WO2001074406A3 - Dendrimer composition for magnetic resonance analysis - Google Patents

Dendrimer composition for magnetic resonance analysis Download PDF

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Publication number
WO2001074406A3
WO2001074406A3 PCT/US2001/010387 US0110387W WO0174406A3 WO 2001074406 A3 WO2001074406 A3 WO 2001074406A3 US 0110387 W US0110387 W US 0110387W WO 0174406 A3 WO0174406 A3 WO 0174406A3
Authority
WO
WIPO (PCT)
Prior art keywords
magnetic
dendrimer
magnetic resonance
cells
metal
Prior art date
Application number
PCT/US2001/010387
Other languages
French (fr)
Other versions
WO2001074406A2 (en
Inventor
Jeff W M Bulte
Trevor Douglas
Original Assignee
Us Gov Health & Human Serv
Jeff W M Bulte
Trevor Douglas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv, Jeff W M Bulte, Trevor Douglas filed Critical Us Gov Health & Human Serv
Priority to AU2001253041A priority Critical patent/AU2001253041A1/en
Publication of WO2001074406A2 publication Critical patent/WO2001074406A2/en
Publication of WO2001074406A3 publication Critical patent/WO2001074406A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1851—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule
    • A61K49/1863—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule the organic macromolecular compound being a polysaccharide or derivative thereof, e.g. chitosan, chitin, cellulose, pectin, starch

Abstract

A magnetic probe that includes magnetic-responsive metal (oxyhydr)oxide particles stabilized by a dendrimer. The magnetic probe may be a magnetic resonance (MR) contrast agent in the form of an aqueous suspension that includes iron oxide particles synthesized in the presence of a carboxy-terminated poly(amidoamine) dendrimer. Such magnetic probes are useful for labeling living cells to render the cells magnetic resonance sensitive by contacting the magnetic probe with the cells to be labeled and allowing the metal (oxyhydr)oxide-dendrimer composition to be internalized by the cell. The magnetic probes can be made by in situ oxidizing a metal ion-containing material in the presence of a dendrimer.
PCT/US2001/010387 2000-03-31 2001-03-30 Dendrimer composition for magnetic resonance analysis WO2001074406A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001253041A AU2001253041A1 (en) 2000-03-31 2001-03-30 Dendrimer composition for magnetic resonance analysis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19336000P 2000-03-31 2000-03-31
US60/193,360 2000-03-31

Publications (2)

Publication Number Publication Date
WO2001074406A2 WO2001074406A2 (en) 2001-10-11
WO2001074406A3 true WO2001074406A3 (en) 2002-10-24

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/010387 WO2001074406A2 (en) 2000-03-31 2001-03-30 Dendrimer composition for magnetic resonance analysis

Country Status (2)

Country Link
AU (1) AU2001253041A1 (en)
WO (1) WO2001074406A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6713173B2 (en) 1996-11-16 2004-03-30 Nanomagnetics Limited Magnetizable device
US6986942B1 (en) 1996-11-16 2006-01-17 Nanomagnetics Limited Microwave absorbing structure
US6815063B1 (en) 1996-11-16 2004-11-09 Nanomagnetics, Ltd. Magnetic fluid
GB2319253A (en) 1996-11-16 1998-05-20 Eric Leigh Mayes Composition, for use in a device, comprising a magnetic layer of domain-separated magnetic particles
US7047041B2 (en) 2002-06-17 2006-05-16 Nokia Corporation Method and device for storing and accessing personal information
ITFI20080117A1 (en) * 2008-06-26 2009-12-27 Colorobbia Italiana Spa USE OF COBALTO FERRITI AS A CONTRAST AGENT FOR MAGNETIC RESONANCE.

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995020405A1 (en) * 1994-01-28 1995-08-03 Nycomed Imaging As Oral magnetic particle formulation
WO1996009840A1 (en) * 1994-09-27 1996-04-04 Nycomed Imaging A/S Contrast agent
GB2311138A (en) * 1996-03-15 1997-09-17 Nycomed Imaging As ESR-enhanced MRI using magnetic particles as contrast agents
WO1998023293A1 (en) * 1996-11-28 1998-06-04 Nihon Schering K.K. Contrast compound, contrast medium for mri, and method for mri
WO2001082899A2 (en) * 2000-05-03 2001-11-08 Mbt Munich Biotechnology Ag Cationic diagnostic, imaging and therapeutic agents associated with activated vascular sites

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995020405A1 (en) * 1994-01-28 1995-08-03 Nycomed Imaging As Oral magnetic particle formulation
WO1996009840A1 (en) * 1994-09-27 1996-04-04 Nycomed Imaging A/S Contrast agent
GB2311138A (en) * 1996-03-15 1997-09-17 Nycomed Imaging As ESR-enhanced MRI using magnetic particles as contrast agents
WO1998023293A1 (en) * 1996-11-28 1998-06-04 Nihon Schering K.K. Contrast compound, contrast medium for mri, and method for mri
WO2001082899A2 (en) * 2000-05-03 2001-11-08 Mbt Munich Biotechnology Ag Cationic diagnostic, imaging and therapeutic agents associated with activated vascular sites

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DALDRUP H E ET AL: "Makromolekulare Kontrastmittel für die MR-Mammographie. Ein neuer Ansatz für die Charakterisierung von Mammatumoren.", DER RADIOLOGE. GERMANY SEP 1997, vol. 37, no. 9, September 1997 (1997-09-01), pages 733 - 740, XP008002339, ISSN: 0033-832X *
DATABASE DISSERTATION ABSTRACTS [online] University Microfilms International; 1999, ZHAO, MINGQI: "Hyperbranched polymer films and dendrimers: Their chemistry and applications", XP002197919, retrieved from DIALOG accession no. 01730684 Database accession no. AADAA-I9957557 *
DATABASE WPI Section Ch Week 199831, Derwent World Patents Index; Class A96, AN 1998-362357, XP002197920 *
DISSERTATION ABSTRACTS INTERNATIONAL, VOLUME 61, SECTION B, NO. 1, PAGE: 240. ABSTRACT OF THESIS (PH.D.), 1999, TEXAS A&M UNIVERSITY, 236 PAGES *
GARCIA M.E. ET AL: "Preparation and characterization of dendrimer-gold colloid nanocomposites", ANALYTICAL CHEMISTRY, 01 JAN 1999, VOL. 71, NO. 1, PAGE(S) 256-258, XP002197956 *
GORMAN C B ET AL: "USE OF A PARAMAGNETIC CORE TO AFFECT LONGITUDINAL NUCLEAR RELAXATION IN DENDRIMERS-A TOOL FOR PROBING DENDRIMER CONFORMATION", MACROMOLECULES, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 31, no. 3, 10 February 1998 (1998-02-10), pages 815 - 822, XP000735827, ISSN: 0024-9297 *

Also Published As

Publication number Publication date
AU2001253041A1 (en) 2001-10-15
WO2001074406A2 (en) 2001-10-11

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