WO2002081528A1 - Polymer specifically recognizing bile acid, process for producing the same, bile acid-absorbing polymer and cholesterol-lowering agents - Google Patents

Polymer specifically recognizing bile acid, process for producing the same, bile acid-absorbing polymer and cholesterol-lowering agents Download PDF

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Publication number
WO2002081528A1
WO2002081528A1 PCT/JP2002/003323 JP0203323W WO02081528A1 WO 2002081528 A1 WO2002081528 A1 WO 2002081528A1 JP 0203323 W JP0203323 W JP 0203323W WO 02081528 A1 WO02081528 A1 WO 02081528A1
Authority
WO
WIPO (PCT)
Prior art keywords
bile acid
polymer
cholesterol
lowering agents
same
Prior art date
Application number
PCT/JP2002/003323
Other languages
French (fr)
Japanese (ja)
Inventor
Takayuki Oka
Shinichiro Kitahara
Original Assignee
Sekisui Chemical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sekisui Chemical Co., Ltd. filed Critical Sekisui Chemical Co., Ltd.
Publication of WO2002081528A1 publication Critical patent/WO2002081528A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/268—Polymers created by use of a template, e.g. molecularly imprinted polymers

Abstract

A polymer capable of more selectively absorbing bile acid alone and cholesterol-lowering agents being excellent in compliance. A polymer specifically recognizing bile acid or a bile acid-absorbing polymer having a specific absorption site, which is formed by the molecular imprinting method, to at least one bile acid or a bile acid complex micell composed of at least one bile acid and a compound capable of forming a micell together with bile acid; and cholesterol-lowering agents containing the same as the main component.
PCT/JP2002/003323 2001-04-05 2002-04-03 Polymer specifically recognizing bile acid, process for producing the same, bile acid-absorbing polymer and cholesterol-lowering agents WO2002081528A1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2001107352 2001-04-05
JP2001-107352 2001-04-05
JP2001-261726 2001-08-30
JP2001261725 2001-08-30
JP2001261726 2001-08-30
JP2001-261725 2001-08-30

Publications (1)

Publication Number Publication Date
WO2002081528A1 true WO2002081528A1 (en) 2002-10-17

Family

ID=27346469

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/003323 WO2002081528A1 (en) 2001-04-05 2002-04-03 Polymer specifically recognizing bile acid, process for producing the same, bile acid-absorbing polymer and cholesterol-lowering agents

Country Status (1)

Country Link
WO (1) WO2002081528A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112472686A (en) * 2020-12-07 2021-03-12 中国药科大学 Lipid nanoparticle of PEG-PLA-SN38 linker and preparation method thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4198395A (en) * 1976-05-25 1980-04-15 Etablissement Viridis Novel hypocholesterolemic resin
WO1993013781A1 (en) * 1992-01-14 1993-07-22 Hisamitsu Pharmaceutical Co., Inc. Cholesterol level depressant
JPH07206687A (en) * 1993-05-20 1995-08-08 Sekisui Chem Co Ltd Cholesterol-level depressing agent for oral administration and its preparation
JPH07241463A (en) * 1994-03-07 1995-09-19 Sekisui Chem Co Ltd Adsorbent for bile acid
JPH07316061A (en) * 1994-05-23 1995-12-05 Sekisui Chem Co Ltd Cholesterol lowering agent
WO1995034588A1 (en) * 1994-06-10 1995-12-21 Geltex Pharmaceuticals, Inc. Cross-linked polymers for removing bile salts from a patient
US20020015690A1 (en) * 2000-06-30 2002-02-07 Green Bernard S. Molecularly imprinted polymers for the treatment and diagnosis of medical conditions

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4198395A (en) * 1976-05-25 1980-04-15 Etablissement Viridis Novel hypocholesterolemic resin
WO1993013781A1 (en) * 1992-01-14 1993-07-22 Hisamitsu Pharmaceutical Co., Inc. Cholesterol level depressant
JPH07206687A (en) * 1993-05-20 1995-08-08 Sekisui Chem Co Ltd Cholesterol-level depressing agent for oral administration and its preparation
JPH07241463A (en) * 1994-03-07 1995-09-19 Sekisui Chem Co Ltd Adsorbent for bile acid
JPH07316061A (en) * 1994-05-23 1995-12-05 Sekisui Chem Co Ltd Cholesterol lowering agent
WO1995034588A1 (en) * 1994-06-10 1995-12-21 Geltex Pharmaceuticals, Inc. Cross-linked polymers for removing bile salts from a patient
US20020015690A1 (en) * 2000-06-30 2002-02-07 Green Bernard S. Molecularly imprinted polymers for the treatment and diagnosis of medical conditions

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112472686A (en) * 2020-12-07 2021-03-12 中国药科大学 Lipid nanoparticle of PEG-PLA-SN38 linker and preparation method thereof

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