WO2001072119A3 - Non-human animal model for growth deficiency and information processing or cognitive function defects and use thereof - Google Patents
Non-human animal model for growth deficiency and information processing or cognitive function defects and use thereof Download PDFInfo
- Publication number
- WO2001072119A3 WO2001072119A3 PCT/EP2001/003733 EP0103733W WO0172119A3 WO 2001072119 A3 WO2001072119 A3 WO 2001072119A3 EP 0103733 W EP0103733 W EP 0103733W WO 0172119 A3 WO0172119 A3 WO 0172119A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- animal model
- human animal
- modified
- cognitive function
- growth
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormones [GH] (Somatotropin)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2001265855A AU2001265855A1 (en) | 2000-03-31 | 2001-04-02 | Non-human animal model for growth deficiency and information processing or cognitive function defects and use thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2000116083 DE10016083A1 (en) | 2000-03-31 | 2000-03-31 | Non-human animal model for growth deficiency and defects in information processing or cognitive function and its use |
DE10016083.2 | 2000-03-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001072119A2 WO2001072119A2 (en) | 2001-10-04 |
WO2001072119A3 true WO2001072119A3 (en) | 2002-02-07 |
Family
ID=7637142
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2001/003733 WO2001072119A2 (en) | 2000-03-31 | 2001-04-02 | Non-human animal model for growth deficiency and information processing or cognitive function defects and use thereof |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU2001265855A1 (en) |
DE (1) | DE10016083A1 (en) |
WO (1) | WO2001072119A2 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020031829A1 (en) * | 2000-08-15 | 2002-03-14 | Brian Zambrowicz | Arrayed collection of genomic clones |
WO2010146059A2 (en) | 2009-06-16 | 2010-12-23 | F. Hoffmann-La Roche Ag | Biomarkers for igf-1r inhibitor therapy |
JP7341230B2 (en) * | 2018-10-24 | 2023-09-13 | コリア リサーチ インスティチュート オブ バイオサイエンス アンド バイオテクノロジー | IGF-1 gene mutation dwarfism animal model and its production method |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990004788A1 (en) * | 1988-10-28 | 1990-05-03 | Genentech, Inc. | Method for identifying active domains and amino acid residues in polypeptides and hormone variants |
WO1999046298A2 (en) * | 1998-03-12 | 1999-09-16 | Universiteit Utrecht | Controlling availability or activity of proteins by use of protease inhibitors or receptor fragments |
-
2000
- 2000-03-31 DE DE2000116083 patent/DE10016083A1/en not_active Withdrawn
-
2001
- 2001-04-02 AU AU2001265855A patent/AU2001265855A1/en not_active Abandoned
- 2001-04-02 WO PCT/EP2001/003733 patent/WO2001072119A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990004788A1 (en) * | 1988-10-28 | 1990-05-03 | Genentech, Inc. | Method for identifying active domains and amino acid residues in polypeptides and hormone variants |
WO1999046298A2 (en) * | 1998-03-12 | 1999-09-16 | Universiteit Utrecht | Controlling availability or activity of proteins by use of protease inhibitors or receptor fragments |
Non-Patent Citations (3)
Title |
---|
JIN L ET AL: "High resolution functional analysis of antibody-antigen interactions", J MOL BIOL, vol. 226, no. 3, 5 August 1992 (1992-08-05), pages 851 - 865, XP001030520 * |
SMITH L ET AL: "Essential role of growth hormone in ischemia-induced retinal neovascularization", SCIENCE, vol. 276, no. 5319, 13 June 1997 (1997-06-13), pages 1706 - 1709, XP002179757 * |
WICAR S ET AL: "Conformational changes in the reversed phase liquid chromatography of recombinant human growth hormone as a function of organic solvent: the molten globule state", ANAL CHEM, vol. 66, no. 22, 15 November 1994 (1994-11-15), pages 3908 - 3915, XP002179758 * |
Also Published As
Publication number | Publication date |
---|---|
DE10016083A1 (en) | 2001-10-18 |
AU2001265855A1 (en) | 2001-10-08 |
WO2001072119A2 (en) | 2001-10-04 |
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