WO2002003919A3 - Structural targets in hepatitis c virus ires element - Google Patents

Structural targets in hepatitis c virus ires element Download PDF

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Publication number
WO2002003919A3
WO2002003919A3 PCT/US2001/021871 US0121871W WO0203919A3 WO 2002003919 A3 WO2002003919 A3 WO 2002003919A3 US 0121871 W US0121871 W US 0121871W WO 0203919 A3 WO0203919 A3 WO 0203919A3
Authority
WO
WIPO (PCT)
Prior art keywords
loop
hepatitis
domain
ires element
virus ires
Prior art date
Application number
PCT/US2001/021871
Other languages
French (fr)
Other versions
WO2002003919A9 (en
WO2002003919A2 (en
Inventor
Joseph D Puglisi
Original Assignee
Univ Leland Stanford Junior
Joseph D Puglisi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior, Joseph D Puglisi filed Critical Univ Leland Stanford Junior
Priority to US10/332,626 priority Critical patent/US20040073380A1/en
Priority to AU2001273365A priority patent/AU2001273365A1/en
Publication of WO2002003919A2 publication Critical patent/WO2002003919A2/en
Publication of WO2002003919A3 publication Critical patent/WO2002003919A3/en
Publication of WO2002003919A9 publication Critical patent/WO2002003919A9/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Molecular structures, computer representations thereof, and methods of analysis are provided for the hepatitis C virus internal ribosome entry site (HCV IRES). Novel features of the structure include the tetraloop fold in domain IIIe, including the array of three major groove exposed Watson-Crick faces (G295, A296, and U297), which loop has been found to be a point of direct contact with the 40S subunit; and the structure comprising the domain IIId loop E and hairpin loop backdone reversion, which places two S turns on the same side of hairpin loop structure.
PCT/US2001/021871 2000-07-10 2001-07-10 Structural targets in hepatitis c virus ires element WO2002003919A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US10/332,626 US20040073380A1 (en) 2001-07-10 2001-07-10 Structural targets in hepatittis c virus ires element
AU2001273365A AU2001273365A1 (en) 2000-07-10 2001-07-10 Structural targets in hepatitis c virus ires element

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21767300P 2000-07-10 2000-07-10
US60/217,673 2000-07-10

Publications (3)

Publication Number Publication Date
WO2002003919A2 WO2002003919A2 (en) 2002-01-17
WO2002003919A3 true WO2002003919A3 (en) 2002-04-18
WO2002003919A9 WO2002003919A9 (en) 2003-04-03

Family

ID=22812031

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/021871 WO2002003919A2 (en) 2000-07-10 2001-07-10 Structural targets in hepatitis c virus ires element

Country Status (2)

Country Link
AU (1) AU2001273365A1 (en)
WO (1) WO2002003919A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999017616A1 (en) * 1997-10-07 1999-04-15 New England Medical Center Hospitals, Inc. Structure-based rational design of compounds to inhibit papillomavirus infection
US5978740A (en) * 1995-08-09 1999-11-02 Vertex Pharmaceuticals Incorporated Molecules comprising a calcineurin-like binding pocket and encoded data storage medium capable of graphically displaying them
US6183121B1 (en) * 1997-08-14 2001-02-06 Vertex Pharmaceuticals Inc. Hepatitis C virus helicase crystals and coordinates that define helicase binding pockets

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5978740A (en) * 1995-08-09 1999-11-02 Vertex Pharmaceuticals Incorporated Molecules comprising a calcineurin-like binding pocket and encoded data storage medium capable of graphically displaying them
US6183121B1 (en) * 1997-08-14 2001-02-06 Vertex Pharmaceuticals Inc. Hepatitis C virus helicase crystals and coordinates that define helicase binding pockets
WO1999017616A1 (en) * 1997-10-07 1999-04-15 New England Medical Center Hospitals, Inc. Structure-based rational design of compounds to inhibit papillomavirus infection

Also Published As

Publication number Publication date
AU2001273365A1 (en) 2002-01-21
WO2002003919A9 (en) 2003-04-03
WO2002003919A2 (en) 2002-01-17

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