WO2002040694A3 - Heterologous expression of taxanes - Google Patents

Heterologous expression of taxanes Download PDF

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Publication number
WO2002040694A3
WO2002040694A3 PCT/DK2001/000763 DK0100763W WO0240694A3 WO 2002040694 A3 WO2002040694 A3 WO 2002040694A3 DK 0100763 W DK0100763 W DK 0100763W WO 0240694 A3 WO0240694 A3 WO 0240694A3
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WO
WIPO (PCT)
Prior art keywords
taxane
synthesis pathway
host cell
dna sequence
taxanes
Prior art date
Application number
PCT/DK2001/000763
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French (fr)
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WO2002040694A2 (en
Inventor
Jesper Vind
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Novozymes As
Jesper Vind
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Publication date
Application filed by Novozymes As, Jesper Vind filed Critical Novozymes As
Priority to EP01996617A priority Critical patent/EP1337657A2/en
Priority to AU2002223504A priority patent/AU2002223504A1/en
Priority to US10/416,974 priority patent/US20040038353A1/en
Publication of WO2002040694A2 publication Critical patent/WO2002040694A2/en
Publication of WO2002040694A3 publication Critical patent/WO2002040694A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes

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  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention relates to a method of heterologous production of a taxane or a related compound by cloning a DNA sequence comprising a taxane synthesis pathway, making a DNA construct wherein said DNA sequence is under control of regulatory elements, introducing said DNA construct into a host cell, growing said host cell under conditions conductive to the production of the taxane in question, and recovering the taxane in question from the culture medium.The invention also relates to the DNA sequence comprising the taxane synthesis pathway, an expression vector comprising the taxane synthesis pathway, and a host cell comprising the expression vector comprising the taxane synthesis pathway being capable of heterologous expression of taxane.
PCT/DK2001/000763 2000-11-17 2001-11-16 Heterologous expression of taxanes WO2002040694A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP01996617A EP1337657A2 (en) 2000-11-17 2001-11-16 Heterologous expression of taxanes
AU2002223504A AU2002223504A1 (en) 2000-11-17 2001-11-16 Heterologous expression of taxanes
US10/416,974 US20040038353A1 (en) 2000-11-17 2001-11-16 Heterologous expression of taxanes

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DKPA200001730 2000-11-17
DKPA200001730 2000-11-17
US25384300P 2000-11-29 2000-11-29
US60/253,843 2000-11-29

Publications (2)

Publication Number Publication Date
WO2002040694A2 WO2002040694A2 (en) 2002-05-23
WO2002040694A3 true WO2002040694A3 (en) 2002-10-03

Family

ID=26068914

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2001/000763 WO2002040694A2 (en) 2000-11-17 2001-11-16 Heterologous expression of taxanes

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EP (1) EP1337657A2 (en)
AU (1) AU2002223504A1 (en)
WO (1) WO2002040694A2 (en)

Cited By (2)

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WO2017000922A1 (en) 2015-07-02 2017-01-05 Novozymes A/S Animal feed compositions and uses thereof
CN108929857B (en) * 2017-05-26 2021-10-29 中国海洋大学 Salicornia europaea-derived marine fungus and application thereof in preparation of topoisomerase I inhibitor

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Patent Citations (1)

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Non-Patent Citations (1)

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Title
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Cited By (2)

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WO2017000922A1 (en) 2015-07-02 2017-01-05 Novozymes A/S Animal feed compositions and uses thereof
CN108929857B (en) * 2017-05-26 2021-10-29 中国海洋大学 Salicornia europaea-derived marine fungus and application thereof in preparation of topoisomerase I inhibitor

Also Published As

Publication number Publication date
AU2002223504A1 (en) 2002-05-27
WO2002040694A2 (en) 2002-05-23
EP1337657A2 (en) 2003-08-27

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