WO2002070491A1 - Nitrogenous heteroaromatic ring derivative having hiv integrase inhibitory activity - Google Patents

Nitrogenous heteroaromatic ring derivative having hiv integrase inhibitory activity Download PDF

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Publication number
WO2002070491A1
WO2002070491A1 PCT/JP2002/001779 JP0201779W WO02070491A1 WO 2002070491 A1 WO2002070491 A1 WO 2002070491A1 JP 0201779 W JP0201779 W JP 0201779W WO 02070491 A1 WO02070491 A1 WO 02070491A1
Authority
WO
WIPO (PCT)
Prior art keywords
heteroaromatic ring
inhibitory activity
nitrogenous heteroaromatic
hiv integrase
ring derivative
Prior art date
Application number
PCT/JP2002/001779
Other languages
French (fr)
Japanese (ja)
Inventor
Masahiro Fuji
Original Assignee
Shionogi & Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co., Ltd. filed Critical Shionogi & Co., Ltd.
Priority to JP2002569811A priority Critical patent/JP4176477B2/en
Publication of WO2002070491A1 publication Critical patent/WO2002070491A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

A compound represented by the formula (I): (I) wherein ring A is a nitrogenous heteroaromatic ring; X is oxygen, sulfur, or NH; and RA is a group represented by the formula (II) (II) (wherein ring B is a nitrogenous heteroaromatic ring), etc. It has integrase inhibitory activity.
PCT/JP2002/001779 2001-03-01 2002-02-27 Nitrogenous heteroaromatic ring derivative having hiv integrase inhibitory activity WO2002070491A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2002569811A JP4176477B2 (en) 2001-03-01 2002-02-27 Nitrogen-containing aromatic heterocyclic derivatives having HIV integrase inhibitory activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001057036 2001-03-01
JP2001-057036 2001-03-01

Publications (1)

Publication Number Publication Date
WO2002070491A1 true WO2002070491A1 (en) 2002-09-12

Family

ID=18916976

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/001779 WO2002070491A1 (en) 2001-03-01 2002-02-27 Nitrogenous heteroaromatic ring derivative having hiv integrase inhibitory activity

Country Status (2)

Country Link
JP (1) JP4176477B2 (en)
WO (1) WO2002070491A1 (en)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003047564A1 (en) * 2001-12-05 2003-06-12 Shionogi & Co., Ltd. Derivative having hiv integrase inhibitory activity
WO2004039803A2 (en) * 2002-10-31 2004-05-13 Pfizer Inc. Hiv-integrase inhibitors, pharmaceutical compositions, and methods for their use
US6867209B1 (en) * 1998-05-22 2005-03-15 Scios, Inc. Indole-type derivatives as inhibitors of p38 kinase
US7001912B2 (en) 2003-01-27 2006-02-21 Agouron Pharmaceuticals, Inc. HIV-integrase inhibitors, pharmaceutical compositions, and methods for their use
US7037908B2 (en) 2003-04-24 2006-05-02 Bristol-Myers Squibb Company HIV integrase inhibitors
US7109186B2 (en) 2002-07-09 2006-09-19 Bristol-Myers Squibb Company HIV integrase inhibitors
US7115601B2 (en) 2004-05-18 2006-10-03 Bristol-Myers Squibb Company HIV integrase inhibitors
US7189726B2 (en) 1999-09-17 2007-03-13 Scios, Inc. Benzofuran derivatives as inhibitors of p38-α kinase
US7468375B2 (en) 2004-04-26 2008-12-23 Pfizer Inc. Inhibitors of the HIV integrase enzyme
WO2009133834A1 (en) * 2008-04-28 2009-11-05 塩野義製薬株式会社 Keto-amide derivative having inhibitory activity on endothelial lipase
US7692014B2 (en) 2004-04-26 2010-04-06 Pfizer, Inc. Inhibitors of the HIV integrase enzyme
US9572813B2 (en) 2001-08-10 2017-02-21 Shionogi & Co., Ltd. Antiviral agent
US10328053B2 (en) 2016-08-26 2019-06-25 Gilead Sciences, Inc. Substituted pyrrolizine compounds and uses thereof
US10836769B2 (en) 2018-02-26 2020-11-17 Gilead Sciences, Inc. Substituted pyrrolizine compounds and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06227980A (en) * 1993-01-15 1994-08-16 Meiji Seika Kaisha Ltd Pyrrolidin-2-ylcarbonyl heterocyclic compound derivative
WO1998045275A1 (en) * 1997-04-07 1998-10-15 Axys Pharmaceuticals Corporation Compounds and compositions for treating diseases associated with serine protease, particularly tryptase, activity

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06227980A (en) * 1993-01-15 1994-08-16 Meiji Seika Kaisha Ltd Pyrrolidin-2-ylcarbonyl heterocyclic compound derivative
US5547978A (en) * 1993-01-15 1996-08-20 Meiji Seika Kaisha, Ltd. Derivatives of pyrrolidin-2-ylcarbonylheterocyclic compounds
WO1998045275A1 (en) * 1997-04-07 1998-10-15 Axys Pharmaceuticals Corporation Compounds and compositions for treating diseases associated with serine protease, particularly tryptase, activity

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6867209B1 (en) * 1998-05-22 2005-03-15 Scios, Inc. Indole-type derivatives as inhibitors of p38 kinase
US7238712B2 (en) * 1999-09-17 2007-07-03 Scios, Inc. Indole-type derivatives as inhibitors of p38 kinase
US7304048B2 (en) * 1999-09-17 2007-12-04 Scios, Inc. Indole-type derivatives as inhibitors of p38 kinase
US7189726B2 (en) 1999-09-17 2007-03-13 Scios, Inc. Benzofuran derivatives as inhibitors of p38-α kinase
US9572813B2 (en) 2001-08-10 2017-02-21 Shionogi & Co., Ltd. Antiviral agent
WO2003047564A1 (en) * 2001-12-05 2003-06-12 Shionogi & Co., Ltd. Derivative having hiv integrase inhibitory activity
US7109186B2 (en) 2002-07-09 2006-09-19 Bristol-Myers Squibb Company HIV integrase inhibitors
WO2004039803A2 (en) * 2002-10-31 2004-05-13 Pfizer Inc. Hiv-integrase inhibitors, pharmaceutical compositions, and methods for their use
WO2004039803A3 (en) * 2002-10-31 2004-09-16 Pfizer Hiv-integrase inhibitors, pharmaceutical compositions, and methods for their use
NL1024676C2 (en) * 2002-10-31 2005-12-14 Pfizer HIV integrase inhibitors, pharmaceutical preparations and methods for their use.
US7368571B2 (en) 2002-10-31 2008-05-06 Pfizer Inc HIV-Integrase inhibitors, pharmaceutical compositions and methods for their use
US7135482B2 (en) 2002-10-31 2006-11-14 Agouron Pharmaceuticals, Inc. HIV-integrase inhibitors, pharmaceutical compositions, and methods for their use
US7138408B2 (en) 2003-01-27 2006-11-21 Agouron Pharmaceuticals, Inc. HIV integrase inhibitors, pharmaceutical compositions and methods for their use
US7001912B2 (en) 2003-01-27 2006-02-21 Agouron Pharmaceuticals, Inc. HIV-integrase inhibitors, pharmaceutical compositions, and methods for their use
US7037908B2 (en) 2003-04-24 2006-05-02 Bristol-Myers Squibb Company HIV integrase inhibitors
US7468375B2 (en) 2004-04-26 2008-12-23 Pfizer Inc. Inhibitors of the HIV integrase enzyme
US7692014B2 (en) 2004-04-26 2010-04-06 Pfizer, Inc. Inhibitors of the HIV integrase enzyme
US7115601B2 (en) 2004-05-18 2006-10-03 Bristol-Myers Squibb Company HIV integrase inhibitors
WO2009133834A1 (en) * 2008-04-28 2009-11-05 塩野義製薬株式会社 Keto-amide derivative having inhibitory activity on endothelial lipase
US10328053B2 (en) 2016-08-26 2019-06-25 Gilead Sciences, Inc. Substituted pyrrolizine compounds and uses thereof
US10874640B2 (en) 2016-08-26 2020-12-29 Gilead Sciences, Inc. Substituted pyrrolizine compounds and uses thereof
US10836769B2 (en) 2018-02-26 2020-11-17 Gilead Sciences, Inc. Substituted pyrrolizine compounds and uses thereof
US11420974B2 (en) 2018-02-26 2022-08-23 Gilead Sciences, Inc. Substituted pyrrolizine compounds and uses thereof

Also Published As

Publication number Publication date
JP4176477B2 (en) 2008-11-05
JPWO2002070491A1 (en) 2004-07-02

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