WO2002043683A1 - Ozone containing oral hygiene compositions - Google Patents
Ozone containing oral hygiene compositions Download PDFInfo
- Publication number
- WO2002043683A1 WO2002043683A1 PCT/IT2000/000498 IT0000498W WO0243683A1 WO 2002043683 A1 WO2002043683 A1 WO 2002043683A1 IT 0000498 W IT0000498 W IT 0000498W WO 0243683 A1 WO0243683 A1 WO 0243683A1
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- WO
- WIPO (PCT)
- Prior art keywords
- composition according
- anyone
- ozone
- articles
- prosthesis
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 29
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 title claims abstract description 16
- 239000000551 dentifrice Substances 0.000 claims abstract description 8
- 239000002324 mouth wash Substances 0.000 claims abstract description 8
- 210000000214 mouth Anatomy 0.000 claims abstract description 6
- 235000015218 chewing gum Nutrition 0.000 claims abstract description 4
- 229940051866 mouthwash Drugs 0.000 claims abstract description 4
- 239000000668 oral spray Substances 0.000 claims abstract description 4
- 239000000243 solution Substances 0.000 claims abstract description 4
- 229940112822 chewing gum Drugs 0.000 claims abstract description 3
- 229940041678 oral spray Drugs 0.000 claims abstract description 3
- 239000011505 plaster Substances 0.000 claims abstract description 3
- 208000028169 periodontal disease Diseases 0.000 claims description 5
- 238000011282 treatment Methods 0.000 claims description 5
- 230000000249 desinfective effect Effects 0.000 claims description 2
- 208000007565 gingivitis Diseases 0.000 claims 1
- 239000000645 desinfectant Substances 0.000 abstract description 5
- 208000002399 aphthous stomatitis Diseases 0.000 abstract description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 206010006326 Breath odour Diseases 0.000 description 4
- 208000032139 Halitosis Diseases 0.000 description 4
- 241000589970 Spirochaetales Species 0.000 description 4
- 235000011187 glycerol Nutrition 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 239000003906 humectant Substances 0.000 description 3
- 239000000600 sorbitol Substances 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 206010018276 Gingival bleeding Diseases 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 230000003412 degenerative effect Effects 0.000 description 2
- LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 210000000981 epithelium Anatomy 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000013355 food flavoring agent Nutrition 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- 208000011759 gum bleeding Diseases 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 229940041616 menthol Drugs 0.000 description 2
- 230000001590 oxidative effect Effects 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 230000001172 regenerating effect Effects 0.000 description 2
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 2
- 229940081974 saccharin Drugs 0.000 description 2
- 235000019204 saccharin Nutrition 0.000 description 2
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 2
- 229960004029 silicic acid Drugs 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000003765 sweetening agent Substances 0.000 description 2
- 239000010936 titanium Substances 0.000 description 2
- 229910052719 titanium Inorganic materials 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- 229920000569 Gum karaya Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 239000004141 Sodium laurylsulphate Substances 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 241000934878 Sterculia Species 0.000 description 1
- 208000008312 Tooth Loss Diseases 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000001785 acacia senegal l. willd gum Substances 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 description 1
- 239000000305 astragalus gummifer gum Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229960005069 calcium Drugs 0.000 description 1
- 235000001465 calcium Nutrition 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229940043256 calcium pyrophosphate Drugs 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 229920003090 carboxymethyl hydroxyethyl cellulose Polymers 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 235000010494 karaya gum Nutrition 0.000 description 1
- 239000000231 karaya gum Substances 0.000 description 1
- 229940039371 karaya gum Drugs 0.000 description 1
- 239000000832 lactitol Substances 0.000 description 1
- 235000010448 lactitol Nutrition 0.000 description 1
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 description 1
- 229960003451 lactitol Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
- 229960002799 stannous fluoride Drugs 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000012258 stirred mixture Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 230000009182 swimming Effects 0.000 description 1
- 150000003509 tertiary alcohols Chemical class 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- WKMXOPXIVBEXRR-UHFFFAOYSA-H tricalcium;diphosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O WKMXOPXIVBEXRR-UHFFFAOYSA-H 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 239000002351 wastewater Substances 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/064—Chewing gum characterised by the composition containing organic or inorganic compounds containing inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61Q11/02—Preparations for deodorising, bleaching or disinfecting dentures
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Definitions
- the present invention refers to a composition for the hygiene of the oral cavity or of prosthesis articles in particular in the form of dentifrice, mouthwash, oral spray, chewing gum, plaster for aphthae or disinfectant solution for prosthesis articles.
- Ozone is an unstable gas with a high oxidizing power that makes it an effective disinfectant. Due to this property it is utilized for the depuration of water as, for example, of wastewater, swimming pool water and the like.
- Ozone is utilized in medicine and it is administered as a gas subcutaneously, intramuscularly or by autohemotherapy in which, the ozone is mixed with the patient's blood and reintroduced in the body.
- US-A-5 945 391 discloses an disinfectant in high concentrations of at least 4,97 g/l
- US-A-5 945 391 discloses a disinfectant containing ozone in high concentrations of at least 4.97 g/l, comprising a glycol or a tertiary alcohol and a compound selected from the group consisting of acetic acid, t-butanol, hydrogen peroxide and mixtures thereof.
- the present invention refers to compositions for the hygiene of the oral cavity or of prosthesis articles, containing ozone and an orally acceptable vehicle.
- the compositions according to the present invention contain ozone in a concentration of from 0.01 to 80 ⁇ g /ml, preferably from 0.5 to 5 ⁇ g /ml.
- the compositions according the present invention allow an optimum disinfection of the oral cavity together with an epithelium regenerative action.
- the disinfecting action of the inventive compositions is performed in depth, acting also against the anaerobic bacterial species, such as spirochetes, allowing the reduction - up to their elimination - of halitosis and of gum bleeding as well as the prevention and treatment of the periodontal disease and of the other gum inflammatory and degenerative conditions.
- Orally acceptable vehicle means any carrier suitable for use in the oral cavity.
- Such vehicles include the usual components of dentifrices, mouthwashes, oral sprays, chewing gums, plasters for aphtes, well known to those skilled in the art.
- the orally acceptable vehicle may be anhydrous but preferably it is an aqueous orally acceptable vehicle capable of forming a semi- solid extrusible material.
- the orally acceptable vehicle will comprise a binder o thickener, such as natural or synthetic gums, e.g., xanthan gum, karaya gum, arabic gum, tragacanth gum, carrageenan, alginates, cellulose derivatives, such as hydroxyethyl cellulose, sodium carboxymethyl cellulose, sodium carboxymethyl hydroxyethyl cellulose or colloidal magnesium aluminum silicate or silica.
- a binder o thickener such as natural or synthetic gums, e.g., xanthan gum, karaya gum, arabic gum, tragacanth gum, carrageenan, alginates, cellulose derivatives, such as hydroxyethyl cellulose, sodium carboxymethyl cellulose, sodium carboxymethyl hydroxyethyl cellulose or colloidal magnesium aluminum silicate or silica.
- synthetic vinyl polymers e.g. polyacrylates or carboxyvinyl polymers , such as CarbopolTM may be used.
- the orally acceptable vehicle usually comprises a humectant such as glycerine, sorbitol, propylene glycol, polyethylene glycol, xylitol, lactitol and other polyhydric alcohols usually in an amount ranging from 15 and 70% by weight of the total composition.
- a humectant such as glycerine, sorbitol, propylene glycol, polyethylene glycol, xylitol, lactitol and other polyhydric alcohols usually in an amount ranging from 15 and 70% by weight of the total composition.
- the orally acceptable vehicle may comprise abrasive substances such as, e.g., silicas, including gels and precipitates thereof, calcium carbonate, calcium orthophosphate dihydrate, calcium pyrophosphate, tricalcium phosphate, calcium polymethaphosphate, insoluble sodium polymethaphosphate, hydrated alumina and the like.
- abrasives are present in an amount ranging from 6 to 70% by weight of the total composition.
- the orally acceptable vehicle may furthermore contain emulsifying agents, flavour and sweetening agents, preservatives, pH adjusting agents, and the like.
- the orally acceptable vehicle usually comprises a water/ethyl alcohol solution and flavouring agents, sweeteners, humectants, emulsifiers.
- humectants glycerine and sorbitol are usually used.
- fibrin or epithelium regenerating substances may be present.
- compositions according to the present invention can be prepared according the usually used methods for preparing dentifrices and mouthwashes but with a final addition of ozone to the mixture by introducing an ozone-containing gas into a mixing vessel that contains the stirred mixture as, for example in US 5 945 391.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Emergency Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Cosmetics (AREA)
Abstract
The present invention refers to a composition containing ozone for the hygiene of the oral cavity or of prothesis articles in particular in the form of dentifrice, mouthwash, oral spray, chewing gum, plaster for aphthae or disinfectant solutions for prosthesis articles.
Description
OZONE CONTAINING ORAL HYGIENE COMPOSITIONS
The present invention refers to a composition for the hygiene of the oral cavity or of prosthesis articles in particular in the form of dentifrice, mouthwash, oral spray, chewing gum, plaster for aphthae or disinfectant solution for prosthesis articles.
Deeply felt problems in dentistry are the elimination of gum bleeding, halitosis and the treatment and prophylaxis of the periodontal disease. Especially the periodontal disease is the major cause of tooth loss. Said gum inflammatory and degenerative conditions, as well as halitosis, are caused by the presence of bacteria, in particular anaerobic bacteria such as the spirochetes. The spirochetes are the chief responsible agent for halitosis and the periodontal disease.
Currently a great number of dentifrices and mouthwashes, having a high cleansing, whitening, refreshing, anti-bacterial action, are present on the marketplace. Said products act only superficially, i.e., in the gingival sulcus (0.5-
1 ,5 mm) and do not perform an anti-bacterial activity against the spirochetes and the resistant species.
Ozone is an unstable gas with a high oxidizing power that makes it an effective disinfectant. Due to this property it is utilized for the depuration of water as, for example, of wastewater, swimming pool water and the like.
Ozone is utilized in medicine and it is administered as a gas subcutaneously, intramuscularly or by autohemotherapy in which, the ozone is mixed with the patient's blood and reintroduced in the body.
US-A-5 945 391 discloses an disinfectant in high concentrations of at least 4,97 g/l US-A-5 945 391 discloses a disinfectant containing ozone in high concentrations of at least 4.97 g/l, comprising a glycol or a tertiary alcohol and a compound selected from the group consisting of acetic acid, t-butanol, hydrogen peroxide and mixtures thereof.
There are also on the marketplace cosmetic preparations in cream or serum, containing ozone, which are used for skin revitalisation.
The present invention refers to compositions for the hygiene of the oral cavity or of prosthesis articles, containing ozone and an orally acceptable vehicle. The compositions according to the present invention contain ozone in a concentration of from 0.01 to 80 μg /ml, preferably from 0.5 to 5 μg /ml. The compositions according the present invention allow an optimum disinfection of the oral cavity together with an epithelium regenerative action. The disinfecting action of the inventive compositions is performed in depth, acting also against the anaerobic bacterial species, such as spirochetes, allowing the reduction - up to their elimination - of halitosis and of gum bleeding as well as the prevention and treatment of the periodontal disease and of the other gum inflammatory and degenerative conditions. Furthermore, the ozone, although a strong oxidant, does not perform an aggressive action against titanium, gold, molybdenum, cobalt, which are metals commonly used in prosthesis articles and osteointeg rated implants, contrary to fluorine and in particular stannous fluoride which are normally used in toothpastes and damage titanium.
Orally acceptable vehicle" means any carrier suitable for use in the oral cavity. Such vehicles include the usual components of dentifrices, mouthwashes, oral sprays, chewing gums, plasters for aphtes, well known to those skilled in the art. In the case of dentifrices the orally acceptable vehicle may be anhydrous but preferably it is an aqueous orally acceptable vehicle capable of forming a semi- solid extrusible material. Generally, the orally acceptable vehicle will comprise a binder o thickener, such as natural or synthetic gums, e.g., xanthan gum, karaya gum, arabic gum, tragacanth gum, carrageenan, alginates, cellulose derivatives, such as hydroxyethyl cellulose, sodium carboxymethyl cellulose, sodium carboxymethyl hydroxyethyl cellulose or colloidal magnesium aluminum silicate or silica. Furthermore, synthetic vinyl polymers, e.g. polyacrylates or carboxyvinyl polymers , such as Carbopol™ may be used. The binder or thickener is usually employed in an amount of from 0.5 to 5.0% by weight of the total composition. Furthermore, the orally acceptable vehicle usually comprises a humectant such as glycerine, sorbitol, propylene glycol, polyethylene glycol, xylitol, lactitol and other polyhydric alcohols usually in an amount ranging from 15 and 70% by weight of the total composition.
Furthermore the orally acceptable vehicle may comprise abrasive substances such as, e.g., silicas, including gels and precipitates thereof, calcium carbonate, calcium orthophosphate dihydrate, calcium pyrophosphate, tricalcium phosphate, calcium polymethaphosphate, insoluble sodium polymethaphosphate, hydrated alumina and the like. Usually the abrasives are present in an amount ranging from 6 to 70% by weight of the total composition.
The orally acceptable vehicle may furthermore contain emulsifying agents, flavour and sweetening agents, preservatives, pH adjusting agents, and the like.
In the case of mouthwashes, the orally acceptable vehicle usually comprises a water/ethyl alcohol solution and flavouring agents, sweeteners, humectants, emulsifiers. As humectants, glycerine and sorbitol are usually used.
In the case of plasters for aphtes, fibrin or epithelium regenerating substances may be present.
The compositions according to the present invention can be prepared according the usually used methods for preparing dentifrices and mouthwashes but with a final addition of ozone to the mixture by introducing an ozone-containing gas into a mixing vessel that contains the stirred mixture as, for example in US 5 945 391.
In the following examples the percentages are reported by weight of the total composition.
EXAMPLE 1
Given herebelow is a dentifrice composition representative of the present invention:
O3 1 μg/ml Glycerine 12.0%
Polyethylene glycol (PEG 400) 3.0%
Xanthan gum 0.9%
Saccharin 0.2% sodium benzoate 0.2%
Sorbitol 38.0%
Hydrated silica (abrasive) 13.0% Hydrated silica (thickener) 11.0% Sodium laurylsulphate 1.3% Menthol 0.5%
Distilled water balance to 100
EXAMPLE 2 Given herebelow is a mouthwash composition representative of the present invention:
O3 1 μg/ml
Glycerine 13.0% Ethylic alcohol 14.0% Distilled water 71.5% Pluronic F 0.5% Saccharin 0.2% Sodium phosphate 0.6% Menthol 0.2%
Claims
I . A composition for the hygiene of the oral cavity and of prosthesis articles
containing ozone and an orally acceptable vehicle.
2. A composition according to claim 1 containing ozone in a concentration of
0.01 to 80 μg/ml.
3. A composition according to claim 1 containing ozone in a concentration of
0.5 to 5 μg/ml.
4. A composition according to anyone of the preceding claims in the form of a dentifrice.
5. A composition according to anyone of the claims 1-3 in the form of a
mouthwash.
6. A composition according to anyone of the claims 1-3 in the form of an oral
spray.
7. A composition according to anyone of the claims 1-3 in the form of a
chewing gum.
8. A composition according to anyone of the claims 1-3 in the form of a
disinfecting solution for prosthesis articles.
9. A composition according to anyone of the claims 1-3 in the form of a plaster for aphtes.
10. A composition according to anyone of the claims 1-7 for the treatment of the periodontal disease.
I I . A composition according to anyone of the claims 1-7 for the treatment of gingivitis.
12. A composition according to anyone of the claims 1 -7 for the treatment of the alithosis.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IT2000/000498 WO2002043683A1 (en) | 2000-11-30 | 2000-11-30 | Ozone containing oral hygiene compositions |
| AU2001222191A AU2001222191A1 (en) | 2000-11-30 | 2000-11-30 | Ozone containing oral hygiene compositions |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IT2000/000498 WO2002043683A1 (en) | 2000-11-30 | 2000-11-30 | Ozone containing oral hygiene compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2002043683A1 true WO2002043683A1 (en) | 2002-06-06 |
Family
ID=11133592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IT2000/000498 WO2002043683A1 (en) | 2000-11-30 | 2000-11-30 | Ozone containing oral hygiene compositions |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU2001222191A1 (en) |
| WO (1) | WO2002043683A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160206521A1 (en) * | 2014-12-19 | 2016-07-21 | Arcadio Maldonado Rodriguez | Gel-Based Compositions and Methods of Use |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2187288A1 (en) * | 1972-06-12 | 1974-01-18 | Nat Patent Develop Corp | Anti-caries aqs prepn - comprising oxidising agents and organic amines |
| US3996126A (en) * | 1973-11-28 | 1976-12-07 | Rasmussen Oeystein | Means for removal of adsorbed film and microorganisms from teeth and oral cavities |
| US4196726A (en) * | 1976-12-23 | 1980-04-08 | Somartec S. A. | Apparatus for dermatological treatment |
| JPS63201113A (en) * | 1987-02-16 | 1988-08-19 | Baiotetsuku Heaa:Kk | Hair growing and restoring method |
| NL1000252C1 (en) * | 1995-04-28 | 1996-10-29 | Martens Ben Peieter Maria | Compsns. contg. ozone |
| RU2146917C1 (en) * | 1998-01-16 | 2000-03-27 | Нижегородская государственная медицинская академия | Method of preventing and treating mouth cavity diseases |
-
2000
- 2000-11-30 AU AU2001222191A patent/AU2001222191A1/en not_active Abandoned
- 2000-11-30 WO PCT/IT2000/000498 patent/WO2002043683A1/en active Application Filing
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2187288A1 (en) * | 1972-06-12 | 1974-01-18 | Nat Patent Develop Corp | Anti-caries aqs prepn - comprising oxidising agents and organic amines |
| US3996126A (en) * | 1973-11-28 | 1976-12-07 | Rasmussen Oeystein | Means for removal of adsorbed film and microorganisms from teeth and oral cavities |
| US4196726A (en) * | 1976-12-23 | 1980-04-08 | Somartec S. A. | Apparatus for dermatological treatment |
| JPS63201113A (en) * | 1987-02-16 | 1988-08-19 | Baiotetsuku Heaa:Kk | Hair growing and restoring method |
| NL1000252C1 (en) * | 1995-04-28 | 1996-10-29 | Martens Ben Peieter Maria | Compsns. contg. ozone |
| RU2146917C1 (en) * | 1998-01-16 | 2000-03-27 | Нижегородская государственная медицинская академия | Method of preventing and treating mouth cavity diseases |
Non-Patent Citations (3)
| Title |
|---|
| DATABASE WPI Section Ch Week 198839, Derwent World Patents Index; Class D21, AN 1988-274938, XP002171690 * |
| DATABASE WPI Section Ch Week 199707, Derwent World Patents Index; Class B06, AN 1997-075620, XP002171691 * |
| DATABASE WPI Section Ch Week 200056, Derwent World Patents Index; Class B06, AN 2000-593111, XP002171692 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160206521A1 (en) * | 2014-12-19 | 2016-07-21 | Arcadio Maldonado Rodriguez | Gel-Based Compositions and Methods of Use |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001222191A1 (en) | 2002-06-11 |
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