WO2002092850A3 - Diagnostic method for osteoporosis and related disorders - Google Patents

Diagnostic method for osteoporosis and related disorders Download PDF

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Publication number
WO2002092850A3
WO2002092850A3 PCT/GB2002/002263 GB0202263W WO02092850A3 WO 2002092850 A3 WO2002092850 A3 WO 2002092850A3 GB 0202263 W GB0202263 W GB 0202263W WO 02092850 A3 WO02092850 A3 WO 02092850A3
Authority
WO
WIPO (PCT)
Prior art keywords
osteoporosis
fra
related disorders
diagnostic method
gene
Prior art date
Application number
PCT/GB2002/002263
Other languages
French (fr)
Other versions
WO2002092850A2 (en
Inventor
Omar Mohammed Eid Algagha
Stuart Hamilton Ralston
Original Assignee
Univ Aberdeen
Omar Mohammed Eid Algagha
Stuart Hamilton Ralston
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Aberdeen, Omar Mohammed Eid Algagha, Stuart Hamilton Ralston filed Critical Univ Aberdeen
Priority to AU2002307954A priority Critical patent/AU2002307954A1/en
Publication of WO2002092850A2 publication Critical patent/WO2002092850A2/en
Publication of WO2002092850A3 publication Critical patent/WO2002092850A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Abstract

Provided are methods and materials for determining the susceptibility of an individual to a disorder which is associated with an abnormal (e.g. low) level of bone mineral density (BMD), the method comprising use of a Fos related antigen-1 gene (Fra-1) marker. The methods may be used e.g. for diagnosis of osteoporosis. Preferred Fra-1 markers include single nucleotide polymorphisms at positions 933, 1301, 4755, 1948, and 2394 of the Fra-1 gene.
PCT/GB2002/002263 2001-05-17 2002-05-17 Diagnostic method for osteoporosis and related disorders WO2002092850A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002307954A AU2002307954A1 (en) 2001-05-17 2002-05-17 Diagnostic method for osteoporosis and related disorders

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0112075.7A GB0112075D0 (en) 2001-05-17 2001-05-17 Diagnostic method for osteoporosis and related disorders
GB0112075.7 2001-05-17

Publications (2)

Publication Number Publication Date
WO2002092850A2 WO2002092850A2 (en) 2002-11-21
WO2002092850A3 true WO2002092850A3 (en) 2003-12-18

Family

ID=9914818

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2002/002263 WO2002092850A2 (en) 2001-05-17 2002-05-17 Diagnostic method for osteoporosis and related disorders

Country Status (3)

Country Link
AU (1) AU2002307954A1 (en)
GB (1) GB0112075D0 (en)
WO (1) WO2002092850A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003292404A1 (en) * 2002-12-13 2004-07-09 Oxagen Limited Genetic susceptibility
US7407753B2 (en) * 2004-05-24 2008-08-05 Yissum Research Development Company Of The Hebrewuniversityofjerusalem Methods, kits and pharmaceutical compositions for diagnosing, delaying onset of, preventing and/or treating osteoporosis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001020031A2 (en) * 1999-09-10 2001-03-22 Kyowa Hakko Kogyo Co Ltd Polymorphisms in a klotho gene

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001020031A2 (en) * 1999-09-10 2001-03-22 Kyowa Hakko Kogyo Co Ltd Polymorphisms in a klotho gene

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
[online] The SNP Consortium Ltd; 1 May 2001 (2001-05-01), XP002254507, retrieved from THE SNP CONSORTIUM LTD Database accession no. rs1151523 *
AERSSENS J ET AL: "Polymorphisms of the VDR, ER and COLIA1 genes and osteoporotic hip fracture in elderly postmenopausal women.", OSTEOPOROSIS INTERNATIONAL: A JOURNAL ESTABLISHED AS RESULT OF COOPERATION BETWEEN THE EUROPEAN FOUNDATION FOR OSTEOPOROSIS AND THE NATIONAL OSTEOPOROSIS FOUNDATION OF THE USA. ENGLAND 2000, vol. 11, no. 7, 2000, pages 583 - 591, XP002254505, ISSN: 0937-941X *
DATABASE SNP [online] NCBI; 5 October 2000 (2000-10-05), XP002254506, retrieved from NCBI Database accession no. rs1151523 *
JOCHUM W ET AL: "Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1.", NATURE MEDICINE. UNITED STATES SEP 2000, vol. 6, no. 9, September 2000 (2000-09-01), pages 980 - 984, XP002254502, ISSN: 1078-8956 *
LOUGHLIN J ET AL: "ASSOCIATION ANALYSIS OF THE VITAMIN D RECEPTOR GENE, THE TYPE I COLLAGEN GENE COL1A1, AND THE ESTROGEN RECEPTOR GENE IN IDIOPATHIC OSTEOARTHRITIS", JOURNAL OF RHEUMATOLOGY, TORONTO, CA, vol. 27, no. 3, March 2000 (2000-03-01), pages 779 - 784, XP009015687, ISSN: 0315-162X *
MATSUO K ET AL: "Fosl1 is a transcriptional target of c-Fos during osteoclast differentiation.", NATURE GENETICS. UNITED STATES FEB 2000, vol. 24, no. 2, February 2000 (2000-02-01), pages 184 - 187, XP002254504, ISSN: 1061-4036 *
UITTERLINDEN A G ET AL: "INTERACTION BETWEEN THE VITAMIN D RECEPTOR GENE AND COLLAGEN TYPE IALPHA1 GENE IN SUSCEPTIBILITY FOR FRACTURE", JOURNAL OF BONE AND MINERAL RESEARCH, NEW YORK, NY, US, vol. 16, no. 2, February 2001 (2001-02-01), pages 379 - 385, XP009015684, ISSN: 0884-0431 *
VIDAL F ET AL: "Gene trap analysis of germ cell signaling to Sertoli cells: NGF-TrkA mediated induction of Fra1 and Fos by post-meiotic germ cells.", JOURNAL OF CELL SCIENCE. ENGLAND JAN 2001, vol. 114, no. Pt 2, January 2001 (2001-01-01), pages 435 - 443, XP002254503, ISSN: 0021-9533 *

Also Published As

Publication number Publication date
GB0112075D0 (en) 2001-07-11
WO2002092850A2 (en) 2002-11-21
AU2002307954A1 (en) 2002-11-25

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