WO2001085151A3 - Chimeric animal model and treatment of psoriasis - Google Patents

Chimeric animal model and treatment of psoriasis Download PDF

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Publication number
WO2001085151A3
WO2001085151A3 PCT/US2001/014988 US0114988W WO0185151A3 WO 2001085151 A3 WO2001085151 A3 WO 2001085151A3 US 0114988 W US0114988 W US 0114988W WO 0185151 A3 WO0185151 A3 WO 0185151A3
Authority
WO
WIPO (PCT)
Prior art keywords
psoriasis
treatment
animal model
chimeric animal
chimeric
Prior art date
Application number
PCT/US2001/014988
Other languages
French (fr)
Other versions
WO2001085151A2 (en
Inventor
Eugene M Farber
Siba P Raychaudhuri
Smriti K Raychaudhuri
Original Assignee
Psoriasis Res Inst
Eugene M Farber
Siba P Raychaudhuri
Smriti K Raychaudhuri
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Psoriasis Res Inst, Eugene M Farber, Siba P Raychaudhuri, Smriti K Raychaudhuri filed Critical Psoriasis Res Inst
Priority to AU2001261324A priority Critical patent/AU2001261324A1/en
Publication of WO2001085151A2 publication Critical patent/WO2001085151A2/en
Publication of WO2001085151A3 publication Critical patent/WO2001085151A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0271—Chimeric animals, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics

Abstract

This invention relates to the treatment of psoriasis by a NGF inhibitor, a composition comprising a NGF inhibitor, an animal model of psoriasis and a method of screening compounds for the treatment of psoriasis.
PCT/US2001/014988 2000-05-08 2001-05-08 Chimeric animal model and treatment of psoriasis WO2001085151A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001261324A AU2001261324A1 (en) 2000-05-08 2001-05-08 Psoriasis treatment

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56657400A 2000-05-08 2000-05-08
US09/566,574 2000-05-08

Publications (2)

Publication Number Publication Date
WO2001085151A2 WO2001085151A2 (en) 2001-11-15
WO2001085151A3 true WO2001085151A3 (en) 2002-05-23

Family

ID=24263461

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/014988 WO2001085151A2 (en) 2000-05-08 2001-05-08 Chimeric animal model and treatment of psoriasis

Country Status (2)

Country Link
AU (1) AU2001261324A1 (en)
WO (1) WO2001085151A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102623994B1 (en) 2015-12-22 2024-01-11 장-노엘 또렐 Composition comprising ambora extract and green tea extract for the treatment of psoriasis, atopic dermatitis, chronic urticaria, antihistamine-resistant itch and senile itch.

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602004023832D1 (en) 2003-05-16 2009-12-10 Univ Laval CNS CHLORIDE MODULATION AND USE THEREOF
EP1653972A1 (en) * 2003-07-23 2006-05-10 Creabilis Therapeutics s.r.l. Topical use of tyrosine kinase inhibitors of microbial origin to prevent and treat skin disorders characterised by excessive cell proliferation
WO2005110490A1 (en) 2004-05-14 2005-11-24 Universite Laval Phospholipase c gamma modulation and uses thereof for management of pain and nociception
MX2008002524A (en) * 2005-08-25 2008-03-14 Creabilis Therapeutics Spa Polymer conjugates of k-252a and derivatives thereof.
ES2352929B1 (en) * 2009-08-14 2012-01-26 Centro De Investigaciones Energeticas. Medioamb Ientales Y Tecnologicas (Ciemat) HUMANIZED PSORIASIS MODEL

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997038093A1 (en) * 1996-04-05 1997-10-16 Brigham & Women's Hospital, Inc. Psoriasis model
WO1997049406A1 (en) * 1996-06-25 1997-12-31 Cephalon, Inc. Use of k-252a derivative for the treatment of peripheral or central nerve disorders, and cytokine overproduction
WO1998044908A1 (en) * 1997-04-07 1998-10-15 The Board Of Trustees Of The Leland Stanford Junior University Method of regulating epithelial growth
WO2000001699A1 (en) * 1998-07-02 2000-01-13 Bayer Aktiengesellschaft Novel indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer
WO2000016756A2 (en) * 1998-09-24 2000-03-30 Innovet Italia S.R.L. Use of n-acylvanillinamide derivatives as agonists of peripheral cannabinoid cb1 receptors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997038093A1 (en) * 1996-04-05 1997-10-16 Brigham & Women's Hospital, Inc. Psoriasis model
WO1997049406A1 (en) * 1996-06-25 1997-12-31 Cephalon, Inc. Use of k-252a derivative for the treatment of peripheral or central nerve disorders, and cytokine overproduction
WO1998044908A1 (en) * 1997-04-07 1998-10-15 The Board Of Trustees Of The Leland Stanford Junior University Method of regulating epithelial growth
WO2000001699A1 (en) * 1998-07-02 2000-01-13 Bayer Aktiengesellschaft Novel indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer
WO2000016756A2 (en) * 1998-09-24 2000-03-30 Innovet Italia S.R.L. Use of n-acylvanillinamide derivatives as agonists of peripheral cannabinoid cb1 receptors

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DAM T ET AL: "Pharmacological modulation of induction and treatment of psoriasis using human skin grafts transplanted onto SCID mice", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 108, no. 4, 1997, pages 572, XP001041554 *
PINCELLI C ET AL: "Autocrine nerve growth factor in human keratinocytes", JOURNAL OF DERMATOLOGICAL SCIENCE, vol. 22, no. 2, February 1999 (1999-02-01), pages 71 - 79, XP001041596 *
PINCELLI C: "Nerve growth factor and keratinocytes: a role in psoriasis.", EUR J DERMATOL, vol. 10, no. 2, March 2000 (2000-03-01), pages 85 - 90, XP002184137 *
RAYCHAUDHURI S ET AL: "Role of neuroimmunologic inflammation in psoriasis in a SCID mouse-human skin animal model", FASEB J, vol. 14, no. 6, 20 April 2000 (2000-04-20), pages A1247, XP002184136 *
YAMAMOTO T ET AL: "Repeated subcutaneous injection of staphylococcal enterotoxin B-stimulated lymphocytes retains epidermal thickness of psoriatic", JOURNAL OF DERMATOLOGICAL SCIENCE, vol. 17, no. 1, May 1998 (1998-05-01), pages 8 - 14, XP001041546 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102623994B1 (en) 2015-12-22 2024-01-11 장-노엘 또렐 Composition comprising ambora extract and green tea extract for the treatment of psoriasis, atopic dermatitis, chronic urticaria, antihistamine-resistant itch and senile itch.

Also Published As

Publication number Publication date
WO2001085151A2 (en) 2001-11-15
AU2001261324A1 (en) 2001-11-20

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