WO2002101057A1 - Transfert genique dans des cellules souches embryonnaires de primate a l'aide d'un virus de l'immunodeficience simienne de pseudo type vsv-g utilise comme vecteur - Google Patents
Transfert genique dans des cellules souches embryonnaires de primate a l'aide d'un virus de l'immunodeficience simienne de pseudo type vsv-g utilise comme vecteur Download PDFInfo
- Publication number
- WO2002101057A1 WO2002101057A1 PCT/JP2002/005225 JP0205225W WO02101057A1 WO 2002101057 A1 WO2002101057 A1 WO 2002101057A1 JP 0205225 W JP0205225 W JP 0205225W WO 02101057 A1 WO02101057 A1 WO 02101057A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- stem cells
- embryonic stem
- vsv
- gene transfer
- immunodeficiency virus
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 6
- 241000288906 Primates Species 0.000 title abstract 5
- 210000001671 embryonic stem cell Anatomy 0.000 title abstract 5
- 241000713311 Simian immunodeficiency virus Species 0.000 title abstract 4
- 241000711975 Vesicular stomatitis virus Species 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 102000012750 Membrane Glycoproteins Human genes 0.000 abstract 1
- 108010090054 Membrane Glycoproteins Proteins 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5073—Stem cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/106—Primate
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
- A01K2267/025—Animal producing cells or organs for transplantation
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2510/00—Genetically modified cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15045—Special targeting system for viral vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
- C12N2810/6072—Vectors comprising as targeting moiety peptide derived from defined protein from viruses negative strand RNA viruses
- C12N2810/6081—Vectors comprising as targeting moiety peptide derived from defined protein from viruses negative strand RNA viruses rhabdoviridae, e.g. VSV
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/22—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Neisseriaceae (F), e.g. Acinetobacter
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- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/479,912 US7323337B2 (en) | 2001-06-08 | 2002-05-29 | Gene transfer into primate embryonic stem cells using VSV-G pseudotyped simian immunodeficiency virus vectors |
CA002449589A CA2449589A1 (en) | 2001-06-08 | 2002-05-29 | Gene transfer into primate embryonic stem cells using vsv-g pseudotyped simian immunodeficiency virus vector |
EP02728191A EP1403374A4 (en) | 2001-06-08 | 2002-05-29 | GENE TRANSFER IN EMBRYONIC PRIMATE STEM CELLS WITH THE VSV-G PSEUDOTYPE MONKEY IMMUNITY WEAK VIRUS VECTOR |
JP2003503807A JPWO2002101057A1 (ja) | 2001-06-08 | 2002-05-29 | Vsv−gシュードタイプ化サル免疫不全ウイルスベクターを用いた霊長類胚性幹細胞への遺伝子導入 |
AU2002258248A AU2002258248C1 (en) | 2001-06-08 | 2002-05-29 | Gene transfer into primate embryonic stem cells using VSV-G pseudotyped simian immunodeficiency virus vector |
KR1020037015930A KR100682708B1 (ko) | 2001-06-08 | 2002-05-29 | Vsv-g 슈도타입화 원숭이 면역부전 바이러스 벡터를 사용한 영장류 배아 줄기세포로의 유전자 도입 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001-174696 | 2001-06-08 | ||
JP2001174696 | 2001-06-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002101057A1 true WO2002101057A1 (fr) | 2002-12-19 |
WO2002101057A8 WO2002101057A8 (fr) | 2004-02-12 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2002/005225 WO2002101057A1 (fr) | 2001-06-08 | 2002-05-29 | Transfert genique dans des cellules souches embryonnaires de primate a l'aide d'un virus de l'immunodeficience simienne de pseudo type vsv-g utilise comme vecteur |
Country Status (7)
Country | Link |
---|---|
US (1) | US7323337B2 (ja) |
EP (1) | EP1403374A4 (ja) |
JP (2) | JPWO2002101057A1 (ja) |
KR (1) | KR100682708B1 (ja) |
CN (1) | CN100557023C (ja) |
CA (1) | CA2449589A1 (ja) |
WO (1) | WO2002101057A1 (ja) |
Cited By (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005087936A1 (ja) * | 2004-03-16 | 2005-09-22 | Dnavec Research Inc. | 胚性幹細胞に遺伝子を導入する方法 |
WO2006090697A1 (ja) * | 2005-02-23 | 2006-08-31 | Dnavec Corporation | Pedfおよびfgf2を含む眼組織細胞におけるアポトーシス変性を伴う疾患の治療薬 |
WO2007049749A1 (ja) | 2005-10-28 | 2007-05-03 | Dnavec Corporation | 血液凝固異常の治療方法 |
US8278284B2 (en) | 2005-02-23 | 2012-10-02 | Masanori Miyazaki | Therapeutic agents for diseases associated with apoptotic degeneration in ocular tissue cells that use SIV-PEDF vectors |
WO2013168403A1 (ja) | 2012-05-08 | 2013-11-14 | 株式会社大塚製薬工場 | トレハロース含有肺塞栓形成予防用哺乳動物細胞懸濁液 |
WO2014208053A1 (ja) | 2013-06-28 | 2014-12-31 | 株式会社大塚製薬工場 | トレハロース及びデキストラン含有哺乳動物細胞移植用溶液 |
EP2993235A1 (en) | 2005-10-28 | 2016-03-09 | ID Pharma Co., Ltd. | Gene transfer into airway epithelial stem cell by using simian lentiviral vector pseudotyped with sendai rna virus spike protein |
WO2018005975A1 (en) | 2016-07-01 | 2018-01-04 | Research Development Foundation | Elimination of proliferating cells from stem cell-derived grafts |
WO2018084228A1 (ja) | 2016-11-04 | 2018-05-11 | 国立大学法人東京大学 | 動物細胞又は動物組織の凍結保存用溶液、凍結物、及び凍結保存方法 |
WO2018097253A1 (ja) | 2016-11-25 | 2018-05-31 | 国立研究開発法人理化学研究所 | 移植用細胞集団及びその製造方法 |
WO2018110159A1 (ja) | 2016-12-14 | 2018-06-21 | 株式会社大塚製薬工場 | 哺乳動物細胞凍結保存液 |
WO2018164240A1 (ja) | 2017-03-08 | 2018-09-13 | 大日本住友製薬株式会社 | 網膜色素上皮細胞の製造方法 |
WO2019017491A1 (ja) | 2017-07-20 | 2019-01-24 | 国立研究開発法人理化学研究所 | 神経組織の保存方法 |
WO2019017492A1 (ja) | 2017-07-20 | 2019-01-24 | 国立研究開発法人理化学研究所 | 連続的な上皮を含む網膜組織の成熟化方法 |
WO2019050015A1 (ja) | 2017-09-08 | 2019-03-14 | 国立研究開発法人理化学研究所 | 網膜組織を含む細胞凝集体及びその製造方法 |
WO2019054514A1 (ja) | 2017-09-14 | 2019-03-21 | 国立研究開発法人理化学研究所 | 網膜組織の製造方法 |
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WO2019103125A1 (ja) | 2017-11-24 | 2019-05-31 | 住友化学株式会社 | 神経系細胞又は神経組織と非神経上皮組織とを含む細胞塊の製造方法及びその細胞塊 |
WO2019103129A1 (ja) | 2017-11-24 | 2019-05-31 | 住友化学株式会社 | 下垂体組織を含む細胞塊の製造方法及びその細胞塊 |
WO2019160148A1 (ja) | 2018-02-19 | 2019-08-22 | 大日本住友製薬株式会社 | 細胞凝集体、細胞凝集体の混合物及びそれらの製造方法 |
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WO2020138430A1 (ja) | 2018-12-28 | 2020-07-02 | 国立研究開発法人理化学研究所 | 網膜系細胞又は網膜組織の障害を伴う疾患の治療薬 |
WO2020184720A1 (ja) | 2019-03-13 | 2020-09-17 | 大日本住友製薬株式会社 | 移植用神経網膜の品質を評価する方法及び移植用神経網膜シート |
WO2020218461A1 (ja) | 2019-04-26 | 2020-10-29 | 株式会社大塚製薬工場 | トレハロースを含む哺乳動物細胞保存用液 |
WO2020218480A1 (ja) | 2019-04-26 | 2020-10-29 | 国立研究開発法人理化学研究所 | 神経網膜と網膜色素上皮細胞とハイドロゲルとを含む複合体及びその製造方法 |
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WO2021100829A1 (ja) | 2019-11-20 | 2021-05-27 | 大日本住友製薬株式会社 | 神経系細胞の凍結方法 |
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WO2023054396A1 (ja) | 2021-09-30 | 2023-04-06 | 住友化学株式会社 | 下垂体組織を含む細胞集団の製造方法及びその細胞集団 |
WO2023054395A1 (ja) | 2021-09-30 | 2023-04-06 | 住友ファーマ株式会社 | 下垂体ホルモン産生細胞を含む細胞凝集体及びその製造方法 |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003056019A1 (en) * | 2001-12-24 | 2003-07-10 | Es Cell International Pte Ltd | Method of transducing es cells |
WO2007014282A2 (en) * | 2005-07-26 | 2007-02-01 | Whitehead Institute For Biomedical Research | Transfection method and uses related thereto |
MX342449B (es) | 2007-08-03 | 2016-09-29 | Pasteur Institut | Vectores de transferencia de gen lentiviral y sus aplicaciones medicinales. |
CN101550406B (zh) * | 2008-04-03 | 2016-02-10 | 北京大学 | 制备多潜能干细胞的方法,试剂盒及用途 |
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Also Published As
Publication number | Publication date |
---|---|
US20040234948A1 (en) | 2004-11-25 |
EP1403374A1 (en) | 2004-03-31 |
AU2002258248B2 (en) | 2006-08-17 |
CN1571844A (zh) | 2005-01-26 |
CN100557023C (zh) | 2009-11-04 |
WO2002101057A8 (fr) | 2004-02-12 |
EP1403374A4 (en) | 2004-07-21 |
AU2002258248B8 (en) | 2006-11-23 |
JPWO2002101057A1 (ja) | 2004-09-24 |
CA2449589A1 (en) | 2002-12-19 |
KR100682708B1 (ko) | 2007-02-15 |
JP2008119006A (ja) | 2008-05-29 |
KR20040003053A (ko) | 2004-01-07 |
US7323337B2 (en) | 2008-01-29 |
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