WO2001044515A3 - Compositions et procede permettant de realiser des reactions biologiques - Google Patents

Compositions et procede permettant de realiser des reactions biologiques Download PDF

Info

Publication number
WO2001044515A3
WO2001044515A3 PCT/US2000/034145 US0034145W WO0144515A3 WO 2001044515 A3 WO2001044515 A3 WO 2001044515A3 US 0034145 W US0034145 W US 0034145W WO 0144515 A3 WO0144515 A3 WO 0144515A3
Authority
WO
WIPO (PCT)
Prior art keywords
biological reactions
performing biological
relates
reactions
multiplicity
Prior art date
Application number
PCT/US2000/034145
Other languages
English (en)
Other versions
WO2001044515A9 (fr
WO2001044515A2 (fr
Inventor
George W Hawkins
Original Assignee
Motorola Inc
George W Hawkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/464,490 external-priority patent/US6589778B1/en
Application filed by Motorola Inc, George W Hawkins filed Critical Motorola Inc
Priority to AU32641/01A priority Critical patent/AU778696B2/en
Priority to EP00991410A priority patent/EP1242819A2/fr
Priority to JP2001545592A priority patent/JP2003517156A/ja
Priority to CA002394275A priority patent/CA2394275A1/fr
Publication of WO2001044515A2 publication Critical patent/WO2001044515A2/fr
Publication of WO2001044515A3 publication Critical patent/WO2001044515A3/fr
Publication of WO2001044515A9 publication Critical patent/WO2001044515A9/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50853—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1816—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using induction heating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

Abstract

La présente invention concerne un dispositif permettant de réaliser des réactions biologiques. D'une manière spécifique, l'invention concerne un dispositif permettant de réaliser des réactions d'hybridation de l'acide nucléique sur une couche substrat possédant plusieurs sites de liaison d'oligonucléotides, au moyen de substrats dotés de couvertures souples.
PCT/US2000/034145 1999-12-15 2000-12-15 Compositions et procede permettant de realiser des reactions biologiques WO2001044515A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU32641/01A AU778696B2 (en) 1999-12-15 2000-12-15 Compositions and methods for performing biological reactions
EP00991410A EP1242819A2 (fr) 1999-12-15 2000-12-15 Compositions et procede permettant de realiser des reactions biologiques
JP2001545592A JP2003517156A (ja) 1999-12-15 2000-12-15 生物学的反応を行う組成物および方法
CA002394275A CA2394275A1 (fr) 1999-12-15 2000-12-15 Compositions et procede permettant de realiser des reactions biologiques

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/464,490 1999-12-15
US09/464,490 US6589778B1 (en) 1999-12-15 1999-12-15 Method and apparatus for performing biological reactions on a substrate surface
US60576600A 2000-06-28 2000-06-28
US09/605,766 2000-06-28

Publications (3)

Publication Number Publication Date
WO2001044515A2 WO2001044515A2 (fr) 2001-06-21
WO2001044515A3 true WO2001044515A3 (fr) 2002-03-07
WO2001044515A9 WO2001044515A9 (fr) 2002-07-04

Family

ID=27040998

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/034145 WO2001044515A2 (fr) 1999-12-15 2000-12-15 Compositions et procede permettant de realiser des reactions biologiques

Country Status (5)

Country Link
EP (1) EP1242819A2 (fr)
JP (1) JP2003517156A (fr)
AU (1) AU778696B2 (fr)
CA (1) CA2394275A1 (fr)
WO (1) WO2001044515A2 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0004296D0 (sv) * 2000-11-23 2000-11-23 Gyros Ab Device and method for the controlled heating in micro channel systems
EP2169383A1 (fr) * 2001-06-15 2010-03-31 Bayer Technology Services GmbH Organe pour l'écoulement à travers des cuvettes et son utilisation
EP1439910A2 (fr) * 2001-07-26 2004-07-28 Motorola, Inc. Systeme et procedes permettant d'effectuer des melanges dans un dispositif microfluidique
CZ297082B6 (cs) * 2002-06-03 2006-09-13 Ing. Ilja Krejcí-Engineering Soucástky s trojrozmernou strukturou pripravené tlustovrstvou technologií a zpusob jejich výroby
US20030235521A1 (en) * 2002-06-21 2003-12-25 Shea Laurence R. Array assay devices and methods of using the same
US7745203B2 (en) 2002-07-31 2010-06-29 Kabushiki Kaisha Toshiba Base sequence detection apparatus and base sequence automatic analyzing apparatus
JP4057967B2 (ja) * 2002-07-31 2008-03-05 株式会社東芝 塩基配列自動解析装置
US6913931B2 (en) 2002-10-03 2005-07-05 3M Innovative Properties Company Devices, methods and systems for low volume microarray processing
US20040101439A1 (en) * 2002-11-21 2004-05-27 Fusco Adam J Biological and chemical reaction devices and methods of manufacture
WO2005016532A2 (fr) * 2003-06-13 2005-02-24 Corning Incorporated Systeme automatise de chambre de reaction pour essais biologiques
DE10340473B4 (de) * 2003-09-03 2007-08-23 Eppendorf Ag Abdeckung einer Hybridisierungskammer
KR100601936B1 (ko) * 2003-12-17 2006-07-14 삼성전자주식회사 접착부 지지체와 2이상의 접착물질을 갖는 마이크로어레이반응 챔버용 패취
DE102004022263A1 (de) * 2004-05-06 2005-12-15 Clondiag Chip Technologies Gmbh Vorrichtung und Verfahren zum Nachweis von molekularen Wechselwirkungen
JP4732135B2 (ja) * 2005-11-10 2011-07-27 キヤノン株式会社 反応装置
JP4705504B2 (ja) * 2006-04-05 2011-06-22 アイダエンジニアリング株式会社 マイクロ流体チップ
CL2008003007A1 (es) * 2007-10-12 2009-10-02 Bigtec Private Ltd Un micro chip con capas de ceramicas de coccion conjunta a baja temperatura (ltcc) formando una camara de reaccion, anillos conductores que rodean a la camara de reaccion y un calentador que suministra calor a los anillos, el metodo de fabricacion del micro chip y un micro dispositivo de reaccion en cadena de polimerasa (pcr).
US20100071614A1 (en) * 2008-09-22 2010-03-25 Momentive Performance Materials, Inc. Fluid distribution apparatus and method of forming the same
JP2010236969A (ja) * 2009-03-31 2010-10-21 Hitachi High-Technologies Corp 核酸分析デバイス，核酸分析装置、及び核酸分析方法
JP6094393B2 (ja) * 2013-06-13 2017-03-15 住友ベークライト株式会社 被覆体、及び被覆体の使用方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997010056A2 (fr) * 1995-09-12 1997-03-20 Becton Dickinson And Company Dispositif et procede d'amplification et de dosage d'adn
WO1999019717A1 (fr) * 1997-10-15 1999-04-22 Aclara Biosciences, Inc. Dispositif a microstructure stratifiee et procede de fabrication de ce dispositif
WO1999042558A1 (fr) * 1998-02-20 1999-08-26 Nanogen, Inc. Dispositifs actifs evolues et procedes d'analyse et de diagnostic en biologie moleculaire
US5945334A (en) * 1994-06-08 1999-08-31 Affymetrix, Inc. Apparatus for packaging a chip

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229297A (en) * 1989-02-03 1993-07-20 Eastman Kodak Company Containment cuvette for PCR and method of use
US5856174A (en) * 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5907703A (en) * 1996-05-08 1999-05-25 Mijenix Corporation Device driver for accessing computer files

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5945334A (en) * 1994-06-08 1999-08-31 Affymetrix, Inc. Apparatus for packaging a chip
WO1997010056A2 (fr) * 1995-09-12 1997-03-20 Becton Dickinson And Company Dispositif et procede d'amplification et de dosage d'adn
WO1999019717A1 (fr) * 1997-10-15 1999-04-22 Aclara Biosciences, Inc. Dispositif a microstructure stratifiee et procede de fabrication de ce dispositif
WO1999042558A1 (fr) * 1998-02-20 1999-08-26 Nanogen, Inc. Dispositifs actifs evolues et procedes d'analyse et de diagnostic en biologie moleculaire

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1242819A2 *

Also Published As

Publication number Publication date
JP2003517156A (ja) 2003-05-20
EP1242819A2 (fr) 2002-09-25
WO2001044515A9 (fr) 2002-07-04
CA2394275A1 (fr) 2001-06-21
WO2001044515A2 (fr) 2001-06-21
AU3264101A (en) 2001-06-25
AU778696B2 (en) 2004-12-16

Similar Documents

Publication Publication Date Title
WO2001054814A3 (fr) Compositions et procedes de realisation de reactions biologiques
WO2001044515A3 (fr) Compositions et procede permettant de realiser des reactions biologiques
WO2004058945A3 (fr) Essais comparatifs d'hybridation de genomes utilisant des caracteres immobilises d'oligonucleotides, et compositions permettant de les mettre en oeuvre
WO2007011722A3 (fr) Systeme de decouverte de reaction
AU2965500A (en) Immobilized nucleic acid hybridization reagent and method
WO2000050869A3 (fr) Detection de polymorphisme nucleotidique simple (snp)
WO2000070088A3 (fr) Immobilisation de biopolymeres non modifies sur des substrats actives par fluorure d'acyle
EP2267439B8 (fr) Biocapteur pour la quantification d'un substrat
WO2004038363A3 (fr) Dispositif et procede de transport et de reaction par bouchons entraines par pression
WO2002088382A3 (fr) Procede d'analyse de chaines d'acide nucleique
WO2000002887A3 (fr) Ligands pour metaux et processus perfectionnes catalyses par des metaux bases sur ceux-ci
AU3959095A (en) A method for enhancing amplification in the polymerase chain reaction employing peptide nucleic acid (pna)
AU3015801A (en) Method for carrying out the parallel sequencing of a nucleic acid mixture on a surface
WO2003053845A3 (fr) Nanolithographie par fonctionnalisation chimique
GB9907813D0 (en) Synthesis
AU5062500A (en) Primers for identifying typing or classifying nucleic acids
WO2000060114A3 (fr) Sequencage de polynucleotide par helicase
AU2003231058A8 (en) Single nucleotide polymorphism analysis using surface invasive cleavage reactions
AU4353500A (en) Substrate including anionic detergent for purifying nucleic acid
AU1680900A (en) Method for immobilizing dna on a carrier
WO2002002795A3 (fr) Procede de sequençage multiplex
WO2002018655A3 (fr) Compositions et procedes conçus pour generer des jeux ordonnes de microechantillons d'adnc simple brin a reference de quantification universelle exacte
AU5920800A (en) Method for fractionating poly(ethylene oxide) formed using metallic cyanide catalyst
AU2003269908A1 (en) Multiplex nucleic acid reactions
AU2877000A (en) Photo-induced nucleic acid hybridization

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 2394275

Country of ref document: CA

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2001 545592

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 32641/01

Country of ref document: AU

AK Designated states

Kind code of ref document: C2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: C2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

COP Corrected version of pamphlet

Free format text: PAGES 1/16-16/16, DRAWINGS, REPLACED BY NEW PAGES 1/12-12/12; DUE TO LATE TRAASMITTAL BY THE RECEIVING OFFICE

WWE Wipo information: entry into national phase

Ref document number: 2000991410

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2000991410

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 10149660

Country of ref document: US

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWG Wipo information: grant in national office

Ref document number: 32641/01

Country of ref document: AU

WWW Wipo information: withdrawn in national office

Ref document number: 2000991410

Country of ref document: EP