WO2001090324A3 - 32263, a putative human biotin transcarboxylase and uses thereof - Google Patents
32263, a putative human biotin transcarboxylase and uses thereof Download PDFInfo
- Publication number
- WO2001090324A3 WO2001090324A3 PCT/US2001/016404 US0116404W WO0190324A3 WO 2001090324 A3 WO2001090324 A3 WO 2001090324A3 US 0116404 W US0116404 W US 0116404W WO 0190324 A3 WO0190324 A3 WO 0190324A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- bre
- nucleic acid
- acid molecules
- molecules
- expression vectors
- Prior art date
Links
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 title abstract 4
- 229960002685 biotin Drugs 0.000 title abstract 2
- 235000020958 biotin Nutrition 0.000 title abstract 2
- 239000011616 biotin Substances 0.000 title abstract 2
- 108010051679 Methylmalonyl-CoA carboxytransferase Proteins 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 abstract 4
- 108020004707 nucleic acids Proteins 0.000 abstract 4
- -1 BRE nucleic acid Chemical class 0.000 abstract 2
- 239000013604 expression vector Substances 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 230000000692 anti-sense effect Effects 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000003259 recombinant expression Methods 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
The invention provides isolated nucleic acids molecules, designated BRE nucleic acid molecules, which encode novel biotin enzyme-related molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing BRE nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a BRE gene has been introduced or disrupted. The invention still further provides isolated BRE proteins, fusion proteins, antigenic peptides and anti-BRE antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2001263342A AU2001263342A1 (en) | 2000-05-19 | 2001-05-21 | 32263, a putative human biotin transcarboxylase and uses thereof |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20596100P | 2000-05-19 | 2000-05-19 | |
| US60/205,961 | 2000-05-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2001090324A2 WO2001090324A2 (en) | 2001-11-29 |
| WO2001090324A3 true WO2001090324A3 (en) | 2002-07-18 |
Family
ID=22764385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2001/016404 WO2001090324A2 (en) | 2000-05-19 | 2001-05-21 | 32263, a putative human biotin transcarboxylase and uses thereof |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU2001263342A1 (en) |
| WO (1) | WO2001090324A2 (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19817948A1 (en) * | 1998-04-17 | 1999-10-21 | Metagen Gesellschaft Fuer Genomforschung Mbh | New nucleic acid sequences expressed in uterine cancer tissues, and derived polypeptides, for treatment of uterine and endometrial cancer and identification of therapeutic agents |
| WO2001007628A2 (en) * | 1999-07-22 | 2001-02-01 | Incyte Genomics, Inc. | Human synthetases |
| EP1074617A2 (en) * | 1999-07-29 | 2001-02-07 | Helix Research Institute | Primers for synthesising full-length cDNA and their use |
-
2001
- 2001-05-21 WO PCT/US2001/016404 patent/WO2001090324A2/en active Application Filing
- 2001-05-21 AU AU2001263342A patent/AU2001263342A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19817948A1 (en) * | 1998-04-17 | 1999-10-21 | Metagen Gesellschaft Fuer Genomforschung Mbh | New nucleic acid sequences expressed in uterine cancer tissues, and derived polypeptides, for treatment of uterine and endometrial cancer and identification of therapeutic agents |
| WO2001007628A2 (en) * | 1999-07-22 | 2001-02-01 | Incyte Genomics, Inc. | Human synthetases |
| EP1074617A2 (en) * | 1999-07-29 | 2001-02-07 | Helix Research Institute | Primers for synthesising full-length cDNA and their use |
Non-Patent Citations (6)
| Title |
|---|
| A. M. LAMHONWAH ET AL.: "HUMAN MITOCHONDRIAL PROPIONYL-CoA CARBOXYLASE: LOCALIZATION OF THE N-TERMINUS OF THE PRO- AND MATURE ALPHA CHAINS IN THE DEDUCED PRIMARY SEQUENCE OF A FULL-LENGTH cDNA", NUCLEIC ACID RES., vol. 17, 1989, pages 4396, XP001026454 * |
| DATABASE EMBL 11 July 2000 (2000-07-11), K. OBATA ET AL.: "Homo sapiens MCC-B mRNA for 3-methylcrotonyl-CoA carboxylase", XP002189965 * |
| DATABASE EMBL 29 September 2000 (2000-09-29), T. ISOGAI ET AL.: "Homo sapiens cDNA FLJ12989 fis, clone NT2RP3000085, moderately similar to acetyl-/propionyl-Coenzyme A carboxylase alpha chain", XP002189964 * |
| DATABASE EMBL 7 March 2000 (2000-03-07), R. STRAUSBERG ET AL.: "xy03h03.x1 NCI-CGAP-Lym12 Homo sapiens cDNA clone", XP002190066 * |
| DATABASE SWISSPROT "PROPIONYL-CoA CARBOXYLASE ALPHA CHAIN, MITOCHONDRIAL PRECURSOR", XP002190065 * |
| DATABASE SWISSPROT 1 May 2000 (2000-05-01), M. D. ADAMS ET AL.: "Drosophila melanogaster CG2118 protein", XP002189966 * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001263342A1 (en) | 2001-12-03 |
| WO2001090324A2 (en) | 2001-11-29 |
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