WO2002052950A1 - Organomineral adsorbent of mycotoxin as an animal feed additive, procedure for production and application - Google Patents
Organomineral adsorbent of mycotoxin as an animal feed additive, procedure for production and application Download PDFInfo
- Publication number
- WO2002052950A1 WO2002052950A1 PCT/YU2001/000032 YU0100032W WO02052950A1 WO 2002052950 A1 WO2002052950 A1 WO 2002052950A1 YU 0100032 W YU0100032 W YU 0100032W WO 02052950 A1 WO02052950 A1 WO 02052950A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- mycotoxins
- adsorbent
- amine
- organomineral
- zeolitic tuff
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
- B01J20/10—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
- B01J20/16—Alumino-silicates
- B01J20/18—Synthetic zeolitic molecular sieves
- B01J20/186—Chemical treatments in view of modifying the properties of the sieve, e.g. increasing the stability or the activity, also decreasing the activity
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/28—Silicates, e.g. perlites, zeolites or bentonites
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
- B01J20/10—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
- B01J20/16—Alumino-silicates
- B01J20/18—Synthetic zeolitic molecular sieves
Definitions
- Organomineral adsorbent of mycotoxins as an animal feed additive, procedure for production and application
- Organomineral mycotoxins adsorbent as animal feed additive, procedure for production and application belongs to the animal feed, addition of mineral additives. According to the International clasification of Patents (MKD 6 ), Section A, Sign mark A23K1/175.
- Technical problem consist of: how to obtain by chemicotechnological preparation of zeolitic tuff, containing over 85% mineral clinoptilolite/heulandite and strictly controled amount of certain organic compound (quaternary amine long carbon chains), surface modified asorbent, in order to attain controled surface charge and hydrophobicity level, what have to lead to organomineral adsorbent, as animal feef additive, which, in the same time adsorbs mycotoxins of different properties in digestive tract of animals.
- New aproach on mycotoxins effects prevention e.g. feed detoxification polluted by mycotoxins, in the World
- feed detoxification polluted by mycotoxins in the World
- Their task is to effectively, selectively and very fast adsorb mycotoxins in situ, in digestive tract, when mineral adsorbent together with polluted feed enter the tract.
- adsorbent bind mycotoxins and in such a way decreases their bioavaillability, e. g. blocked their resorption in organs and cancel their toxicity.
- Mycotoxins from chemical side, represent very wide spectar of complex organic compounds with different functional groups and therefore different characterictics. According to its use in the case coexist, more than one mycotoxin with different characteristics (polarity, functional groups, anionic or cationic character etc), adsorbent need to have in the same time active centers on the surface, different but strictly controled characteristics. As this problem is very complex, investigations in this field, in the World, are very intensive, particularly last years.
- the Patent understand chemical-technological processing of zeolite tuff, containing 85% of clinoptilolite, by three steps comminition, activation and milling with sodium chloride up to the particle size max. 60 micrometers.
- Obtained powdered product is a mineral adsorbent of mycotoxins out of animal feed, in the digestive tract of animals. It is added to the mycotoxin contaminated feed in the amount of 0.2 to 0.5%, depending on the contaminated level of feed mix.
- Patent YU No P- 177/98 (assignee Institute for Technology of Nuclear and Other Mineral Raw Materials, Belgrade, Yugoslavia).
- Patent contain procedure for production of mineral adsorbents applaying three steps comminution of zeolitic tuff, containing 85% clinoptilolite, up to particle size 150 micrometers, than with potassium chloride, in dependance of the exchangable potassium content in the raw tuff, it is activated and milled up to max. 60 micrometers. Obtained material is wet classified on centrifuge, separating particles below 10 micrometers and packed as a 25% suspension in water for future application. If the 25% suspension is filtrated, dried and desintegrated, than mycotoxin mineral adsorbent is obtained as a powder.
- As an animal feed additive it is mixed in the feed mix in the amount of 0.3 to 0.5%.
- Mycotoxins secondary metabolites produced by fungi (moulds) are highly toxic for numerous number of animals (swines, cattle, sheeps, horses, dogs, cats, rabbits), poultry (chickens, turkey, ducks, gooses), laboratory animals and humans.
- Mycotoxicosis are deseases caused by consuming feedstuff contaminated by mycotoxins, they are not infective but could not be treated by any medication.
- Well known mycotoxicosis of domestic animals are aflatoxicosis, ochratoxicosis, zearalenone toxicosis and trichothecene toxicosis.
- estimation is that more than 25% of cereals are contaminated by mycotoxins. As the resorption of mycotoxins is very fast in meat, milk and eggs, their presence in animal foodstuff is toxic, not only for animals but also for humans.
- the essence of invention lies in controled correction of surface properties charge by modification processes with organic compounds - radicals, on previously processed zeolitic tuff by known procedures - three steps comminution, wet classification to 25%) suspension.
- Zeolitic tuff containing more than 80%) of mineral clinoptilolite/heulandite, prepared by known technological processes comminution, wet classification and preparation of 25%> suspension, attaining balance of exchangeable cations, maintaining negative surface charge as a result of isomorphic supstitution of Al 3+ by divalent cations (Ca or Mg 2+ ).
- Such a surface adsorbs polar mycotoxins.
- Presence of organic phase, used for modification, is limited not only for obtaining desired product characteristics (surface charge, hydrophobicity) but, also, from the side of permited amounts to be consumed by a live organism, because over the certain concentration they become toxic.
- a new organomineral adsorbent of mycotoxins of controled surface charge and controled hydrophobicity level is obtained as a product of reaction take place in suspension, by known processes, previously prepared and processed mineral component - zeolitic tuff, containing > 80% mineral clinoptilolite/heulandite and quaternary amine high molecule weight.
- Quaternaiy amine is exchanged quantitatively and compitly irreversible with inorganic cations on the external surface of the zeolitic tuff.
- Molecule of the quaternary amine is very large to be settled in structural channels of zeolitic tuff and interior exchange sites stay free for reaction with smaller cations, such as inorganic cations.
- Organic additive e.g. organic compound is prepared as a dispersion in warm distiled water.
- Organic component is quaternary amine with long carbon chains, usually, dioctadecyldimethyl amine, octadecylthreemethyl amine, octadecyldimethylbenzyl amine or similar compound are used.
- Organic component is added in amount of 0.5 - 5.0 meq/lOOg of prepared mineral component - zeolitic tuff, containing min. 80% mineral clinoptilolite/heulandite.
- Type of ammine as far as its amount depends on type and quantity of mycotoxins to be adsorbed.
- Organomineral adsorbent is prepared in accordance to the next example:
- zeolitic tuff containing min 80% of mineral clinoptilolite/heulandite by known processes, as three steps comminution up to max 100 micrometers, wet classifying and prepared as water suspension of 20-50 wt% is transfered in the mixer and mixed (min 4 000 r/m) or better in turbo mixer.
- activator - organic component in the amount of 0.5-5.0 meq/lOOg mineral component, dispersed in hot distiled water is added.
- Ratio solid : liquid is from 1 : 1 to 1 : 5.
- Organic component is quaternary amins with long carbon chain, usually dioctadecyldimethyl amine, octadecylthreemethyl amine, octadecyldimethylbenzyl amine or similar ones.
- Amine type and quantity to be applicated depends on type and quantity of mycotoxins to be adsorbed.
- the obtained suspension is filtered (20%) and cake is dried directly (50%) in batch dryirs at the temperature from 80-100°C. After drying the cake is desintegrated in "knife mill” up to particle size below 100 micrometers. Obtained product is organomineral adsorbent of mycotoxins, as powder which is packed for the appication.
- organomineral adsorbent of mycotoxins obtained by organic modification, well balanced surgace charge is achieved, which enables wide spectmm of mycotoxin, of different polarity, adsorption.
- Amine is bind to zeolitic tuff by cation exchange of natural exchangeable cations (Ca 2+ ) which is located at the surface of zeolitic tuff.
- organomineral adsorbent of mycotoxins is of controlled surface charge and controlled hydrophobicity level.
- Organomineral adsorbent of mycotoxins which is hydrophobic, can be easily mixed in various mixtures, such as premixes or feedmixes.
- Obtained organomineral adsorbent of mycotoxins does not adsorb vitamins (A, D, E, group B), aminoacids and does not influence on availability of mikroelements (Cu, Zn, Mn and Co); does not adsorb P, N and Ca.
- obtained organomineral adsorbent of mycotoxins, in powder state is added to animal feed directly or through premix, in amount of 0.2 wt% to feed mix to preventing toxication by mycotoxins present in animal feed, without any harmful effects.
- the amount of 0.2 wt% of this mycotoxin adsorbent is sufficient to prevent toxication of animals, which consumed the feed contaminated with zearalenone, up to 10 mg/kg.
- the presence of 0.2 wt% of this adsorbent in feed mix has no negative effect on state of health and production results and could be used in prevention.
- Organomineral adsorbent of mycotoxins prevent toxication only if it is present in the feedstuff polluted with mycotoxins. This organomineral adsorbent will bind mycotoxins in digestive tract of animals before they would be resorbed by organism, because the adsorption rate of mycotoxins on adsorbent is higher than rate of resorption, even in the case of zearalenone, for which is showed that the 50% of initialy amount is resopted for less than 5 minute, while 99% for less than 1 hour.
- adsorbent to be present in animal feed, as a preventive additive, because in case of animal toxication, e. g. resorption of mycotoxins in organism, detoxification is such a cases is imposible. Later addition of organomineral adsorbent would prevent only further toxication of animals.
- organomineral adsorbent had a great influence on pigs state of health: number of sick pigs in experimental groups were considerable lower than in control groups (Farm I, less for 7%, Farm II - less for 40%). - Number of dead pigs were lower in experimental than in control groups (Farm I - less for 7%, Farm II - less for 66%>).
- Pigs fed with the feed containing 0.2% of mineral adsorbent had a higher gain per feeding day for 10% (Farm I), 4.4%> for Farm II and 10.7% for Farm III (0.1% of adsorbent).
- Feed conversion is lower for 14%> (Farm I), 4% for Farm II and 2% for Farm III in experimental group.
- Feedstuff contains 5.2 mg/kg of zearalenone.
- Farm II 0.2% of adsorbent was added for experimental group (122 fattering swine) and control group had 114 swine.
- Feedstuff contains 5.5 mg/kg of zearalenone.
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Inorganic Chemistry (AREA)
- Animal Husbandry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Birds (AREA)
- Fodder In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SK1236-2002A SK12362002A3 (en) | 2000-12-28 | 2001-12-24 | Organomineral adsorbent of mycotoxin as an animal feed additive, procedure for production and application |
HU0300377A HUP0300377A3 (en) | 2000-12-28 | 2001-12-24 | Organomineral adsorbent of mycotoxin as an animal feed additive, procedure for production and application |
HR20020706A HRPK20020706B3 (en) | 2000-12-28 | 2002-08-28 | Organomineral adsorbent of mycotoxin as an animal feed additive, procedure for production and application |
BG107098A BG107098A (en) | 2000-12-28 | 2002-09-13 | Organomineral adsorbent of mycotoxin as animal feed additive, procedure for production and application |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
YUP083800 | 2000-12-28 | ||
YUP-838/00 | 2000-12-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002052950A1 true WO2002052950A1 (en) | 2002-07-11 |
Family
ID=25551643
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/YU2001/000032 WO2002052950A1 (en) | 2000-12-28 | 2001-12-24 | Organomineral adsorbent of mycotoxin as an animal feed additive, procedure for production and application |
Country Status (6)
Country | Link |
---|---|
BG (1) | BG107098A (en) |
CZ (1) | CZ20022905A3 (en) |
HR (1) | HRPK20020706B3 (en) |
HU (1) | HUP0300377A3 (en) |
SK (1) | SK12362002A3 (en) |
WO (1) | WO2002052950A1 (en) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007056686A1 (en) | 2005-11-04 | 2007-05-18 | Hill's Pet Nutrition, Inc. | Methods and compositions for improving stool quality |
CN100455206C (en) * | 2006-03-29 | 2009-01-28 | 浙江大学 | Manganese supplementing feed additive having controlled slow-release type manganese, its preparation and use method |
EP2279787A1 (en) * | 2009-06-29 | 2011-02-02 | Adiveter S.L. | Mycotoxin adsorbent |
US8496984B2 (en) | 2008-12-29 | 2013-07-30 | Cubena, Inc. | Compositions and methods for decontamination of animal feed containing mycotoxins typical for both northern and southern climates |
CN103846078A (en) * | 2014-03-14 | 2014-06-11 | 中国科学院兰州化学物理研究所盱眙凹土应用技术研发中心 | Preparation method of illite smectite mixed clay mycotoxin adsorbent |
WO2015075686A1 (en) | 2013-11-25 | 2015-05-28 | Nutek, S.A. De C.V. | Mycotoxin absorbent and the use thereof in balanced food for animals |
US9924735B2 (en) | 2014-02-26 | 2018-03-27 | Kemin Industries, Inc. | Application of beta zeolite as multi-toxin and pesticide binder in animal feed |
JP2019116399A (en) * | 2017-12-27 | 2019-07-18 | 東レ株式会社 | Method for producing crystalline zeolite |
CN111296725A (en) * | 2020-03-03 | 2020-06-19 | 武汉轻工大学 | Application of cellulose microspheres and feed |
CN115024392A (en) * | 2022-06-15 | 2022-09-09 | 长沙傲鑫生物工程有限公司 | Preparation method for loading metal ion compound by using non-metallic mineral |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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DE29808635U1 (en) * | 1998-05-13 | 1998-07-30 | Brunner, Manfred, 81925 München | Human food or animal feed containing zeolites for adsorbing toxic substances, especially mycotoxins |
DE19821509A1 (en) * | 1998-05-13 | 1999-11-18 | Manfred Brunner | Adsorption of toxins in human- or animal-food production |
US6045834A (en) * | 1998-04-17 | 2000-04-04 | Alltech, Inc. | Compositions and methods for removal of mycotoxins from animal feed |
DE19900813A1 (en) * | 1999-01-12 | 2000-07-13 | Sued Chemie Ag | Mycotoxin adsorbent |
-
2001
- 2001-12-24 WO PCT/YU2001/000032 patent/WO2002052950A1/en not_active Application Discontinuation
- 2001-12-24 SK SK1236-2002A patent/SK12362002A3/en unknown
- 2001-12-24 HU HU0300377A patent/HUP0300377A3/en unknown
- 2001-12-24 CZ CZ20022905A patent/CZ20022905A3/en unknown
-
2002
- 2002-08-28 HR HR20020706A patent/HRPK20020706B3/en not_active IP Right Cessation
- 2002-09-13 BG BG107098A patent/BG107098A/en unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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US6045834A (en) * | 1998-04-17 | 2000-04-04 | Alltech, Inc. | Compositions and methods for removal of mycotoxins from animal feed |
DE29808635U1 (en) * | 1998-05-13 | 1998-07-30 | Brunner, Manfred, 81925 München | Human food or animal feed containing zeolites for adsorbing toxic substances, especially mycotoxins |
DE19821509A1 (en) * | 1998-05-13 | 1999-11-18 | Manfred Brunner | Adsorption of toxins in human- or animal-food production |
DE19900813A1 (en) * | 1999-01-12 | 2000-07-13 | Sued Chemie Ag | Mycotoxin adsorbent |
Non-Patent Citations (5)
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ACTA VETERINARIA (BELGRADE), vol. 44, no. 5-6, 1994, pages 309 - 318, ISSN: 0567-8315 * |
ACTA VETERINARIA (BELGRADE), vol. 46, no. 4, 1996, pages 227 - 234, ISSN: 0567-8315 * |
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1994, TOMASEVIC-CANOVIC MAGDALENA ET AL: "The adsorption effects of a mineral adsorber of the clinoptilolite type part 1: Adsorption of aflatoxins B1 and G2.", XP002196266, Database accession no. PREV199598131792 * |
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1996, TOMASEVIC-CANOVIC MAGDALENA ET AL: "Adsorption effects of mineral adsorber on the clinoptilolite basis. Part II: Adsorption behaviour in the presence of aminoacids and vitamins.", XP002196267, Database accession no. PREV199699267041 * |
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Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007056686A1 (en) | 2005-11-04 | 2007-05-18 | Hill's Pet Nutrition, Inc. | Methods and compositions for improving stool quality |
CN100455206C (en) * | 2006-03-29 | 2009-01-28 | 浙江大学 | Manganese supplementing feed additive having controlled slow-release type manganese, its preparation and use method |
US8496984B2 (en) | 2008-12-29 | 2013-07-30 | Cubena, Inc. | Compositions and methods for decontamination of animal feed containing mycotoxins typical for both northern and southern climates |
EP2279787A1 (en) * | 2009-06-29 | 2011-02-02 | Adiveter S.L. | Mycotoxin adsorbent |
US8257774B2 (en) | 2009-06-29 | 2012-09-04 | Adiveter, S.L. | Mycotoxin adsorbent |
CN105792665A (en) * | 2013-11-25 | 2016-07-20 | 纽泰克股份公司 | Mycotoxin absorbent and the use thereof in balanced food for animals |
WO2015075686A1 (en) | 2013-11-25 | 2015-05-28 | Nutek, S.A. De C.V. | Mycotoxin absorbent and the use thereof in balanced food for animals |
CN105792665B (en) * | 2013-11-25 | 2018-02-09 | 纽泰克股份公司 | Mold toxin sorbent and its purposes in balance animal feed |
US9924735B2 (en) | 2014-02-26 | 2018-03-27 | Kemin Industries, Inc. | Application of beta zeolite as multi-toxin and pesticide binder in animal feed |
US9968116B2 (en) | 2014-02-26 | 2018-05-15 | Kemin Industries, Inc. | Application of beta zeolite as multi-toxin binder in animal feed and related methods |
CN103846078B (en) * | 2014-03-14 | 2016-01-20 | 中国科学院兰州化学物理研究所盱眙凹土应用技术研发中心 | Preparation method of illite-montmorillonite mixed clay mycotoxin adsorbent |
CN103846078A (en) * | 2014-03-14 | 2014-06-11 | 中国科学院兰州化学物理研究所盱眙凹土应用技术研发中心 | Preparation method of illite smectite mixed clay mycotoxin adsorbent |
JP2019116399A (en) * | 2017-12-27 | 2019-07-18 | 東レ株式会社 | Method for producing crystalline zeolite |
JP7052346B2 (en) | 2017-12-27 | 2022-04-12 | 東レ株式会社 | Method for producing crystalline zeolite |
CN111296725A (en) * | 2020-03-03 | 2020-06-19 | 武汉轻工大学 | Application of cellulose microspheres and feed |
CN115024392A (en) * | 2022-06-15 | 2022-09-09 | 长沙傲鑫生物工程有限公司 | Preparation method for loading metal ion compound by using non-metallic mineral |
Also Published As
Publication number | Publication date |
---|---|
HUP0300377A3 (en) | 2003-07-28 |
HRPK20020706B3 (en) | 2005-04-30 |
HUP0300377A2 (en) | 2003-06-28 |
SK12362002A3 (en) | 2003-01-09 |
CZ20022905A3 (en) | 2003-02-12 |
HRP20020706A2 (en) | 2003-12-31 |
BG107098A (en) | 2003-04-30 |
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