WO2001047519A1 - Powdery biotin preparations - Google Patents

Powdery biotin preparations Download PDF

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Publication number
WO2001047519A1
WO2001047519A1 PCT/JP2000/008758 JP0008758W WO0147519A1 WO 2001047519 A1 WO2001047519 A1 WO 2001047519A1 JP 0008758 W JP0008758 W JP 0008758W WO 0147519 A1 WO0147519 A1 WO 0147519A1
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WIPO (PCT)
Prior art keywords
water
soluble
phosphate
piotin
biotin
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PCT/JP2000/008758
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French (fr)
Japanese (ja)
Inventor
Kunihiko Furuzawa
Original Assignee
Sumitomo Chemical Company, Limited
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Application filed by Sumitomo Chemical Company, Limited filed Critical Sumitomo Chemical Company, Limited
Priority to AU17363/01A priority Critical patent/AU1736301A/en
Publication of WO2001047519A1 publication Critical patent/WO2001047519A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals

Definitions

  • the present invention relates to a powdered preparation of piotin.
  • Vitamins are essential nutrients for humans and animals, and their deficiency has a significant effect on growth and health.Therefore, various foods and feeds containing vitamins to supplement them are known. Have been. By the way, biotin, a kind of vitamins, is also necessary for the growth of animals and plants, but has poor water solubility, and there has been a demand for a water-soluble powdery formulation that can be easily administered. Disclosure of the invention
  • the present invention provides a powdery preparation of piotin, particularly a pulverulent preparation having excellent solubility in water, comprising 0.1 to 40% by weight, preferably 2 to 40% by weight of piotin, 60-9.8% by weight, preferably 60-98% by weight of water-soluble saccharide and 0:!-40% by weight, preferably 2-40% by weight of water-soluble saccharide
  • the present invention relates to a powdery preparation of biotin containing one or more water-soluble salts selected from the group consisting of a water-soluble phosphate and a water-soluble carbonate.
  • a water-soluble saccharide that can be used in the fields of medicine, food, and feed is used.
  • Specific examples include monosaccharides such as glucose, lactose, galactose, fructose, and xylose; trehalose; Examples include disaccharides such as sucrose and maltose, and polysaccharides such as soluble starch.
  • These saccharides may be used alone, or two or more types may be used in combination. Is also good.
  • the soluble starch is a water-soluble dextrin obtained by partially hydrolyzing starch by an enzyme, a dilute acid, or heating.
  • the water-soluble salt used in the present invention is a water-soluble phosphate or a water-soluble carbonate.
  • water-soluble means that the solubility at 20 ° C. in water is 1% by weight or more.
  • Specific examples of the water-soluble salt include sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium phosphate, potassium dihydrogen phosphate, potassium dihydrogen phosphate, potassium phosphate, ammonium dihydrogen phosphate, diammonium hydrogen phosphate, phosphorus Acid ammonium, sodium carbonate, sodium bicarbonate, and ammonium bicarbonate.
  • the biotin preparation of the present invention may contain, in addition to biotin, the water-soluble saccharide and the above-mentioned water-soluble salt, auxiliary agents such as a fungicide and an antistatic agent for improving fluidity.
  • auxiliary agents such as a fungicide and an antistatic agent for improving fluidity.
  • the fungicide include sorbic acid, sodium sorbate, potassium sorbate, propionic acid, and sodium propionate.
  • Specific examples of the antistatic agent include calcined silica.
  • the antifungal agent and the antistatic agent are usually used such that each contains 0.1 to 2% by weight based on the total weight of the biotin preparation.
  • the biotin preparation of the present invention has excellent solubility in water, it is convenient to use by adding it to drinking water, etc., for example, about 100 to 10,000 times by weight, preferably 50 to 8000 times by weight. Diluted with water to a certain degree and used for animals such as humans, livestock, and pets. Further, the biotin preparation of the present invention can be used as it is in a feed as it is, and the amount of addition is usually about 1 g to 1 kg per ton of the feed.
  • Example 1 The same operation as in Example 1 was carried out except for using each component and the amount thereof shown in Table 1, to obtain each dust.
  • Example 2 1 g of the powder obtained in Example 1 was placed in a container, 1 Om1 of water was added thereto, and the mixture was stirred, and completely dissolved within 5 minutes.
  • Example 1 10 g of the powder obtained in Example 1 was sealed in an aluminum After storing in a thermostat for 2 weeks, the same test was performed, and it was completely dissolved within 5 minutes.
  • the content of piotin was measured after measuring the content of piotin, sealed in an aluminum bag, and stored in a thermostat at 54 ° C for 2 weeks. When the amount was measured, no change in the content of piotin was observed before and after storage.

Abstract

Powdery biotin preparations highly soluble in water which contain from 0.1 to 40% by weight of biotin, from 60 to 99.8% by weight of water-soluble saccharides and from 0.1 to 40% by weight of one or more water-soluble salts selected from the group consisting of water-soluble phosphoric acid salts and water-soluble carbonic acid salts.

Description

明 細 書 粉状ピオチン製剤 技術分野  Description Powdered biotin preparation Technical field
本発明は、 ピオチンの粉状製剤に関する。 冃景： 技術  The present invention relates to a powdered preparation of piotin. Landscape: Technology
ビタミン類は人や動物等にとって必須の栄養素であり、 その欠乏は成長、 健 康に重大な影響を及ぼすことから、 これを補充するためにビタミン類を含有す る種々の食品、 飼料等が知られている。 ところで、 ビタミン類の一種であるビ ォチンも動植物の生育に必要な物質であるが、 水溶性に乏しいことから、 簡単 に投与できる水溶性の粉状製剤の開発が望まれていた。 発明の開示  Vitamins are essential nutrients for humans and animals, and their deficiency has a significant effect on growth and health.Therefore, various foods and feeds containing vitamins to supplement them are known. Have been. By the way, biotin, a kind of vitamins, is also necessary for the growth of animals and plants, but has poor water solubility, and there has been a demand for a water-soluble powdery formulation that can be easily administered. Disclosure of the invention
本発明は、 ピオチンの粉状製剤、 特に、 水に対する優れた溶解性を有する粉 状製剤を提供するものであり、 0 . 1〜4 0重量％、 好ましくは 2〜4 0重量 %のピオチン、 6 0〜9 9 . 8重量％、 好ましくは 6 0〜9 8重量％の水溶性 糖類 （water-soluble saccharide) 並びに 0 . ：!〜 4 0重量％、 好ましくは 2 〜 4 0重量％の水溶性燐酸塩及び水溶性炭酸塩からなる群より選ばれる一種以 上の水溶性塩を含有するピオチンの粉状製剤に関するものである。  The present invention provides a powdery preparation of piotin, particularly a pulverulent preparation having excellent solubility in water, comprising 0.1 to 40% by weight, preferably 2 to 40% by weight of piotin, 60-9.8% by weight, preferably 60-98% by weight of water-soluble saccharide and 0:!-40% by weight, preferably 2-40% by weight of water-soluble saccharide The present invention relates to a powdery preparation of biotin containing one or more water-soluble salts selected from the group consisting of a water-soluble phosphate and a water-soluble carbonate.
本発明において用いられる糖類としては、 医薬、 食品、 飼料分野において利 用できる水溶性のものが用いられ、 具体例としては、 グルコース、 ラク ] ス 、 ガラクトース、 フラクトース、 キシロース等の単糖類、 トレハロース、 蔗糖 、 マル! ス等の二糖類、 可溶性澱粉 （soluble starch) 等の多糖類等を挙げ ることができ、 これらの糖類は単独で用いてもよく、 また、 2種類以上を組み 合わせて用いてもよい。 尚、 可溶性澱粉とは、 澱粉を酵素、 希酸、 加熱等によ り部分加水分解して得られる水に溶け易いデキストリンである。  As the saccharide used in the present invention, a water-soluble saccharide that can be used in the fields of medicine, food, and feed is used. Specific examples include monosaccharides such as glucose, lactose, galactose, fructose, and xylose; trehalose; Examples include disaccharides such as sucrose and maltose, and polysaccharides such as soluble starch. These saccharides may be used alone, or two or more types may be used in combination. Is also good. The soluble starch is a water-soluble dextrin obtained by partially hydrolyzing starch by an enzyme, a dilute acid, or heating.
本発明において用いられる水溶性塩は水溶性燐酸塩又は水溶性炭酸塩であり 、 ここで水溶性とは水に対する 2 0 °Cにおける溶解度が 1重量％以上であるこ とを意味している。 該水溶性塩の具体例としては、 燐酸二水素ナトリウム、 燐 酸水素ニナトリウム、 燐酸ナトリウム、 燐酸二水素カリウム、 燐酸水素二カリ ゥム、 燐酸カリウム、 燐酸二水素アンモニゥム、 燐酸水素二アンモニゥム、 燐 酸アンモニゥム、 炭酸ナトリウム、 炭酸水素ナトリウム、 炭酸水素アンモニゥ ムがあげられる。 The water-soluble salt used in the present invention is a water-soluble phosphate or a water-soluble carbonate. Here, “water-soluble” means that the solubility at 20 ° C. in water is 1% by weight or more. Specific examples of the water-soluble salt include sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium phosphate, potassium dihydrogen phosphate, potassium dihydrogen phosphate, potassium phosphate, ammonium dihydrogen phosphate, diammonium hydrogen phosphate, phosphorus Acid ammonium, sodium carbonate, sodium bicarbonate, and ammonium bicarbonate.
本発明のピオチン製剤は、 ピオチン、 水溶性糖類及び上記の水溶性塩の他に 、 例えば防黴剤や、 流動性向上のための静電気防止剤等の補助剤を含有しても よい。 防黴剤の具体例としては、 ソルビン酸、 ソルビン酸ナトリウム、 ソルビ ン酸カリウム、 プロピオン酸、 プロピオン酸ナトリウムがあげられ、 静電気防 止剤の具体例としては、 焼成シリカがあげられる。 防黴剤や静電気防止剤は、 ピオチン製剤の全重量に対して、 通常、 各々が 0 . 1〜2重量％含有されるよ うに用いられる。  The biotin preparation of the present invention may contain, in addition to biotin, the water-soluble saccharide and the above-mentioned water-soluble salt, auxiliary agents such as a fungicide and an antistatic agent for improving fluidity. Specific examples of the fungicide include sorbic acid, sodium sorbate, potassium sorbate, propionic acid, and sodium propionate. Specific examples of the antistatic agent include calcined silica. The antifungal agent and the antistatic agent are usually used such that each contains 0.1 to 2% by weight based on the total weight of the biotin preparation.
本発明のピオチン製剤は、 例えば、 ピオチン、 水溶性糖類及び上記の水溶性 塩を、 混合、 微細粉枠することにより得られる。 例えば、 所定量のピオチン、 水溶性糖類及び上記の水溶性塩、 さらに必要により防黴剤、 静電気防止剤等を ミキサーで、 室温又は必要により冷却しながら、 1 500〜3000 rpmにて、 5〜3 0分程度攪拌混合することにより得られる。 本発明のピオチン製剤は粉状であ り、 通常、 その 9 5重量％を超える量が 1 5 0メッシュ篩を通過する程度の大 きさである。  The biotin preparation of the present invention can be obtained, for example, by mixing and finely pulverizing biotin, a water-soluble saccharide and the above water-soluble salt. For example, a predetermined amount of biotin, a water-soluble saccharide and the above-mentioned water-soluble salt, and, if necessary, a fungicide, an antistatic agent, etc., with a mixer at room temperature or, if necessary, cooling at 1,500 to 3,000 rpm for 5 to 5 minutes. It is obtained by stirring and mixing for about 30 minutes. The biotin preparation of the present invention is in the form of a powder, and is generally large enough that more than 95% by weight of the preparation passes through a 150 mesh sieve.
本発明のピオチン製剤は水に対する溶解性が優れることから、 飲料水等に添 加して使用するのに便利であり、 例えば、 重量割合で 1 0〜10000 倍程度、 好ま しくは 50〜8000倍程度に水で希釈して人、 家畜、 ペット等の動物に供される。 また、 本発明のピオチン製剤をそのまま飼料に添加して使用することもでき、 添加量は、 通常、 飼料 1 トンあたり 1 g〜 1 k g程度である。  Since the biotin preparation of the present invention has excellent solubility in water, it is convenient to use by adding it to drinking water, etc., for example, about 100 to 10,000 times by weight, preferably 50 to 8000 times by weight. Diluted with water to a certain degree and used for animals such as humans, livestock, and pets. Further, the biotin preparation of the present invention can be used as it is in a feed as it is, and the amount of addition is usually about 1 g to 1 kg per ton of the feed.
尚、 本発明のピオチン製剤は、 保存時の吸湿を避けるために、 アルミ袋や内 装がアルミコ一ティングされた紙袋、 ポリ袋等に包装された状態で保存するの が好ましい。 実施例 The biotin preparation of the present invention is preferably stored in an aluminum bag or a paper bag or a plastic bag in which the inner part is coated with aluminum in order to avoid moisture absorption during storage. Example
以下、 実施例により本発明をさらに詳細に説明するが、 本発明はこれらに限 定されるものではない。  Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited thereto.
実施例 1  Example 1
ピオチン 2重量部、 アミコール 6 L (日澱化学株式会社製可溶性澱粉） 9 6 重量部、 燐酸水素ニナトリウム 2重量部及びソルビン酸 0 . 0 1重量部をジュ —サーミキサーで解砕、 混合して微粉末状の白色粉剤 （粒径： < 1 0 0 m) を得た。  2 parts by weight of piotin, 6 parts by weight of AMICOL (soluble starch manufactured by Nisseki Chemical Co., Ltd.), 96 parts by weight of disodium hydrogen phosphate and 0.01 part by weight of sorbic acid were crushed and mixed with a juicer mixer. As a result, a fine powdery white powder (particle diameter: <100 m) was obtained.
実施例 2 9  Example 2 9
表 1に示す各成分及びその量を用いる以外は実施例 1と同様の操作を行い、 各 粉剤を得た。  The same operation as in Example 1 was carried out except for using each component and the amount thereof shown in Table 1, to obtain each dust.
Figure imgf000004_0001
試験例 1
Figure imgf000004_0001
Test example 1
実施例 1で得られた粉剤 1 gを容器中に取り、 .れに水1 O m 1を加えて攪 拌したところ、 5分以内に完全に溶解した。  1 g of the powder obtained in Example 1 was placed in a container, 1 Om1 of water was added thereto, and the mixture was stirred, and completely dissolved within 5 minutes.
また、 実施例 1で得られた粉剤 1 0 gをアル- ：ゥム袋中に密封し、 5 4 °C の恒温器中で 2週間保存した後上記と同じ試験を行ったところ、 5分以内に完 全に溶解した。 Also, 10 g of the powder obtained in Example 1 was sealed in an aluminum After storing in a thermostat for 2 weeks, the same test was performed, and it was completely dissolved within 5 minutes.
参考例 Reference example
実施例 1及び 2で得られた粉剤につき、 ピオチンの含有量を測定した後アル ミニゥム袋中に密封し、 5 4 °Cの恒温器中で 2週間保存した後、 製剤中のピオ チンの含有量を測定したところ、 保存前後でピオチンの含有量の変化は全く認 められなかった。 産業上の利用可能性  For the powder obtained in Examples 1 and 2, the content of piotin was measured after measuring the content of piotin, sealed in an aluminum bag, and stored in a thermostat at 54 ° C for 2 weeks. When the amount was measured, no change in the content of piotin was observed before and after storage. Industrial applicability
本発明の粉状製剤は水に対する溶解性が優れ、 かつ保存安定性においても優 れていることから、 本発明によって、 通常は水に溶解し難いビタミン類の一種 であるピオチンを容易にそして速やかに溶解することが可能となる。  Since the powdery preparation of the present invention has excellent solubility in water and excellent storage stability, the present invention makes it possible to easily and quickly obtain biotin, which is a kind of vitamin which is usually hardly soluble in water, by the present invention. Can be dissolved.

Claims

請 求 の 範 囲 The scope of the claims
I . 0 . 1〜4 0重量％のピオチン、 6 0〜9 9 . 8重量％の水溶性糖類 並びに 0 . 1〜4 0重量％の水溶性燐酸塩及び水溶性炭酸塩からなる群より選 ばれる一種以上の水溶性塩を含有するピオチンの粉状製剤。 I. selected from the group consisting of 0.1 to 40% by weight of biotin, 60 to 99.8% by weight of a water-soluble saccharide, and 0.1 to 40% by weight of a water-soluble phosphate and a water-soluble carbonate. Piotin powder formulation containing one or more water-soluble salts.
2 . 水溶性塩が燐酸二水素ナトリウム、 燐酸水素ニナトリウム、 燐酸ナト リウム、 燐酸二水素カリウム、 燐酸水素二カリウム、 燐酸カリウム、 燐酸二水 素アンモニゥム、 燐酸水素二アンモニゥム、 燐酸アンモニゥム、 炭酸ナトリウ ム、 炭酸水素ナトリゥム又は炭酸水素アンモニゥムである請求項 1に記載のビ ォチンの粉状製剤。  2. The water-soluble salt is sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium phosphate, potassium dihydrogen phosphate, dipotassium hydrogen phosphate, potassium phosphate, ammonium dihydrogen phosphate, diammonium hydrogen phosphate, ammonium phosphate, sodium carbonate The powdery preparation of biotin according to claim 1, which is sodium hydrogencarbonate or ammonium hydrogencarbonate.
3 . 水溶性塩が燐酸水素ニナトリゥムである請求項 1に記載のピオチンの 粉状製剤。  3. The powdery preparation of piotin according to claim 1, wherein the water-soluble salt is ninadium hydrogen phosphate.
4. 水溶性塩が燐酸水素二アンモニゥムである請求項 1に記載のピオチン の粉状製剤。  4. The powdery preparation of piotin according to claim 1, wherein the water-soluble salt is diammonium hydrogen phosphate.
5 . 水溶性塩が燐酸力リゥムである請求項 1に記載のピオチンの粉状製剤 5. The powdery preparation of piotin according to claim 1, wherein the water-soluble salt is phosphoric acid lime.
6. 水溶性塩が燐酸ナトリゥムである請求項 1に記載のピオチンの粉状製 剤。 6. The powdery biotin preparation according to claim 1, wherein the water-soluble salt is sodium phosphate.
7 . 水溶性塩が炭酸ナトリゥムである請求項 1に記載のピオチンの粉状製 剤。  7. The powdery preparation of piotin according to claim 1, wherein the water-soluble salt is sodium carbonate.
8. 水溶性塩が炭酸水素アンモニゥムである請求項 1に記載のピオチンの 粉状製剤。  8. The powdery preparation of piotin according to claim 1, wherein the water-soluble salt is ammonium bicarbonate.
9. 水溶性塩が炭酸水素ナトリゥムである請求項 1に記載のピオチンの粉状 製剤。  9. The powdery preparation of piotin according to claim 1, wherein the water-soluble salt is sodium bicarbonate.
1 0. 水溶性糖類が、 グルコース、 ラクトース、 ガラクトース、 フラク 1 ^一 ス、 キシロース、 トレハロース、 蔗糖、 マルト一ス又は可溶性澱粉である請求 項 1に記載のピオチンの粉状製剤。 10. The powdery preparation of biotin according to claim 1, wherein the water-soluble saccharide is glucose, lactose, galactose, fruc-lose, xylose, trehalose, sucrose, maltose or soluble starch.
I I . 水溶性糖類が可溶性澱粉である請求項 1に記載のピオチンの粉状製剤  I I. The powdery preparation of piotin according to claim 1, wherein the water-soluble saccharide is soluble starch.
PCT/JP2000/008758 1999-12-24 2000-12-11 Powdery biotin preparations WO2001047519A1 (en)

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EP0036902A1 (en) * 1980-04-01 1981-10-07 Sumitomo Chemical Company, Limited Process for the production of water-soluble biotin-containing preparations and their use as additives to feed supplements
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JPH11130663A (en) * 1997-08-25 1999-05-18 Taisho Pharmaceut Co Ltd Solid formulation blended with slightly water soluble ingredient

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