WO2002030437A1 - Citrus composition for hygiene, care or protection of teats - Google Patents

Citrus composition for hygiene, care or protection of teats Download PDF

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Publication number
WO2002030437A1
WO2002030437A1 PCT/FR2001/002937 FR0102937W WO0230437A1 WO 2002030437 A1 WO2002030437 A1 WO 2002030437A1 FR 0102937 W FR0102937 W FR 0102937W WO 0230437 A1 WO0230437 A1 WO 0230437A1
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WIPO (PCT)
Prior art keywords
composition according
film
care
hygiene
teats
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PCT/FR2001/002937
Other languages
French (fr)
Inventor
Franzjosef Scholl
Jacky Moulin
Damien Pfleger
Original Assignee
Laboratoires Ceetal S.A.
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Priority to AU2001293918A priority Critical patent/AU2001293918A1/en
Publication of WO2002030437A1 publication Critical patent/WO2002030437A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08—Magnoliopsida [dicotyledons]
    • A01N65/36—Rutaceae [Rue family], e.g. lime, orange, lemon, corktree or pricklyash
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone

Definitions

  • Milking hygiene and more particularly the care and disinfection of the teats are important, both for the quality of the milk and for the health of the animals.
  • the care provided consists essentially of applications of treatment solutions, by soaking or spraying.
  • the purpose of these applications is to destroy the germs and microorganisms present on the skin of the teats and also to improve the quality and resistance of the skin. Indeed, during milking the skin of animals can be irritated by milking machines and these irritations, if the surface of the skin is damaged, can then be the site of microbial attacks causing for example mastitis. Other infections can also be caused by contamination from one animal to another by milking equipment, by the environment of the animal and possible stains, the pathogenic microorganisms being mainly Escherichia coli, Streptococcus, klebsiella and Staphylococcus Aureus.
  • the active products used are disinfectants or local antiseptics to destroy the pathogenic flora and softeners and emollients, even superfats, for skin care and the fight against irritation.
  • the products used are essentially iodophores, chlorhexidine, sulfonamides, Septigon ® and various other products which all have drawbacks, for example the use of iodophores leads to high concentrations of iodine in the milk; Septigon ® must be diluted at the time of use, and sodium chlorite is irritating.
  • the softeners and emollients used are products like allantoin, glycerin, petrolatum and / or lanolin.
  • compositions are known, used by soaking immediately after milking, making it possible to obtain protection of the teats and to reduce the risks of cracks and chapping, and comprising in combination a care product and a disinfecting agent sorbic acid derivative, cf. FR-A-2 777 461 in the name of the Applicant.
  • the products used should, if possible, inactivate most of the pathogenic germs present, completely, quickly and durably and at the same time have low toxicity and good tissue tolerance.
  • the lactiferous duct remaining open after milking for about half an hour does not represent a pathway for the introduction of pathogenic microorganisms into the teat and cannot be the site of the development of pathogenic microorganisms between two milking , microorganisms which would then pollute the milk of the next milking.
  • one way to limit the risk of introducing these pathogenic microorganisms into the milk duct would be to be able to obstruct it immediately after milking. All these requirements are often found in opposition to the intrinsic properties of substances.
  • the choice of a substance in the area of teat hygiene or applications are daily throughout the lactation period is all the more difficult as the risks of addiction and irritation are increased tenfold by these repeated and daily uses for long periods.
  • the effect depends on the concentration and, in most cases, also on the duration of application.
  • the active products used must therefore have disinfectant properties and be able to remain in contact with the teat, ideally between two milkings, without causing any irritation or side effect and without risk of addiction.
  • the products used must also be able to be removed easily by simple washing and wet wiping before milking, without risk of causing abrasion or irritation during this disposal. These products must also have high stability at room temperature and in contact with air and have no toxicity.
  • compositions containing antimicrobial and antifungal, or even anti-inflammatory active ingredients ultimately leads to addiction of the microorganisms to the products used, requiring the use of other chemical families of active products, but also resulting in the increase doses used.
  • These products active ingredients are also likely to be assimilated systemically, with the risk of finding them in milk and other food products from treated animals.
  • This natural plant extract is non-irritant, non-phytotoxic, compatible with antibiotics such as sulfa drugs and very stable.
  • Citrus liquid extract is a complex biological liquid derived from natural citric extracts, which has a polysynergic action of its own organic components which are in their natural state, ascorbic acid and its derivatives, citric acid, polypeptides, amino acids, fatty acids, flavonoids, tocopherols and sugars.
  • This polysynergic action of the organic components of the citrus extract has the advantage in the use as teat care product, of being based on organic components belonging to different chemical families, which avoids any risk addiction of microorganisms.
  • the Applicant has developed formulations based on citrus extract in aqueous phase comprising polymers of film-forming nature. These formulations comprising polymers of film-forming nature also have properties of obstruction of the lactiferous channel by the formation of a deposit forming a cover which closes the lactiferous channel by drying after application.
  • the present invention therefore relates to a composition for hygiene, care and protection of the teats, characterized in that it comprises in combination, in an aqueous medium (suspension or solution), at least one film-forming polymer soluble in water and a liquid extract of citrus.
  • the film-forming polymer formed of long molecular chains, in solution or in suspension with the other ingredients in water, goes after application, when the water evaporates, precipitate and form a network of macromolecules, which by overlapping between them, generate a film.
  • the entangled and unbound polymer macromolecules make it possible to form a flexible film, which allows the skin to breathe while enclosing in this network, ingredients which can thus act as long as the film remains applied.
  • the film thus generated also makes it possible to create a physical barrier of protection.
  • the composition according to the invention makes it possible to deposit on the teat a non-crosslinked polymeric film, sufficiently resistant to allow the prolonged action of citrus between two drafts, but also sufficiently soluble in water to allow its simple and rapid elimination at the time of Trafficking.
  • This composition for the hygiene, the care and the protection of the teats comprises in aqueous solution, from 0.1 to 20% by weight of a film-forming polymer and from 0.01 to 1% by weight of citrus liquid extract.
  • film-forming products are, for example, non-crosslinked and non-crosslinkable polymeric materials dissolved, but also crosslinkable organic polymers used in suspension, capable of forming, after evaporation of the solvents, a film of variable thickness.
  • the film-forming polymer is chosen from film-forming polymers such as acrylic and vinyl resins, and preferably polymers having the capacity to form a film without crosslinking reaction such as polyvinyl alcohol.
  • compositions according to the invention may also comprise an alcohol, such as for example ethyl alcohol or isopropyl alcohol in proportions of between 2 and 15% by volume which, by evaporating after application, makes it possible to reduce the time of drying and activating the formation of the protective film on the teat, this drying time being one of the critical factors, in particular for closing the milk duct which remains open as soon as possible after milking.
  • the compositions according to the invention further comprise an emollient agent alone or as a mixture; this emollient agent is present in the composition in proportions which vary from 0.1% to 10%, alone or as a mixture.
  • the emollient and / or superfatting agents are chosen from lanolin, allantoin, petrolatum, sorbitol and glycerin, alone or as a mixture, for example a combination of petrolatum and lanolin in respective proportions of 0.1 to 7 %.
  • compositions according to the invention can additionally have a plasticizing effect on the compositions according to the invention.
  • the compositions according to the invention also contain a preservative, in proportions varying from 0.1 to 3%, chosen from the group consisting of orthophenylphenol and its salts, phenoxy-2-ethanol, polyhexamethylene biguanide, isopropylmetacresol, chlorophene, chlorhexidine, phenoxypropanol, phenoxyethanol, sorbic acid and its salts, bromo-2-nitro-2-propanediol and esters of parahydroxybenzoic acid such as ethylparaben, isobutylparaben, benzylparaben, methylparaben, butylparaben and more particularly paraben, for tolerance criteria but also for its intrinsic properties with respect to certain microorganisms such as Staphylococcus aureus.
  • compositions according to the invention further comprise a food pigment making it possible to protect the skin of the teats against UV rays, and also to carry out a visual check for the presence of the care agent on the teats; this pigment is added to the mixture in proportions which vary from 0.01 to 0.5% by weight.
  • compositions according to the invention further comprise a thickening agent in proportions which vary from 0.01 to 5% by weight.
  • This thickening agent makes it possible to obtain aqueous compositions according to the invention of sufficient viscosity to allow easy application by soaking without excessive deposition, and also without loss of product before the formation of the film by drying.
  • This thickening agent is chosen from xanthan gums, acrylic resins and polysaccharides.
  • the composition according to the invention preferably has the following formula, defined in% relative to the total weight of the composition:
  • Emollient (single or mixed) from 0.1 to 1 0%
  • the invention also relates to the process for preparing a composition according to the invention comprising the following steps:
  • the teat care and hygiene method according to the invention comprises the application by soaking on the teat of a composition characterized in that it comprises in combination in aqueous solution at least one film-forming product and a liquid citrus extract.
  • a dip cup filled with the composition according to the invention is used for soaking, and this soaking is carried out immediately after the end of the milking throughout the lactation period.
  • the soaking must be carried out within half an hour after milking, for a few seconds by teat so as to close the lactation duct before it closes and deposit a thin layer of composition which, when dried, will form a film allowing the action of the citrus extract, protect the teat from external aggressions, and fight against microorganisms.
  • composition according to the invention has one of the following formulations:
  • Polyvinyl alcohol PVA BP 1 7 4% Vaseline oil (MARCOL 82 C ® w s) 1% Lanolin (LANOTEX 730 ® ) 2% Xanthan gum (RHODIGEL ® ) 0.4% Colorant (VISCOLO ® GREEN) 0.2 %
  • Water qs 100 Among the microorganisms responsible for mastitis and against which the compositions according to the invention are effective, mention may be made of staphylococcus aureus, streptococcus faecalis, pseudomonas aeruginosa, escherichia coli and salmonela.
  • compositions according to the invention is generated by a polysynergy of the various constituents of citrus, in particular ascorbic acid, citric acid, bioflavonoids and peptides.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Mycology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
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  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
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Abstract

The invention concerns a composition for providing hygiene, care and protection for teats, characterised in that it comprises in combination, in aqueous medium 0.1 to 20 wt. % of a film-forming polymer and 0.01 to 1 wt % of a citrus liquid extract.

Description

COMPOSITION A BASE DE CITRUS POUR L'HYGIENE, LE SOIN OU LA COMPOSITION BASED ON CITRUS FOR HYGIENE, CARE OR
PROTECTION DES TRAYONSPROTECTION OF TRAYONS
L'hygiène de la traite et plus particulièrement le soin et la désinfection des trayons sont importants, tant pour la qualité du lait que pour la santé des animaux.Milking hygiene and more particularly the care and disinfection of the teats are important, both for the quality of the milk and for the health of the animals.
Les soins prodigués consistent essentiellement en des applications de solutions de traitement, par trempage ou pulvérisation.The care provided consists essentially of applications of treatment solutions, by soaking or spraying.
Ces applications ont pour but la destruction des germes et microorganismes présents sur la peau des trayons et également l'amélioration de la qualité et de la résistance de la peau. En effet, durant la traite la peau des animaux peut être irritée par les machines à traire et ces irritations, si la surface de la peau est lésée, peuvent ensuite être le siège d'attaques microbiennes provoquant par exemple des mammites. D'autres infections peuvent également être provoquées par la contamination d'un animal à l'autre par le matériel de traite, par l'environnement de l'animal et les souillures possibles, les microorganismes pathogènes étant essentiellement Escherichia coli, Streptococcus, klebsiella et Staphylococcus Aureus. Les produits actifs utilisés sont des désinfectants ou des antiseptiques locaux pour détruire la flore pathogène et des adoucissants et émollients, voire des surgraissants, pour les soins de la peau et la lutte contre l'irritation.The purpose of these applications is to destroy the germs and microorganisms present on the skin of the teats and also to improve the quality and resistance of the skin. Indeed, during milking the skin of animals can be irritated by milking machines and these irritations, if the surface of the skin is damaged, can then be the site of microbial attacks causing for example mastitis. Other infections can also be caused by contamination from one animal to another by milking equipment, by the environment of the animal and possible stains, the pathogenic microorganisms being mainly Escherichia coli, Streptococcus, klebsiella and Staphylococcus Aureus. The active products used are disinfectants or local antiseptics to destroy the pathogenic flora and softeners and emollients, even superfats, for skin care and the fight against irritation.
En tant que désinfectants et antiseptiques, les produits utilisés sont essentiellement des iodophores, la chlorhexidine, des sulfamides, le Septigon® et différents autres produits qui présentent tous des inconvénients, par exemple l'utilisation des iodophores entraîne des concentrations élevées d'iode dans le lait ; le Septigon® doit être dilué au moment de l'emploi, et le chlorite de sodium est irritant. Les adoucissants et émollients utilisés sont des produits comme l'allantoïne, la glycérine, la vaseline et/ou la lanoline.As disinfectants and antiseptics, the products used are essentially iodophores, chlorhexidine, sulfonamides, Septigon ® and various other products which all have drawbacks, for example the use of iodophores leads to high concentrations of iodine in the milk; Septigon ® must be diluted at the time of use, and sodium chlorite is irritating. The softeners and emollients used are products like allantoin, glycerin, petrolatum and / or lanolin.
On connaît des compositions, utilisées par trempage immédiatement après la traite, permettant d'obtenir une protection des trayons et de réduire les risques de crevasses et de gerçures, et comportant en combinaison un produit de soin et un agent désinfectant dérivé de l'acide sorbique, cf. FR-A-2 777 461 au nom de la Demanderesse.Compositions are known, used by soaking immediately after milking, making it possible to obtain protection of the teats and to reduce the risks of cracks and chapping, and comprising in combination a care product and a disinfecting agent sorbic acid derivative, cf. FR-A-2 777 461 in the name of the Applicant.
Les produits utilisés doivent si possible inactiver la plupart des germes pathogènes présents, de façon complète, rapide et durable et en même temps posséder une faible toxicité et une bonne tolérance tissulaire.The products used should, if possible, inactivate most of the pathogenic germs present, completely, quickly and durably and at the same time have low toxicity and good tissue tolerance.
Il est également souhaitable que le canal lactifère restant ouvert après la traite pendant environ une demi-heure ne représente pas une voie d'introduction des microorganismes pathogènes dans le trayon et ne puisse pas être le siège d'un développement de microorganismes pathogènes entre deux traites, microorganismes qui viendraient ensuite polluer le lait de la traite suivante.It is also desirable that the lactiferous duct remaining open after milking for about half an hour does not represent a pathway for the introduction of pathogenic microorganisms into the teat and cannot be the site of the development of pathogenic microorganisms between two milking , microorganisms which would then pollute the milk of the next milking.
Idéalement un moyen de limiter le risque d'introduction de ces microorganismes pathogènes dans le canal lactifère serait de pouvoir l'obstruer immédiatement après la traite. Toutes ces exigences se trouvent souvent en opposition avec les propriétés intrinsèques des substances. Le choix d'une substance dans le domaine de l'hygiène des trayons ou les applications sont quotidiennes durant toute la période de lactation est d'autant plus difficile que les risques d'accoutumance et d'irritation sont décuplés par ces utilisations répétées et quotidiennes pendant de longues périodes.Ideally, one way to limit the risk of introducing these pathogenic microorganisms into the milk duct would be to be able to obstruct it immediately after milking. All these requirements are often found in opposition to the intrinsic properties of substances. The choice of a substance in the area of teat hygiene or applications are daily throughout the lactation period is all the more difficult as the risks of addiction and irritation are increased tenfold by these repeated and daily uses for long periods.
De plus, l'effet dépend de la concentration et, dans la plupart des cas, également de la durée d'application.In addition, the effect depends on the concentration and, in most cases, also on the duration of application.
Les produits actifs utilisés doivent donc avoir des propriétés désinfectantes et pouvoir rester en contact avec le trayon, idéalement entre deux traites, sans provoquer aucune irritation ou effet secondaire et sans risque d'accoutumance.The active products used must therefore have disinfectant properties and be able to remain in contact with the teat, ideally between two milkings, without causing any irritation or side effect and without risk of addiction.
Les produits utilisés doivent également pouvoir être enlevés facilement par simple lavage et essuyage humide avant la traite, sans risque de provoquer une abrasion ou irritation lors de cette élimination. Ces produits doivent également avoir une stabilité élevée à température ambiante et au contact de l'air et ne présenter aucune toxicité.The products used must also be able to be removed easily by simple washing and wet wiping before milking, without risk of causing abrasion or irritation during this disposal. These products must also have high stability at room temperature and in contact with air and have no toxicity.
L'application répétée de compositions, contenant des principes actifs antimicrobiens et antifongiques, voire anti-inflammatoires conduit à terme à une accoutumance des microorganismes aux produits utilisés, nécessitant le recours à d'autres familles chimiques de produits actifs, mais entraînant également l'augmentation des doses utilisées. Ces produits actifs sont également susceptibles d'être assimilés par voie systémique, avec le risque de les retrouver dans le lait et les autres produits alimentaires issus des animaux traités.The repeated application of compositions containing antimicrobial and antifungal, or even anti-inflammatory active ingredients ultimately leads to addiction of the microorganisms to the products used, requiring the use of other chemical families of active products, but also resulting in the increase doses used. These products active ingredients are also likely to be assimilated systemically, with the risk of finding them in milk and other food products from treated animals.
On connaît l'activité germicide à large spectre et à biodisponibilité importante de l'extrait de citrus.The broad-spectrum and highly bioavailable germicidal activity of citrus extract is known.
Cet extrait végétal naturel est non irritant, non phytotoxique, compatible avec les antibiotiques comme les sulfamides et très stable.This natural plant extract is non-irritant, non-phytotoxic, compatible with antibiotics such as sulfa drugs and very stable.
L'extrait liquide de citrus est un liquide biologique complexe provenant d'extraits citriques naturels, qui possède une action polysynergique de ses propres composants organiques qui sont à l'état naturel, l'acide ascorbique et ses dérivés, l'acide citrique, les polypeptides, les acides aminés, les acides gras, les flavonoïdes, les tocophérols et les sucres. Cette action polysynergique des composants organiques de l'extrait de citrus présente l'avantage dans l'utilisation comme produit de soin du trayon, d'être basée sur des composants organiques appartenant à des familles chimiques différentes, ce qui permet d'éviter tout risque d'accoutumance des microorganismes.Citrus liquid extract is a complex biological liquid derived from natural citric extracts, which has a polysynergic action of its own organic components which are in their natural state, ascorbic acid and its derivatives, citric acid, polypeptides, amino acids, fatty acids, flavonoids, tocopherols and sugars. This polysynergic action of the organic components of the citrus extract has the advantage in the use as teat care product, of being based on organic components belonging to different chemical families, which avoids any risk addiction of microorganisms.
Son action antioxydante lui permet d'être microbicide dans une large fourchette de pH, et il est actuellement listé dans les G.R.A.S. (Generaly Recognized As Safe) par la F.D.A. (Food and DrugIts antioxidant action allows it to be microbicide in a wide pH range, and it is currently listed in the G.R.A.S. (Generaly Recognized As Safe) by the F.D.A. (Food and Drug
Administration) des U.S. A.Administration) of U.S.A.
La Demanderesse a donc mis en évidence que l'utilisation de formulations à base de citrus, dans l'application à l'hygiène du trayon des mammifères lactifères permet d'éviter le développement des résistances microbiennes et également les réactions d'intolérance et d'irritation.The Applicant has therefore demonstrated that the use of citrus-based formulations, in the application to the teat hygiene of lactiferous mammals makes it possible to avoid the development of microbial resistances and also the reactions of intolerance and of irritation.
Cependant le citrus n'a pas d'effet radical immédiat, il fonctionne avec une action microbicide résiduelle sur les microorganismes, et une action combinée sur le cytoplasme, tout en coagulant les protéines membranaires microbiennes. Le contact entre le milieu dans lequel les microorganismes doivent être détruits et l'extrait de citrus doit donc nécessairement être un contact prolongé.However, citrus has no immediate radical effect, it works with a residual microbicidal action on microorganisms, and a combined action on the cytoplasm, while coagulating microbial membrane proteins. The contact between the medium in which the microorganisms are to be destroyed and the citrus extract must therefore necessarily be a prolonged contact.
Pour permettre cette action prolongée dans le temps de l'extrait de citrus, sans altérer ses propriétés spécifiques et sa biodisponibilité, la Demanderesse a mis au point des formulations à base d'extrait de citrus en phase aqueuse comportant des polymères à caractère filmogène. Ces formulations comportant des polymères à caractère filmogène possèdent également des propriétés d'obstruction du canal lactifère par la formation d'un dépôt formant un opercule qui vient obturer le canal lactifère en séchant après l'application. La présente invention concerne donc une composition pour l'hygiène, le soin et la protection des trayons, caractérisée en ce qu'elle comprend en combinaison, en milieu aqueux (suspension ou solution), au moins un polymère filmogène soluble dans l'eau et un extrait liquide de citrus. Le polymère filmogène, formé de longues chaînes moléculaires, en solution ou en suspension avec les autres ingrédients dans l'eau, va après l'application, lorsque l'eau s'évapore, précipiter et former un réseau de macromolécules, qui en se recouvrant entre elles, génèrent un film.To allow this action prolonged over time of the citrus extract, without altering its specific properties and its bioavailability, the Applicant has developed formulations based on citrus extract in aqueous phase comprising polymers of film-forming nature. These formulations comprising polymers of film-forming nature also have properties of obstruction of the lactiferous channel by the formation of a deposit forming a cover which closes the lactiferous channel by drying after application. The present invention therefore relates to a composition for hygiene, care and protection of the teats, characterized in that it comprises in combination, in an aqueous medium (suspension or solution), at least one film-forming polymer soluble in water and a liquid extract of citrus. The film-forming polymer, formed of long molecular chains, in solution or in suspension with the other ingredients in water, goes after application, when the water evaporates, precipitate and form a network of macromolecules, which by overlapping between them, generate a film.
Les macromolécules de polymère enchevêtrées et non liées permettent de former un film souple, qui autorise la respiration de la peau tout en enfermant dans ce réseau, des ingrédients qui peuvent ainsi agir tant que le film reste appliqué.The entangled and unbound polymer macromolecules make it possible to form a flexible film, which allows the skin to breathe while enclosing in this network, ingredients which can thus act as long as the film remains applied.
Le film ainsi généré permet également de créer une barrière physique de protection. La composition selon l'invention permet de déposer sur le trayon un film polymérique non réticulé, suffisamment résistant pour permettre l'action prolongée du citrus entre deux traites, mais également suffisamment soluble dans l'eau pour permettre son élimination simple et rapide au moment de la traite. Cette composition pour l'hygiène, le soin et la protection des trayons comprend en solution aqueuse, de 0, 1 à 20 % en poids d'un polymère filmogène et de 0,01 à 1 % en poids d'extrait liquide de citrus.The film thus generated also makes it possible to create a physical barrier of protection. The composition according to the invention makes it possible to deposit on the teat a non-crosslinked polymeric film, sufficiently resistant to allow the prolonged action of citrus between two drafts, but also sufficiently soluble in water to allow its simple and rapid elimination at the time of Trafficking. This composition for the hygiene, the care and the protection of the teats comprises in aqueous solution, from 0.1 to 20% by weight of a film-forming polymer and from 0.01 to 1% by weight of citrus liquid extract.
Ces produits filmogènes sont par exemple des matériaux polymériques non réticulés et non reticulables mis en solution, mais aussi des polymères organiques reticulables mis en oeuvre en suspension, susceptibles de former après évaporation des solvants un film d'épaisseur variable.These film-forming products are, for example, non-crosslinked and non-crosslinkable polymeric materials dissolved, but also crosslinkable organic polymers used in suspension, capable of forming, after evaporation of the solvents, a film of variable thickness.
Le polymère filmogène est choisi parmi les polymères filmogènes comme les résines acryliques, vinyliques, et de préférence les polymères ayant la capacité de former un film sans réaction de réticulation comme l'alcool polyvinylique. Par l'utilisation de polymères filmogènes non réticulés en solution aqueuse, on obtient des films perméables à l'oxygène et souple, qui permettent de garder les matières actives en contact avec les trayons, tout en formant une barrière physique pour protéger par exemple des salissures.The film-forming polymer is chosen from film-forming polymers such as acrylic and vinyl resins, and preferably polymers having the capacity to form a film without crosslinking reaction such as polyvinyl alcohol. By the use of non-crosslinked film-forming polymers in aqueous solution, films which are permeable to oxygen and flexible are obtained, which make it possible to keep the active materials in contact with the teats, while forming a physical barrier to protect, for example, from dirt .
Néanmoins, ces films demeurent suffisamment fins pour n'entraîner ni gêne, ni intolérance, et ne pas entraver la respiration cutanée.However, these films remain thin enough not to cause discomfort or intolerance, and not to interfere with skin breathing.
Les compositions selon l'invention peuvent comprendre en outre un alcool, comme par exemple l'alcool éthylique ou l'alcool isopropylique dans des proportions comprises entre 2 et 1 5 % en volume qui en s'évaporant après application permet de diminuer le temps de séchage et d'activer la formation du film protecteur sur le trayon, ce temps de séchage étant l'un des facteurs critiques, notamment pour obturer le plus rapidement possible le canal lactifère qui reste ouvert après la traite. Les compositions selon l'invention comprennent en outre un agent émollient seul ou en mélange ; cet agent émollient est présent dans la composition dans des proportions qui varient de 0, 1 à 1 0 %, seul ou en mélange.The compositions according to the invention may also comprise an alcohol, such as for example ethyl alcohol or isopropyl alcohol in proportions of between 2 and 15% by volume which, by evaporating after application, makes it possible to reduce the time of drying and activating the formation of the protective film on the teat, this drying time being one of the critical factors, in particular for closing the milk duct which remains open as soon as possible after milking. The compositions according to the invention further comprise an emollient agent alone or as a mixture; this emollient agent is present in the composition in proportions which vary from 0.1% to 10%, alone or as a mixture.
Les agents émollients et/ou surgraissants sont choisis parmi la lanoline, l'allantoïne, la vaseline, le sorbitol et la glycérine, seuls ou en mélange, par exemple une association de vaseline et de lanoline dans des proportions respectives de 0, 1 à 7 %.The emollient and / or superfatting agents are chosen from lanolin, allantoin, petrolatum, sorbitol and glycerin, alone or as a mixture, for example a combination of petrolatum and lanolin in respective proportions of 0.1 to 7 %.
La glycérine et/ou la lanoline peuvent complémentairement avoir un effet plastifiant sur les compositions selon l'invention. Les compositions selon l'invention contiennent en outre un conservateur, dans des proportions variant de 0, 1 à 3%, choisis parmi le groupe constitué par l'orthophénylphénol et ses sels, le phénoxy-2-éthanol, le polyhexaméthylène biguanide, l'isopropylmétacrésol, le chlorophène, la chlorhexidine, le phénoxypropanol, le phénoxyéthanol, l'acide sorbique et ses sels, le bromo-2-nitro-2-propanedîol et les esters de l'acide parahydroxybenzoïque comme l'éthylparaben, l'isobutylparaben, le benzylparaben, le méthylparaben, le butylparaben et plus particulièrement le paraben, pour des critères de tolérance mais également pour ses propriétés intrinsèques vis à vis de certains microorganismes comme les Staphylococcus aureus. Les compositions selon l'invention comprennent en outre un pigment alimentaire permettant de protéger la peau des trayons contre les rayons U.V, et également d'effectuer un contrôle visuel de la présence de l'agent de soin sur les trayons ; ce pigment est ajouté au mélange dans des proportions qui varient de 0,01 à 0,5 % en poids.Glycerin and / or lanolin can additionally have a plasticizing effect on the compositions according to the invention. The compositions according to the invention also contain a preservative, in proportions varying from 0.1 to 3%, chosen from the group consisting of orthophenylphenol and its salts, phenoxy-2-ethanol, polyhexamethylene biguanide, isopropylmetacresol, chlorophene, chlorhexidine, phenoxypropanol, phenoxyethanol, sorbic acid and its salts, bromo-2-nitro-2-propanediol and esters of parahydroxybenzoic acid such as ethylparaben, isobutylparaben, benzylparaben, methylparaben, butylparaben and more particularly paraben, for tolerance criteria but also for its intrinsic properties with respect to certain microorganisms such as Staphylococcus aureus. The compositions according to the invention further comprise a food pigment making it possible to protect the skin of the teats against UV rays, and also to carry out a visual check for the presence of the care agent on the teats; this pigment is added to the mixture in proportions which vary from 0.01 to 0.5% by weight.
Dans un mode de réalisation préféré les compositions selon l'invention comportent en outre un agent épaississant dans des proportions qui varient de 0,01 à 5 % en poids. Cet agent épaississant permet d'obtenir des compositions aqueuses selon l'invention d'une viscosité suffisante pour permettre une application aisée par trempage sans dépôt excessif, et également sans perte de produit avant la formation du film par séchage.In a preferred embodiment, the compositions according to the invention further comprise a thickening agent in proportions which vary from 0.01 to 5% by weight. This thickening agent makes it possible to obtain aqueous compositions according to the invention of sufficient viscosity to allow easy application by soaking without excessive deposition, and also without loss of product before the formation of the film by drying.
Cet agent épaississant est choisi parmi les gommes de xanthane, les résines acryliques et les polysaccharides. La composition selon l'invention présente préférentiellement la formule suivante, définie en % par rapport au poids total de la composition :This thickening agent is chosen from xanthan gums, acrylic resins and polysaccharides. The composition according to the invention preferably has the following formula, defined in% relative to the total weight of the composition:
Filmogène de 0, 1 à 20 %Filmogenic from 0.1 to 20%
Alcool de 0 à 1 5 % Conservateur de 0, 1 à 3%Alcohol from 0 to 1 5% Preservative from 0, 1 to 3%
Agent émollient (seul ou en mélange) de 0, 1 à 1 0 %Emollient (single or mixed) from 0.1 to 1 0%
Epaississant de 0,01 à 5 %Thickener from 0.01 to 5%
Pigment de 0,01 à 0,5 %Pigment from 0.01 to 0.5%
Citrus de 0,01 à 1 % Eau qsp 1 00Citrus from 0.01 to 1% Water qs 1 00
L'invention concerne également le procédé de préparation d'une composition selon l'invention comprenant les étapes suivantes :The invention also relates to the process for preparing a composition according to the invention comprising the following steps:
- solubilisation sous agitation du polymère filmogène dans l'eau, - solubilisation dans l'eau des extraits de citrus, des émollients, conservateurs, pigments, agents épaississants, alcool organique et autres ingrédients en maintenant sous agitation,- solubilization with stirring of the film-forming polymer in water, - solubilization in water of citrus extracts, emollients, preservatives, pigments, thickening agents, organic alcohol and other ingredients while stirring,
- puis mélange des deux solutions obtenues jusqu'à homogénéisation complète. La méthode de soin et d'hygiène des trayons selon l'invention comprend l'application par trempage sur le trayon d'une composition caractérisée en ce qu'elle comprend en combinaison en solution aqueuse au moins un produit filmogène et un extrait liquide de citrus.- then mixing of the two solutions obtained until complete homogenization. The teat care and hygiene method according to the invention comprises the application by soaking on the teat of a composition characterized in that it comprises in combination in aqueous solution at least one film-forming product and a liquid citrus extract.
On utilise pour le trempage un gobelet trempeur rempli de composition selon l'invention, et ce trempage est effectué immédiatement après la fin de la traite durant toute la période de lactation.A dip cup filled with the composition according to the invention is used for soaking, and this soaking is carried out immediately after the end of the milking throughout the lactation period.
Le trempage doit être effectué dans la demi-heure qui suit la traite, pendant quelques secondes par trayon de façon à obturer le canal de lactation avant sa fermeture et déposer une fine couche de composition qui en séchant formera un film permettant l'action de l'extrait de citrus, de protéger le trayon des agressions extérieures, et de lutter contre les microorganismes.The soaking must be carried out within half an hour after milking, for a few seconds by teat so as to close the lactation duct before it closes and deposit a thin layer of composition which, when dried, will form a film allowing the action of the citrus extract, protect the teat from external aggressions, and fight against microorganisms.
A titre d'exemple, et de façon non limitative, une composition selon l'invention a l'une des formulations suivantes :By way of example, and without limitation, a composition according to the invention has one of the following formulations:
Formulation 1 :Formulation 1:
Alcool polyvinylique (PVA BP 1 7®) 4 % Huile de vaseline (MARCOL 82 C®) 1 % Gomme de xanthane (RHODIGEL®) 0,4 % Colorant (VERT VISCOLO®) 0,2 % Citrus (CITREX CENTROFLORA®) 0,2 %Polyvinyl alcohol (PVA BP 1 7 ® ) 4% Vaseline oil (MARCOL 82 C ® ) 1% Xanthan gum (RHODIGEL ® ) 0.4% Colorant (VERT VISCOLO ® ) 0.2% Citrus (CITREX CENTROFLORA ® ) 0 .2%
Lanoline (LANOTEX 730®) 2 % Eau qsp 100Lanolin (LANOTEX 730 ® ) 2% Water qs 100
Formulation IIFormulation II
Alcool polyvinylique (PVA BP 1 7 4 % Huile de vaseline (MARCOL 82 C ®ws) 1 % Lanoline (LANOTEX 730®) 2 % Gomme de xanthane (RHODIGEL®) 0,4 % Colorant (VERT VISCOLO®) 0,2 %Polyvinyl alcohol (PVA BP 1 7 4% Vaseline oil (MARCOL 82 C ® w s) 1% Lanolin (LANOTEX 730 ® ) 2% Xanthan gum (RHODIGEL ® ) 0.4% Colorant (VISCOLO ® GREEN) 0.2 %
Citrus (CITREX CENTROFLORA®) 0,2 %Citrus (CITREX CENTROFLORA ® ) 0.2%
Alcool isopropylique 3 %Isopropyl alcohol 3%
Paraben 0,5 %Paraben 0.5%
Eau qsp 100 Parmi les microorganismes responsables des mammites et contre lesquels les compositions selon l'invention sont efficaces, on peut citer staphylococcus aureus, streptococcus faecalis, pseudomonas aeruginosa, escherichia coli et salmonela.Water qs 100 Among the microorganisms responsible for mastitis and against which the compositions according to the invention are effective, mention may be made of staphylococcus aureus, streptococcus faecalis, pseudomonas aeruginosa, escherichia coli and salmonela.
L'action microbiostatique et microbicide des compositions selon l'invention est générée par une polysynergie des différents constituants du citrus, notamment l'acide ascorbique, l'acide citrique, les bioflavonoïdes et les peptides. The microbiostatic and microbicide action of the compositions according to the invention is generated by a polysynergy of the various constituents of citrus, in particular ascorbic acid, citric acid, bioflavonoids and peptides.

Claims

REVENDICATIONS
I . Composition pour l'hygiène, le soin ou la protection des trayons, caractérisée en ce qu'elle comprend en combinaison, en milieu aqueux, au moins un polymère filmogène et un extrait liquide de citrus. I. Hygiene, care or protection composition for teats, characterized in that it comprises, in combination, in an aqueous medium, at least one film-forming polymer and a liquid citrus extract.
2. Composition pour l'hygiène, le soin et la protection des trayons, caractérisée en ce qu'elle comprend en solution aqueuse, de 0, 1 à 20 % en poids d'un polymère filmogène et de 0,01 à 1 % en poids d'extrait liquide de citrus.2. Composition for hygiene, care and protection of the teats, characterized in that it comprises in aqueous solution, from 0.1 to 20% by weight of a film-forming polymer and from 0.01 to 1% in weight of liquid citrus extract.
3. Composition selon la revendication 1 , caractérisée en ce que le polymère filmogène est choisi parmi les résines acryliques, vinyliques et est de préférence l'alcool polyvinylique.3. Composition according to claim 1, characterized in that the film-forming polymer is chosen from acrylic and vinyl resins and is preferably polyvinyl alcohol.
4. Composition selon l'une quelconques des revendications précédentes caractérisée en ce qu'elle comprend de 2 à 1 5 % d'alcool.4. Composition according to any one of the preceding claims, characterized in that it comprises from 2 to 15% of alcohol.
5. Composition selon la revendication 4, caractérisée en ce que l'alcool est de l'alcool isopropylique.5. Composition according to claim 4, characterized in that the alcohol is isopropyl alcohol.
6. Composition selon l'une quelconque des revendications précédentes, caractérisée en ce qu'elle comprend en outre un agent émollient, seul ou en mélange.6. Composition according to any one of the preceding claims, characterized in that it also comprises an emollient agent, alone or as a mixture.
7. Composition selon l'une quelconque des revendications précédentes, caractérisée en ce qu'elle comprend de 0, 1 à 10 % d'agent émollient, seul ou en mélange.7. Composition according to any one of the preceding claims, characterized in that it comprises from 0.1 to 10% of emollient agent, alone or as a mixture.
8. Composition selon l'une quelconque des revendications 6 ou 7, caractérisée en ce que les agents émollients sont choisis parmi la lanoline, la vaseline, l'allantoïne, le sorbitol et la glycérine. 8. Composition according to any one of claims 6 or 7, characterized in that the emollient agents are chosen from lanolin, petrolatum, allantoin, sorbitol and glycerin.
9. Composition selon l'une quelconque des revendications précédentes caractérisées en ce qu'elle comprend de 0, 1 à 3 % d'un conservateur.9. Composition according to any one of the preceding claims, characterized in that it comprises from 0.1 to 3% of a preservative.
1 0. Composition selon la revendication 9 caractérisée en ce que le conservateur est choisi parmi le groupe constitué par les esters de l'acide parahydroxybenzoïque, comme le paraben.1 0. Composition according to claim 9 characterized in that the preservative is chosen from the group consisting of esters of parahydroxybenzoic acid, such as paraben.
I I . Composition selon l'une quelconque des revendications précédentes, caractérisée en ce qu'elle comprend en outre un pigment.I I. Composition according to any one of the preceding claims, characterized in that it also comprises a pigment.
1 2. Composition selon l'une quelconque des revendications précédentes, caractérisée en ce qu'elle comprend de 0,01 à 0,5 % de pigment. 1 2. Composition according to any one of the preceding claims, characterized in that it comprises from 0.01 to 0.5% of pigment.
1 3. Composition selon l'une quelconque des revendications précédentes, caractérisée en ce qu'elle comprend en outre un agent épaississant.1 3. Composition according to any one of the preceding claims, characterized in that it further comprises a thickening agent.
1 4. Composition selon l'une quelconque des revendications précédentes, caractérisée en ce qu'elle comprend de 0,01 à 5 % d'agent épaississant.1 4. Composition according to any one of the preceding claims, characterized in that it comprises from 0.01 to 5% of thickening agent.
1 5. Composition selon l'une quelconque des revendications 1 3 ou 1 4, caractérisée en ce que l'agent épaississant est choisi parmi les gommes de xanthane, les résines acryliques et les polysaccharides. 1 6. Procédé de préparation d'une composition selon l'une quelconque des revendications 1 à 1 5, comprenant les étapes de solubilisation du polymère filmogène sous agitation, puis solubilisation des extraits de citrus, émollients, conservateurs, pigments, agents épaississants, alcool organique, puis mélange des deux solutions obtenues respectivement.1 5. Composition according to any one of claims 1 3 or 1 4, characterized in that the thickening agent is chosen from xanthan gums, acrylic resins and polysaccharides. 1 6. A method of preparing a composition according to any one of claims 1 to 1 5, comprising the steps of solubilization of the film-forming polymer with stirring, then solubilization of citrus extracts, emollients, preservatives, pigments, thickening agents, alcohol organic, then mixing of the two solutions obtained respectively.
1 7. Méthode de soin et d'hygiène des trayons, caractérisée en ce qu'elle comprend l'application par trempage sur le trayon d'une composition selon l'une quelconque des revendications 1 à 1 5. 1 7. Teat care and hygiene method, characterized in that it comprises the application by soaking on the teat of a composition according to any one of claims 1 to 1 5.
PCT/FR2001/002937 2000-09-20 2001-09-20 Citrus composition for hygiene, care or protection of teats WO2002030437A1 (en)

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FR0011988A FR2814072B1 (en) 2000-09-20 2000-09-20 CITRUS-BASED COMPOSITION FOR HYGIENE, CARE OR PROTECTION OF TRAY
FR00/11988 2000-09-20

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FR2814072A1 (en) 2002-03-22
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