WO2002080974A1 - Utilisation medicale d'inhibiteur de production de cytokine - Google Patents

Utilisation medicale d'inhibiteur de production de cytokine Download PDF

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Publication number
WO2002080974A1
WO2002080974A1 PCT/JP2002/003354 JP0203354W WO02080974A1 WO 2002080974 A1 WO2002080974 A1 WO 2002080974A1 JP 0203354 W JP0203354 W JP 0203354W WO 02080974 A1 WO02080974 A1 WO 02080974A1
Authority
WO
WIPO (PCT)
Prior art keywords
cytokine production
production inhibitor
medicinal use
novel medicinal
antiinflammatory agent
Prior art date
Application number
PCT/JP2002/003354
Other languages
English (en)
Japanese (ja)
Inventor
Shigeru Ushiyama
Tomio Kimura
Original Assignee
Sankyo Company, Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Company, Limited filed Critical Sankyo Company, Limited
Publication of WO2002080974A1 publication Critical patent/WO2002080974A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

L'invention concerne un médicament, ne possédant pas les effets secondaires d'un agent anti-inflammatoire non stéroïdien, permettant l'administration simultanée, séparée ou par intermittence de l'agent anti-inflammatoire non stéroïdien avec un inhibiteur de production de cytokine inflammatoire.
PCT/JP2002/003354 2001-04-04 2002-04-03 Utilisation medicale d'inhibiteur de production de cytokine WO2002080974A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001105615 2001-04-04
JP2001-105615 2001-04-04

Publications (1)

Publication Number Publication Date
WO2002080974A1 true WO2002080974A1 (fr) 2002-10-17

Family

ID=18958272

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/003354 WO2002080974A1 (fr) 2001-04-04 2002-04-03 Utilisation medicale d'inhibiteur de production de cytokine

Country Status (1)

Country Link
WO (1) WO2002080974A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004009592A1 (fr) * 2002-07-19 2004-01-29 Sankyo Company, Limited Compose amine tertiaire bicyclique insature

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0595546A1 (fr) * 1992-10-28 1994-05-04 Shionogi & Co., Ltd. Dérivés de benzylidène
EP0799823A1 (fr) * 1996-04-05 1997-10-08 Sankyo Company Limited Dérivés de 1,2-diphénylpyrrole, leur préparation et leur utilisation thérapeutique
EP0865788A1 (fr) * 1995-09-13 1998-09-23 Kabushiki Kaisha Yakult Honsha Inhibiteur specifique de cyclo-oxygenase 2 et agent anti-inflammatoire
WO1999006404A1 (fr) * 1997-07-29 1999-02-11 Almirall Prodesfarma S.A. Derives de 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazine et compositions pharmaceutiques a base de ces derives
JPH11180871A (ja) * 1997-09-26 1999-07-06 Sankyo Co Ltd １，２−ジフェニルピロール誘導体を含有する医薬
EP1070711A2 (fr) * 1999-07-21 2001-01-24 Sankyo Company Limited Dérivés de pyrrole hétéroaryl substitués, leur préparation et leur utilisation thérapeutique

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0595546A1 (fr) * 1992-10-28 1994-05-04 Shionogi & Co., Ltd. Dérivés de benzylidène
EP0865788A1 (fr) * 1995-09-13 1998-09-23 Kabushiki Kaisha Yakult Honsha Inhibiteur specifique de cyclo-oxygenase 2 et agent anti-inflammatoire
EP0799823A1 (fr) * 1996-04-05 1997-10-08 Sankyo Company Limited Dérivés de 1,2-diphénylpyrrole, leur préparation et leur utilisation thérapeutique
WO1999006404A1 (fr) * 1997-07-29 1999-02-11 Almirall Prodesfarma S.A. Derives de 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazine et compositions pharmaceutiques a base de ces derives
JPH11180871A (ja) * 1997-09-26 1999-07-06 Sankyo Co Ltd １，２−ジフェニルピロール誘導体を含有する医薬
EP1070711A2 (fr) * 1999-07-21 2001-01-24 Sankyo Company Limited Dérivés de pyrrole hétéroaryl substitués, leur préparation et leur utilisation thérapeutique

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004009592A1 (fr) * 2002-07-19 2004-01-29 Sankyo Company, Limited Compose amine tertiaire bicyclique insature

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