WO2002036632A3 - Single nucleotide polymorphisms in nucleic acids encoding human olfactory receptor-like polypeptides - Google Patents

Single nucleotide polymorphisms in nucleic acids encoding human olfactory receptor-like polypeptides Download PDF

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Publication number
WO2002036632A3
WO2002036632A3 PCT/US2001/031744 US0131744W WO0236632A3 WO 2002036632 A3 WO2002036632 A3 WO 2002036632A3 US 0131744 W US0131744 W US 0131744W WO 0236632 A3 WO0236632 A3 WO 0236632A3
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WO
WIPO (PCT)
Prior art keywords
polypeptides
single nucleotide
nucleotide polymorphisms
olfactory receptor
nucleic acids
Prior art date
Application number
PCT/US2001/031744
Other languages
French (fr)
Other versions
WO2002036632A8 (en
WO2002036632A2 (en
Inventor
John P Ii Alsobrook
Catherine E Burgess
William M Grosse
Denise M Lepley
Muralidhara Padigaru
Kimberly A Spytek
Original Assignee
Curagen Corp
John P Ii Alsobrook
Catherine E Burgess
William M Grosse
Denise M Lepley
Muralidhara Padigaru
Kimberly A Spytek
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/777,789 external-priority patent/US20030087815A1/en
Application filed by Curagen Corp, John P Ii Alsobrook, Catherine E Burgess, William M Grosse, Denise M Lepley, Muralidhara Padigaru, Kimberly A Spytek filed Critical Curagen Corp
Priority to AU2001296804A priority Critical patent/AU2001296804A1/en
Publication of WO2002036632A2 publication Critical patent/WO2002036632A2/en
Publication of WO2002036632A8 publication Critical patent/WO2002036632A8/en
Publication of WO2002036632A3 publication Critical patent/WO2002036632A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • General Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention provides novel isolated nucleic acid sequences having single nucleotide polymorphisms that encode olfactory receptor-like polypeptides and the polypeptides so encoded. Also provided are the antibodies that immunospecifically bind to these polypeptides or any derivative, variant, mutant or fragment of the polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.
PCT/US2001/031744 2000-11-02 2001-10-09 Single nucleotide polymorphisms in nucleic acids encoding human olfactory receptor-like polypeptides WO2002036632A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001296804A AU2001296804A1 (en) 2000-11-02 2001-10-09 Single nucleotide polymorphisms in nucleic acids encoding human olfactory receptor-like polypeptides

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US24529200P 2000-11-02 2000-11-02
US60/245,292 2000-11-02
US09/777,789 US20030087815A1 (en) 2000-02-07 2001-02-06 Novel polypeptides and nucleic acids encoding same
US09/777,789 2001-02-06
US32375501P 2001-09-20 2001-09-20
US60/323,755 2001-09-20

Publications (3)

Publication Number Publication Date
WO2002036632A2 WO2002036632A2 (en) 2002-05-10
WO2002036632A8 WO2002036632A8 (en) 2002-09-06
WO2002036632A3 true WO2002036632A3 (en) 2003-08-14

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/031744 WO2002036632A2 (en) 2000-11-02 2001-10-09 Single nucleotide polymorphisms in nucleic acids encoding human olfactory receptor-like polypeptides

Country Status (1)

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WO (1) WO2002036632A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004106935A2 (en) * 2003-05-27 2004-12-09 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 103 (gpr103)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0867508A2 (en) * 1997-03-28 1998-09-30 Smithkline Beecham Corporation Olfactory receptor of the 7-transmembrane receptor family - OLRCC15 receptor
WO2000021985A2 (en) * 1998-10-14 2000-04-20 Genset Genes encoding olfactory receptors and biallelic markers thereof
WO2001027158A2 (en) * 1999-10-08 2001-04-19 Digiscents Olfactory receptor sequences
WO2001057215A2 (en) * 2000-02-07 2001-08-09 Curagen Corporation Human g-protein coupled receptor polypeptides and polynucleotides having homology with odorant receptors
WO2001057085A2 (en) * 2000-02-02 2001-08-09 Incyte Genomics, Inc. G-protein coupled receptors
WO2001068805A2 (en) * 2000-03-13 2001-09-20 Senomyx, Inc. Human olfactory receptors and genes encoding same
WO2002024726A2 (en) * 2000-09-22 2002-03-28 Chemcom S.A. Olfactory and pheromones g-protein coupled receptors

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0867508A2 (en) * 1997-03-28 1998-09-30 Smithkline Beecham Corporation Olfactory receptor of the 7-transmembrane receptor family - OLRCC15 receptor
WO2000021985A2 (en) * 1998-10-14 2000-04-20 Genset Genes encoding olfactory receptors and biallelic markers thereof
WO2001027158A2 (en) * 1999-10-08 2001-04-19 Digiscents Olfactory receptor sequences
WO2001057085A2 (en) * 2000-02-02 2001-08-09 Incyte Genomics, Inc. G-protein coupled receptors
WO2001057215A2 (en) * 2000-02-07 2001-08-09 Curagen Corporation Human g-protein coupled receptor polypeptides and polynucleotides having homology with odorant receptors
WO2001068805A2 (en) * 2000-03-13 2001-09-20 Senomyx, Inc. Human olfactory receptors and genes encoding same
WO2002024726A2 (en) * 2000-09-22 2002-03-28 Chemcom S.A. Olfactory and pheromones g-protein coupled receptors

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL, HEIDELBERG, FRG [online] 1 December 2001 (2001-12-01), FUCHS, T. ET AL.: "Olfactory receptor (Fragment)", XP002218199, Database accession no. Q96R40 *
DATABASE EMBL, HEIDELBERG, FRG [online] 1 May 2000 (2000-05-01), STROTMANN, J. ET AL.: "OLFACTORY RECEPTOR", XP002176433, retrieved from MUS MUSCULUS Database accession no. Q9QZ18 *
DATABASE EMBL, HEIDELBERG, FRG [online] 1 October 2000 (2000-10-01), ROUQUIER, S. ET AL.: "Olfactory receptor (Fragment)", XP002218195, Database accession no. Q9N1K1 *
DATABASE EMBL, HEIDELBERG, FRG [online] 10 December 1999 (1999-12-10), CORBY, N.: "Human DNA sequence from clone RP11-112J3 on chromosome 9p13.1-13.3", XP002176432, Database accession no. AL133410 *
DATABASE EMBL, HEIDELBERG, FRG [online] 14 March 2000 (2000-03-14), ROUQUIER, S. ET AL.: "Macaca sylvanus olfactory receptor (MSY172) gene, partial cds.", XP002218194, Database accession no. AF179792 *
DATABASE EMBL, HEIDELBERG, FRG [online] 27 August 2001 (2001-08-27), FUCHS, T. ET AL.: "Homo sapiens clone OR13J1 olfactory receptor gene, partial cds.", XP002218198, Database accession no. AF399603 *
DATABASE EMBL, HEIDELBERG, FRG [online] 30 July 2001 (2001-07-30), XP002218196, Database accession no. AAH32075 *
DATABASE EMBL, HEIDELBERG, FRG [online] 30 July 2001 (2001-07-30), XP002218197, Database accession no. AAG71899 *
GILAD, Y. ET AL.: "Dichotomy of single-nucleotide polymorphism haplotypes in olfactor receptor genes and pseudogenes", NATURE GENETICS, vol. 26, no. 2, October 2000 (2000-10-01), pages 221 - 224, XP002218193 *
KRISHNA, N.S.R. ET AL.: "Glutathione and gamma-glutamyl transpeptidase are differentially distributed in the olfactory mucosa of rats", CELL & TISSUE RESEARCH, vol. 270, no. 3, December 1992 (1992-12-01), pages 475 - 484, XP008009742 *
ROUQUIER, S. ET AL.: "The olfactory receptor gene repertoire in primates and mouse: Evidence for reduction of the functional fraction in primates", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 97, no. 6, 14 March 2000 (2000-03-14), pages 2870 - 2874, XP002194872 *
STROTMANN, J. ET AL.: "Small subfamily of olfactory receptor genes: structural features, expression pattern and genomic organization", GENE, vol. 236, no. 2, 20 August 1999 (1999-08-20), pages 281 - 291, XP004178064 *

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WO2002036632A8 (en) 2002-09-06
WO2002036632A2 (en) 2002-05-10

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