WO2001079496A3 - Ligand for herpes simplex virus entry mediator and methods of use - Google Patents

Ligand for herpes simplex virus entry mediator and methods of use Download PDF

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Publication number
WO2001079496A3
WO2001079496A3 PCT/US2001/011857 US0111857W WO0179496A3 WO 2001079496 A3 WO2001079496 A3 WO 2001079496A3 US 0111857 W US0111857 W US 0111857W WO 0179496 A3 WO0179496 A3 WO 0179496A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
ligand
entry mediator
virus entry
herpes simplex
Prior art date
Application number
PCT/US2001/011857
Other languages
French (fr)
Other versions
WO2001079496A2 (en
Inventor
Carl F Ware
Original Assignee
Jolla Inst Allergy Immunolog
Carl F Ware
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/524,325 external-priority patent/US6998108B1/en
Application filed by Jolla Inst Allergy Immunolog, Carl F Ware filed Critical Jolla Inst Allergy Immunolog
Priority to DE60129010T priority Critical patent/DE60129010T2/en
Priority to JP2001577479A priority patent/JP2003531152A/en
Priority to AU5338701A priority patent/AU5338701A/en
Priority to EP01926879A priority patent/EP1274840B1/en
Priority to CA2406132A priority patent/CA2406132C/en
Publication of WO2001079496A2 publication Critical patent/WO2001079496A2/en
Publication of WO2001079496A3 publication Critical patent/WO2001079496A3/en
Priority to AU2007201279A priority patent/AU2007201279B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Abstract

A novel polypeptide ligand, p30, or LIGHT, for herpes virus entry mediator, HVEM, is provided. p30 is useful for modulating immune responses and in inhibiting infection and/or subsequent proliferation by herpes virus. HVEM fusion proteins are also provided. Methods for treating subjects with lymphoid cell disorders, tumors, autoimmune diseases, inflammatory disorders of those having or suspected of having a herpes virus infection, utilizing p30 and the fusion proteins of the invention, are also provided.
PCT/US2001/011857 2000-03-13 2001-04-11 Ligand for herpes simplex virus entry mediator and methods of use WO2001079496A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
DE60129010T DE60129010T2 (en) 2000-04-12 2001-04-11 LIGAND OF THE CELL INTRUSION-PROCESSING PROTEIN OF HERPES SIMPLEX AND METHODS FOR ITS USE
JP2001577479A JP2003531152A (en) 2000-04-12 2001-04-11 Ligands to herpes simplex virus entry mediators and methods of use
AU5338701A AU5338701A (en) 2000-04-12 2001-04-11 Ligand for herpes simplex virus entry mediator and methods of use
EP01926879A EP1274840B1 (en) 2000-04-12 2001-04-11 Ligand for herpes simplex virus entry mediator and methods of use
CA2406132A CA2406132C (en) 2000-04-12 2001-04-11 Ligand for herpes simplex virus entry mediator and methods of use
AU2007201279A AU2007201279B2 (en) 2000-03-13 2007-03-23 Ligand for herpes simplex virus entry mediator and methods of use

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/524,325 US6998108B1 (en) 1997-07-07 2000-03-13 Antibodies to p30 polypeptides and methods making and using same
US54909600A 2000-04-12 2000-04-12
US09/549,096 2000-04-12

Publications (2)

Publication Number Publication Date
WO2001079496A2 WO2001079496A2 (en) 2001-10-25
WO2001079496A3 true WO2001079496A3 (en) 2002-08-29

Family

ID=27061465

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/011857 WO2001079496A2 (en) 2000-03-13 2001-04-11 Ligand for herpes simplex virus entry mediator and methods of use

Country Status (1)

Country Link
WO (1) WO2001079496A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU771013B2 (en) * 1996-03-22 2004-03-11 Human Genome Sciences, Inc. Apoptosis inducing molecule II
AU4778700A (en) * 1999-05-21 2000-12-12 Takeda Chemical Industries Ltd. Liver function controlling agents
EP1336619A3 (en) * 2002-02-19 2003-12-10 Millenium Pharmaceuticals, Inc. Combination of a HVEM-LIGHT inhibitor and an immunosuppressive agent in the treatment or prevention of immune disorders
CA2482938A1 (en) * 2002-04-12 2003-10-23 Human Genome Sciences, Inc. Antibodies that specifically bind to tr2
FR2845692A1 (en) * 2002-10-15 2004-04-16 France Hybrides Producing mammals resistant to infection by alpha-herpes virus, particularly pigs resistant to pseudorabies, by expressing transgene encoding fusion of receptor domain and immunoglobulin
US7811983B2 (en) 2003-06-11 2010-10-12 The University Of Chicago Increased T-cell tumor infiltration and eradication of metastases by mutant light
ES2297479T3 (en) * 2003-06-11 2008-05-01 The University Of Chicago INFILTRATION INCREASED IN TUMOR OF CELLS T BY THE MUTANT LIGTH.
DK2292663T3 (en) 2006-08-28 2013-11-04 Kyowa Hakko Kirin Co Ltd Antagonistic human-light specific human monoclonal antibodies
JP2010539243A (en) 2007-09-18 2010-12-16 ラ ホヤ インスティテュート フォア アラージー アンド イムノロジー LIGHT inhibitors for the treatment of asthma, lung and airway inflammation, respiratory, interstitial, pulmonary and fibrotic diseases
CA2858876A1 (en) 2011-12-15 2013-06-20 The University Of Chicago Methods and compositions for cancer therapy using mutant light molecules with increased affinity to receptors

Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997004658A1 (en) * 1995-07-28 1997-02-13 Northwestern University Herpes simplex virus 1 entry into cells mediated by a novel member of the tnf/ngf receptor family
WO1997034911A1 (en) * 1996-03-22 1997-09-25 Human Genome Sciences, Inc. Apoptosis inducing molecule ii
WO1998003648A1 (en) * 1996-07-19 1998-01-29 Takeda Chemical Industries, Ltd. Fas ligand-like protein, its production and use
WO1998017313A2 (en) * 1996-10-25 1998-04-30 Biogen, Inc. Soluble lymphotoxin-beta receptors, anti-lymphotoxin receptor antibodies, and anti-lymphotoxin ligand antibodies as therapeutic agents for the treatment of immunological diseases
WO1998018824A1 (en) * 1996-10-30 1998-05-07 Human Genome Sciences, Inc. Human tumor necrosis factor receptor-like 2
WO1998025967A1 (en) * 1996-12-12 1998-06-18 Genentech, Inc. Hvem polypeptides and uses thereof
WO1998051346A1 (en) * 1997-05-12 1998-11-19 Smithkline Beecham Corporation Human tumor necrosis factor receptor-like 2 (tr2) antibodies
WO1999002563A1 (en) * 1997-07-07 1999-01-21 La Jolla Institute For Allergy And Immunology Ligand for herpes simplex virus entry mediator and methods of use
EP0897114A2 (en) * 1997-08-13 1999-02-17 Smithkline Beecham Corporation A method of identifying agonist and antagonists for tumor necrosis related receptors TR1 and TR2
WO1999011662A1 (en) * 1997-09-05 1999-03-11 Millennium Biotherapeutics, Inc. Novel molecules of the tnfr-ligand-related protein family and uses thereof
WO1999035262A2 (en) * 1998-01-07 1999-07-15 Human Genome Sciences, Inc. Apoptosis inducing molecule ii
WO1999042584A1 (en) * 1998-02-20 1999-08-26 Human Genome Sciences, Inc. Apoptosis inducing molecule ii and methods of use
WO2000010591A1 (en) * 1998-08-18 2000-03-02 The Trustees Of The University Of Pennsylvania Peptides for inhibition of herpes simplex virus entry
WO2000014230A1 (en) * 1998-09-03 2000-03-16 Millennium Pharmaceuticals, Inc. Novel molecules of the herpes virus-entry-mediator-related protein family and uses thereof
WO2000021558A1 (en) * 1998-10-09 2000-04-20 Biogen, Inc. Reversal of viral-induced systemic shock and respiratory distress by blockade of the lymphotoxin beta pathway
WO2000053223A1 (en) * 1999-03-11 2000-09-14 Human Genome Sciences, Inc. Apoptosis inducing molecule ii and methods of use

Patent Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997004658A1 (en) * 1995-07-28 1997-02-13 Northwestern University Herpes simplex virus 1 entry into cells mediated by a novel member of the tnf/ngf receptor family
WO1997034911A1 (en) * 1996-03-22 1997-09-25 Human Genome Sciences, Inc. Apoptosis inducing molecule ii
WO1998003648A1 (en) * 1996-07-19 1998-01-29 Takeda Chemical Industries, Ltd. Fas ligand-like protein, its production and use
WO1998017313A2 (en) * 1996-10-25 1998-04-30 Biogen, Inc. Soluble lymphotoxin-beta receptors, anti-lymphotoxin receptor antibodies, and anti-lymphotoxin ligand antibodies as therapeutic agents for the treatment of immunological diseases
WO1998018824A1 (en) * 1996-10-30 1998-05-07 Human Genome Sciences, Inc. Human tumor necrosis factor receptor-like 2
WO1998025967A1 (en) * 1996-12-12 1998-06-18 Genentech, Inc. Hvem polypeptides and uses thereof
WO1998051346A1 (en) * 1997-05-12 1998-11-19 Smithkline Beecham Corporation Human tumor necrosis factor receptor-like 2 (tr2) antibodies
WO1999002563A1 (en) * 1997-07-07 1999-01-21 La Jolla Institute For Allergy And Immunology Ligand for herpes simplex virus entry mediator and methods of use
EP0897114A2 (en) * 1997-08-13 1999-02-17 Smithkline Beecham Corporation A method of identifying agonist and antagonists for tumor necrosis related receptors TR1 and TR2
WO1999011662A1 (en) * 1997-09-05 1999-03-11 Millennium Biotherapeutics, Inc. Novel molecules of the tnfr-ligand-related protein family and uses thereof
WO1999035262A2 (en) * 1998-01-07 1999-07-15 Human Genome Sciences, Inc. Apoptosis inducing molecule ii
WO1999042584A1 (en) * 1998-02-20 1999-08-26 Human Genome Sciences, Inc. Apoptosis inducing molecule ii and methods of use
WO2000010591A1 (en) * 1998-08-18 2000-03-02 The Trustees Of The University Of Pennsylvania Peptides for inhibition of herpes simplex virus entry
WO2000014230A1 (en) * 1998-09-03 2000-03-16 Millennium Pharmaceuticals, Inc. Novel molecules of the herpes virus-entry-mediator-related protein family and uses thereof
WO2000021558A1 (en) * 1998-10-09 2000-04-20 Biogen, Inc. Reversal of viral-induced systemic shock and respiratory distress by blockade of the lymphotoxin beta pathway
WO2000053223A1 (en) * 1999-03-11 2000-09-14 Human Genome Sciences, Inc. Apoptosis inducing molecule ii and methods of use

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
HARROP J A ET AL: "Herpesvirus entry mediator ligand (HVEM-L), a novel ligand for (HVEM/TR2, stimulates proliferation of T cells and inhibits HT29 cell growth", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 273, no. 42, 16 October 1998 (1998-10-16), pages 27548 - 27556, XP002109996, ISSN: 0021-9258 *
HARROP J ET AL: "Antibodies to TR2 (herpesvirus entry mediator), a new member of the TNF receptor superfamily, block T cell proliferation, expression of activation markers, and production of cytokines", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 161, no. 4, 15 August 1998 (1998-08-15), pages 1786 - 1794, XP002143292, ISSN: 0022-1767 *
HARROP J ET AL: "HVEM-L, A NOVEL LIGAND FOR HVEM/TR2, STIMULATES NF-KB DEPENDENT TRANSCRIPTION AND T CELL PROLIFERATION", JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, MARY ANN LIEBERT, NEW YORK, NY, US, vol. 18, no. 5, 1998, pages A - 39, XP000914784, ISSN: 1079-9907 *
HUANG T ET AL: "ANTI-IDIOTYPIC ANTIBODIES MIMICKING GLYCOPROTEIN D HOF HERPES SIMPLEX VIRUS IDENTIFY A CELLULAR PROTEIN REQUIRED FOR VIRUS SPREAD FROM CELL TO CELL AND VIRUS-INDUCED POLYKARYOCYTOSIS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 93, 1 March 1996 (1996-03-01), pages 1836 - 1840, XP002911959, ISSN: 0027-8424 *
KWON B S ET AL: "A NEWLY IDENTIFIED MEMBER OF THE TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY WITH A WIDE TISSUE DISTRIBUTION AND INVOLVEMENT IN LYMPHOCYTE ACTIVATION", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 272, no. 22, 30 May 1997 (1997-05-30), pages 14272 - 14276, XP002062425, ISSN: 0021-9258 *
MAURI D N ET AL: "LIGHT, A NEW MEMBER OF THE TNF SUPERFAMILY, AND LYMPHOTOXIN ALPHA ARE LIGANDS FOR HERPESVIRUS ENTRY MEDIATOR", IMMUNITY, CELL PRESS, US, vol. 8, January 1998 (1998-01-01), pages 21 - 30, XP002915183, ISSN: 1074-7613 *
MONTGOMERY R I ET AL: "HERPES SIMPLEX VIRUS-1 ENTRY INTO CELLS MEDIATED BY A NOVEL MEMBER OF THE TNF/NGF RECEPTOR FAMILY", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 87, 1 November 1996 (1996-11-01), pages 427 - 436, XP002911958, ISSN: 0092-8674 *
PUGLIELLI M T ET AL: "Reversal of virus -induced systemic shock and respiratory failure by blockade of the lymphotoxin pathway", NATURE MEDICINE, NATURE PUBLISHING, CO, US, vol. 5, no. 12, December 1999 (1999-12-01), pages 1370 - 1374, XP002132900, ISSN: 1078-8956 *
ZHAI Y ET AL: "LIGHT, A NOVEL LIGAND FOR LYMPHOTOXIN BETA RECEPTOR AND TR2/HVEM INDUCES APOPTOSIS AND SUPPRESSES IN VIVO TUMOR FORMATION VIA GENE TRANSFER", JOURNAL OF CLINICAL INVESTIGATION, NEW YORK, NY, US, vol. 102, no. 6, September 1998 (1998-09-01), pages 1142 - 1151, XP002947576, ISSN: 0021-9738 *

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