WO2002080918A1 - Remedial or prophylactic agent for frequent urination or urinary incontinence - Google Patents

Remedial or prophylactic agent for frequent urination or urinary incontinence Download PDF

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Publication number
WO2002080918A1
WO2002080918A1 PCT/JP2002/003295 JP0203295W WO02080918A1 WO 2002080918 A1 WO2002080918 A1 WO 2002080918A1 JP 0203295 W JP0203295 W JP 0203295W WO 02080918 A1 WO02080918 A1 WO 02080918A1
Authority
WO
WIPO (PCT)
Prior art keywords
represents hydrogen
urinary incontinence
hydrogen
frequent urination
remedial
Prior art date
Application number
PCT/JP2002/003295
Other languages
French (fr)
Japanese (ja)
Inventor
Toshiaki Tanaka
Kuniaki Kawamura
Morihiro Fujimura
Toshikazu Komagata
Jun Miyakawa
Ko Hasebe
Original Assignee
Toray Industries, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries, Inc. filed Critical Toray Industries, Inc.
Publication of WO2002080918A1 publication Critical patent/WO2002080918A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system

Abstract

A novel remedy or preventive for frequent urination or urinary incontinence which is reduced in side effect. The remedy or preventive for frequent urination or urinary incontinence contains as the active ingredient a specific 6-substituted morphinan derivative represented by the following general formula (I) or a pharmacologically acceptable acid addition salt thereof. (I) [In formula (I), R1 represents hydrogen, etc.; R?2 and R3¿ each independently represents hydrogen, etc.; A represents NR4- (wherein R4 is hydrogen, etc.), -S-, or -O-; R5 represents an optionally substituted organic group having a basic skeleton represented by any of the formulae (1): (1) (wherein R10 is hydrogen, etc.); R6 represents hydrogen and R7 represents hydrogen, etc. or R?6 and R7¿ in combination represent -O-, etc.; and R8 represents hydrogen, etc.]. An example of the derivative is 17-(2-(2-thiophenyl)ethyl)-4,5a-epoxy-3,14ß-dihydroxy-6ß-(N-methylanilino)morphinan methanesulfonate.
PCT/JP2002/003295 2001-04-02 2002-04-02 Remedial or prophylactic agent for frequent urination or urinary incontinence WO2002080918A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001103109 2001-04-02
JP2001-103109 2001-04-02

Publications (1)

Publication Number Publication Date
WO2002080918A1 true WO2002080918A1 (en) 2002-10-17

Family

ID=18956218

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/003295 WO2002080918A1 (en) 2001-04-02 2002-04-02 Remedial or prophylactic agent for frequent urination or urinary incontinence

Country Status (1)

Country Link
WO (1) WO2002080918A1 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004033457A1 (en) * 2002-10-09 2004-04-22 Toray Industries, Inc. Remedies or preventives for urinary frequency or urinary incontinence and morphinan derivatives having nitrogen-containing heterocyclic group
EP1758452A1 (en) * 2004-05-28 2007-03-07 Human Biomolecular Research Institute Synthesis of metabolically stable analgesics, pain medications and other agents
JP2011512360A (en) * 2008-02-14 2011-04-21 アルカーメス，インコーポレイテッド Selective opioid compounds
JP2013534208A (en) * 2010-07-16 2013-09-02 マリンクロッド エルエルシー (+)-Morphinan as an antagonist of Toll-like receptor 9 and its therapeutic use
JP2015535260A (en) * 2012-10-30 2015-12-10 ネクター セラピューティクス Solid salts of α-6-MPEG6-O-hydroxycodone as opioid agonists and uses thereof
US10363251B2 (en) 2009-07-16 2019-07-30 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03218379A (en) * 1989-11-13 1991-09-25 Chugai Pharmaceut Co Ltd Novel morphine derivative
WO1993015081A1 (en) * 1992-01-23 1993-08-05 Toray Industries, Inc. Morphinan derivative and medicinal use
WO1995001178A1 (en) * 1993-06-30 1995-01-12 Toray Industries, Inc. Antitussive
WO1995003308A1 (en) * 1993-07-23 1995-02-02 Toray Industries, Inc. Morphinan derivative and medicinal use
WO1996022276A1 (en) * 1995-01-20 1996-07-25 Nippon Shinyaku Co., Ltd. Ethylamine derivatives and drugs
JPH09501156A (en) * 1993-07-30 1997-02-04 ザ．ウェルカム．ファウンデーション．リミテッド Piperazine compounds for use in therapy
JPH0977771A (en) * 1995-09-14 1997-03-25 Toray Ind Inc Production of iminium salt
DE19602960A1 (en) * 1995-12-20 1997-07-31 Nycomed Arzneimittel Gmbh New morphine derivatives
WO1999044065A1 (en) * 1998-02-26 1999-09-02 University Of Strathclyde Immunoassays involving surface enhanced raman scattering

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03218379A (en) * 1989-11-13 1991-09-25 Chugai Pharmaceut Co Ltd Novel morphine derivative
WO1993015081A1 (en) * 1992-01-23 1993-08-05 Toray Industries, Inc. Morphinan derivative and medicinal use
WO1995001178A1 (en) * 1993-06-30 1995-01-12 Toray Industries, Inc. Antitussive
WO1995003308A1 (en) * 1993-07-23 1995-02-02 Toray Industries, Inc. Morphinan derivative and medicinal use
JPH09501156A (en) * 1993-07-30 1997-02-04 ザ．ウェルカム．ファウンデーション．リミテッド Piperazine compounds for use in therapy
WO1996022276A1 (en) * 1995-01-20 1996-07-25 Nippon Shinyaku Co., Ltd. Ethylamine derivatives and drugs
JPH0977771A (en) * 1995-09-14 1997-03-25 Toray Ind Inc Production of iminium salt
DE19602960A1 (en) * 1995-12-20 1997-07-31 Nycomed Arzneimittel Gmbh New morphine derivatives
DE19602959A1 (en) * 1995-12-20 1997-07-31 Nycomed Arzneimittel Gmbh New morphine derivatives
JP2000505066A (en) * 1995-12-20 2000-04-25 ニコムド イメージング エイエス Morphine derivatives with analgesic activity
WO1999044065A1 (en) * 1998-02-26 1999-09-02 University Of Strathclyde Immunoassays involving surface enhanced raman scattering

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
A. DRAY ET AL.: "Inhibition of urinary bladder contractions by a spinal action of morphine and other opioids", THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 231, no. 2, 1984, pages 254 - 260, XP002952992 *
A. DRAY ET AL.: "Morphine and the centrally-mediated inhibition of urinary bladder motility in the rat", BRAIN RESEARCH, vol. 297, no. 1, 1984, pages 191 - 195, XP002952993 *
A. DRAY ET AL.: "Opioids and central inhibition of urinary bladder motility", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 98, 1984, pages 155 - 156, XP002952995 *
MAXSON LIU ET AL.: "The synthesis of some 6,7-annulated codeines", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1: ORGANIC AND BIO-ORGANIC CHEMISTRY, no. 3, 1999, pages 241 - 244, XP002952989 *
P.S. PORTOGHESE ET AL.: "Synthesis of naltrexone-derived delta-opioid antagonists. Role of conformation of the delta address moiety", J. MED. CHEMICAL, vol. 37, no. 5, 1994, pages 579 - 585, XP002952991 *
WOLFGANG BRANDT: "A uniform molecular model of delta opioid agonist and antagonist pharmacophore conformations", JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, vol. 12, no. 6, 1998, pages 615 - 621, XP002952990 *
YASUHIKO IGAWA ET AL.: "Effects of morphine metabolites on micturition in normal, unanaesthetized rats", BR. J. PHARMACOL., vol. 110, no. 1, 1993, pages 257 - 262, XP002952994 *

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004033457A1 (en) * 2002-10-09 2004-04-22 Toray Industries, Inc. Remedies or preventives for urinary frequency or urinary incontinence and morphinan derivatives having nitrogen-containing heterocyclic group
US7320984B2 (en) 2002-10-09 2008-01-22 Toray Industries, Inc. Remedies or preventives for urinary frequency or urinary incontinence and morphinan derivatives having nitrogen-containing heterocyclic group
EP1758452A1 (en) * 2004-05-28 2007-03-07 Human Biomolecular Research Institute Synthesis of metabolically stable analgesics, pain medications and other agents
EP1758452A4 (en) * 2004-05-28 2009-08-05 Human Biomolecular Res Inst Synthesis of metabolically stable analgesics, pain medications and other agents
JP2011512360A (en) * 2008-02-14 2011-04-21 アルカーメス，インコーポレイテッド Selective opioid compounds
US9040552B2 (en) 2008-02-14 2015-05-26 Alkermes, Inc. Selective opioid compounds
US9562014B2 (en) 2009-07-16 2017-02-07 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
US10363251B2 (en) 2009-07-16 2019-07-30 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
US10604488B2 (en) 2009-07-16 2020-03-31 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
US11142502B2 (en) 2009-07-16 2021-10-12 Mallinckrodt Llc (+)-morphinans as antagonists of Toll-like receptor 9 and therapeutic uses thereof
JP2013534208A (en) * 2010-07-16 2013-09-02 マリンクロッド エルエルシー (+)-Morphinan as an antagonist of Toll-like receptor 9 and its therapeutic use
JP2015535260A (en) * 2012-10-30 2015-12-10 ネクター セラピューティクス Solid salts of α-6-MPEG6-O-hydroxycodone as opioid agonists and uses thereof

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