WO2003029819A1 - Procede pour le criblage preventif / le traitement des maladies d'os ou d'articulations - Google Patents
Procede pour le criblage preventif / le traitement des maladies d'os ou d'articulations Download PDFInfo
- Publication number
- WO2003029819A1 WO2003029819A1 PCT/JP2002/009949 JP0209949W WO03029819A1 WO 2003029819 A1 WO2003029819 A1 WO 2003029819A1 JP 0209949 W JP0209949 W JP 0209949W WO 03029819 A1 WO03029819 A1 WO 03029819A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- remedy
- bone
- joint diseases
- screening
- preventive
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
- C12N9/6491—Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96486—Metalloendopeptidases (3.4.24)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
- G01N2400/02—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates involving antibodies to sugar part of glycoproteins
Abstract
L'invention concerne un procédé pour le criblage préventif / le traitement des maladies d'os ou d'articulations et un procédé pour cribler un composé ou son sel qui favorise ou inhibe la décomposition d'un protéoglycane caractérisé par l'utilisation de cellules utilisant MMP-19 et MT3-MMP.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001303314 | 2001-09-28 | ||
JP2001-303314 | 2001-09-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003029819A1 true WO2003029819A1 (fr) | 2003-04-10 |
Family
ID=19123415
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2002/009949 WO2003029819A1 (fr) | 2001-09-28 | 2002-09-26 | Procede pour le criblage preventif / le traitement des maladies d'os ou d'articulations |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2003029819A1 (fr) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH1080283A (ja) * | 1996-04-25 | 1998-03-31 | Takeda Chem Ind Ltd | 新規タンパク質およびそのdna |
WO2001049309A2 (fr) * | 1999-12-29 | 2001-07-12 | Pfizer Limited | Composition pour le traitement de tissu lese |
WO2001066766A2 (fr) * | 2000-03-06 | 2001-09-13 | Darwin Molecular Corporation | Nouvelle metalloproteinase matricielle (mmp-25) exprimee dans des cellules de la peau |
-
2002
- 2002-09-26 WO PCT/JP2002/009949 patent/WO2003029819A1/fr active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH1080283A (ja) * | 1996-04-25 | 1998-03-31 | Takeda Chem Ind Ltd | 新規タンパク質およびそのdna |
WO2001049309A2 (fr) * | 1999-12-29 | 2001-07-12 | Pfizer Limited | Composition pour le traitement de tissu lese |
WO2001066766A2 (fr) * | 2000-03-06 | 2001-09-13 | Darwin Molecular Corporation | Nouvelle metalloproteinase matricielle (mmp-25) exprimee dans des cellules de la peau |
Non-Patent Citations (1)
Title |
---|
TAKAHISA T. ET AL.: "Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library", J. BIOL. CHEM., vol. 270, no. 39, 29 September 1995 (1995-09-29), pages 23013 - 23020, XP002925884 * |
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