WO2001051664A3 - Method of detecting and characterizing a neoplasm - Google Patents

Method of detecting and characterizing a neoplasm Download PDF

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Publication number
WO2001051664A3
WO2001051664A3 PCT/US2001/001081 US0101081W WO0151664A3 WO 2001051664 A3 WO2001051664 A3 WO 2001051664A3 US 0101081 W US0101081 W US 0101081W WO 0151664 A3 WO0151664 A3 WO 0151664A3
Authority
WO
WIPO (PCT)
Prior art keywords
detecting
neoplasm
characterizing
disclosed
methods
Prior art date
Application number
PCT/US2001/001081
Other languages
French (fr)
Other versions
WO2001051664A2 (en
Inventor
Katherine J Martin
Arthur Pardee
Ruth Di Sager
Original Assignee
Dana Farber Cancer Inst Inc
Katherine J Martin
Arthur Pardee
Pardee Arthur Hm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Inst Inc, Katherine J Martin, Arthur Pardee, Pardee Arthur Hm filed Critical Dana Farber Cancer Inst Inc
Publication of WO2001051664A2 publication Critical patent/WO2001051664A2/en
Publication of WO2001051664A3 publication Critical patent/WO2001051664A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)

Abstract

Disclosed are methods of detecting neoplasms, such as breast carcinomas, using differentially expressed genes. Also disclosed are methods of identifying agents for treating neoplasms.
PCT/US2001/001081 2000-01-12 2001-01-12 Method of detecting and characterizing a neoplasm WO2001051664A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17566900P 2000-01-12 2000-01-12
US60/175,669 2000-01-12

Publications (2)

Publication Number Publication Date
WO2001051664A2 WO2001051664A2 (en) 2001-07-19
WO2001051664A3 true WO2001051664A3 (en) 2002-09-06

Family

ID=22641159

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/001081 WO2001051664A2 (en) 2000-01-12 2001-01-12 Method of detecting and characterizing a neoplasm

Country Status (1)

Country Link
WO (1) WO2001051664A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6763307B2 (en) 2000-03-06 2004-07-13 Bioseek, Inc. Patient classification
US6656695B2 (en) 2000-03-06 2003-12-02 Bioseek, Inc. Biomap characterization of biologically active agents
WO2002099421A2 (en) * 2001-05-18 2002-12-12 Thomas Jefferson University Specific microarrays for breast cancer screening
US20040231909A1 (en) 2003-01-15 2004-11-25 Tai-Yang Luh Motorized vehicle having forward and backward differential structure
JP4943074B2 (en) * 2006-07-03 2012-05-30 シスメックス株式会社 Method and apparatus for determining cancer metastasis
GB201000688D0 (en) * 2010-01-15 2010-03-03 Diagenic Asa Product and method
EP2922971B1 (en) * 2012-11-20 2018-10-17 Lund, Tore Eiliv Gene expression profile in diagnostics

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996029430A1 (en) * 1995-03-17 1996-09-26 John Wayne Cancer Institute Detection of melanoma or breast metastases with a multiple marker assay
WO1999001581A1 (en) * 1997-07-02 1999-01-14 Genzyme Corporation P53 influenced gene expression
WO1999044062A1 (en) * 1998-02-25 1999-09-02 The United States Of America As Represented By The Secretary Department Of Health And Human Services Cellular arrays for rapid molecular profiling

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996029430A1 (en) * 1995-03-17 1996-09-26 John Wayne Cancer Institute Detection of melanoma or breast metastases with a multiple marker assay
WO1999001581A1 (en) * 1997-07-02 1999-01-14 Genzyme Corporation P53 influenced gene expression
WO1999044062A1 (en) * 1998-02-25 1999-09-02 The United States Of America As Represented By The Secretary Department Of Health And Human Services Cellular arrays for rapid molecular profiling

Non-Patent Citations (17)

* Cited by examiner, † Cited by third party
Title
BREAST CANCER RESEARCH AND TREATMENT, vol. 37, no. 2, 1996, pages 179 - 188, ISSN: 0167-6806 *
CANCER RESEARCH, vol. 60, no. 8, April 2000 (2000-04-01), pages 2232 - 2238, ISSN: 0008-5472 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1992, MATSUMURA YASUHIRO ET AL: "Significance of CD44 gene products for cancer diagnosis and disease evaluation.", XP002188524, Database accession no. PREV199395040761 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1996, BUESO-RAMOS CARLOS E ET AL: "Abnormal expression of MDM-2 in breast carcinomas.", XP002188523, Database accession no. PREV199698698113 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; April 2000 (2000-04-01), MARTIN KATHERINE J ET AL: "Linking gene expression patterns to therapeutic groups in breast cancer.", XP002188525, Database accession no. PREV200000214990 *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; DRABEROVA E ET AL: "Expression of class III beta-tubulin in normal and neoplastic human tissues.", XP002188292, retrieved from STN Database accession no. 1998200544 *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; RANGANATHAN S ET AL: "Immunohistochemical analysis of beta-tubulin isotypes in human prostate carcinoma and benign prostatic hypertrophy.", XP002188293, retrieved from STN Database accession no. 97265698 *
HISTOCHEMISTRY AND CELL BIOLOGY, (1998 MAR) 109 (3) 231-9. *
JIANG MING ET AL: "p21/waf1/cip1 and mdm-2 expression in breast carcinoma patients as related to prognosis.", INTERNATIONAL JOURNAL OF CANCER, vol. 74, no. 5, 21 October 1997 (1997-10-21), pages 529 - 534, XP002188291, ISSN: 0020-7136 *
LANCET (NORTH AMERICAN EDITION), vol. 340, no. 8827, 1992, pages 1053 - 1058, ISSN: 0099-5355 *
MARTIN K J ET AL: "IDENTIFICATION AND VERIFICATION OF DIFFERENTIAL DISPLAY CDNAS USINGGENE-SPECIFIC PRIMERS AND HYBRIDIZATION ARRAYS", BIOTECHNIQUES, EATON PUBLISHING, NATICK, US, vol. 24, no. 6, 1 June 1998 (1998-06-01), pages 1018 - 1024,1026, XP000780498, ISSN: 0736-6205 *
MARTIN KATHERINE J ET AL: "High-sensitivity array analysis of gene expression for the early detection of disseminated breast tumor cells in peripheral blood.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 98, no. 5, 27 February 2001 (2001-02-27), February 27, 2001, pages 2646 - 2651, XP002188522, ISSN: 0027-8424 *
MARTIN, K. J. (1) ET AL: "A hybridization array assay using differential display-identified markers for early detection and staging of breast cancer.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, (MARCH, 1999) VOL. 40, PP. 319. MEETING INFO.: 90TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH PHILADELPHIA, PENNSYLVANIA, USA APRIL 10-14, 1999 AMERICAN, XP001026342 *
PROSTATE, (1997 MAR 1) 30 (4) 263-8. *
SGROI D C ET AL: "IN VIVO GENE EXPRESSION PROFILE ANALYSIS OF HUMAN BREAST CANCER PROGRESSION", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 59, no. 22, 15 November 1999 (1999-11-15), pages 5656 - 5661, XP000994514, ISSN: 0008-5472 *
TANAKA TAKEO ET AL: "Prognostic discrimination among neuroblastomas according to Ha-ras/trk A gene expression: A comparison of the profiles of neuroblastomas detected clinically and those detected through mass screening.", CANCER, vol. 83, no. 8, 15 October 1998 (1998-10-15), pages 1626 - 1633, XP002188290, ISSN: 0008-543X *
YOUNGS SARA J ET AL: "Chemokines induce migrational responses in human breast carcinoma cell lines.", INTERNATIONAL JOURNAL OF CANCER, vol. 71, no. 2, 1997, pages 257 - 266, XP002166394, ISSN: 0020-7136 *

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