WO2002044403A3 - Markers for testing analogs of vitamin d and therapeutical uses - Google Patents

Markers for testing analogs of vitamin d and therapeutical uses Download PDF

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Publication number
WO2002044403A3
WO2002044403A3 PCT/CA2001/001689 CA0101689W WO0244403A3 WO 2002044403 A3 WO2002044403 A3 WO 2002044403A3 CA 0101689 W CA0101689 W CA 0101689W WO 0244403 A3 WO0244403 A3 WO 0244403A3
Authority
WO
WIPO (PCT)
Prior art keywords
vitamin
analogs
markers
therapeutical uses
testing
Prior art date
Application number
PCT/CA2001/001689
Other languages
French (fr)
Other versions
WO2002044403A2 (en
Inventor
John H White
Original Assignee
Univ Mcgill
John H White
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Mcgill, John H White filed Critical Univ Mcgill
Priority to AU2002221397A priority Critical patent/AU2002221397A1/en
Publication of WO2002044403A2 publication Critical patent/WO2002044403A2/en
Publication of WO2002044403A3 publication Critical patent/WO2002044403A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Abstract

The invention relates to markers for testing analogs of vitamin D and therapeutical uses of vitamin D and analogs. More particularly, the invention relates to the regulation of gene expression by vitamin D and analogs thereof and related uses, including, without limitation the use of vitamin D and analogs thereof as chemopreventative and genoprotective agents.
PCT/CA2001/001689 2000-11-29 2001-11-28 Markers for testing analogs of vitamin d and therapeutical uses WO2002044403A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002221397A AU2002221397A1 (en) 2000-11-29 2001-11-28 Markers for testing analogs of vitamin d and therapeutical uses

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US25374600P 2000-11-29 2000-11-29
US60/253,746 2000-11-29
US28772901P 2001-05-02 2001-05-02
US60/287,729 2001-05-02

Publications (2)

Publication Number Publication Date
WO2002044403A2 WO2002044403A2 (en) 2002-06-06
WO2002044403A3 true WO2002044403A3 (en) 2003-10-02

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2001/001689 WO2002044403A2 (en) 2000-11-29 2001-11-28 Markers for testing analogs of vitamin d and therapeutical uses

Country Status (2)

Country Link
AU (1) AU2002221397A1 (en)
WO (1) WO2002044403A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1607098A1 (en) * 2004-05-28 2005-12-21 Cognis France, S.A.S. Cosmetic use of an active ingredient that increases Gadd45 gene expression
AU2005267629A1 (en) * 2004-07-28 2006-02-02 Lipopeptide Ab New use
US8239136B2 (en) 2005-10-21 2012-08-07 Genenews Inc. Method, computer system and computer-readable medium for determining a probability of colorectal cancer in a test subject
CN109122581A (en) * 2018-09-18 2019-01-04 南通市第二人民医院 Fra-1 and application of the XPA compound in cell cycle regulating

Non-Patent Citations (22)

* Cited by examiner, † Cited by third party
Title
AKUTSU NAOTAKE ET AL: "Regulation of gene expression by 1alpha,25-dihydroxyvitamin D3 and its analog EB1089 under growth-inhibitory conditions in squamous carcinoma cells.", MOLECULAR ENDOCRINOLOGY, vol. 15, no. 7, July 2001 (2001-07-01), pages 1127 - 1139, XP002227920, ISSN: 0888-8809 *
BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1312, no. 2, 1996, pages 99 - 104, ISSN: 0006-3002 *
BIOFACTORS, vol. 10, no. 4, 1999, pages 329 - 338, ISSN: 0951-6433 *
BIOLOGY OF REPRODUCTION, vol. 60, no. 3, March 1999 (1999-03-01), pages 567 - 572, ISSN: 0006-3363 *
BLOOD, vol. 89, no. 6, 1997, pages 2105 - 2112, ISSN: 0006-4971 *
BOEHM M F ET AL: "NOVEL NONSECOSTEROIDAL VITAMIN D MIMICS EXERT VDR-MODULATING ACTIVITIES WITH LESS CALCIUM MOBILIZATION THAN 1,25- DIHYDROXYVITAMIN D3", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 6, no. 5, 6 April 1999 (1999-04-06), pages 265 - 275, XP000852987, ISSN: 1074-5521 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1996, BAUDET CHRISTEL ET AL: "1,25-dihydroxyvitamin D3 induces programmed cell death in a rat glioma cell line.", XP002227921, Database accession no. PREV199799338541 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1996, STIO MARIAS ET AL: "Effect of 1,25-dihydroxyvitamin D-3 on proliferation in senescent IMR-90 human fibroblasts.", XP002227924, Database accession no. PREV199699264226 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1996, WATANABE SHIN-ICHI ET AL: "Expression of cytidine deaminase in human solid tumors and its regulation by 1 alpha,25-dihydroxyvitamin D-3.", XP002227926, Database accession no. PREV199699100001 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1996, ZHANG FAN ET AL: "Increased stringency of the 1,25-dihydroxyvitamin D-3-induced G1 to S phase block in polyploid HL60 cells.", XP002227923, Database accession no. PREV199699084071 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1997, PICHAUD F ET AL: "1,25-dihydroxyvitamin D-3 induces NAD-(+)-dependent 15-hydroxyprostaglandin dehydrogenase in human neonatal monocytes.", XP002227928, Database accession no. PREV199799467282 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1999, SCHUETZE NORBERT ET AL: "The selenoprotein thioredoxin reductase is expressed in peripheral blood monocytes and THP1 human myeloid leukemia cells - regulation by 1,25-dihydroxyvitamin D3 and selenite.", XP002227925, Database accession no. PREV200000094230 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; August 1998 (1998-08-01), CHEN YIXIANG ET AL: "Regulation of the expression of enzymes involved in the replication of DNA in chemically induced monocytic/macrophagic differentiation of HL-60 leukemia cells.", XP002227927, Database accession no. PREV199800365288 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; March 1999 (1999-03-01), AGARWAL CHAPLA ET AL: "Vitamin D regulates human ectocervical epithelial cell proliferation and insulin-like growth factor-binding protein-3 level.", XP002227922, Database accession no. PREV199900201296 *
FENG XU ET AL: "Thyroid hormone regulation of hepatic genes in vivo detected by complementary DNA microarray.", MOLECULAR ENDOCRINOLOGY, vol. 14, no. 7, July 2000 (2000-07-01), pages 947 - 955, XP002227918, ISSN: 0888-8809 *
HANSEN C MORK ET AL: "Seocalcitol (EB 1089): A vitamin D analogue of anti-cancer potential. Background, design, synthesis, pre-clinical and clinical evaluation.", CURRENT PHARMACEUTICAL DESIGN, vol. 6, no. 7, May 2000 (2000-05-01), pages 803 - 828, XP008012519, ISSN: 1381-6128 *
JOURNAL OF CELLULAR PHYSIOLOGY, vol. 168, no. 1, 1996, pages 18 - 25, ISSN: 0021-9541 *
JOURNAL OF NEUROSCIENCE RESEARCH, vol. 46, no. 5, 1996, pages 540 - 550, ISSN: 0360-4012 *
LEUKEMIA RESEARCH, vol. 22, no. 8, August 1998 (1998-08-01), pages 697 - 703, ISSN: 0145-2126 *
LIU MIN ET AL: "Transcriptional activation of the Cdk inhibitor p21 by vitamin D-3 leads to the induced differentiation of the myelomonocytic cell line U937.", GENES & DEVELOPMENT, vol. 10, no. 2, 1996, pages 142 - 153, XP008012538, ISSN: 0890-9369 *
MECHANISMS OF AGEING AND DEVELOPMENT, vol. 91, no. 1, 1996, pages 23 - 36, ISSN: 0047-6374 *
ROTS NYNKE Y ET AL: "A differential screen for ligand-regulated genes: Identification of HoxA10 as a target of vitamin D3 induction in myeloid leukemic cells.", MOLECULAR AND CELLULAR BIOLOGY, vol. 18, no. 4, April 1998 (1998-04-01), pages 1911 - 1918, XP002227919, ISSN: 0270-7306 *

Also Published As

Publication number Publication date
AU2002221397A1 (en) 2002-06-11
WO2002044403A2 (en) 2002-06-06

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