WO2002017968A3 - Sensitization of cancer cells to immunoconjugate-induced cell death by transfection with il-13 receptor alpha chain-2 - Google Patents
Sensitization of cancer cells to immunoconjugate-induced cell death by transfection with il-13 receptor alpha chain-2 Download PDFInfo
- Publication number
- WO2002017968A3 WO2002017968A3 PCT/US2001/025663 US0125663W WO0217968A3 WO 2002017968 A3 WO2002017968 A3 WO 2002017968A3 US 0125663 W US0125663 W US 0125663W WO 0217968 A3 WO0217968 A3 WO 0217968A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- chain
- transfection
- cancer cells
- immunoconjugate
- sensitization
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2001284978A AU2001284978A1 (en) | 2000-08-31 | 2001-08-15 | Sensitization of cancer cells to immunoconjugate-induced cell death by transfection with il-13 receptor alpha chain |
US10/250,998 US20040136959A1 (en) | 2001-08-15 | 2001-08-15 | Sensitization of cancer cells to immunoconjugate-induced cell death by transfection with il -13 receptor alpha chain |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22984200P | 2000-08-31 | 2000-08-31 | |
US60/229,842 | 2000-08-31 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2002017968A2 WO2002017968A2 (en) | 2002-03-07 |
WO2002017968A3 true WO2002017968A3 (en) | 2002-04-18 |
WO2002017968A9 WO2002017968A9 (en) | 2002-07-04 |
Family
ID=22862891
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/025663 WO2002017968A2 (en) | 2000-08-31 | 2001-08-15 | Sensitization of cancer cells to immunoconjugate-induced cell death by transfection with il-13 receptor alpha chain-2 |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU2001284978A1 (en) |
WO (1) | WO2002017968A2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004087758A2 (en) * | 2003-03-26 | 2004-10-14 | Neopharm, Inc. | Il 13 receptor alpha 2 antibody and methods of use |
GB2400662B (en) * | 2003-04-15 | 2006-08-09 | Westerngeco Seismic Holdings | Active steering for marine seismic sources |
US9623117B2 (en) * | 2011-04-04 | 2017-04-18 | Wisconsin Alumni Research Foundation | Method for selective targeting and entry of bacterial toxins to cells |
US9828428B2 (en) | 2012-11-07 | 2017-11-28 | Pfizer Inc. | Anti-IL-13 receptor alpha 2 antibodies and antibody-drug conjugates |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996029417A1 (en) * | 1995-03-15 | 1996-09-26 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Il-13 receptor specific chimeric proteins and uses thereof |
WO2001058479A1 (en) * | 2000-02-08 | 2001-08-16 | The Penn State Research Foundation | Immunotherapy using interleukin 13 receptor subunit alpha 2 |
-
2001
- 2001-08-15 WO PCT/US2001/025663 patent/WO2002017968A2/en active Application Filing
- 2001-08-15 AU AU2001284978A patent/AU2001284978A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996029417A1 (en) * | 1995-03-15 | 1996-09-26 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Il-13 receptor specific chimeric proteins and uses thereof |
WO2001058479A1 (en) * | 2000-02-08 | 2001-08-16 | The Penn State Research Foundation | Immunotherapy using interleukin 13 receptor subunit alpha 2 |
Non-Patent Citations (8)
Title |
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BLOOD, vol. 87, no. 10, 1996, pages 4333 - 4339, ISSN: 0006-4971 * |
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1996, PURI RAJ K ET AL: "Targeting of interleukin-13 receptor on human renal cell carcinoma cells by a recombinant chimeric protein composed of interleukin-13 and a truncated form of pseudomonas exotoxin A (PE38QQR).", XP002187041, Database accession no. PREV199698827740 * |
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; JOSHI, BHARAT H. ET AL: "Preclinical studies with IL-13PE38QQR for therapy of malignant glioma", XP002187040, retrieved from STN Database accession no. 135:316994 HCA * |
DEBINSKI W ET AL: "HUMAN GLIOMA CELLS OVEREXPRESS RECEPTORS FOR INTERLEUKIN 13 AND AREEXTREMELY SENSITIVE TO A NOVEL CHIMERIC PROTEIN COMPOSED OF INTERLEUKIN 13 AND PSEUDOMONAS EXOTOXIN 1", CLINICAL CANCER RESEARCH, THE ASSOCIATION, DENVILLE, NJ, US, vol. 1, no. 11, 1 November 1995 (1995-11-01), pages 1253 - 1258, XP000579743, ISSN: 1078-0432 * |
DRUG NEWS PERSPECT. (2000), 13(10), 599-605 * |
JOSHI BHARAT H ET AL: "Interleukin-13 receptor alpha chain: A novel tumor-associated transmembrane protein in primary explants of human malignant gliomas.", CANCER RESEARCH, vol. 60, no. 5, 1 March 2000 (2000-03-01), pages 1168 - 1172, XP002946432, ISSN: 0008-5472 * |
KAWAKAMI KOJI ET AL: "Gene transfer of interleukin-13 receptor alpha2 chain dramatically enhances the antitumor effect of IL-13 receptor targeted cytotoxin in an immunodeficient animal model of human prostate cancer.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, vol. 42, March 2001 (2001-03-01), 92nd Annual Meeting of the American Association for Cancer Research;New Orleans, LA, USA; March 24-28, 2001, March, 2001, pages 686, XP002187037, ISSN: 0197-016X * |
KAWAKAMI KOJI ET AL: "Sensitization of cancer cells to interleukin 13-Pseudomonas exotoxin-induced cell death by gene transfer of interleukin 13 receptor alpha chain.", HUMAN GENE THERAPY, vol. 11, no. 13, 1 September 2000 (2000-09-01), pages 1829 - 1835, XP002187039, ISSN: 1043-0342 * |
Also Published As
Publication number | Publication date |
---|---|
WO2002017968A2 (en) | 2002-03-07 |
AU2001284978A1 (en) | 2002-03-13 |
WO2002017968A9 (en) | 2002-07-04 |
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