (fr) 2015-10-29 2020-02-26 Innoblative Designs, Inc. Dispositifs d'ablation de tissu à tamis sphérique
EP3410972B1 (fr) 2016-02-02 2021-03-10 Innoblative Designs, Inc. Système d'ablation de tissu cavitaire
WO2017151431A1 (fr) 2016-03-01 2017-09-08 Innoblative Designs, Inc. Résection et coagulation de tissu
CN105796135A (zh) * 2016-03-03 2016-07-27 上海导向医疗***有限公司 真空辅助乳腺样本活检与旋切***
US10070921B2 (en) 2016-10-17 2018-09-11 Innoblative Designs, Inc. Treatment devices and methods
US10912602B2 (en) 2016-11-08 2021-02-09 Innoblative Designs, Inc. Electrosurgical tissue and vessel sealing device
JP2020530785A (ja) 2017-07-26 2020-10-29 イノブレイティブ デザインズ， インコーポレイテッド アブレーション能力を有する低侵襲関節運動アセンブリ
CN113974863B (zh) * 2021-12-03 2023-06-30 郑州大学第一附属医院 一种乳腺肿瘤穿刺活检实施定位装置

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5590655A (en) * 1993-09-20 1997-01-07 Hussman; Karl L. Frameless laser guided stereotactic localization system
US20020052545A1 (en) * 2000-10-03 2002-05-02 Klimberg V. Suzanne Method for detecting and excising nonpalpable lesions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6375634B1 (en) * 1997-11-19 2002-04-23 Oncology Innovations, Inc. Apparatus and method to encapsulate, kill and remove malignancies, including selectively increasing absorption of x-rays and increasing free-radical damage to residual tumors targeted by ionizing and non-ionizing radiation therapy
WO2001074252A2 (fr) * 2000-03-31 2001-10-11 Rita Medical Systems Inc. Biopsie des tissus, appareil et procede de traitement

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5590655A (en) * 1993-09-20 1997-01-07 Hussman; Karl L. Frameless laser guided stereotactic localization system
US20020052545A1 (en) * 2000-10-03 2002-05-02 Klimberg V. Suzanne Method for detecting and excising nonpalpable lesions

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Publication number Publication date
WO2003049594A3 (fr) 2003-12-11
US20030125640A1 (en) 2003-07-03
US6978788B2 (en) 2005-12-27
AU2002366635A8 (en) 2003-06-23
AU2002366635A1 (en) 2003-06-23

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