WO2001092494A3 - 50250, a human lipase and uses thereof - Google Patents

50250, a human lipase and uses thereof Download PDF

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Publication number
WO2001092494A3
WO2001092494A3 PCT/US2001/017334 US0117334W WO0192494A3 WO 2001092494 A3 WO2001092494 A3 WO 2001092494A3 US 0117334 W US0117334 W US 0117334W WO 0192494 A3 WO0192494 A3 WO 0192494A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
acid molecules
expression vectors
provides isolated
molecules
Prior art date
Application number
PCT/US2001/017334
Other languages
French (fr)
Other versions
WO2001092494A2 (en
Inventor
Rosana Kapeller-Libermann
Original Assignee
Millennium Pharm Inc
Kapeller Libermann Rosana
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc, Kapeller Libermann Rosana filed Critical Millennium Pharm Inc
Priority to EP01937794A priority Critical patent/EP1311688A2/en
Priority to AU2001263493A priority patent/AU2001263493A1/en
Publication of WO2001092494A2 publication Critical patent/WO2001092494A2/en
Publication of WO2001092494A3 publication Critical patent/WO2001092494A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention provides isolated nucleic acid molecules, designated LP nucleic acid molecules, which encode novel LP-related lipase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing LP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an LP gene has been introduced or disrupted. The invention still further provides isolated LP proteins, fusion proteins, antigenic peptides and anti-LP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
PCT/US2001/017334 2000-05-26 2001-05-29 50250, a human lipase and uses thereof WO2001092494A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01937794A EP1311688A2 (en) 2000-05-26 2001-05-29 50250, a human lipase and uses thereof
AU2001263493A AU2001263493A1 (en) 2000-05-26 2001-05-29 50250, a novel human lipase and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20750600P 2000-05-26 2000-05-26
US60/207,506 2000-05-26

Publications (2)

Publication Number Publication Date
WO2001092494A2 WO2001092494A2 (en) 2001-12-06
WO2001092494A3 true WO2001092494A3 (en) 2002-04-11

Family

ID=22770863

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/017334 WO2001092494A2 (en) 2000-05-26 2001-05-29 50250, a human lipase and uses thereof

Country Status (3)

Country Link
EP (1) EP1311688A2 (en)
AU (1) AU2001263493A1 (en)
WO (1) WO2001092494A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001016334A2 (en) * 1999-09-01 2001-03-08 Incyte Genomics, Inc. Human hydrolytic enzymes
WO2001057190A2 (en) * 2000-02-03 2001-08-09 Hyseq, Inc. Novel nucleic acids and polypeptides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001016334A2 (en) * 1999-09-01 2001-03-08 Incyte Genomics, Inc. Human hydrolytic enzymes
WO2001057190A2 (en) * 2000-02-03 2001-08-09 Hyseq, Inc. Novel nucleic acids and polypeptides

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE EM_EST EBI; 13 July 1999 (1999-07-13), NCI-CGAP: "Homo sapiens cDNA clone IMAGE:2405992", XP002187884 *
DATABASE EM_EST EBI; 3 July 1997 (1997-07-03), HILLIER L ET AL.: "Homo sapiens cDNA clone IMAGE:757217", XP002187885 *
DATABASE GSN EBI; 9 August 2001 (2001-08-09), TANG Y T ET AL.: "Human protein SEQ ID NO: 3600", XP002187888 *
DATABASE GSP EBI; 9 August 2001 (2001-08-09), TANG Y T ET AL.: "Human polynucleotide SEQ ID NO: 2616", XP002187887 *
DATABASE SWALL EBI; 31 October 1997 (1997-10-31), LIN X ET AL.: "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana", XP002187886 *
LIN X ET AL., NATURE, vol. 402, no. 6763, 1999, pages 761 - 768 *

Also Published As

Publication number Publication date
AU2001263493A1 (en) 2001-12-11
EP1311688A2 (en) 2003-05-21
WO2001092494A2 (en) 2001-12-06

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