WO2002089727A3 - Methods of using cytokine c17 - Google Patents

Methods of using cytokine c17 Download PDF

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Publication number
WO2002089727A3
WO2002089727A3 PCT/US2002/011869 US0211869W WO02089727A3 WO 2002089727 A3 WO2002089727 A3 WO 2002089727A3 US 0211869 W US0211869 W US 0211869W WO 02089727 A3 WO02089727 A3 WO 02089727A3
Authority
WO
WIPO (PCT)
Prior art keywords
cells
endothelial
hematopoietic
useful
cells expressing
Prior art date
Application number
PCT/US2002/011869
Other languages
French (fr)
Other versions
WO2002089727A9 (en
WO2002089727A2 (en
Inventor
Linzhao Cheng
Young Sung
Original Assignee
Univ Johns Hopkins
Linzhao Cheng
Young Sung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins, Linzhao Cheng, Young Sung filed Critical Univ Johns Hopkins
Priority to AU2002340544A priority Critical patent/AU2002340544A1/en
Publication of WO2002089727A2 publication Critical patent/WO2002089727A2/en
Publication of WO2002089727A9 publication Critical patent/WO2002089727A9/en
Publication of WO2002089727A3 publication Critical patent/WO2002089727A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

We have found that C17 protein stimulates the growth of endothelial and hematopoietic cells expressing the CD34 marker. In bone marrow and blood, rare populations of cells expressing CD34 are immature precursors for both hematopoietic and endothelial cells, including hematopoietic stem cells, endothelial progenitor cells and hemangioblasts. This finding makes C17 useful for promotion of angiogenesis and makes it a target for drugs for antiangiogenesis. Thus C17 specific molecules will be useful for treating tumors and leukemias, as well as for treating wounds to encourage healing.
PCT/US2002/011869 2001-05-03 2002-05-01 Methods of using cytokine c17 WO2002089727A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002340544A AU2002340544A1 (en) 2001-05-03 2002-05-01 Methods of using cytokine c17

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US28808301P 2001-05-03 2001-05-03
US60/288,083 2001-05-03
US13269202A 2002-04-26 2002-04-26
US10/132,692 2002-04-26

Publications (3)

Publication Number Publication Date
WO2002089727A2 WO2002089727A2 (en) 2002-11-14
WO2002089727A9 WO2002089727A9 (en) 2003-01-09
WO2002089727A3 true WO2002089727A3 (en) 2009-06-11

Family

ID=26830635

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/011869 WO2002089727A2 (en) 2001-05-03 2002-05-01 Methods of using cytokine c17

Country Status (2)

Country Link
AU (1) AU2002340544A1 (en)
WO (1) WO2002089727A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9522217B2 (en) 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
CA2563329C (en) 2004-04-30 2016-01-26 Orbus Medical Technologies, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
WO2006111198A1 (en) * 2005-04-18 2006-10-26 Associazione Foresta Per La Ricerca Nella Riproduzione Umana Use of pde-5 inhibitors for endothelial repair of tissues impaired by trauma or disease
CA2703184A1 (en) * 2007-10-26 2009-04-30 Genentech, Inc. Inhibition of urokinase-type plasminogen activator (upa) activity
EP3012269A1 (en) 2014-10-20 2016-04-27 Erhard Hofer Cytokine-like 1 (CYTL1) protein and uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LIU X. ET AL.: "Molecular cloning and chromosomal mapping of a candidate cytokine gene selectively expressed in human CD34+ cells", GENOMICS, vol. 65, no. 3, 1 May 2000 (2000-05-01), pages 283 - 292, XP004439369 *
ZHAOHUI Y. ET AL.: "Specific expression of a novel cytokine-like gene in human CD34+ cells", BLOOD, vol. 96, no. 11, 16 November 2000 (2000-11-16), pages 142B, XP002967535 *

Also Published As

Publication number Publication date
WO2002089727A9 (en) 2003-01-09
WO2002089727A2 (en) 2002-11-14
AU2002340544A1 (en) 2002-11-18
AU2002340544A8 (en) 2009-07-30

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