WO2003026632A3 - Substituted phenol compounds useful for anesthesia and sedation - Google Patents

Substituted phenol compounds useful for anesthesia and sedation Download PDF

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Publication number
WO2003026632A3
WO2003026632A3 PCT/US2002/030477 US0230477W WO03026632A3 WO 2003026632 A3 WO2003026632 A3 WO 2003026632A3 US 0230477 W US0230477 W US 0230477W WO 03026632 A3 WO03026632 A3 WO 03026632A3
Authority
WO
WIPO (PCT)
Prior art keywords
sedation
substituted phenol
phenol compounds
anesthesia
compounds useful
Prior art date
Application number
PCT/US2002/030477
Other languages
French (fr)
Other versions
WO2003026632A2 (en
Inventor
Thomas E Jenkins
Yu-Hua Ji
Huiwei Wu
Jennifer Bolton
Original Assignee
Theravance Inc
Thomas E Jenkins
Yu-Hua Ji
Huiwei Wu
Jennifer Bolton
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Inc, Thomas E Jenkins, Yu-Hua Ji, Huiwei Wu, Jennifer Bolton filed Critical Theravance Inc
Priority to CA002459125A priority Critical patent/CA2459125A1/en
Priority to AU2002334675A priority patent/AU2002334675A1/en
Priority to EP02799635A priority patent/EP1430017A2/en
Publication of WO2003026632A2 publication Critical patent/WO2003026632A2/en
Publication of WO2003026632A3 publication Critical patent/WO2003026632A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C07C69/88—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with esterified carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention provides substituted phenol compounds and pharmaceutical compositions containing substituted phenol compounds which are useful for inducing or maintaining anesthesia or sedation in a mammal. This invention also provides methods for inducing or maintaining anesthesia or sedation in a mammal using substituted phenol compounds.
PCT/US2002/030477 2001-09-26 2002-09-26 Substituted phenol compounds useful for anesthesia and sedation WO2003026632A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002459125A CA2459125A1 (en) 2001-09-26 2002-09-26 Substituted phenol compounds useful for anesthesia and sedation
AU2002334675A AU2002334675A1 (en) 2001-09-26 2002-09-26 Substituted phenol compounds useful for anesthesia and sedation
EP02799635A EP1430017A2 (en) 2001-09-26 2002-09-26 Substituted phenol compounds useful for anesthesia and sedation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32504401P 2001-09-26 2001-09-26
US60/325,044 2001-09-26

Publications (2)

Publication Number Publication Date
WO2003026632A2 WO2003026632A2 (en) 2003-04-03
WO2003026632A3 true WO2003026632A3 (en) 2003-08-21

Family

ID=23266196

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/030477 WO2003026632A2 (en) 2001-09-26 2002-09-26 Substituted phenol compounds useful for anesthesia and sedation

Country Status (5)

Country Link
US (2) US6815555B2 (en)
EP (1) EP1430017A2 (en)
AU (1) AU2002334675A1 (en)
CA (1) CA2459125A1 (en)
WO (1) WO2003026632A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1430017A2 (en) * 2001-09-26 2004-06-23 Theravance, Inc. Substituted phenol compounds useful for anesthesia and sedation
US20080161400A1 (en) * 2006-10-26 2008-07-03 Xenoport, Inc. Use of forms of propofol for treating diseases associated with oxidative stress
WO2008157627A1 (en) * 2007-06-21 2008-12-24 Xenoport, Inc. Use of propofol prodrugs for treating alcohol withdrawal, central pain, anxiety or pruritus
US20090076141A1 (en) * 2007-09-14 2009-03-19 Xenoport, Inc. Use of Propofol Prodrugs for Treating Neuropathic Pain
CA2911845C (en) 2013-05-09 2019-08-13 Sichuan Haisco Pharmaceutical Co., Ltd. Phenol derivative and preparation method and use in medicine thereof
CN108264460A (en) * 2017-01-03 2018-07-10 天地人和生物科技有限公司 It is a kind of to anaesthetize class compound and preparation method thereof and application medically
CN112250566B (en) * 2020-10-26 2022-01-04 四川大学 2, 6-diisopropyl phenol compound and preparation method and application thereof
KR20230132568A (en) * 2021-01-28 2023-09-15 힌예 파마슈티컬 컴퍼니, 리미티드 Phenol derivatives and their applications in medicine

Citations (7)

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Publication number Priority date Publication date Assignee Title
US3790648A (en) * 1971-02-17 1974-02-05 Ciba Geigy Corp Process for the manufacture of benzylphosphonates
US3808296A (en) * 1971-04-22 1974-04-30 Ciba Geigy Corp Bicyclic phosphorus compounds and process for making same
US3887638A (en) * 1972-07-12 1975-06-03 Allied Chem Antistatic fiber containing chain-extended tetrols based on diamines
JPS61218558A (en) * 1985-03-23 1986-09-29 Kanegafuchi Chem Ind Co Ltd 3,5-diisopropyl-4-hydroxystyrene derivative
US5155122A (en) * 1988-11-29 1992-10-13 Warner-Lambert Company 3,5-di-tertiary-butyl-4-hydroxyphenyl-1,3,4-thiadiazoles, and oxadiazoles and 3,5-di-tertiary-butyl-4-hydroxy-phenyl-1,2,4-thiadazoles, oxadiazoles and triazoles as antiinflammatory agents
US5510361A (en) * 1994-10-20 1996-04-23 The Procter & Gamble Company Di-tert-butylphenol compounds with heterocyclic moiety, useful as anti-inflammatory agents
WO2001026656A2 (en) * 1999-10-11 2001-04-19 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) 5-membered heterocycle derivatives and use thereof as monoamine oxidase inhibitors

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US5395752A (en) 1993-03-19 1995-03-07 Ciba Corning Diagnostics Corp. Long emission wavelength chemiluminescent compounds and their use in test assays
DE4325623A1 (en) 1993-07-30 1995-02-23 Bayer Ag Use of substituted phenols as fatigue inhibitors for dynamically stressed elastomers
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3790648A (en) * 1971-02-17 1974-02-05 Ciba Geigy Corp Process for the manufacture of benzylphosphonates
US3808296A (en) * 1971-04-22 1974-04-30 Ciba Geigy Corp Bicyclic phosphorus compounds and process for making same
US3887638A (en) * 1972-07-12 1975-06-03 Allied Chem Antistatic fiber containing chain-extended tetrols based on diamines
JPS61218558A (en) * 1985-03-23 1986-09-29 Kanegafuchi Chem Ind Co Ltd 3,5-diisopropyl-4-hydroxystyrene derivative
US5155122A (en) * 1988-11-29 1992-10-13 Warner-Lambert Company 3,5-di-tertiary-butyl-4-hydroxyphenyl-1,3,4-thiadiazoles, and oxadiazoles and 3,5-di-tertiary-butyl-4-hydroxy-phenyl-1,2,4-thiadazoles, oxadiazoles and triazoles as antiinflammatory agents
US5510361A (en) * 1994-10-20 1996-04-23 The Procter & Gamble Company Di-tert-butylphenol compounds with heterocyclic moiety, useful as anti-inflammatory agents
WO2001026656A2 (en) * 1999-10-11 2001-04-19 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) 5-membered heterocycle derivatives and use thereof as monoamine oxidase inhibitors

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Also Published As

Publication number Publication date
US6815555B2 (en) 2004-11-09
WO2003026632A2 (en) 2003-04-03
EP1430017A2 (en) 2004-06-23
AU2002334675A1 (en) 2003-04-07
CA2459125A1 (en) 2003-04-03
US20030119790A1 (en) 2003-06-26
US20050032753A1 (en) 2005-02-10
US7226946B2 (en) 2007-06-05

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