WO2003047605A1 - Products of natural substance of organic iodine content - Google Patents
Products of natural substance of organic iodine content Download PDFInfo
- Publication number
- WO2003047605A1 WO2003047605A1 PCT/HU2002/000138 HU0200138W WO03047605A1 WO 2003047605 A1 WO2003047605 A1 WO 2003047605A1 HU 0200138 W HU0200138 W HU 0200138W WO 03047605 A1 WO03047605 A1 WO 03047605A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- iodine
- solution
- product
- amylose
- natural
- Prior art date
Links
- 229910052740 iodine Inorganic materials 0.000 title claims abstract description 195
- 239000011630 iodine Substances 0.000 title claims abstract description 194
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 title claims abstract description 184
- 239000005445 natural material Substances 0.000 title claims abstract description 18
- 238000000034 method Methods 0.000 claims abstract description 63
- 229920000642 polymer Polymers 0.000 claims abstract description 35
- 238000002156 mixing Methods 0.000 claims abstract description 22
- 239000000084 colloidal system Substances 0.000 claims abstract description 20
- 239000000843 powder Substances 0.000 claims abstract description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000012530 fluid Substances 0.000 claims abstract description 12
- -1 iodine ions Chemical class 0.000 claims abstract description 12
- 238000004519 manufacturing process Methods 0.000 claims abstract description 11
- 239000007787 solid Substances 0.000 claims abstract description 5
- 230000008859 change Effects 0.000 claims abstract description 3
- 238000001816 cooling Methods 0.000 claims abstract description 3
- 229920000856 Amylose Polymers 0.000 claims description 59
- 229920002472 Starch Polymers 0.000 claims description 37
- 239000008107 starch Substances 0.000 claims description 35
- 239000002994 raw material Substances 0.000 claims description 32
- 235000019698 starch Nutrition 0.000 claims description 32
- 239000000126 substance Substances 0.000 claims description 28
- 239000000203 mixture Substances 0.000 claims description 24
- 229920000945 Amylopectin Polymers 0.000 claims description 21
- 229920001202 Inulin Polymers 0.000 claims description 13
- 229940029339 inulin Drugs 0.000 claims description 13
- 239000001814 pectin Substances 0.000 claims description 13
- 229920001277 pectin Polymers 0.000 claims description 13
- 235000010987 pectin Nutrition 0.000 claims description 13
- 229920002488 Hemicellulose Polymers 0.000 claims description 12
- 239000001913 cellulose Substances 0.000 claims description 12
- 229920002678 cellulose Polymers 0.000 claims description 12
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims description 12
- 240000008042 Zea mays Species 0.000 claims description 10
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 10
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 10
- 238000009835 boiling Methods 0.000 claims description 10
- 235000005822 corn Nutrition 0.000 claims description 10
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims description 10
- 240000004713 Pisum sativum Species 0.000 claims description 9
- 235000010582 Pisum sativum Nutrition 0.000 claims description 9
- 235000007238 Secale cereale Nutrition 0.000 claims description 9
- 240000005979 Hordeum vulgare Species 0.000 claims description 8
- 235000007340 Hordeum vulgare Nutrition 0.000 claims description 8
- 244000017020 Ipomoea batatas Species 0.000 claims description 8
- 235000002678 Ipomoea batatas Nutrition 0.000 claims description 8
- 240000003183 Manihot esculenta Species 0.000 claims description 8
- 235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 claims description 8
- 240000008790 Musa x paradisiaca Species 0.000 claims description 8
- 235000018290 Musa x paradisiaca Nutrition 0.000 claims description 8
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- 241000209056 Secale Species 0.000 claims description 8
- 244000061456 Solanum tuberosum Species 0.000 claims description 8
- 235000002595 Solanum tuberosum Nutrition 0.000 claims description 8
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- 235000021307 Triticum Nutrition 0.000 claims description 8
- 235000009566 rice Nutrition 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 7
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 5
- 239000008103 glucose Substances 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 claims description 4
- DKNPRRRKHAEUMW-UHFFFAOYSA-N Iodine aqueous Chemical compound [K+].I[I-]I DKNPRRRKHAEUMW-UHFFFAOYSA-N 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 2
- 239000000047 product Substances 0.000 abstract description 93
- 239000013589 supplement Substances 0.000 abstract description 12
- 235000015872 dietary supplement Nutrition 0.000 abstract description 6
- 239000000243 solution Substances 0.000 description 87
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 36
- 241001465754 Metazoa Species 0.000 description 11
- 229960004839 potassium iodide Drugs 0.000 description 11
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 7
- 230000008569 process Effects 0.000 description 7
- 235000002639 sodium chloride Nutrition 0.000 description 7
- 239000012265 solid product Substances 0.000 description 7
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 6
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- 210000001685 thyroid gland Anatomy 0.000 description 6
- 206010067997 Iodine deficiency Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 239000006260 foam Substances 0.000 description 5
- 235000006479 iodine deficiency Nutrition 0.000 description 5
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 4
- 150000001720 carbohydrates Chemical class 0.000 description 4
- 235000005911 diet Nutrition 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000012467 final product Substances 0.000 description 4
- 150000007524 organic acids Chemical class 0.000 description 4
- 239000011591 potassium Substances 0.000 description 4
- 229910052700 potassium Inorganic materials 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 239000011573 trace mineral Substances 0.000 description 4
- 235000013619 trace mineral Nutrition 0.000 description 4
- 241000282412 Homo Species 0.000 description 3
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000037213 diet Effects 0.000 description 3
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- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 229920002261 Corn starch Polymers 0.000 description 2
- 229930091371 Fructose Natural products 0.000 description 2
- 239000005715 Fructose Substances 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
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- 239000003637 basic solution Substances 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
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- 206010010774 Constipation Diseases 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/18—Iodine; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
Definitions
- the invention relates to products of natural substance of organic iodine content for intake of iodine to living organisms and methods for producing said products, which serve as nutritional supplements and fodder supplements of organic bond iodine to recover iodine requirements of living organism by natural nutritional supplements.
- Iodine deficiency in the diet has several direct and indirect effects and it influences both physical conditions and physiological processes, the state of mind.
- Symptoms and diseases due to iodine deficiency in the diet are:
- lymphatic drainage lymphatic drainage
- iodine deficiency of a pregnant woman affects the baby as well (smaller brain volume, lower IQ, tendency to disorders of the thyroid gland).
- radioactive iodine gets directly to the organism, where it is accumulated in the thyroid gland and may cause adverse changes, in given case cancer.
- Iodine supply of the organism is directly linked with disposal of heavy metals (Pb, Hg, Cd, Sr) from the organism.
- disposal of heavy metals becomes blocked, which can cause problems especially under city dwelling circumstances.
- Methods of iodine intake presently known and applied are as follows:
- One of the methods of iodine intake presently known and applied is primary intake, which means directly through food, for example with the use of iodized table salt, thyroid gland hormones of iodine content, tablets containing potassium-iodide or potassium iodade, in case of animals with the use of fodder with iodine content.
- the other method of iodine intake presently known and applied is secondary intake, which occurs with the use of foods or raw materials with high or increased iodine content, for example sea-weeds, sea fish or other seafood. Secondary intake is also possible in case of humans through foods like milk, egg, iodized vegetable oil, iodized food supplements, iodized bakery products and pastries. In case of animals secondary intake is possible through fodder with increased iodine content, which makes possible production of iodized eggs, resp. iodized milk besides providing the animals with the necessary iodine.
- Hungarian patent No. HU 205 379 deals with the production of iodized yeast (Candida utilis, Saccharomyces cerevisiae).
- the gist of the method made known here is, that when yeast is multiplied salts of trace elements can be dosed into the starter solution which will be intracellular built into the cell in the form of organic compounds.
- Trace elements are more effective in a biologically transformed form and they can be used in fodder, foods, drugs and cosmetics.
- Hungarian patent No. HU 178 298 makes known a method for determining the trace element requirements of cattle for the production of fodder supplement.
- This method measure the mineral and trace element content of fodder and blood serum and salts and oxides of the elements to be recovered are mixed to the fodder.
- the blood serum of the animals to be fed the contents of phosphorus, calcium, magnesium, potassium, sodium, copper, zinc, manganese and cobalt furthermore in given case the contents of iron, iodine and chlorine as well.
- Difference between the values measured in the fodder and those of the generally in the agriculture approved fodder-value limits is determined as well as difference between the values measured in the blood serum and those of the values of blood serum approved by animal physiology.
- Additional elements are dosed to the fodder supplement in case the value of the relevant element is lower both in the fodder and in the blood serum, or in case the value is lower only in the blood serum, but the difference of the two values is bigger, than half of the difference measured in the fodder and that of the approved value.
- Iodine can have valence 1-, 1+, 3+, 5+, 7+ and 0 in chemical bonds. Iodine incidence in compounds is most frequent with valence 1-, which is biologically inactive. Iodine with valence 1+ is biologically the most active form and this is eventually the dark violet crystalline iodine, which quickly sublimates at normal pressure. This property is true for salts of iodine 1-, because iodine leaves these salts after a while. For example potassium iodide (KI) which is hygroscopic and after iodine leaves the compound due to moisture absorbed, K+OH- is left behind.
- KI potassium iodide
- This compound is not suitable any more for ensuring intake of iodine.
- the use of so-called iodized table salt is not sufficient enough for the intake of iodine as it contains potassium-iodide, which can be stored in a dark, air-tight place. In case of longer or improper storing, which is quite common during distribution it loses its iodine content in a few months' time or even within a shorter period.
- potassium-iodide for iodine intake is not suitable, because certain tests show, that it has an adverse side affect on the blood-forming organs in living organisms.
- Potassium in the form of a salt compound is solved in the saliva can be built in directly to the thyroid gland and it is not absolutely safe, as this way iodine can be overdosed, resulting in adverse consequences.
- Potassium iodide (K+I-) is generally replaced by potassium iodate (K+I 5+ O3 ⁇ ) but iodine of valence 3+, 5+ 6+ 7+ is biologically not active enough.
- Iodine is intaken in iodine with valence 1+ in the natural foods being the most common and most suitable form for both human beings and animals. Seafood also contains iodine in this bond.
- Hungarian patent No. HU 210 025 describes a solution suitable for production of a polyvinyl-pyrroiidone-iodine compound.
- the polyvidon complex is formed in an alkyl alcohol preferably in a 96 volume % ethanol or water in a way, that polyvinyl-pyrrolidone is solved in both cases in a concentration of 5.0-80.0%, and iodion is solved in this solution so, that the final solution contain 0.1-10.0 volume % iodine.
- the drug produced this way can be directly used.
- Another method uses polyvinyl-alcohol, which is made by polymerization of a macro molecule. Scientific study of this method proved, that if this gets into reaction with iodine, then in case of certain molecule structure a compound with iodine 1+ valence can be made.
- iodine is able to bond to the long chains of amylose and appears as bonded iodine I-I (0) so, that the neutral iodine molecule breaks up in the amylose chain and each atom gets one I + valence.
- cellulose, hemicellulose, inulin, pectin are also suitable for bonding iodine with valence 1+.
- the invention relates to a product of natural substance of organic iodine content for intake of iodine to living organisms, said product contains iodine in complex bond, which is characterized by that, the product is a solid powder containing positively charged iodine ions in complex bond with a natural biological polymer.
- the natural biological polymer is a mixture of amylose and/or amylose and amylopectin of vegetal origin, and/or cellulose, and/or hemicellulose, and/or inulin, and/or pectin, and/or a mixture of all said substances.
- the natural biological polymer applied as raw material of the product is starch extracted from a natural vegetal substance, said vegetal substance can be in given case barley, banana, potato, wheat, corn, rice, rye, tapioca, pea, sweet potato.
- the particle size of the product is 1 100 ⁇ m and active iodine content is maximum
- the invention relates furthermore to a product of natural substance of organic iodine content for intake of iodine to living organisms, which is characterized by that, the product is a fluid colloid solution containing positively charged iodine ions in complex bond with the natural biological polymer in a water-solution or in an alcohol-water-solution.
- the natural biological polymer is a mixture of amylose and/or amylose and amylopectin of vegetal origin, and/or cellulose, and/or hemicellulose, and/or inulin, and/or pectin, and/or a mixture of all said substances.
- the natural biological polymer applied as raw material of the product is starch extracted from a natural vegetal substance
- said vegetal substance can be in given case barley, banana, potato, wheat, corn, rice, rye, tapioca, pea, sweet potato.
- colloidal size of the product is between 30....40 glucose anhydride and 2000 glucose anhydride and active iodine content of the product per millimeter is between a few grams and a few thousand micrograms, preferably 500....1500 micrograms counted on mass of amylose.
- the invention relates furthermore to a method for producing a product of natural substance of organic iodine content for intake of iodine to living organisms, which is characterized by that, during the method iodine solution is added to a natural biological polymer and the product obtained is dried at low temperature and then shredded.
- the natural biological polymer is a mixture of amylose and/or amylose and amylopectin of vegetal origin, and/or cellulose, and/or hemicellulose, and/or inulin, and/or pectin, and/or a mixture of all said substances and the iodine solution is a water-solution or alcohol-solution or water-alcohol solution of iodine, or water-solution or alcohol- solution of a mixture of iodine and ootassium iodide.
- vegetal substance applied as raw material of the natural biological polymer is barley, banana, potato, wheat, corn, rice, rye, tapioca, pea, sweet potato.
- a iodine-solution containing 3...24 mass % iodine counted on the mass of amylose is dosed to 100 weight-fraction of amylose or to a mixture of 70-30% of amylose and amylopectin.
- the invention relates furthermore to a method for producing a product of natural substance of organic iodine content for intake of iodine to living organisms, which is characterized by that, during the method a natural biological polymer is solved in cold or warm water, thus becoming a colloid solution when in case of change of consistency cooling is applied, and iodine solution is added to this colloid solution with mixing and the product obtained is homogenized and stabilized.
- the natural biological polymer is a mixture of amylose and/or amylose and amylopectin of vegetal origin, and/or cellulose, and/or hemicellulose, and/or inulin, and/or pectin, and/or a mixture of all said substances and the iodine solution is a water-solution or alcohol-solution or water-alcohol solution of iodine, or water-solution or alcohol- solution of a mixture of iodine and potassium iodide.
- the raw material of the natural biological polymer applied during the method is vegetal substance, in given case barley, banana, potato, wheat, corn, rice, rye, tapioca, pea, sweet potato.
- the natural biological polymer applied during the method is pre-treated with heating or boiling between 60...100°C and then the pre-treated materials are mixed for preferably 1...5 minutes preferably between 10...25°C and the ready colloid solution is stabilized by setting pH value and is stored preferably in a dark, cool place between 0...25°C.
- a iodine-solution containing 3...24 mass % iodine counted on the mass of amylose is dosed to 100 weight-fraction of amylose or to a mixture of 70-30% of amylose and amylopectin.
- a general example for the method according to the invention When preparing the product of solid, powder form, a iodine solution containing iodine is dosed to a preferably air-dry, powder form of starch, and the stabile iodine- starch substance is dried at a low temperature, then shredded and sieved. The reaction takes place without waste, every iodine atom is built in the structure of starch, drying serves only removal of water taken along with iodine. This way no free iodine, which might have toxic effect in the living organism, is left in the final product.
- reaction takes place quite quickly in the colloid solution, in a few seconds, maximum 1-3 minutes.
- Product of the solid material takes 2-10 minutes, preferably 6-8 minutes.
- Product of the colloid solution according to the invention can take place with cold or warm suspension of starch.
- starch of high amylose content in which the long chain starch content (amylose) is minimum 50...70...80 %, or the raw material is pure amylose, which can be produced by disintegration with amylopectin enzyme.
- the iodine solution applied for the product according to the invention contains: -iodine solution
- -Lugol's solution (version 1) which is made from 20 ml water solution of 10 gram potassium iodide (KI) and 5 gram iodine (I), which is filled up to 100 ml at the end of product,
- the rate of mixing of the abovementioned materials is as follows: 100 part starch and
- the calculated quantity of iodine solution is mixed to the powder used as raw material, during which the reaction of iodine with starch takes place very quickly. After having dried and shredded the final product is ready, and can be used as food or fodder supplement for direct intake of iodine of natural base.
- the raw material is water suspension of starch, which is brought to boiling point while being mixed (pasting).
- the foam developing on top of the solution is removed and the solution is cooled to room temperature. The cooled solution is mixed at room temperature and during mixing the iodine solution enumerated above is reacted with it.
- nicotinic acid B3 vitamin
- pH of the solution is set alkaline.
- the solution is homogenized resulting in a fluid iodine product.
- Iodine concentration of the final product can vary from a few micrograms to a few milligrams per milliliter depending on the quantity of iodine solution added.
- Quantity of iodine solution must be carefully chosen as no free iodine can be left in the transformed starch, because toxic affects of iodine are kept.
- the starch used is a grainy powder, which is mixed with cold water, brought to boiling point, foam removed. During this process the starch is collodized, pasted. Then it is cooled and reacted with the iodine solution of calculated quantity. In order to get one unit, one ml/1000 microgram (1 mg) iodine in the fluid product, 7.8....8 parts Lugol's solution (1) must be added.
- the iodine content of the products according to the invention is 17-22% counted on the mass of amylose.
- Medium value of iodine bonding capacity of amylose fraction of the starch is abt. 19-20%.
- water solution of starch heat treatment can be or can not be applied.
- a water colloid solution can be made both ways. In case of cold process water soluble starch derivatives (amylum solubile) are applied.
- Raw material can be starch of 1% up to 70-100% amylose.
- any macro molecules of natural or nature-identical origin consisting of long chains similar to the structure of starch, for example carbo hydrate chain, or glucose or fructose chain and iodine is ready to bond among the chains to the structure of the macro molecule, with 1+ valence.
- inulin fructtose anhydride chain
- pectin polymer of macro molecules of uron-acids
- High amylose corn with 70% amylose content is applied as raw material, having 30% amylopectin content.
- a solution of 5% iodine and 2% potassium iodide is added to this raw material until iodine concentration of 19...21% counted on iodine is reached.
- the smell of iodine disappears, and the color of the product changes to dark blue, then black.
- the product made this way is dried to air-dry at a low temperature. After drying the product is shredded, then stored at a cool place free of light.
- the amylose first becomes violet-colored, then bluish-black.
- Amylopectin does not get into reaction, but its color is oppressed by the color of the other parts of the product.
- Active iodine content of the product is 12...14%.
- High amylose corn with 70% amylose content is applied as raw material, having 30% amylopectin content.
- the raw material is added to pre-heated water during mixing, then it is heated, in given case brought to boiling point.
- the foam created during boiling is removed, then the fluid is cooled to 20...25°C.
- a solution of 5% iodine and 2% potassium iodide is added until iodine concentration of 19...21% counted on iodine is reached.
- the amylose first becomes violet-colored, then bluish-black in the product and meanwhile the smell of iodine disappears.
- Amylopectin does not get into reaction, but its color is oppressed by the color of the other parts of the product.
- the solution produced this way is stabilized by adding nicotinic acid or other organic acid, pH is set according to the known method, then it is homogenized.
- the product is sealed air-tight and kept in a dark, cool place. Active iodine content of the product is 12...14% counted on dry material.
- Products 1 and two are dosed on basis of weight depending on the daily iodine requirement or the required iodine intake.
- the daily iodine requirement is 3...5 micrograms/weight kilo, the rate of which in certain cases can be the multiply of this, e.g. in case of sportsmen, or blue-collar workers or in case of disease.
- Example 3
- Corn starch of 1% amylose content is applied as raw material, having 99% amylopectin content.
- a solution of iodine solved in water or in ethyl alcohol is added to this raw material having low capacity of iodine bonding until iodine concentration of 17...24% counted on amylose is reached.
- the smell of iodine disappears, and the color of the product changes to dark blue.
- the quantity of iodine added should be determined so, that the quantity of the active iodine or iodine should not exceed 1/5 of the actual amylose content, that is preferable 15...20%.
- the product During mixing and dosing the product is considerably swollen and becomes jelly-like because of its 99% amylopectin content.
- the product made this way is dried to air-dry at a low temperature. After drying the product is shredded, then stored at a cool place free of light.
- Active iodine content of the product made this way is 2000 micrograms/gram, which can be mainly applied for retard products and fodder of low iodine content, for example for children and chicks. In case of animals the active iodine requirement if 3-7 mg per weight kilo.
- Waxy corn starch with 1% amylose content is applied as raw material, having 99% amylopectin content.
- the raw material is made into a colloide solution, suspended in a way, that 20 grams is added to pre-heated water during mixing, then it is heated, in given case brought to boiling point. Heating, pasting lasts as long as the purpose requires.
- the foam created during boiling is removed, then the fluid is cooled to 20...25°C.
- Active iodine content of the product made this way is 20-40 microgram/milliliter which can be mainly used for retard products and fodder. It is also suitable for producing products of low iodine content, for example for children and chicks. In case of animals iodine requirement of active iodine is 3-7 microgram/weight kilo. 5- 10 ml solution should be dosed counted on 70 kilos weight.
- flavoured iodine supplement colloide solution with the method according to the invention:
- Raw material is 4 grams starch extracted from peas with 100% amylose content , to' which 6 grams of fructose, 0.2 grams of citric acid or ascorbic acid is added and filled up with distilled water to 197-200 milliliter and during slow mixing, at a slow pace 0.5 millilitre of iodine tincture (solutio iodi spirituosa) of 5% is added.
- pH is set according to the known method, preferably by adding an organic acid to it, then it is homogenized.
- the product is a dark blue fluid, which should by stored sealed air-tight in a dark, cool place. Active iodine content of the product made this way is 4000 microgram/milliliter, which is twenty-fold of the daily requirement per millilitre, therefore dosing is made by drops accordingly.
- Lugol's solution (1) is instilled.
- the solution produced this way is homogenized and stabilized.
- the iodine content of the complex iodine solution of blue color and organic bond is 1000 microgram/milliliter.
- This solution should be stored in a light-free, dark, cool place preferably between 0-25° C, preferably at 0°C.
- One kilogram of air-dry rye starch with 25% amylose content is applied as raw material. During mixing 300 milliliter Lugol's solution (1) or Lugol's solution (2) is added and after taking place of the reaction it is dried at a temperature of 15-25 °C during spinning for six hours. The product made this way is shredded and stored at store-room temperature in a sealed packing. Active iodine content of the product is
- Raw material is air-dry ground cellulose, for example vegetal stalk, or other material of high cellulose content, for example cotton, which is firstly swollen in a basic solution, then during mixing an iodine solution is added. The product made is dried at low temperature and then shredded.
- Raw material is air-dry ground hemicellulose, for example skin of sun-flower-seed, or corn-cob, which are shredded, swollen, and iodine solution is added to during mixing.
- the product made is dried at low temperture and then shredded.
- Raw material used is inulin available in nature, for example Jerusalem artichoke with inulin content of 15-35%, dried and ground. During mixing iodine solution is added to it, then the product made is dried at low temperature and shredded.
- Raw material is air-dry pectin powder, or vegetal substance of high pectin content, which is firstly swollen in a basic solution, then during mixing iodine solution is added.
- the product made is dried at low temperature and shredded.
- iodine compounds of various alkali metals and alkali earth metals can be used in the same way instead of various compounds of potassium, such as sodium, calcium, magnesium compounds with iodide.
- dosage of powder form product according to the invention is as follows:
- the powder form product of 1...3 microgram active iodine is added to food or fodder supplements in proportion to the weight kilogram of the consumer, but if necessary in case of sportsmen and blue collar workers a larger rate can be added.
- dosage of colloid solution product according to the invention is as follows: 1...3 microgram active iodine of the product of colloid solution is added to food or fodder supplements in proportion to the weight kilogram of the consumer, but if necessary a larger rate can be added.
- the advantage of the invention is, that iodine appears in its biologically and physiologically most active 1+ valence state in the products and in the complex compounds of natural or artificial, but nature-identical polymers of macro molecules its aseptic, antiseptic affect is increased resulting in eliminating pathogens or preventing their reproduction.
- the iodine built into the long chain of natural polymers loses its entire toxicity.
- the iodine in the products according to the invention is biologically active, antiseptic and non-toxic. There is no side-effect of the iodine intake of long chain in the organism, only starch bonded with iodine is taken in, which is not available in nature in this form, but in optimal case it is in the same bond as in case of iodine resources of organic bond available in nature.
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Abstract
The invention relates to products of natural substance of organic iodine content for intake of iodine to living organisms and methods for producing said products, which serve as nutritional supplements and fodder supplements of organic bond iodine to recover iodine requirements of living organism by natural nutritional supplements. The invention relates to a product of natural substance of organic iodine content for intake of iodine to living organisms, said product contains iodine in complex bond, which is characterized by that, the product is a solid powder containing positively charged iodine ions in complex bond with a natural biological polymer. The invention relates furthermore to a product of natural substance of organic iodine content for intake of iodine to living organisms, which is characterized by that, the product is a fluid colloid solution containing positively charged iodine ions in complex bond with the natural biological polymer in a water-solution or in an alcohol-water-solution. The invention relates furthermore to a method for producing a product of natural substance of organic iodine content for intake of iodine to living organisms, which is characterized by that, during the method iodine solution is added to a dry natural biological polymer and the product obtained is dried at low temperature and then shredded. The invention relates furthermore to a method for producing a product of natural substance of organic iodine content for intake of iodine to living organisms, which is characterized by that, during the method a natural biological polymer is solved in cold or warm water, thus becoming a colloid solution when in case of change of consistency cooling is applied, and iodine solution is added to this colloid solution with mixing and the product obtained is homogenized and stabilized.
Description
Products of natural substance of organic iodine content
The invention relates to products of natural substance of organic iodine content for intake of iodine to living organisms and methods for producing said products, which serve as nutritional supplements and fodder supplements of organic bond iodine to recover iodine requirements of living organism by natural nutritional supplements.
Nowadays in many parts of the world as well as in our country the majority of population suffers from iodine deficiency in the diet and the necessary quantity of iodine is not supplied in any other way either. Iodine deficiency in the diet has several direct and indirect effects and it influences both physical conditions and physiological processes, the state of mind.
Symptoms and diseases due to iodine deficiency in the diet are:
Inadequate dietary iodine causes reduced function of the thyroid gland and colloid nodular goiter occurs.
Symptoms:
- metabolic diseases of fat, protein, carbohydrate (weight gain, or weight loss, cool limbs) "
- increase of cholesterol and triglyceride (cardiovascular disorders)
- increase of permeability of capillary vessels
- retardation of lymphatic drainage (lymphedema)
- hormonal deficiencies (decreased sexual desire)
- abnormal menstrual periods (profuse or extended bleeding) and other gynecological diseases
- infertility, frequent abortion in case of pregnancy, prematurity, heavy labor
- fibrocystic breast disease, vaginitis, Candida infection, chlamydia
- dry, flaky skin, Xerosis, Winter itch
- brittle, dry, falling hair
- thin, brittle nails
- muscle weakness, rigidity, pain, skeletal limb abnormalities
- breathlessness
- constipation
- kidney disorders
- psychic disorders, mental sluggishness (headache, depression, weakness, problems of concentration, forgetfulness)
According to data by relative text books, iodine deficiency of a pregnant woman affects the baby as well (smaller brain volume, lower IQ, tendency to disorders of the thyroid gland). In case of population with iodine deficiency in the event of a nuclear accident radioactive iodine gets directly to the organism, where it is accumulated in the thyroid gland and may cause adverse changes, in given case cancer. Iodine supply of the organism is directly linked with disposal of heavy metals (Pb, Hg, Cd, Sr) from the organism. In case of deficiency of iodine supply disposal of heavy
metals becomes blocked, which can cause problems especially under city dwelling circumstances.
Methods of iodine intake presently known and applied are as follows: One of the methods of iodine intake presently known and applied is primary intake, which means directly through food, for example with the use of iodized table salt, thyroid gland hormones of iodine content, tablets containing potassium-iodide or potassium iodade, in case of animals with the use of fodder with iodine content.
The other method of iodine intake presently known and applied is secondary intake, which occurs with the use of foods or raw materials with high or increased iodine content, for example sea-weeds, sea fish or other seafood. Secondary intake is also possible in case of humans through foods like milk, egg, iodized vegetable oil, iodized food supplements, iodized bakery products and pastries. In case of animals secondary intake is possible through fodder with increased iodine content, which makes possible production of iodized eggs, resp. iodized milk besides providing the animals with the necessary iodine.
In the state of art there are various products and methods for producing products suitable for iodine intake. Hungarian patent No. HU 205 379 deals with the production of iodized yeast (Candida utilis, Saccharomyces cerevisiae). The gist of the method made known here is, that when yeast is multiplied salts of trace elements can be dosed into the starter solution which will be intracellular built into the cell in the form of organic compounds. Trace elements are more effective in a biologically transformed form and they can be used in fodder, foods, drugs and cosmetics.
Hungarian patent No. HU 178 298 makes known a method for determining the trace element requirements of cattle for the production of fodder supplement. This method measure the mineral and trace element content of fodder and blood serum and salts and oxides of the elements to be recovered are mixed to the fodder. During the method in the blood serum of the animals to be fed the contents of phosphorus, calcium, magnesium, potassium, sodium, copper, zinc, manganese and cobalt furthermore in given case the contents of iron, iodine and chlorine as well. Difference between the values measured in the fodder and those of the generally in the agriculture approved fodder-value limits is determined as well as difference between the values measured in the blood serum and those of the values of blood serum approved by animal physiology. Additional elements are dosed to the fodder supplement in case the value of the relevant element is lower both in the fodder and in the blood serum, or in case the value is lower only in the blood serum, but the difference of the two values is bigger, than half of the difference measured in the fodder and that of the approved value.
The presently known solutions for iodine intake are not satisfactory as food supplements for humans and fodder supplements for animals. The iodine provided in potassium iodide, in potassium iodate or in thyroid gland hormones frequently has side effects and the rate of intake can not be controlled, so overdose can easily
occur. W.R. Ghent and partner make known a few methods presently known for iodine intake and their side effects in the article called 'Iodine Replacement in Firocystyc Disease of the Breast' (Can J Ssurg 36, 1993: 453-60), furthermore Z.E.Mielens and collegues in an article called 'The Effect of Oral Iodides on Inflammation' (Texas Rrep Biol Med 26, 1968: 117-21).
Intake and bonding of iodine take place at present as follows: Iodine can have valence 1-, 1+, 3+, 5+, 7+ and 0 in chemical bonds. Iodine incidence in compounds is most frequent with valence 1-, which is biologically inactive. Iodine with valence 1+ is biologically the most active form and this is eventually the dark violet crystalline iodine, which quickly sublimates at normal pressure. This property is true for salts of iodine 1-, because iodine leaves these salts after a while. For example potassium iodide (KI) which is hygroscopic and after iodine leaves the compound due to moisture absorbed, K+OH- is left behind. This compound is not suitable any more for ensuring intake of iodine. The use of so-called iodized table salt is not sufficient enough for the intake of iodine as it contains potassium-iodide, which can be stored in a dark, air-tight place. In case of longer or improper storing, which is quite common during distribution it loses its iodine content in a few months' time or even within a shorter period.
The use of potassium-iodide for iodine intake is not suitable, because certain tests show, that it has an adverse side affect on the blood-forming organs in living organisms. Potassium in the form of a salt compound is solved in the saliva can be built in directly to the thyroid gland and it is not absolutely safe, as this way iodine can be overdosed, resulting in adverse consequences. Potassium iodide (K+I-) is generally replaced by potassium iodate (K+I 5+ O3~) but iodine of valence 3+, 5+ 6+ 7+ is biologically not active enough. Iodine is intaken in iodine with valence 1+ in the natural foods being the most common and most suitable form for both human beings and animals. Seafood also contains iodine in this bond.
Iodine is able to make bonds with valence 1+ in synthetic or natural systems of macro molecules. Hungarian patent No. HU 210 025 describes a solution suitable for production of a polyvinyl-pyrroiidone-iodine compound. During the process the polyvidon complex is formed in an alkyl alcohol preferably in a 96 volume % ethanol or water in a way, that polyvinyl-pyrrolidone is solved in both cases in a concentration of 5.0-80.0%, and iodion is solved in this solution so, that the final solution contain 0.1-10.0 volume % iodine. The drug produced this way can be directly used.
Another method uses polyvinyl-alcohol, which is made by polymerization of a macro molecule. Scientific study of this method proved, that if this gets into reaction with iodine, then in case of certain molecule structure a compound with iodine 1+ valence can be made.
We aimed to work out a method with the solution according to the invention, which makes possible optimal intake and use of iodine of organic bond to living organisms as food or fodder supplement.
When working out the solution according to the invention we examined which natural substance can establish a bond with iodine 1+. We realized, that there are natural substances with macro molecules, that are able to bond with iodine 1+. Such substance is starch amilum in Latin, which is used for storing nutrients by plants. It is one of the main materials of nutrients for human beings and for animals. Starch is a long chain of carbohydrate with a long section and with an arm branch. The long chain is amylose, the arm branch is amylopectin. During our preliminary tests we found, that iodine is able to bond to the long chains of amylose and appears as bonded iodine I-I (0) so, that the neutral iodine molecule breaks up in the amylose chain and each atom gets one I + valence. We furthermore realized, that several other types of natural polymers, for example cellulose, hemicellulose, inulin, pectin are also suitable for bonding iodine with valence 1+.
When working out the solution according to the invention, we realized, if this reaction can be properly carried out, then this disintegrated iodine molecule appears in the bond with an atomic valence 1+ 1+ and the amylose part of the starch becomes an organic macro anion (-) and 1+ becomes the cation in the system. With the consolidation of iodine secondary spiral structures develop in the amylose, where iodine of oxidizing character 1+ is needed. This way iodine appears in its most active 1+ valence form, which is biologically and physiologically the most active form. This way aseptic and antiseptic affect of iodine in complex compounds with synthetic and natural polymers of macro molecules is greatly increased.
When working out the product of solid powder form, we realized, that in case a iodine solution containing iodine is mixed to dry powder form starch, then a stabile iodine-starch is made, which after drying at low temperature and after shredding can be applied as a natural iodine supplement product.
When working out the product of fluid colloid solution, we realized, that in case a iodine solution containing iodine is dosed to a preferable heat-treated water- suspension of starch, then such a iodine-starch is made, that after homogenization and stabilization it can be used as a fluid natural iodine supplement.
The invention relates to a product of natural substance of organic iodine content for intake of iodine to living organisms, said product contains iodine in complex bond, which is characterized by that, the product is a solid powder containing positively charged iodine ions in complex bond with a natural biological polymer.
One of the preferred embodiments of the product according to the invention, the natural biological polymer is a mixture of amylose and/or amylose and amylopectin of vegetal origin, and/or cellulose, and/or hemicellulose, and/or inulin, and/or pectin, and/or a mixture of all said substances.
Another preferred embodiment of the product according to the invention, the natural biological polymer applied as raw material of the product is starch extracted from a natural vegetal substance, said vegetal substance can be in given case barley, banana, potato, wheat, corn, rice, rye, tapioca, pea, sweet potato.
In a further preferred embodiment of the product according to the invention, the particle size of the product is 1 100 μm and active iodine content is maximum
3....24 %, preferably 1....5 % counted on mass % of amylose.
The invention relates furthermore to a product of natural substance of organic iodine content for intake of iodine to living organisms, which is characterized by that, the product is a fluid colloid solution containing positively charged iodine ions in complex bond with the natural biological polymer in a water-solution or in an alcohol-water-solution.
One of the preferred embodiments of the product according to the invention, the natural biological polymer is a mixture of amylose and/or amylose and amylopectin of vegetal origin, and/or cellulose, and/or hemicellulose, and/or inulin, and/or pectin, and/or a mixture of all said substances.
Another preferred embodiment of the product according to the invention, the natural biological polymer applied as raw material of the product is starch extracted from a natural vegetal substance, said vegetal substance can be in given case barley, banana, potato, wheat, corn, rice, rye, tapioca, pea, sweet potato.
In a further preferred embodiment of the product according to the invention, colloidal size of the product is between 30....40 glucose anhydride and 2000 glucose anhydride and active iodine content of the product per millimeter is between a few grams and a few thousand micrograms, preferably 500....1500 micrograms counted on mass of amylose.
The invention relates furthermore to a method for producing a product of natural substance of organic iodine content for intake of iodine to living organisms, which is characterized by that, during the method iodine solution is added to a natural biological polymer and the product obtained is dried at low temperature and then shredded.
One of the preferred applications of the method according to the invention, the natural biological polymer is a mixture of amylose and/or amylose and amylopectin of vegetal origin, and/or cellulose, and/or hemicellulose, and/or inulin, and/or pectin, and/or a mixture of all said substances and the iodine solution is a water-solution or alcohol-solution or water-alcohol solution of iodine, or water-solution or alcohol- solution of a mixture of iodine and ootassium iodide.
Another preferred application of the method according to the invention, vegetal substance applied as raw material of the natural biological polymer is barley, banana, potato, wheat, corn, rice, rye, tapioca, pea, sweet potato.
In a further preferred application of the method according to the invention, during the method mixing of raw materials takes place preferably between 10...25°C temperature, drying takes place preferably between 6...12 hours at preferably 15...25°C temperature.
In a further preferred application of the method according to the invention, during the method a iodine-solution containing 3...24 mass % iodine counted on the mass of amylose is dosed to 100 weight-fraction of amylose or to a mixture of 70-30% of amylose and amylopectin.
The invention relates furthermore to a method for producing a product of natural substance of organic iodine content for intake of iodine to living organisms, which is characterized by that, during the method a natural biological polymer is solved in cold or warm water, thus becoming a colloid solution when in case of change of consistency cooling is applied, and iodine solution is added to this colloid solution with mixing and the product obtained is homogenized and stabilized.
One of the preferred applications of the method according to the invention, the natural biological polymer is a mixture of amylose and/or amylose and amylopectin of vegetal origin, and/or cellulose, and/or hemicellulose, and/or inulin, and/or pectin, and/or a mixture of all said substances and the iodine solution is a water-solution or alcohol-solution or water-alcohol solution of iodine, or water-solution or alcohol- solution of a mixture of iodine and potassium iodide.
Another preferred application of the method according to the invention, the raw material of the natural biological polymer applied during the method is vegetal substance, in given case barley, banana, potato, wheat, corn, rice, rye, tapioca, pea, sweet potato.
In a further preferred application of the method according to the invention, the natural biological polymer applied during the method is pre-treated with heating or boiling between 60...100°C and then the pre-treated materials are mixed for preferably 1...5 minutes preferably between 10...25°C and the ready colloid solution is stabilized by setting pH value and is stored preferably in a dark, cool place between 0...25°C.
In a further preferred application of the method according to the invention, during the method a iodine-solution containing 3...24 mass % iodine counted on the mass of amylose is dosed to 100 weight-fraction of amylose or to a mixture of 70-30% of amylose and amylopectin.
Solutions according to the invention are set forth by the following examples:
A general example for the method according to the invention: When preparing the product of solid, powder form, a iodine solution containing iodine is dosed to a preferably air-dry, powder form of starch, and the stabile iodine- starch substance is dried at a low temperature, then shredded and sieved. The reaction takes place without waste, every iodine atom is built in the structure of starch, drying serves only removal of water taken along with iodine. This way no free iodine, which might have toxic effect in the living organism, is left in the final product.
The reaction takes place quite quickly in the colloid solution, in a few seconds, maximum 1-3 minutes. Product of the solid material takes 2-10 minutes, preferably 6-8 minutes. Product of the colloid solution according to the invention can take place with cold or warm suspension of starch.
In a possible preferred application of the method according to the invention starch of high amylose content is used, in which the long chain starch content (amylose) is minimum 50...70...80 %, or the raw material is pure amylose, which can be produced by disintegration with amylopectin enzyme.
The iodine solution applied for the product according to the invention contains: -iodine solution
-tincture of iodine (solutio iodi spirituosa)
-Lugol's solution (version 1) which is made from 20 ml water solution of 10 gram potassium iodide (KI) and 5 gram iodine (I), which is filled up to 100 ml at the end of product,
-Lugol's solution (version 2) which is made from 20 ml water solution of 2 gram potassium iodide (KI) and 5 gram iodine (I), which is filled up to 100 ml at the end of product
During a possible production of the product of powder form according to the invention the rate of mixing of the abovementioned materials is as follows: 100 part starch and
30 part iodine solution with potassium iodide (Lugol's solution No.l) from which after the mixing and drying for air-dry state at low temperature a substance is created, which in given case contains 1.5 % biologically active iodine. In case of proper storing at room temperature the iodine is not released from the substance.
During the method according to the invention the calculated quantity of iodine solution is mixed to the powder used as raw material, during which the reaction of iodine with starch takes place very quickly. After having dried and shredded the final product is ready, and can be used as food or fodder supplement for direct intake of iodine of natural base.
When making the colloid iodine-starch solution in given case the raw material is water suspension of starch, which is brought to boiling point while being mixed (pasting). During the process the foam developing on top of the solution is removed and the solution is cooled to room temperature. The cooled solution is mixed at room temperature and during mixing the iodine solution enumerated above is reacted with it. For the stabilization a little organic acid, for example nicotinic acid (B3 vitamin) is added and pH of the solution is set alkaline. Then the solution is homogenized resulting in a fluid iodine product. Iodine concentration of the final product can vary from a few micrograms to a few milligrams per milliliter depending on the quantity of iodine solution added. Quantity of iodine solution must be carefully chosen as no free iodine can be left in the transformed starch, because toxic affects of iodine are kept.
For making a possible application of the product according to the invention the starch used is a grainy powder, which is mixed with cold water, brought to boiling point, foam removed. During this process the starch is collodized, pasted. Then it is cooled and reacted with the iodine solution of calculated quantity. In order to get one unit, one ml/1000 microgram (1 mg) iodine in the fluid product, 7.8....8 parts Lugol's solution (1) must be added.
The iodine content of the products according to the invention is 17-22% counted on the mass of amylose. Medium value of iodine bonding capacity of amylose fraction of the starch is abt. 19-20%. During making water solution of starch heat treatment can be or can not be applied. A water colloid solution can be made both ways. In case of cold process water soluble starch derivatives (amylum solubile) are applied. Raw material can be starch of 1% up to 70-100% amylose.
For the reaction of starch solution - iodine solution the absorbing capacity of the colloid starch solution is not fully used, but under-dosed, to make sure that the total quantity of the iodine solution gets into reaction and is bonded, so no free iodine of toxic effect is left in the final product.
A few further preferred embodiments of the product according to the invention and a few further applications of the method are set forth as follows:
It is possible to make use for the product according to the invention of any macro molecules of natural or nature-identical origin consisting of long chains similar to the structure of starch, for example carbo hydrate chain, or glucose or fructose chain and iodine is ready to bond among the chains to the structure of the macro molecule, with 1+ valence.
Accordingly use of the following substances is possible as natural biological polymers:
- starch (amilum), of at least a little amylose content, respectively pure amylose,
- hemicellulose (xylane, arabane, carbohydrates of five carbon atoms)
- inulin (fructose anhydride chain)
- pectin (polymer of macro molecules of uron-acids)
- other similar substances suitable for human or animal consumption of polymers
Furthermore as raw materials for the product syntethically made, but nature-identical biological polymers can also be used, accordingly every macro molecule consisting of long chains similar to the structure of starch, and iodine is ready to bond among the chains to the structure of the macro molecule, with 1+ valence and is suitable for consumption by humans or animals.
Making of a few preferable embodiments of the product according to the invention is set forth with the realization of the following examples:
Example 1
Making of solid product of powder form:
High amylose corn with 70% amylose content is applied as raw material, having 30% amylopectin content. During slow mixing at a slow pace a solution of 5% iodine and 2% potassium iodide is added to this raw material until iodine concentration of 19...21% counted on iodine is reached. During the process the smell of iodine disappears, and the color of the product changes to dark blue, then black. The product made this way is dried to air-dry at a low temperature. After drying the product is shredded, then stored at a cool place free of light. The amylose first becomes violet-colored, then bluish-black. Amylopectin does not get into reaction, but its color is oppressed by the color of the other parts of the product. Active iodine content of the product is 12...14%.
Example 2
Making of colloide solution:
High amylose corn with 70% amylose content is applied as raw material, having 30% amylopectin content. Firstly the raw material is added to pre-heated water during mixing, then it is heated, in given case brought to boiling point. The foam created during boiling is removed, then the fluid is cooled to 20...25°C. At this temperature, during slow mixing, at a slow pace a solution of 5% iodine and 2% potassium iodide is added until iodine concentration of 19...21% counted on iodine is reached. The amylose first becomes violet-colored, then bluish-black in the product and meanwhile the smell of iodine disappears.
Amylopectin does not get into reaction, but its color is oppressed by the color of the other parts of the product.The solution produced this way is stabilized by adding nicotinic acid or other organic acid, pH is set according to the known method, then it is homogenized. The product is sealed air-tight and kept in a dark, cool place. Active iodine content of the product is 12...14% counted on dry material.
Products 1 and two are dosed on basis of weight depending on the daily iodine requirement or the required iodine intake. The daily iodine requirement is 3...5 micrograms/weight kilo, the rate of which in certain cases can be the multiply of this, e.g. in case of sportsmen, or blue-collar workers or in case of disease.
Example 3:
Making of solid product of powder form:
Corn starch of 1% amylose content is applied as raw material, having 99% amylopectin content. During slow mixing at a slow pace a solution of iodine solved in water or in ethyl alcohol is added to this raw material having low capacity of iodine bonding until iodine concentration of 17...24% counted on amylose is reached. During the process the smell of iodine disappears, and the color of the product changes to dark blue. The quantity of iodine added should be determined so, that the quantity of the active iodine or iodine should not exceed 1/5 of the actual amylose content, that is preferable 15...20%. During mixing and dosing the product is considerably swollen and becomes jelly-like because of its 99% amylopectin content.The product made this way is dried to air-dry at a low temperature. After drying the product is shredded, then stored at a cool place free of light.
Active iodine content of the product made this way is 2000 micrograms/gram, which can be mainly applied for retard products and fodder of low iodine content, for example for children and chicks. In case of animals the active iodine requirement if 3-7 mg per weight kilo.
Example 4:
Making of colloide solution:
Waxy corn starch with 1% amylose content is applied as raw material, having 99% amylopectin content. Firstly the raw material is made into a colloide solution, suspended in a way, that 20 grams is added to pre-heated water during mixing, then it is heated, in given case brought to boiling point. Heating, pasting lasts as long as the purpose requires. The foam created during boiling is removed, then the fluid is cooled to 20...25°C.
During slow mixing at a slow pace a solution of iodine solved in water or in ethyl alcohol is added to this raw material having low capacity of iodine bonding until iodine concentration of 17...24% counted on amylose is reached. During the process the smell of iodine disappears and the color of the product becomes dark blue. The solution produced this way is stabilized by adding nicotinic acid or other organic acid, pH is set according to the known method, then it is homogenized. Stabilization is necessary in case of product to be stored for a longer period. The product made this way is a very gelatinoid colloide material The product is sealed air-tight and kept in a dark, cool place until used.
Active iodine content of the product made this way is 20-40 microgram/milliliter which can be mainly used for retard products and fodder. It is also suitable for producing products of low iodine content, for example for children and chicks. In case of animals iodine requirement of active iodine is 3-7 microgram/weight kilo. 5- 10 ml solution should be dosed counted on 70 kilos weight.
Example 5
Making of flavoured iodine supplement colloide solution with the method according to the invention:
Raw material is 4 grams starch extracted from peas with 100% amylose content , to' which 6 grams of fructose, 0.2 grams of citric acid or ascorbic acid is added and filled up with distilled water to 197-200 milliliter and during slow mixing, at a slow pace 0.5 millilitre of iodine tincture (solutio iodi spirituosa) of 5% is added.
The solution produced this way is stabilized , pH is set according to the known method, preferably by adding an organic acid to it, then it is homogenized. The product is a dark blue fluid, which should by stored sealed air-tight in a dark, cool place. Active iodine content of the product made this way is 4000 microgram/milliliter, which is twenty-fold of the daily requirement per millilitre, therefore dosing is made by drops accordingly.
Example 6
Making of colloide fluid:
2 decagrams of air-dry wheat starch with 25% amylose content is applied as raw material. This quantity is filled up to one liter with distilled water, then after having brought to boiling point, boiled for five minutes. The foam created during boiling is removed, then the fluid is cooled to room temperature.During mixing, 20 milliliter
Lugol's solution (1) is instilled.
The solution produced this way is homogenized and stabilized. The iodine content of the complex iodine solution of blue color and organic bond is 1000 microgram/milliliter. This solution should be stored in a light-free, dark, cool place preferably between 0-25° C, preferably at 0°C.
Example 7
Making of solid product of powder form:
One kilogram of air-dry rye starch with 25% amylose content is applied as raw material. During mixing 300 milliliter Lugol's solution (1) or Lugol's solution (2) is added and after taking place of the reaction it is dried at a temperature of 15-25 °C during spinning for six hours. The product made this way is shredded and stored at store-room temperature in a sealed packing. Active iodine content of the product is
15000 microgram/gram.
Further examples of making the product according to the invention with various organic bio polymers.
Example 8
Making of solid product of powder form from cellulose: Raw material is air-dry ground cellulose, for example vegetal stalk, or other material of high cellulose content, for example cotton, which is firstly swollen in a basic solution, then during mixing an iodine solution is added. The product made is dried at low temperature and then shredded.
Example 9
Making of solid product of powder form from hemicellulose. Raw material is air-dry ground hemicellulose, for example skin of sun-flower-seed, or corn-cob, which are shredded, swollen, and iodine solution is added to during mixing. The product made is dried at low temperture and then shredded.
Example 10
Making of solid product of powder form from inulin. Raw material used is inulin available in nature, for example Jerusalem artichoke with inulin content of 15-35%, dried and ground. During mixing iodine solution is added to it, then the product made is dried at low temperature and shredded.
Example 11
Making of solid product of powder form from pectin: Raw material is air-dry pectin powder, or vegetal substance of high pectin content, which is firstly swollen in a basic solution, then during mixing iodine solution is added. The product made is dried at low temperature and shredded.
For making the products according to the invention and during the methods according to the invention iodine compounds of various alkali metals and alkali earth metals can be used in the same way instead of various compounds of potassium, such as sodium, calcium, magnesium compounds with iodide.
Application, dosage of powder form product according to the invention is as follows: The powder form product of 1...3 microgram active iodine is added to food or fodder supplements in proportion to the weight kilogram of the consumer, but if necessary in case of sportsmen and blue collar workers a larger rate can be added.
Application, dosage of colloid solution product according to the invention is as follows: 1...3 microgram active iodine of the product of colloid solution is added to food or fodder supplements in proportion to the weight kilogram of the consumer, but if necessary a larger rate can be added.
The advantage of the invention is, that iodine appears in its biologically and physiologically most active 1+ valence state in the products and in the complex compounds of natural or artificial, but nature-identical polymers of macro molecules its aseptic, antiseptic affect is increased resulting in eliminating pathogens or preventing their reproduction.
According to the method of the invention the iodine built into the long chain of natural polymers loses its entire toxicity. The iodine in the products according to the invention is biologically active, antiseptic and non-toxic. There is no side-effect of the iodine intake of long chain in the organism, only starch bonded with iodine is taken in, which is not available in nature in this form, but in optimal case it is in the same bond as in case of iodine resources of organic bond available in nature.
Claims
1. Product of natural substance of organic iodine content for intake of iodine to living organisms, said product contains iodine in complex bond characterized by that, the product is a solid powder containing positively charged iodine ions in complex bond with a natural biological polymer.
2. A product according to claim 1 characterized by that, the natural biological polymer is a mixture of amylose and/or amylose and amylopectin of vegetal origin, and/or cellulose, and/or hemicellulose, and/or inulin, and/or pectin, and/or a mixture of all said substances.
3. A product according to claim 1 or 2 characterized by that, the natural biological polymer applied as raw material of the product is starch extracted from a natural vegetal substance, said vegetal substance can be in given case barley, banana, potato, wheat, corn, rice, rye, tapioca, pea, sweet potato.
4. A product according to any of claims 1 to 3 characterized by that, the particle size of the product is 1 100 μm and active iodine content is maximum 3....24 %, preferably 1....5 % counted on mass % of amylose.
5. A product of natural substance of organic iodine content for intake of iodine to living organisms characterized by that, the product is a fluid colloid solution containing positively charged iodine ions in complex bond with the natural biological polymer in a water-solution or in an alcohol-water-solution.
6. A product according to claim 5 characterized by that, the natural biological polymer is a mixture of amylose and/or amylose and amylopectin of vegetal origin, and/or cellulose, and/or hemicellulose, and/or inulin, and/or pectin, and/or a mixture of all said substances.
7. A product according to claim 5 or 6 characterized by that the natural biological polymer applied as raw material of the product is starch extracted from a natural vegetal substance, said vegetal substance can be in given case barley, banana, potato, wheat, corn, rice, rye, tapioca, pea, sweet potato.
8. A product according to any of claims 5 to 7 characterized by that colloidal size of the product is between 30....40 glucose anhydride and 2000 glucose anhydride and active iodine content of the product per millimeter is between a few grams and a few thousand micrograms, preferably 500....1500 micrograms counted on mass of amylose.
9. Method for producing a product of natural substance of organic iodine content for intake of iodine to living organisms characterized by that, during the method iodine solution is added to a dry natural biological polymer and the product obtained is dried at low temperature and then shredded.
10. Method according to claim 9 characterized by that, the natural biological polymer is a mixture of amylose and/or amylose and amylopectin of vegetal origin, and/or cellulose, and/or hemicellulose, and/or inulin, and/or pectin, and/or a mixture of all said substances and the iodine solution is a water-solution or alcohol-solution or water-alcohol solution of iodine, or water-solution or alcohol-solution of a mixture of iodine and potassium iodide.
11. Method according to claim 9 or 10 characterized by that, vegetal substance applied as raw material of the natural biological polymer is barley, banana, potato, wheat, corn, rice, rye, tapioca, pea, sweet potato.
12. Method according to any of claims 9 to 11 characterized by that, during the method mixing of raw materials takes place preferably between 10...25°C temperature, drying takes place preferably between 6...12 hours at preferably 15...25°C temperature.
13. Method according to any of claims 9 to 11 characterized by that, during the method a iodine-solution containing 3...24 mass % iodine counted on the mass of amylose is dosed to 100 weight-fraction of amylose or to a mixture of 70-30% of amylose and amylopectin.
14. Method for producing a product of natural substance of organic iodine content for intake of iodine to living organisms characterized by that, during the method a natural biological polymer is solved in cold or warm water, thus becoming a colloid solution when in case of change of consistency cooling is applied, and iodine solution is added to this colloid solution with mixing and the product obtained is homogenized and stabilized.
15. Method according to claim 14 characterized by that, the natural biological polymer is a mixture of amylose and/or amylose and amylopectin of vegetal origin, and or cellulose, and/or hemicellulose, and/or inulin, and/or pectin, and/or a mixture of all said substances and the iodine solution is a water-solution or alcohol-solution or water-alcohol solution of iodine, or water-solution or alcohol-solution of a mixture of iodine and potassium iodide.
16. Method according to claim 14 or 15 characterized by that, the raw material of the natural biological polymer applied during the method is vegetal substance, in given case barley, banana, potato, wheat, corn, rice, rye, tapioca, pea, sweet potato.
17. Method according to any of claims 14 to 16 characterized by that, the natural biological polymer applied during the method is pre-treated with heating or boiling between 60...100°C and then the pre-treated materials are mixed for preferably 1...5 minutes preferably between 10...25°C and the ready colloid solution is stabilized by setting pH value and is stored preferably in a dark, cool place between 0...25°C.
18. Method according to any of claims 14 to 17 characterized by that, during the method a iodine-solution containing 3...24 mass % iodine counted on the mass of amylose is dosed to 100 weight-fraction of amylose or to a mixture of 70-30% of amylose and amylopectin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2002349170A AU2002349170A1 (en) | 2001-12-06 | 2002-12-06 | Products of natural substance of organic iodine content |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUP0105261 | 2001-12-06 | ||
| HU0105261A HUP0105261A2 (en) | 2001-12-06 | 2001-12-06 | Natural based composition with organic bounds containing iodine for introducing iodine into living organs and processes for their production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2003047605A1 true WO2003047605A1 (en) | 2003-06-12 |
Family
ID=89979965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/HU2002/000138 WO2003047605A1 (en) | 2001-12-06 | 2002-12-06 | Products of natural substance of organic iodine content |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU2002349170A1 (en) |
| HU (1) | HUP0105261A2 (en) |
| WO (1) | WO2003047605A1 (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011152800A1 (en) * | 2010-05-31 | 2011-12-08 | Bulik Jozef | Method of production of nutritive supplement |
| ITFI20100146A1 (en) * | 2010-07-13 | 2012-01-14 | Antonio Dimida | EVERYWHERE PREPARABLE DRINK FOR THE INTEGRATION OF IODINE IN FOOD DIETS |
| RU2496347C2 (en) * | 2011-11-23 | 2013-10-27 | Общество с ограниченной ответственностью "Технопарк МГУТУ" | Biologically active food additive for iodine deficit prophylactics |
| RU2611839C1 (en) * | 2016-03-29 | 2017-03-01 | Федеральное Государственное Бюджетное Образовательное Учреждение Высшего Образования "Московский Государственный Университет Технологий И Управления Имени К.Г. Разумовского (Первый Казачий Университет)" | Composition for production of iodine-containing biologically active food additives |
| RU2611830C1 (en) * | 2016-03-29 | 2017-03-01 | Федеральное Государственное Бюджетное Образовательное Учреждение Высшего Образования "Московский Государственный Университет Технологий И Управления Имени К.Г. Разумовского (Первый Казачий Университет)" | Production method for iodine-containing biologically active food additive |
| US10034899B2 (en) | 2013-11-27 | 2018-07-31 | BioPharmX, Inc. | Solid oral dosage form for breast symptoms |
| RU2716585C1 (en) * | 2019-01-09 | 2020-03-12 | Федеральное Государственное Бюджетное Образовательное Учреждение Высшего Образования "Московский Государственный Университет Технологий И Управления Имени К.Г. Разумовского (Первый Казачий Университет)" | Method for producing iodine-containing biologically active food additive |
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| US3733405A (en) * | 1971-05-10 | 1973-05-15 | Watkins Salt Co | Stabilizer for ethylene diamine dihydriodide |
| EP0172984A1 (en) * | 1984-08-07 | 1986-03-05 | Euro-Celtique S.A. | Iodophor composition |
| WO1992017190A1 (en) * | 1991-03-28 | 1992-10-15 | Ghent William R | Dry starch-iodine pharmaceutical formulations |
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| WO2011152800A1 (en) * | 2010-05-31 | 2011-12-08 | Bulik Jozef | Method of production of nutritive supplement |
| ITFI20100146A1 (en) * | 2010-07-13 | 2012-01-14 | Antonio Dimida | EVERYWHERE PREPARABLE DRINK FOR THE INTEGRATION OF IODINE IN FOOD DIETS |
| RU2496347C2 (en) * | 2011-11-23 | 2013-10-27 | Общество с ограниченной ответственностью "Технопарк МГУТУ" | Biologically active food additive for iodine deficit prophylactics |
| US10034899B2 (en) | 2013-11-27 | 2018-07-31 | BioPharmX, Inc. | Solid oral dosage form for breast symptoms |
| RU2611839C1 (en) * | 2016-03-29 | 2017-03-01 | Федеральное Государственное Бюджетное Образовательное Учреждение Высшего Образования "Московский Государственный Университет Технологий И Управления Имени К.Г. Разумовского (Первый Казачий Университет)" | Composition for production of iodine-containing biologically active food additives |
| RU2611830C1 (en) * | 2016-03-29 | 2017-03-01 | Федеральное Государственное Бюджетное Образовательное Учреждение Высшего Образования "Московский Государственный Университет Технологий И Управления Имени К.Г. Разумовского (Первый Казачий Университет)" | Production method for iodine-containing biologically active food additive |
| RU2716585C1 (en) * | 2019-01-09 | 2020-03-12 | Федеральное Государственное Бюджетное Образовательное Учреждение Высшего Образования "Московский Государственный Университет Технологий И Управления Имени К.Г. Разумовского (Первый Казачий Университет)" | Method for producing iodine-containing biologically active food additive |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002349170A1 (en) | 2003-06-17 |
| HU0105261D0 (en) | 2002-02-28 |
| HUP0105261A2 (en) | 2003-08-28 |
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