WO2002060948A1 - Nouvelle proteine recepteur couplee a une proteine g et adn correspondant - Google Patents

Nouvelle proteine recepteur couplee a une proteine g et adn correspondant Download PDF

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Publication number
WO2002060948A1
WO2002060948A1 PCT/JP2002/000707 JP0200707W WO02060948A1 WO 2002060948 A1 WO2002060948 A1 WO 2002060948A1 JP 0200707 W JP0200707 W JP 0200707W WO 02060948 A1 WO02060948 A1 WO 02060948A1
Authority
WO
WIPO (PCT)
Prior art keywords
protein
ligand
screening
novel
dna
Prior art date
Application number
PCT/JP2002/000707
Other languages
English (en)
Japanese (ja)
Inventor
Takeo Moriya
Takashi Ito
Yasushi Shintani
Nobuyuki Miyajima
Original Assignee
Takeda Chemical Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries, Ltd. filed Critical Takeda Chemical Industries, Ltd.
Publication of WO2002060948A1 publication Critical patent/WO2002060948A1/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Abstract

La présente invention concerne une nouvelle protéine utile pour cribler un agoniste et/ou un antagoniste; une protéine d'origine humaine ou son sel; un ADN codant cette protéine; une méthode de détermination d'un ligand pour la protéine; une méthode de criblage et/ou une trousse de criblage permettant de détecter un composé capable d'altérer les propriétés de liaison du ligand envers la protéine; des composés obtenus à l'aide de la méthode de criblage ou des sels de ces derniers, et autres. La protéine d'origine humaine ou l'ADN codant cette dernière peuvent être utilisés pour: (1) déterminer un ligand pour la protéine; (2) préparer des prophylactiques et/ou des médicaments pour des maladies associées à l'hypofonction de ladite protéine; (3) cribler un composé (un agoniste, un antagoniste ou autre) capable d'altérer les propriétés de liaison de la protéine selon l'invention envers le ligand, et autres.
PCT/JP2002/000707 2001-01-31 2002-01-30 Nouvelle proteine recepteur couplee a une proteine g et adn correspondant WO2002060948A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2001-24193 2001-01-31
JP2001024193 2001-01-31
JP2001-65292 2001-03-08
JP2001065292 2001-03-08

Publications (1)

Publication Number Publication Date
WO2002060948A1 true WO2002060948A1 (fr) 2002-08-08

Family

ID=26608674

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/000707 WO2002060948A1 (fr) 2001-01-31 2002-01-30 Nouvelle proteine recepteur couplee a une proteine g et adn correspondant

Country Status (1)

Country Link
WO (1) WO2002060948A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001077330A2 (fr) * 2000-04-06 2001-10-18 Pharmacia & Upjohn Company Recepteurs couples a une proteine g
DE10019120A1 (de) * 2000-04-18 2001-10-25 Michael Brues PAFR2:gen, cDNA, Expression, Aminosäuresequenz
WO2001098351A2 (fr) * 2000-06-16 2001-12-27 Incyte Genomics, Inc. Recepteurs couples a la proteine g

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001077330A2 (fr) * 2000-04-06 2001-10-18 Pharmacia & Upjohn Company Recepteurs couples a une proteine g
DE10019120A1 (de) * 2000-04-18 2001-10-25 Michael Brues PAFR2:gen, cDNA, Expression, Aminosäuresequenz
WO2001098351A2 (fr) * 2000-06-16 2001-12-27 Incyte Genomics, Inc. Recepteurs couples a la proteine g

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KUNZ, D. ET AL.: "The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression and construction of a novel epitope-bearing analog", J. BIOL. CHEM., vol. 267, no. 13, 1992, pages 9101 - 9106, XP002951003 *

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