WO2002056824A3 - Pressure cycling inactivation of pathogens in biological materials used for therapeutics or vaccines - Google Patents

Pressure cycling inactivation of pathogens in biological materials used for therapeutics or vaccines Download PDF

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Publication number
WO2002056824A3
WO2002056824A3 PCT/US2001/041623 US0141623W WO02056824A3 WO 2002056824 A3 WO2002056824 A3 WO 2002056824A3 US 0141623 W US0141623 W US 0141623W WO 02056824 A3 WO02056824 A3 WO 02056824A3
Authority
WO
WIPO (PCT)
Prior art keywords
biological materials
parvovirus
vaccines
therapeutics
pathogens
Prior art date
Application number
PCT/US2001/041623
Other languages
French (fr)
Other versions
WO2002056824A2 (en
Inventor
Robert A Hess
Mark M Manak
Sandra K Dusing
Original Assignee
Boston Biomedica Inc
Robert A Hess
Mark M Manak
Sandra K Dusing
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Biomedica Inc, Robert A Hess, Mark M Manak, Sandra K Dusing filed Critical Boston Biomedica Inc
Priority to AU2002246493A priority Critical patent/AU2002246493A1/en
Publication of WO2002056824A2 publication Critical patent/WO2002056824A2/en
Publication of WO2002056824A3 publication Critical patent/WO2002056824A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention is based on the discovery that viruses, bacteria or fungi present in biological materials can be inactivated without substantial loss of protein function, using high pressure at temperatures above or below room temperature (e.g., below 0 °C or above 30 °C). The new methods can be used to decontaminate recombinant protein solutions, serum, plasma, and other biological materials, which can be contaminated with viruses such as parvoviruses (e.g., human parvovirus, porcine parvovirus, and murine parvovirus) and retroviruses such as human immunodeficiency virus (HIV), herpesviruses (e.g., herpes simplex virus, HSV), flaviviruses (e.g., hepatitis C virus, HCV), reoviruses, and picornaviruses,bacteria (e.g., Bacillus, Enterococcus, Staphylococcus, Listeria, Pseudomonas) or fungi (e.g., Candida).
PCT/US2001/041623 2000-08-10 2001-08-08 Pressure cycling inactivation of pathogens in biological materials used for therapeutics or vaccines WO2002056824A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002246493A AU2002246493A1 (en) 2000-08-10 2001-08-08 Pressure cycling inactivation of pathogens in biological materials used for therapeutics or vaccines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63614900A 2000-08-10 2000-08-10
US09/636,149 2000-08-10

Publications (2)

Publication Number Publication Date
WO2002056824A2 WO2002056824A2 (en) 2002-07-25
WO2002056824A3 true WO2002056824A3 (en) 2003-03-13

Family

ID=24550622

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/041623 WO2002056824A2 (en) 2000-08-10 2001-08-08 Pressure cycling inactivation of pathogens in biological materials used for therapeutics or vaccines

Country Status (2)

Country Link
AU (1) AU2002246493A1 (en)
WO (1) WO2002056824A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004275764B2 (en) 2003-09-22 2010-01-14 Baxter Healthcare S.A. High-pressure sterilization to terminally sterilize pharmaceutical preparations and medical products
EP2165717A1 (en) 2008-08-27 2010-03-24 Nordmark Arzneimittel GmbH & Co.KG Method for reducing viral and microbial load on biological extracts containing solids
DE102009038758A1 (en) 2008-08-27 2010-03-04 Nordmark Arzneimittel Gmbh & Co. Kg Reducing the viral and microbial load of the solid material-containing biological extract, useful as e.g. food, comprises providing the extract comprising biologically active substance e.g. enzymes and subjecting to high pressure treatment
ES2385958T3 (en) 2008-11-03 2012-08-06 Nordmark Arzneimittel Gmbh & Co.Kg Procedure to reduce the viral and microbial load of pancreatin
FR2947456B1 (en) 2009-07-06 2012-03-09 Univ Bordeaux 1 PROCESS FOR INACTIVATION OF AT LEAST ONE PATHOGENIC AGENT IN A HUMAN BLOOD PLASMA SAMPLE
US9493744B2 (en) * 2012-06-20 2016-11-15 Genentech, Inc. Methods for viral inactivation and other adventitious agents
US9169302B2 (en) 2012-08-30 2015-10-27 Merial, Inc. Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins
ZA201501696B (en) 2012-08-30 2016-01-27 Merial Ltd Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins
CN102899272B (en) * 2012-10-16 2014-07-09 中国农业大学 Method for inducing bacteria to enter viable but nonculturable state

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3579999A (en) * 1968-08-08 1971-05-25 Redeco Method and apparatus for the preservation of biological substances
US3677022A (en) * 1969-07-24 1972-07-18 Redeco Method for extending the useful storage period of biological substances such as blood
WO1999022868A1 (en) * 1997-10-31 1999-05-14 Bbi Bioseq, Inc. Pressure-enhanced extraction and purification
US6270723B1 (en) * 1998-06-15 2001-08-07 Bbi Bioseq, Inc. Rapid cryobaric sterilization and vaccine preparation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3579999A (en) * 1968-08-08 1971-05-25 Redeco Method and apparatus for the preservation of biological substances
US3677022A (en) * 1969-07-24 1972-07-18 Redeco Method for extending the useful storage period of biological substances such as blood
WO1999022868A1 (en) * 1997-10-31 1999-05-14 Bbi Bioseq, Inc. Pressure-enhanced extraction and purification
US6270723B1 (en) * 1998-06-15 2001-08-07 Bbi Bioseq, Inc. Rapid cryobaric sterilization and vaccine preparation

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HASHIMUZE ET AL.: "Kinetic analysis of yeast inactivation by high pressure treatment at low temperatures", BIOSCI. BIOTECH. BIOCHEM., vol. 59, no. 8, 1995, pages 1455 - 1458, XP000530302 *
JURKIEWICZ ET AL.: "Inactivation of simian immunodeficiency virus by hydrostatic pressure", PROC. NATL. ACAD. SCI. USA, vol. 92, July 1995 (1995-07-01), pages 6935 - 6937, XP002951612 *
OLIVEIRA ET AL.: "Low temperature and pressure stability of picornaviruses: implications for virus uncoating", BIOPHYSICAL JOURNAL, vol. 76, March 1999 (1999-03-01), pages 1270 - 1279, XP002145658 *

Also Published As

Publication number Publication date
WO2002056824A2 (en) 2002-07-25
AU2002246493A1 (en) 2002-07-30

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