WO2002015857A1 - Oral composition - Google Patents
Oral composition Download PDFInfo
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- WO2002015857A1 WO2002015857A1 PCT/JP2001/007148 JP0107148W WO0215857A1 WO 2002015857 A1 WO2002015857 A1 WO 2002015857A1 JP 0107148 W JP0107148 W JP 0107148W WO 0215857 A1 WO0215857 A1 WO 0215857A1
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- Prior art keywords
- sodium
- particles
- oral composition
- colored
- acid
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/064—Chewing gum characterised by the composition containing organic or inorganic compounds containing inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Definitions
- the present invention relates to an oral composition for removing a colored pellicle.
- the present inventors have conducted intensive studies in order to respond to the above demand, and as a result, have found that the linear water-soluble polyphosphate has an average particle size of 50 to 1, m and a collapse strength of 10 to 20. It was found that the combined use of 0 g and Z particles significantly improved the effect of removing tooth stains (colored pellicles) colored by tobacco and tea astringent. That is, it has been known that a linear water-soluble polyphosphate such as sodium pyrophosphate has been used as a component for removing stains on teeth (Japanese Patent Application Laid-Open No.
- Hei 9-19796 / 66 It is also known to incorporate the above particles into a composition for oral cavity (Japanese Unexamined Patent Publication (Kokai) No. Hei 10-182,389, Japanese Patent Application Laid-Open No. 7-55040). No. 1-2999211, Japanese Unexamined Patent Publication No. Hei. 4-238416, Japanese Translation of PCT International Publication No. 10-5505843) is a linear water-soluble polyphosphate, and the above particles. Even if each is used alone The effect of removing colored pellicles is low even when particles having a particle diameter outside the above-mentioned average particle size range or the disintegration strength range are used. The present inventors have found that a remarkable colored pellicle removing effect can be obtained when an acid salt is used in combination with particles having the above-mentioned specific average particle size and disintegration strength.
- the linear water-soluble polyphosphate used in the oral composition of the present invention has the following general formula (1)
- M n + 2 P n 0 3 n + 1 (1) ( and ⁇ , M represents a N a or K, n is an integer of 2 or more.)
- sodium metaphosphate and potassium metaphosphate are particularly preferred.
- the blending amount of the above polyphosphate is preferably 0.1 to 10% (mass percentage, the same applies hereinafter), particularly preferably 1 to 6% of the whole composition. If the amount is too small, an excellent effect of removing colored pellicles cannot be obtained. If the amount is too large, the taste of the composition may deteriorate.
- particles having an average particle size of 50 to 1, OOOM and a breaking strength of 10 to 200 g / particle are used in combination with the polyphosphate.
- those obtained by forming a water-insoluble powder into granules without or with the use of a binder can be used, and in particular, those without a binder are preferred.
- Water-insoluble powders include dibasic calcium phosphate, tribasic calcium phosphate, insoluble calcium metaphosphate, silica, aluminum hydroxide, magnesium phosphate, red iron oxide, calcium carbonate, calcium pyrophosphate, zeolite, and aluminosilicate Salts, magnesium carbonate, zirconosilicate, calcium sulfate, and the like, and mixtures thereof can be used, and silica is particularly preferable.
- the particles used in the present invention have an average particle diameter of 50 to 1, as described above, preferably 100 to 700 m, more preferably 200 to 400 m / xm. belongs to.
- the disintegration strength is 10 to 200 g / piece, preferably 30 to 100 g / piece, and more preferably 50 to 80 gZ pieces. Particles having an average particle size of less than 50 m and particles having a disintegration strength of less than 10 g ia do not have an excellent effect of removing colored pellicles, and particles having an average particle size of more than 100 m and disintegration strength Particles higher than 20 Og / particle cause foreign body sensation and discomfort in the oral cavity.
- the collapse strength is the maximum stress value (g) per piece when the particles are immersed in water for 60 seconds and then pressed under the conditions of a plunger diameter of 10 mm and a compression speed of 1 OmmZmin. You.
- the mixing amount of the above particles is preferably 0.1% to 10%, particularly preferably 1% to 5% of the whole composition. If the amount is too small, an excellent effect of removing colored pellicles cannot be obtained, and if the amount is too large, the usability may be reduced.
- the oral composition of the present invention can be prepared and applied as toothpaste, dentifrice such as liquid toothpaste, dental cream, dental whitening pack, mouthwash, dental whitening solution, etc.
- Ordinary components according to the type can be blended.
- an abrasive, a binder, a thickener, a surfactant, a sweetener, a fragrance and the like can be blended in a usual amount.
- abrasives include calcium hydrogen phosphate dihydrate, calcium tertiary phosphate, calcium carbonate, calcium pyrophosphate, aluminum hydroxide, silicic anhydride, aluminum silicate, insoluble sodium metaphosphate,
- magnesium phosphate, magnesium carbonate, calcium sulfate, bentonite, zirconium silicate, polymethyl methacrylate, and other synthetic resins can be blended within a range that does not impair the effects of the present invention.
- binder examples include cellulose derivatives such as carrageenan, sodium carboxymethylcellulose, methylcellulose, and hydroxyethylcellulose; alginic acid derivatives such as sodium alginate and propylene dalicol alginate; One or two of gums such as xanthan gum, suelan gum, tragacanth gum, and karaya gum; synthetic binders such as polyvinyl alcohol, sodium polyacrylate, and carboxyvinyl polymer; and inorganic binders such as silica gel, pea gum, and labonite. More than one species may be included.
- cellulose derivatives such as carrageenan, sodium carboxymethylcellulose, methylcellulose, and hydroxyethylcellulose
- alginic acid derivatives such as sodium alginate and propylene dalicol alginate
- One or two of gums such as xanthan gum, suelan gum, tragacanth gum, and karaya gum
- synthetic binders such as polyvinyl alcohol,
- one or more polyhydric alcohols such as glycerin, sorbitol, propylene glycol, polyethylene blend, alcohol, xylitol, maltitol, and lactitol may be blended.
- an anionic surfactant such as sodium lauryl sulfate, a nonionic surfactant such as decaglyceryl perphosphate and myristate diethanolamide, and an amphoteric surfactant such as a bayonein-based surfactant can be blended.
- an anionic surfactant such as sodium lauryl sulfate, a nonionic surfactant such as decaglyceryl perphosphate and myristate diethanolamide, and an amphoteric surfactant such as a bayonein-based surfactant can be blended.
- the fragrance ingredients include menthol, anethol, carvone, eugenol, limonene, n-decyl alcohol, citronellol, ⁇ -terpineol, cineole, linalool, ethyl linalool, peniline, timole, peppermint oil, spearmint Flavors such as oil, Winyuichi green oil, T-shaped oil, and eucalyptus oil can be used alone or in combination.
- sweeteners such as saccharin sodium, stepioside, dali tillitin, perillartin, and thaumatin can be used.
- cationic fungicides such as chlorhexidine, benzethonium chloride, benzalkonium chloride, cetylpyridinium chloride, decanidium chloride, triclosan, hinokitiol, and piozole.
- phenolic compounds dextranase, mutanase, lysozyme, amylase, protease, lytic enzymes, enzymes such as superoxide Day Sum synthetase, vitamin E, vitamins such as vitamin B 6, sodium Monofuruororin acid, Al forces such Monofuruororin acid Kariumu Li-metal monofluorophosphate, sodium fluoride, fluorides such as stannous fluoride, tranexamic acid, epsilon amino cabronic acid, aluminum chlorohydroxyl allantoin, dihydrocholesta Lumpur, glycyrrhizin acid, glycyrrhetinic acid, Pisaporo Ichiru, Guriserofo Sufeto, chlorophyll, sodium chloride, the active ingredient publicly known, such as water-soluble inorganic phosphoric acid compounds may be formulated alone or in combination.
- the oral composition according to the present invention has an excellent colored pellicle removing effect. You.
- the color difference is measured using the color of the hydroxyapatite pellet (hereinafter referred to as HAP) as a reference value (L0). Treat the measured HAP with saliva at 37 ° C for 30 minutes. After 3 minutes, rinse the HAP with deionized water, then remove the water droplets on the HAP.
- HAP hydroxyapatite pellet
- HAP was repeatedly immersed in 0.5% aqueous albumin solution ⁇ 3% Japanese tea + 1% coffee + 1% black tea extraction aqueous solution ⁇ 0.6% iron ammonium citrate aqueous solution for 1 hour each. This operation was continued for 50 cycles. Removed from the coloring liquid, dried at room temperature for one day, lightly brushed the surface of HAP in running water to remove weakly adhered coloring matter, air-dried again, and measured the color difference of the colored HAP produced (L1) . After applying the dentifrice to the toothbrush and brushing the surface of the prepared colored HAP 1,000 times, the color difference was measured (L2), and the colored pellicle removing effect was calculated by the following formula. 1) One (L0-L2)
- Particle A average particle size 300 rn, crushing strength 60 gZ, silica particles
- Particle B average particle size 10 m, collapse strength 60 g / piece, silica particles
- Particle C average particle diameter 300 urn, decay strength 6 gZ, silica particles
- the colored pellicle-removed particles were immersed in water for 60 seconds, and after 60 seconds, removed from the water and measured for the maximum stress when the plunger diameter was 1 Omm and the compression speed was 1 Omm / min. did.
- Particle A 4.0% Sodium pyrophosphate 3.0 Sodium tririboliphosphate 4,0 Xanthan gum 0,2 Sodium polyacrylate 0,2 Butylparaben 0,
- Particle A 1.0% sodium pyrophosphate 4.0 Ethanol 5 0 Glycerin 0 0
Abstract
An oral composition for the removal of discolored pellicle, characterized by containing one or more linear water-soluble polyphosphate salts of the general formula (1): Mn+2PnO3n+1 (1) (wherein M is Na or K; and n is an integer of 2 or above) and particles having a mean diameter of 50 to 1,000 µm and a fracture strength of 10 to 200 g/particle.
Description
明 細 書 Specification
口腔用組成物 技術分野 Oral composition Technical field
本発明は、 着色ペリクルの除去に用いる口腔用組成物に関する。 背景技術 The present invention relates to an oral composition for removing a colored pellicle. Background art
従来、 様々なアプローチによりタバコャニゃ茶渋などで着色した歯を白くする 方法が検討されてきた。 例えば、 清掃性の高い研磨剤の開発、 過酸化物による白 色化、 ポリエチレングリコールなどの溶剤による着色物の溶解、 キレート剤によ る鉄イオンなどの除去、 再石灰化による歯面の平滑化などがある。 しかしながら 、 過酸化物を用いる方法以外は効果が不充分であり、 また、 過酸化物による方法 も、 ェナメル質表面の有機物が脱却して耐酸性が低下するなどの問題点も指摘さ れ、 我が国では歯科医のみが可能な処置となっている。 Conventionally, various approaches have been considered to whiten teeth that have been colored with tobacco and tea astringent. For example, development of abrasives with high cleaning properties, whitening with peroxides, dissolving of coloring matter with solvents such as polyethylene glycol, removal of iron ions with chelating agents, smoothing of tooth surfaces by remineralization and so on. However, the effect is insufficient except for the method using peroxide, and the method using peroxide has also been pointed out with problems such as the removal of organic substances on the enamel surface and a decrease in acid resistance. Is a procedure that can only be performed by dentists.
以上のことから、 穏和な条件で効果的に、 かつ自分で手軽に歯を白く保っため に、 付着した汚れを効率的に除去する必要があり、 その組成物の開発が待たれて いる。 発明の開示 In view of the above, it is necessary to efficiently remove adhered dirt in order to keep teeth white effectively and easily under mild conditions, and development of such compositions is awaited. Disclosure of the invention
本発明者らは， 上記要望に応えるため鋭意検討を行った結果、 直鎖状の水溶性 ポリリン酸塩と平均粒径が 5 0〜1 , mであり、 かつ崩壊強度が 1 0〜 2 0 0 g Z個の粒子とを併用することにより、 タバコャニ、 茶渋などで着色した 歯牙の汚れ （着色ペリクル） を除去する効果が顕著に高くなることを知見した。 即ち、 従来よりピロリン酸ナトリゥム等の直鎖状水溶性ポリリン酸塩が歯の汚 れを除去する成分として用いられていることは公知であり （特開平 9一 1 7 5 9 6 6号、 特開平 1 0— 1 8 2 3 8 9号、 特表平 7— 5 0 5 4 0 0号公報） 、 また 上記のような粒子を口腔用組成物に配合することも知られている （特開平 1一 2 9 9 2 1 1号、 特開平 4一 2 4 3 8 1 6号、 特表平 1 0— 5 0 5 8 4 3号公報） が、 直鎖状水溶性ポリリン酸塩、 上記粒子をそれぞれ単独使用しても着色べリク
ル除去効果は低く、 また粒子として上記平均粒径の範囲外のもの、 崩壊強度の範 囲外のものを用いても同様に着色ペリクル除去効果が低いにもかかわらず、 直鎖 状水溶性ポリリン酸塩と上記特定平均粒径及び崩壊強度の粒子とを併用した場合 、 顕著な着色ペリクル除去効果が得られることを知見し、 本発明をなすに至った The present inventors have conducted intensive studies in order to respond to the above demand, and as a result, have found that the linear water-soluble polyphosphate has an average particle size of 50 to 1, m and a collapse strength of 10 to 20. It was found that the combined use of 0 g and Z particles significantly improved the effect of removing tooth stains (colored pellicles) colored by tobacco and tea astringent. That is, it has been known that a linear water-soluble polyphosphate such as sodium pyrophosphate has been used as a component for removing stains on teeth (Japanese Patent Application Laid-Open No. Hei 9-19796 / 66, It is also known to incorporate the above particles into a composition for oral cavity (Japanese Unexamined Patent Publication (Kokai) No. Hei 10-182,389, Japanese Patent Application Laid-Open No. 7-55040). No. 1-2999211, Japanese Unexamined Patent Publication No. Hei. 4-238416, Japanese Translation of PCT International Publication No. 10-5505843) is a linear water-soluble polyphosphate, and the above particles. Even if each is used alone The effect of removing colored pellicles is low even when particles having a particle diameter outside the above-mentioned average particle size range or the disintegration strength range are used. The present inventors have found that a remarkable colored pellicle removing effect can be obtained when an acid salt is used in combination with particles having the above-mentioned specific average particle size and disintegration strength.
発明を実施するための最良の形態 BEST MODE FOR CARRYING OUT THE INVENTION
以下、 本発明につき更に詳しく説明する。 Hereinafter, the present invention will be described in more detail.
本発明の口腔用組成物において用いられる直鎖状の水溶性ポリリン酸塩は、 下 記一般式 （1 ) The linear water-soluble polyphosphate used in the oral composition of the present invention has the following general formula (1)
Mn + 2 P n 03 n + 1 ( 1 ) (伹し、 Mは N a又は Kを示し、 nは 2以上の整数である。 ） M n + 2 P n 0 3 n + 1 (1) ( and伹, M represents a N a or K, n is an integer of 2 or more.)
で示されるもので、 重合度 n = 2のピロリン酸ナトリゥムゃピロリン酸カリゥム 、 n = 3のトリポリリン酸ナトリウムやトリポリリン酸カリウム、 n = 4のテト ラボリリン酸ナトリウムゃテトラポリリン酸カリウム、 高重合度のメタリン酸ナ トリゥムゃメタリン酸カリゥムなどが挙げられ、 これらの 1種を単独で又は 2種 以上を組み合わせて用いることができる。 これらの中では、 特にピロリン酸ナト リウムが好ましい。 In the formula, the polymerization degree is sodium pyrophosphate and potassium pyrophosphate with n = 2, sodium tripolyphosphate and potassium tripolyphosphate with n = 3, sodium tetrapolyphosphate and potassium tetrapolyphosphate with n = 4, high polymerization degree Examples thereof include sodium metaphosphate and potassium metaphosphate. One of these can be used alone, or two or more can be used in combination. Of these, sodium pyrophosphate is particularly preferred.
上記ポリリン酸塩の配合量は、 組成物全体の 0 . 1〜 1 0 % (質量百分率、 以 下同じ） 、 特に 1〜6 %とすることが好ましい。 配合量が少なすぎると、 優れた 着色ペリクル除去効果が得られず、 多すぎると、 組成物の味が悪くなる場合があ る。 The blending amount of the above polyphosphate is preferably 0.1 to 10% (mass percentage, the same applies hereinafter), particularly preferably 1 to 6% of the whole composition. If the amount is too small, an excellent effect of removing colored pellicles cannot be obtained. If the amount is too large, the taste of the composition may deteriorate.
本発明は、 上記ポリリン酸塩に、 平均粒径が 5 0〜1， O O O mであり、 崩 壊強度が 1 0〜2 0 0 g /個である粒子を併用する。 In the present invention, particles having an average particle size of 50 to 1, OOOM and a breaking strength of 10 to 200 g / particle are used in combination with the polyphosphate.
この場合、 該粒子は、 水不溶性粉体を結合剤を用いずに又は用いて顆粒状に形 成したものが使用できるが、 特には、 結合剤を用いないものがよい。 In this case, as the particles, those obtained by forming a water-insoluble powder into granules without or with the use of a binder can be used, and in particular, those without a binder are preferred.
水不溶性粉体としては、 第二リン酸カルシウム、 第三リン酸カルシウム、 不溶 性メタリン酸カルシウム、 シリカ、 水酸化アルミニウム、 リン酸マグネシウム、 ベンガラ、 炭酸カルシウム、 ピロリン酸カルシウム、 ゼォライト、 アルミノ珪酸
塩、 炭酸マグネシウム、 ジルコノシリケ一卜、 硫酸カルシウムなどや、 これらの 混合物が拳げられ、 特にシリカが好適である。 Water-insoluble powders include dibasic calcium phosphate, tribasic calcium phosphate, insoluble calcium metaphosphate, silica, aluminum hydroxide, magnesium phosphate, red iron oxide, calcium carbonate, calcium pyrophosphate, zeolite, and aluminosilicate Salts, magnesium carbonate, zirconosilicate, calcium sulfate, and the like, and mixtures thereof can be used, and silica is particularly preferable.
本発明で用いる粒子は、 上記の通り、 平均粒径が 5 0〜1， O O O tmのもの であり、 好ましくは 1 0 0〜7 0 0 m、 更に好ましくは 2 0 0〜4 0 0 /xmの ものである。 また、 崩壊強度が 1 0〜2 0 0 g /個、 好ましくは 3 0〜1 0 0 g /個、 更に好ましくは 5 0〜8 0 g Z個のものである。 平均粒径が 5 0 mより 小さい粒子及び崩壊強度が 1 0 g iaより低い粒子は、 優れた着色ペリクル除去 効果が得られず、 平均粒径が 1 , 0 0 0 mより大きい粒子及び崩壊強度が 2 0 O g/個より高い粒子は、 口腔内での異物感、 不快感が生じる。 The particles used in the present invention have an average particle diameter of 50 to 1, as described above, preferably 100 to 700 m, more preferably 200 to 400 m / xm. belongs to. The disintegration strength is 10 to 200 g / piece, preferably 30 to 100 g / piece, and more preferably 50 to 80 gZ pieces. Particles having an average particle size of less than 50 m and particles having a disintegration strength of less than 10 g ia do not have an excellent effect of removing colored pellicles, and particles having an average particle size of more than 100 m and disintegration strength Particles higher than 20 Og / particle cause foreign body sensation and discomfort in the oral cavity.
なお、 崩壊強度は、 粒子を水に 6 0秒浸漬後、 プランジャー直径 1 0 mm、 圧 縮速度 1 O mmZm i nの条件で加圧した時の 1個当りの最大応力値 （g) であ る。 The collapse strength is the maximum stress value (g) per piece when the particles are immersed in water for 60 seconds and then pressed under the conditions of a plunger diameter of 10 mm and a compression speed of 1 OmmZmin. You.
上記粒子の配合量は、 組成物全体の 0 . ；!〜 1 0 %、 特に 1〜5 %であること が好ましい。 配合量が少なすぎると、 優れた着色ペリクル除去効果が得られず、 多すぎると、 使用感が低下する場合がある。 The mixing amount of the above particles is preferably 0.1% to 10%, particularly preferably 1% to 5% of the whole composition. If the amount is too small, an excellent effect of removing colored pellicles cannot be obtained, and if the amount is too large, the usability may be reduced.
本発明の口腔用組成物は、 練歯磨、 液状歯磨等の歯磨類、 デンタルクリーム、 デンタル美白パック、 洗口剤、 デンタル美白液などとして調製、 適用できるが、 本発明の口腔用組成物には、 その種類に応じた通常の成分を配合することができ る。 例えば、 歯磨剤の場合には、 研磨剤、 粘結剤、 粘稠剤、 界面活性剤、 甘味剤 、 香料などを常用量で配合し得る。 The oral composition of the present invention can be prepared and applied as toothpaste, dentifrice such as liquid toothpaste, dental cream, dental whitening pack, mouthwash, dental whitening solution, etc. Ordinary components according to the type can be blended. For example, in the case of a dentifrice, an abrasive, a binder, a thickener, a surfactant, a sweetener, a fragrance and the like can be blended in a usual amount.
例えば、 研磨剤としては、 リン酸水素カルシウム■ 2水和物、 第三リン酸カル シゥム、 炭酸カルシウム、 ピロリン酸カルシウム、 水酸化アルミニウム、 無水ケ ィ酸、 ケィ酸アルミニウム、 不溶性メタリン酸ナトリウム、 第三リン酸マグネシ ゥム、 炭酸マグネシウム、 硫酸カルシウム、 ベントナイト、 ケィ酸ジルコニウム 、 ポリメタクリル酸メチル、 その他の合成樹脂等の 1種又は 2種以上を本発明の 効果を損なわない範囲で配合し得る。 For example, abrasives include calcium hydrogen phosphate dihydrate, calcium tertiary phosphate, calcium carbonate, calcium pyrophosphate, aluminum hydroxide, silicic anhydride, aluminum silicate, insoluble sodium metaphosphate, One or more of magnesium phosphate, magnesium carbonate, calcium sulfate, bentonite, zirconium silicate, polymethyl methacrylate, and other synthetic resins can be blended within a range that does not impair the effects of the present invention.
また、 粘結剤としては、 カラギ一ナン、 カルポキシメチルセルロースナトリウ ム、 メチルセルロース、 ヒドロキシェチルセルロース等のセルロース誘導体、 ァ ルギン酸ナ卜リゥム、 アルギン酸プロピレンダリコール等のアルギン酸誘導体、
キサンタンガム、 シユエランガム、 トラガントガム、 カラャガム等のガム類、 ポ リビニルアルコール、 ポリアクリル酸ナトリウム、 カルボキシビ二ルポリマー等 の合成粘結剤、 シリカゲル、 ピーガム、 ラボナイト等の無機粘結剤等の 1種又は 2種以上を配合し得る。 Examples of the binder include cellulose derivatives such as carrageenan, sodium carboxymethylcellulose, methylcellulose, and hydroxyethylcellulose; alginic acid derivatives such as sodium alginate and propylene dalicol alginate; One or two of gums such as xanthan gum, suelan gum, tragacanth gum, and karaya gum; synthetic binders such as polyvinyl alcohol, sodium polyacrylate, and carboxyvinyl polymer; and inorganic binders such as silica gel, pea gum, and labonite. More than one species may be included.
保湿剤としては、 グリセリン、 ソルビット、 プロピレングリコール、 ポリェチ レンダリコール、 キシリトール、 マルチトール、 ラクチトール等の多価アルコ一 ルの 1種又は 2種以上を配合し得る。 As the humectant, one or more polyhydric alcohols such as glycerin, sorbitol, propylene glycol, polyethylene blend, alcohol, xylitol, maltitol, and lactitol may be blended.
界面活性剤としては、 ラウリル硫酸ナトリゥム等のァニオン性界面活性剤、 ラ ゥリン酸デカグリセリル、 ミリスチン酸ジエタノールアミド等の非イオン性界面 活性剤、 ベ夕イン系等の両性界面活性剤を配合し得る。 As the surfactant, an anionic surfactant such as sodium lauryl sulfate, a nonionic surfactant such as decaglyceryl perphosphate and myristate diethanolamide, and an amphoteric surfactant such as a bayonein-based surfactant can be blended. .
香料成分としては、 メントール、 ァネトール、 カルボン、 オイゲノ一ル、 リモ ネン、 n—デシルアルコール、 シトロネロール、 α—テルピネオール、 シネオ一 ル、 リナロール、 ェチルリナロール、 ヮニリン、 チモ一ル、 ペパーミント油、 ス ペアミント油、 ウィン夕一グリーン油、 丁字油、 ユーカリ油等の香料を単独で又 は組み合わせて配合し得るほか、 サッカリンナトリウム、 ステピオサイド、 ダリ チルリチン、 ペリラルチン、 ソーマチン等の甘味剤を配合し得る。 The fragrance ingredients include menthol, anethol, carvone, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol, cineole, linalool, ethyl linalool, peniline, timole, peppermint oil, spearmint Flavors such as oil, Winyuichi green oil, T-shaped oil, and eucalyptus oil can be used alone or in combination. In addition, sweeteners such as saccharin sodium, stepioside, dali tillitin, perillartin, and thaumatin can be used.
また、 本発明においては、 クロルへキシジン、 ベンゼトニゥムクロライド、 ベ ンザルコニゥムクロライド、 セチルピリジニゥムクロライド、 デカニゥムクロラ イドなどの陽イオン性殺菌剤、 トリクロサン、 ヒノキチォ一ル、 ピオゾールなど のフエノール性化合物、 デキストラナーゼ、 ムタナーゼ、 リゾチーム、 アミラー ゼ、 プロテアーゼ、 溶菌酵素、 スーパーオキサイドデイスムターゼなどの酵素、 ビタミン E、 ビタミン B 6などのビタミン類、 モノフルォロリン酸ナトリウム、 モノフルォロリン酸カリゥムなどのアル力リ金属モノフルォロリン酸塩、 フッ化 ナトリウム、 フッ化第 1錫などのフッ化物、 トラネキサム酸、 ィプシロンアミノ カブロン酸、 アルミニウムクロルヒドロキシルアラントイン、 ジヒドロコレスタ ノール、 グリチルリチン酸類、 グリチルレチン酸、 ピサポロ一ル、 グリセロフォ スフェート、 クロロフィル、 塩化ナトリウム、 水溶性無機リン酸化合物などの公 知の有効成分を 1種又は 2種以上配合し得る。 Also, in the present invention, cationic fungicides such as chlorhexidine, benzethonium chloride, benzalkonium chloride, cetylpyridinium chloride, decanidium chloride, triclosan, hinokitiol, and piozole. phenolic compounds, dextranase, mutanase, lysozyme, amylase, protease, lytic enzymes, enzymes such as superoxide Day Sum synthetase, vitamin E, vitamins such as vitamin B 6, sodium Monofuruororin acid, Al forces such Monofuruororin acid Kariumu Li-metal monofluorophosphate, sodium fluoride, fluorides such as stannous fluoride, tranexamic acid, epsilon amino cabronic acid, aluminum chlorohydroxyl allantoin, dihydrocholesta Lumpur, glycyrrhizin acid, glycyrrhetinic acid, Pisaporo Ichiru, Guriserofo Sufeto, chlorophyll, sodium chloride, the active ingredient publicly known, such as water-soluble inorganic phosphoric acid compounds may be formulated alone or in combination.
本発明に係る口腔用組成物は、 優れた着色ペリクル除去効果を有するものであ
る。 The oral composition according to the present invention has an excellent colored pellicle removing effect. You.
以下、 実施例及び比較例を示し、 本発明を具体的に説明するが、 本発明は下記 の実施例に制限されるものではない。 なお、 下記の例において％は質量百分率を 示す。 Hereinafter, the present invention will be specifically described with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples. In the following examples,% indicates mass percentage.
[比較例 1〜5、 実施例 1] [Comparative Examples 1 to 5, Example 1]
表 1に示す成分を配合した歯磨剤を調製し、 歯の着色ペリクル除去効果を以下 の方法により評価した。 結果を表 1に併記する。 A dentifrice containing the components shown in Table 1 was prepared, and the effect of removing colored pellicles on teeth was evaluated by the following method. The results are shown in Table 1.
〈歯の着色ペリクル除去効果テスト〉 <Tooth coloring pellicle removal effect test>
まず最初に、 ハイドロキシアパタイトペレット （以下、 HAPという） の色を 基準値として色差を測定する （L0) 。 測定した HAPを 37°Cで 30分間唾液 処理する。 3分後、 HAPをイオン交換水ですすぎ、 続いて H A P上の水滴を取 り除く。 First, the color difference is measured using the color of the hydroxyapatite pellet (hereinafter referred to as HAP) as a reference value (L0). Treat the measured HAP with saliva at 37 ° C for 30 minutes. After 3 minutes, rinse the HAP with deionized water, then remove the water droplets on the HAP.
次に、 HAPを 0. 5%アルブミン水溶液→3%日本茶 + 1%コーヒ一 + 1% 紅茶の抽出水溶液→0. 6 %クェン酸鉄アンモニゥム水溶液各々に 1時間ずつ繰 り返して浸漬し、 この操作を 50サイクル続けた。 着色液から取り出し、 常温で 1日乾燥後、 流水中で軽く HAPの表面をブラッシングして付着の弱い着色物を 除去した後、 再び風乾し、 作製した着色 HAPの色差を測定した （L 1) 。 歯磨剤を歯ブラシに付け、 作製した着色 H A Pの表面を 1 , 000回ブラッシ ングした後の色差を測定し （L2) 、 次式により着色ペリクル除去効果を求めた 着色ペリクル除去効果 = (L0-L 1) 一 (L0-L2)
Next, HAP was repeatedly immersed in 0.5% aqueous albumin solution → 3% Japanese tea + 1% coffee + 1% black tea extraction aqueous solution → 0.6% iron ammonium citrate aqueous solution for 1 hour each. This operation was continued for 50 cycles. Removed from the coloring liquid, dried at room temperature for one day, lightly brushed the surface of HAP in running water to remove weakly adhered coloring matter, air-dried again, and measured the color difference of the colored HAP produced (L1) . After applying the dentifrice to the toothbrush and brushing the surface of the prepared colored HAP 1,000 times, the color difference was measured (L2), and the colored pellicle removing effect was calculated by the following formula. 1) One (L0-L2)
ほ 1 ] [1]
粒子 B ：平均粒径 1 0 m、 崩壊強度 6 0 g/個、 シリカ粒子 Particle B: average particle size 10 m, collapse strength 60 g / piece, silica particles
粒子 C ：平均粒径 3 0 0 u rn, 崩壊強度 6 gZ個、 シリカ粒子 Particle C: average particle diameter 300 urn, decay strength 6 gZ, silica particles
なお、 崩壊強度は下記のようにして測定した。 In addition, the collapse strength was measured as follows.
崩壊強度の測定法 Method for measuring collapse strength
着色ペリクル除去粒子を水に 6 0秒浸漬し、 6 0秒経過後、 水から取り出して 、 プランジャー直径 1 O mm、 圧縮速度 1 O mm/m i nの条件で加圧した時の 最大応力を測定した。 The colored pellicle-removed particles were immersed in water for 60 seconds, and after 60 seconds, removed from the water and measured for the maximum stress when the plunger diameter was 1 Omm and the compression speed was 1 Omm / min. did.
表 1の結果より、 平均粒径と、 崩壊強度が本発明の範囲にある粒子とポリリン 酸塩を併用することで、 歯牙の着色べリクルを効率的に除去できることが確認さ れた。 From the results in Table 1, it was confirmed that by using particles and polyphosphate having an average particle size and a disintegration strength within the range of the present invention, colored vesicles of teeth can be efficiently removed.
以下、 処方例を示す。
[実施例 2] Hereinafter, examples of prescription are shown. [Example 2]
粒子 A 3 0% Particle A 30%
卜リボリリン酸ナトリウム 1 0 Sodium tririboliphosphate 1 0
リン酸ニ水素カルシウム 45 0 Calcium dihydrogen phosphate 45 0
プロピレングリコ一ル 3 0 Propylene glycol 30
カルポキシメチルセルロース 0 Carboxymethylcellulose 0
カラギーナン 0 2 Carrageenan 0 2
ブチルパラベン 0. 2 Butylparaben 0.2
70%ソルビ! ル 22. 0 70% Sorbi! Le 22. 0
安息香酸ナトリゥム 0. 2 Sodium benzoate 0.2
モノフルォロリン酸ナトリゥム 0. 7 Sodium monofluorophosphate 0.7
増粘性シリカ 3 Thickening silica 3
二酸化チタン titanium dioxide
ラウリル硫酸ナトリウム 1. 0 Sodium lauryl sulfate 1.0
香料 1. 4 Perfume 1.4
精製水 . バランス Purified water. Balance
計 00. 0 % Total 00.0%
[実施例 3] 練歯磨 [Example 3] Toothpaste
粒子 D 5. 0 % Particle D 5.0%
(平均粒径 400 m、 崩壊強度 100 g/個、 炭酸カルシウム粒子） ピロリン酸ナトリウム 1, 0 (Average particle size 400 m, disintegration strength 100 g / piece, calcium carbonate particles) Sodium pyrophosphate 1, 0
キサンタンガム 0, 4 Xanthan gum 0, 4
アルギン酸ナトリウム 0 6 Sodium alginate 0 6
塩化セチルピリジニゥム 0 2 Cetylpyridinium chloride 0 2
水酸化アルミニウム 40 0 Aluminum hydroxide 40 0
70%ソルビトール 30. 0 70% sorbitol 30.0
プロピレングリコール 3. 0 Propylene glycol 3.0
ラウリル硫酸： 0. 8
リスチン酸ジエタノールァマイド 1. 0 Lauryl sulfate: 0.8 Listitic acid diethanolamide 1.0
0. 2 メチルパラベン 0. 1 香料 1. 0 精製水 ― 一 パランス 0.2 Methylparaben 0.1 Perfume 1.0 Purified water ― 1
00. 0 % 00. 0%
[実施例 4] 液状歯磨 [Example 4] Liquid toothpaste
粒子 A 4. 0 % ピロリン酸ナトリウム 3. 0 卜リボリリン酸ナトリウム 4, 0 キサンタンガム 0, 2 ポリアクリル酸ナトリウム 0, 2 ブチルパラベン 0,Particle A 4.0% Sodium pyrophosphate 3.0 Sodium tririboliphosphate 4,0 Xanthan gum 0,2 Sodium polyacrylate 0,2 Butylparaben 0,
70%ソルビ! ル 43 0 沈降性シリカ 15 0 プロピレングリコール 2 0 グリセリン 28 0 安息香酸ナトリゥム 0 2 トラネキサム酸 0 05 フッ化ナトリウム 0 2 1 ラウリル硫酸ナトリウム 1. 5 香料 1. 0 精製水 パランス 計 100. 0% 70% Sorbi! 43 0 Precipitated silica 15 0 Propylene glycol 20 Glycerin 28 0 Sodium benzoate 0 2 Tranexamic acid 0 05 Sodium fluoride 0 2 1 Sodium lauryl sulfate 1.5 Fragrance 1.0 Purified water Balance 100. 0%
[実施例 5] 洗口剤 [Example 5] Mouthwash
粒子 A 1 · 0 % ピロリン酸ナトリウム 4. 0
エタノール 5 0 グリセリン 0 0 Particle A 1.0% sodium pyrophosphate 4.0 Ethanol 5 0 Glycerin 0 0
0 ポリオキシェチレン硬化ヒマシ油 0 安息香酸ナトリウム 0 3 香料 0 5 精製水 ― ― ― バランス 0 Polyoxyethylene hydrogenated castor oil 0 Sodium benzoate 0 3 Fragrance 0 5 Purified water ― ― ― Balance
00. 0 % 00. 0%
[実施例 6] 口中清涼剤 [Example 6] Oral freshener
粒子 D 3 0 % テトラポリリン酸ナトリウム 0 エタノール 30 0 グリセリン 15 0 サッカリンナトリウム 0 3 ショ糖脂肪酸エステル 3 0 香料 1. 0 精製水 _ バランス 計 100. 0 % Particle D 3 0% Sodium tetrapolyphosphate 0 Ethanol 30 0 Glycerin 150 Saccharin sodium 0 3 Sucrose fatty acid ester 3 0 Fragrance 1.0 Purified water _ Balance total 100.0%
[実施例 7] ナュ— [Example 7] News
粒子 D 3. 0 % ピロリン酸ナトリウム 1 0 ガムベース 41 0 クェン酸 2 0 マルチトール 40 0 グリセリン 1 0 Particle D 3.0% sodium pyrophosphate 10 gum base 41 0 citric acid 20 maltitol 40 0 glycerin 10
10 0 香料 1 5
バランス 10 0 Fragrance 1 5 balance
100. 0% 100. 0%
[実施例 8 ] [Example 8]
下記ゲル状組成物を粘着層とするレー 製歯牙貼付シ一ト (そのまま歯牙にシートを貼付して適用する) Lay tooth sticking sheet with the following gel composition as an adhesive layer (Apply the sheet as it is to the tooth)
ゲル状組成物 Gel composition
粒子 A 4. 0% Particle A 4.0%
ピロリン酸ナトリウム 3. 0 Sodium pyrophosphate 3.0
ラウリル硫酸ナトリウム 2. 0 Sodium lauryl sulfate 2.0
エタノール 8. 0 Ethanol 8.0
ソルビット 30 0 Sorbit 30 0
ヒドロキシェチルセルロース 4 5 Hydroxyethyl cellulose 4 5
アルギン酸ナトリウム 2 5 Sodium alginate 25
0 02 0 02
香料 0 Fragrance 0
5N塩酸 （pH調整剤） 5N hydrochloric acid (pH adjuster)
精製水 バランス Purified water balance
計 00. 0% Total 00.0%
[実施例 9] [Example 9]
下記練歯磨状組成物とシリコーンゴム製マウス 1 —との組み合わせ （使用時 に練歯磨状組成物を充填し、 嚙んで適用する） Combination of the following toothpaste composition and a silicone rubber mouse 1 (fill the toothpaste composition at the time of use and apply by applying)
練歯磨状組成物 Toothpaste-like composition
粒子 A 1. 0% Particle A 1.0%
トリポリリン酸ナトリウム 5. 0 Sodium tripolyphosphate 5.0
ピロリン酸ナトリウム 5. 0 ソルビット 15. 0
キシリトール 10. 0 無水ケィ酸 20. 0 キサンタンガム 2. 0 カラギーナン 0. 5 サッカ 11 0. 1 香料 1. 0 精製水 バランス Sodium pyrophosphate 5.0 Sorbit 15.0 Xylitol 10.0 Caic anhydride 20.0 Xanthan gum 2.0 Carrageenan 0.5 Sacchar 11 0.1 Fragrance 1.0 Purified water Balance
00. 0%
00. 0%
Claims
1. 下記一般式 （1) 1. The following general formula (1)
Mn + 2Pn03n+1 (1) (但し、 Mは Na又は Kを示し、 nは 2以上の整数である。 ） M n + 2 P n 0 3n + 1 (1) ( where, M represents a Na or K, n is an integer of 2 or more.)
で示される直鎖状の水溶性ポリリン酸塩の 1種又は 2種以上を含有すると共に、 平均粒径が 50〜 1， 000 mであり、 かつ崩壌強度が 10〜 200 g Z個で ある粒子を含有することを特徴とする着色ペリクル除去用口腔用組成物。 Contains one or more linear water-soluble polyphosphates represented by, has an average particle size of 50 to 1,000 m, and has a crushing strength of 10 to 200 g Z An oral composition for removing colored pellicles, comprising particles.
2. ポリリン酸塩がピロリン酸ナトリゥムである請求項 1記載の口腔用組成物。
2. The oral composition according to claim 1, wherein the polyphosphate is sodium pyrophosphate.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2001278788A AU2001278788A1 (en) | 2000-08-23 | 2001-08-21 | Oral composition |
| KR10-2003-7002483A KR20030040411A (en) | 2000-08-23 | 2001-08-21 | Oral composition |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000251890A JP2002068947A (en) | 2000-08-23 | 2000-08-23 | Composition for oral cavity |
| JP2000-251890 | 2000-08-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2002015857A1 true WO2002015857A1 (en) | 2002-02-28 |
Family
ID=18741229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/JP2001/007148 WO2002015857A1 (en) | 2000-08-23 | 2001-08-21 | Oral composition |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP2002068947A (en) |
| KR (1) | KR20030040411A (en) |
| AU (1) | AU2001278788A1 (en) |
| WO (1) | WO2002015857A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004010962A1 (en) * | 2002-07-31 | 2004-02-05 | Bon-Gil Koo | Liquid composition for protecting oral cavities and teeth of pet animals and use thereof in plaything for pet animals |
| CN104189773A (en) * | 2014-09-19 | 2014-12-10 | 徐德玲 | Traditional Chinese medicine composition for pain relief and detumescence after fracture |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5961013B2 (en) * | 2012-03-02 | 2016-08-02 | 花王株式会社 | Dentifrice |
| JP7376976B2 (en) * | 2017-12-26 | 2023-11-09 | 小林製薬株式会社 | Oral composition for deodorizing tobacco odor |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3767791A (en) * | 1971-06-03 | 1973-10-23 | Colgate Palmolive Co | Dental cream containing abrasive agglomerates |
| JPH01299211A (en) * | 1988-05-25 | 1989-12-04 | Kao Corp | Dentifrice |
| JPH04243816A (en) * | 1991-01-28 | 1992-08-31 | Kao Corp | Granule agent and composition for oral cavity containing the same agent |
| WO1996009033A1 (en) * | 1994-09-21 | 1996-03-28 | Crosfield Limited | Granular compositions |
-
2000
- 2000-08-23 JP JP2000251890A patent/JP2002068947A/en active Pending
-
2001
- 2001-08-21 AU AU2001278788A patent/AU2001278788A1/en not_active Abandoned
- 2001-08-21 KR KR10-2003-7002483A patent/KR20030040411A/en not_active Application Discontinuation
- 2001-08-21 WO PCT/JP2001/007148 patent/WO2002015857A1/en active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3767791A (en) * | 1971-06-03 | 1973-10-23 | Colgate Palmolive Co | Dental cream containing abrasive agglomerates |
| JPH01299211A (en) * | 1988-05-25 | 1989-12-04 | Kao Corp | Dentifrice |
| JPH04243816A (en) * | 1991-01-28 | 1992-08-31 | Kao Corp | Granule agent and composition for oral cavity containing the same agent |
| WO1996009033A1 (en) * | 1994-09-21 | 1996-03-28 | Crosfield Limited | Granular compositions |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004010962A1 (en) * | 2002-07-31 | 2004-02-05 | Bon-Gil Koo | Liquid composition for protecting oral cavities and teeth of pet animals and use thereof in plaything for pet animals |
| CN104189773A (en) * | 2014-09-19 | 2014-12-10 | 徐德玲 | Traditional Chinese medicine composition for pain relief and detumescence after fracture |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002068947A (en) | 2002-03-08 |
| KR20030040411A (en) | 2003-05-22 |
| AU2001278788A1 (en) | 2002-03-04 |
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