WO2002005818A3 - Novel method of use of multidrug resistance modulators - Google Patents

Novel method of use of multidrug resistance modulators Download PDF

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Publication number
WO2002005818A3
WO2002005818A3 PCT/US2001/016516 US0116516W WO0205818A3 WO 2002005818 A3 WO2002005818 A3 WO 2002005818A3 US 0116516 W US0116516 W US 0116516W WO 0205818 A3 WO0205818 A3 WO 0205818A3
Authority
WO
WIPO (PCT)
Prior art keywords
multidrug resistance
novel method
resistance modulators
modulators
mammal
Prior art date
Application number
PCT/US2001/016516
Other languages
French (fr)
Other versions
WO2002005818A2 (en
Inventor
Anne Hollins Dantzig
Kevin Lynn Law
James Jacob Starling
Original Assignee
Lilly Co Eli
Anne Hollins Dantzig
Kevin Lynn Law
James Jacob Starling
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli, Anne Hollins Dantzig, Kevin Lynn Law, James Jacob Starling filed Critical Lilly Co Eli
Priority to AU2001269708A priority Critical patent/AU2001269708A1/en
Publication of WO2002005818A2 publication Critical patent/WO2002005818A2/en
Publication of WO2002005818A3 publication Critical patent/WO2002005818A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A method of suppressing multidrug resistance in a mammal by administering an effective amount of a 10,11-methanodibenzosuberane derivative or a pharmaceutically acceptable salt thereof.
PCT/US2001/016516 2000-07-18 2001-07-05 Novel method of use of multidrug resistance modulators WO2002005818A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001269708A AU2001269708A1 (en) 2000-07-18 2001-07-05 Novel method of use of multidrug resistance modulators

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21922200P 2000-07-18 2000-07-18
US60/219,222 2000-07-18

Publications (2)

Publication Number Publication Date
WO2002005818A2 WO2002005818A2 (en) 2002-01-24
WO2002005818A3 true WO2002005818A3 (en) 2003-01-16

Family

ID=22818379

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/016516 WO2002005818A2 (en) 2000-07-18 2001-07-05 Novel method of use of multidrug resistance modulators

Country Status (2)

Country Link
AU (1) AU2001269708A1 (en)
WO (1) WO2002005818A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1898916A4 (en) * 2005-07-06 2008-10-15 Kanisa Pharmaceuticals Inc Zosuquidar, daunorubicin, and cytarabine for the treatment of cancer

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994024107A1 (en) * 1993-04-19 1994-10-27 Syntex (U.S.A.) Inc. 10,11-methanodibenzosuberane derivatives used as chemosensitizing agents
WO1997048689A1 (en) * 1996-06-17 1997-12-24 Eli Lilly And Company Drug resistance and multidrug resistance modulators
WO1998022112A1 (en) * 1996-11-22 1998-05-28 Eli Lilly And Company Drug resistance and multidrug resistance modulators
WO1999017757A1 (en) * 1997-10-08 1999-04-15 Dzieglewska Hanna Eva USE OF P-GLYCOPROTEIN (Pgp) INHIBITORS IN THE TREATMENT OF CANCER
WO2000075121A2 (en) * 1999-06-03 2000-12-14 Eli Lilly And Company Process for preparing 10,11-methanobenzosuberane derivatives

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994024107A1 (en) * 1993-04-19 1994-10-27 Syntex (U.S.A.) Inc. 10,11-methanodibenzosuberane derivatives used as chemosensitizing agents
WO1997048689A1 (en) * 1996-06-17 1997-12-24 Eli Lilly And Company Drug resistance and multidrug resistance modulators
WO1998022112A1 (en) * 1996-11-22 1998-05-28 Eli Lilly And Company Drug resistance and multidrug resistance modulators
WO1999017757A1 (en) * 1997-10-08 1999-04-15 Dzieglewska Hanna Eva USE OF P-GLYCOPROTEIN (Pgp) INHIBITORS IN THE TREATMENT OF CANCER
WO2000075121A2 (en) * 1999-06-03 2000-12-14 Eli Lilly And Company Process for preparing 10,11-methanobenzosuberane derivatives

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 131, no. 19, 8 November 1999, Columbus, Ohio, US; abstract no. 252206b, DANTZIG,AQ.H. ET AL.: "Selectivity of the multidrug resistance modulator LY335979, for P-glycoprotein and effect on cytochrome P-450 activities." page 36; XP002204882 *
G.L.LUKER ET AL.: "Effects if Cholesterol and Enantiomeric Cholesterol on P-Glycoprotein Localization and Function in Low-Density Membrane Domains", BIOCHEMISTRY, vol. 39, 7 June 2000 (2000-06-07), pages 7651 - 7661, XP002204874 *
G.L.LUKER ET AL.: "Multidrug Resistance (MDR1) P-glycoprotein Enhances Esterification of Plasma Membrane Cholesterol", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 11, 1999, USA, pages 6979 - 6991, XP002204873 *
J. PHARMACOL. EXP. THER., vol. 290, no. 2, 1999, pages 854 - 862 *

Also Published As

Publication number Publication date
AU2001269708A1 (en) 2002-01-30
WO2002005818A2 (en) 2002-01-24

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