WO2003033507A1 - Derives d'acide benzylmalonique et inhibiteurs de proteasomes les contenant - Google Patents
Derives d'acide benzylmalonique et inhibiteurs de proteasomes les contenant Download PDFInfo
- Publication number
- WO2003033507A1 WO2003033507A1 PCT/JP2002/010451 JP0210451W WO03033507A1 WO 2003033507 A1 WO2003033507 A1 WO 2003033507A1 JP 0210451 W JP0210451 W JP 0210451W WO 03033507 A1 WO03033507 A1 WO 03033507A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- remedies
- acid derivatives
- alkyl
- diseases
- contaiing
- Prior art date
Links
- JAEJSNFTJMYIEF-UHFFFAOYSA-N 2-benzylpropanedioic acid Chemical class OC(=O)C(C(O)=O)CC1=CC=CC=C1 JAEJSNFTJMYIEF-UHFFFAOYSA-N 0.000 title abstract 2
- 229940079156 Proteasome inhibitor Drugs 0.000 title 1
- 239000003207 proteasome inhibitor Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 206010009900 Colitis ulcerative Diseases 0.000 abstract 1
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
- 102000004245 Proteasome Endopeptidase Complex Human genes 0.000 abstract 1
- 108090000708 Proteasome Endopeptidase Complex Proteins 0.000 abstract 1
- 201000006704 Ulcerative Colitis Diseases 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000000043 antiallergic agent Substances 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 208000037976 chronic inflammation Diseases 0.000 abstract 1
- 208000037893 chronic inflammatory disorder Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229960003444 immunosuppressant agent Drugs 0.000 abstract 1
- 239000003018 immunosuppressive agent Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003536246A JPWO2003033507A1 (ja) | 2001-10-12 | 2002-10-08 | ベンジルマロン酸誘導体およびそれを含有するプロテアソーム阻害薬 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001314732 | 2001-10-12 | ||
JP2001-314732 | 2001-10-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003033507A1 true WO2003033507A1 (fr) | 2003-04-24 |
Family
ID=19132996
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2002/010451 WO2003033507A1 (fr) | 2001-10-12 | 2002-10-08 | Derives d'acide benzylmalonique et inhibiteurs de proteasomes les contenant |
Country Status (2)
Country | Link |
---|---|
JP (1) | JPWO2003033507A1 (fr) |
WO (1) | WO2003033507A1 (fr) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005021558A2 (fr) * | 2003-08-14 | 2005-03-10 | Cephalon, Inc. | Inhibiteurs de proteasomes et procedes d'utilisation de ceux-ci |
EP2088205A1 (fr) | 2008-02-11 | 2009-08-12 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | PSMB10 : marqueur de diagnostic et cible thérapeutique de rejet chronique |
EP2377868A1 (fr) | 2004-03-30 | 2011-10-19 | Millennium Pharmaceuticals, Inc. | Synthèse de Bortezomib |
US8283367B2 (en) | 2005-02-11 | 2012-10-09 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
US8513218B2 (en) | 2010-03-31 | 2013-08-20 | Millennium Pharmaceuticals, Inc. | Derivatives of 1-amino-2-cyclopropylethylboronic acid |
US8530694B2 (en) | 2007-08-06 | 2013-09-10 | Millennium Pharmaceuticals, Inc. | Proteasome inhibitors |
US8541590B2 (en) | 2009-12-22 | 2013-09-24 | Cephalon, Inc. | Proteasome inhibitors and processes for their preparation, purification and use |
US8664200B2 (en) | 2008-09-29 | 2014-03-04 | Millennium Pharmaceuticals, Inc. | Derivatives of 1-amino-2-cyclobutylethylboronic acid |
US8859504B2 (en) | 2008-06-17 | 2014-10-14 | Millennium Pharmaceuticals, Inc. | Boronate ester compounds and pharmaceutical compositions thereof |
US9126997B1 (en) | 2010-09-07 | 2015-09-08 | Northwestern University | Synergistic effect of glucocorticoid receptor agonists in combination with proteosome inhibitors for treating leukemia and myeloma |
US11241448B2 (en) | 2014-05-20 | 2022-02-08 | Millennium Pharmaceuticals, Inc. | Methods for cancer therapy |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996013266A1 (fr) * | 1994-10-28 | 1996-05-09 | Proscript, Inc. | Composes d'esters et d'acides boroniques, leur synthese et leurs utilisations |
US5814622A (en) * | 1996-02-27 | 1998-09-29 | Adir Et Compagnie | Compounds derived from boronic acid |
-
2002
- 2002-10-08 WO PCT/JP2002/010451 patent/WO2003033507A1/fr active Application Filing
- 2002-10-08 JP JP2003536246A patent/JPWO2003033507A1/ja active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996013266A1 (fr) * | 1994-10-28 | 1996-05-09 | Proscript, Inc. | Composes d'esters et d'acides boroniques, leur synthese et leurs utilisations |
US5814622A (en) * | 1996-02-27 | 1998-09-29 | Adir Et Compagnie | Compounds derived from boronic acid |
Cited By (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9233115B2 (en) | 2003-08-14 | 2016-01-12 | Millennium Pharmaceuticals Inc. | Proteasome inhibitors and methods of using the same |
JP4917431B2 (ja) * | 2003-08-14 | 2012-04-18 | セファロン、インク. | プロテアソーム阻害剤及びそれらを使用する方法 |
JP2007502304A (ja) * | 2003-08-14 | 2007-02-08 | セファロン、インク. | プロテアソーム阻害剤及びそれらを使用する方法 |
EA010804B1 (ru) * | 2003-08-14 | 2008-12-30 | Сефэлон, Инк. | ПРОИЗВОДНЫЕ БОРОНОВОЙ КИСЛОТЫ (ВАРИАНТЫ), СПОСОБ ИХ ПОЛУЧЕНИЯ, ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ, КОМПОЗИЦИЯ ДЛЯ ИНГИБИРОВАНИЯ АКТИВНОСТИ ПРОТЕАСОМ, СПОСОБЫ ИНГИБИРОВАНИЯ АКТИВНОСТИ ПРОТЕАСОМЫ, ФАКТОРА ТРАНСКРИПЦИИ NF-kB И ДЕГРАДАЦИИ БЕЛКА И СПОСОБ ЛЕЧЕНИЯ РАКА |
US7915236B2 (en) | 2003-08-14 | 2011-03-29 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
US7576206B2 (en) | 2003-08-14 | 2009-08-18 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
US8546608B2 (en) | 2003-08-14 | 2013-10-01 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
WO2005021558A3 (fr) * | 2003-08-14 | 2005-05-12 | Cephalon Inc | Inhibiteurs de proteasomes et procedes d'utilisation de ceux-ci |
US8058262B2 (en) | 2003-08-14 | 2011-11-15 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
WO2005021558A2 (fr) * | 2003-08-14 | 2005-03-10 | Cephalon, Inc. | Inhibiteurs de proteasomes et procedes d'utilisation de ceux-ci |
CN107474062A (zh) * | 2004-03-30 | 2017-12-15 | 千禧药品公司 | 硼的酯和酸化合物的合成 |
EP2377868A1 (fr) | 2004-03-30 | 2011-10-19 | Millennium Pharmaceuticals, Inc. | Synthèse de Bortezomib |
US8283367B2 (en) | 2005-02-11 | 2012-10-09 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
US8530694B2 (en) | 2007-08-06 | 2013-09-10 | Millennium Pharmaceuticals, Inc. | Proteasome inhibitors |
US8772536B2 (en) | 2007-08-06 | 2014-07-08 | Millennium Pharmaceuticals, Inc. | Proteasome inhibitors |
US8871745B2 (en) | 2007-08-06 | 2014-10-28 | Millennium Pharmaceuticals, Inc. | Proteasome inhibitors |
EP2088205A1 (fr) | 2008-02-11 | 2009-08-12 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | PSMB10 : marqueur de diagnostic et cible thérapeutique de rejet chronique |
US10604538B2 (en) | 2008-06-17 | 2020-03-31 | Millenium Pharmaceuticals, Inc. | Boronate ester compounds and pharmaceutical compositions thereof |
US11485746B2 (en) | 2008-06-17 | 2022-11-01 | Millennium Pharmaceuticals, Inc. | Boronate ester compounds and pharmaceutical compositions thereof |
US10526351B2 (en) | 2008-06-17 | 2020-01-07 | Millennium Pharmaceuticals, Inc. | Boronate ester compounds and pharmaceutical compositions thereof |
US9175018B2 (en) | 2008-06-17 | 2015-11-03 | Millennium Pharmaceuticals, Inc. | Boronate ester compounds and pharmaceutical compositions thereof |
US9175017B2 (en) | 2008-06-17 | 2015-11-03 | Millennium Pharmaceuticals, Inc. | Boronate ester compounds and pharmaceutical compositions thereof |
US8859504B2 (en) | 2008-06-17 | 2014-10-14 | Millennium Pharmaceuticals, Inc. | Boronate ester compounds and pharmaceutical compositions thereof |
US10035811B2 (en) | 2008-09-29 | 2018-07-31 | Millennium Pharmaceuticals, Inc. | Derivatives of 1-amino-2-cyclobutylethylboronic acid |
US8664200B2 (en) | 2008-09-29 | 2014-03-04 | Millennium Pharmaceuticals, Inc. | Derivatives of 1-amino-2-cyclobutylethylboronic acid |
US9771381B2 (en) | 2008-09-29 | 2017-09-26 | Millennium Pharmaceuticals, Inc. | Derivatives of 1-amino-2-cyclobutylethylboronic acid |
US8541590B2 (en) | 2009-12-22 | 2013-09-24 | Cephalon, Inc. | Proteasome inhibitors and processes for their preparation, purification and use |
US8513218B2 (en) | 2010-03-31 | 2013-08-20 | Millennium Pharmaceuticals, Inc. | Derivatives of 1-amino-2-cyclopropylethylboronic acid |
US9023832B2 (en) | 2010-03-31 | 2015-05-05 | Millennium Pharmaceuticals, Inc. | Derivatives of 1-amino-2-cyclopropylethylboronic acid |
US8703743B2 (en) | 2010-03-31 | 2014-04-22 | Millennium Pharmaceuticals, Inc. | Derivatives of 1-amino-2-cyclopropylethylboronic acid |
US9126997B1 (en) | 2010-09-07 | 2015-09-08 | Northwestern University | Synergistic effect of glucocorticoid receptor agonists in combination with proteosome inhibitors for treating leukemia and myeloma |
US11241448B2 (en) | 2014-05-20 | 2022-02-08 | Millennium Pharmaceuticals, Inc. | Methods for cancer therapy |
Also Published As
Publication number | Publication date |
---|---|
JPWO2003033507A1 (ja) | 2005-02-03 |
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