WO2001042205A3 - Treatment of inflammatory bowel disease with vitamin d compounds - Google Patents

Treatment of inflammatory bowel disease with vitamin d compounds Download PDF

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Publication number
WO2001042205A3
WO2001042205A3 PCT/US2000/042393 US0042393W WO0142205A3 WO 2001042205 A3 WO2001042205 A3 WO 2001042205A3 US 0042393 W US0042393 W US 0042393W WO 0142205 A3 WO0142205 A3 WO 0142205A3
Authority
WO
WIPO (PCT)
Prior art keywords
vitamin
inflammatory bowel
bowel disease
compounds
treatment
Prior art date
Application number
PCT/US2000/042393
Other languages
French (fr)
Other versions
WO2001042205A2 (en
Inventor
Margherita T Cantorna
Original Assignee
Penn State Res Found
Margherita T Cantorna
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Penn State Res Found, Margherita T Cantorna filed Critical Penn State Res Found
Priority to JP2001543506A priority Critical patent/JP2003516386A/en
Priority to AU45100/01A priority patent/AU4510001A/en
Priority to EP00992552A priority patent/EP1233942A2/en
Priority to CA002390859A priority patent/CA2390859A1/en
Publication of WO2001042205A2 publication Critical patent/WO2001042205A2/en
Publication of WO2001042205A3 publication Critical patent/WO2001042205A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A method of treating inflammatory bowel disease, particularly ulcerative colitis and Crohn's disease, is disclosed. The method involves administering a vitamin D compound in an amount effective to treat the disease. The administration of a vitamin D compound also prevents the development of or delays the onset of inflammatory bowel disease in susceptible individuals.
PCT/US2000/042393 1999-12-02 2000-11-30 Treatment of inflammatory bowel disease with vitamin d compounds WO2001042205A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2001543506A JP2003516386A (en) 1999-12-02 2000-11-30 Treatment of inflammatory bowel disease with vitamin D compounds
AU45100/01A AU4510001A (en) 1999-12-02 2000-11-30 Treatment of inflammatory bowel disease with vitamin d compounds
EP00992552A EP1233942A2 (en) 1999-12-02 2000-11-30 Treatment of inflammatory bowel disease with vitamin d compounds
CA002390859A CA2390859A1 (en) 1999-12-02 2000-11-30 Treatment of inflammatory bowel disease with vitamin d compounds

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US16850199P 1999-12-02 1999-12-02
US60/168,501 1999-12-02
US19782700P 2000-04-14 2000-04-14
US60/197,827 2000-04-14
US20863200P 2000-06-01 2000-06-01
US60/208,632 2000-06-01
US23190600P 2000-09-11 2000-09-11
US60/231,906 2000-09-11

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/969,394 Continuation US20050070513A1 (en) 1999-12-02 2004-10-20 Treatment of inflammatory bowel disease with vitamin D compounds

Publications (2)

Publication Number Publication Date
WO2001042205A2 WO2001042205A2 (en) 2001-06-14
WO2001042205A3 true WO2001042205A3 (en) 2002-03-21

Family

ID=27496796

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/042393 WO2001042205A2 (en) 1999-12-02 2000-11-30 Treatment of inflammatory bowel disease with vitamin d compounds

Country Status (5)

Country Link
EP (1) EP1233942A2 (en)
JP (1) JP2003516386A (en)
AU (1) AU4510001A (en)
CA (1) CA2390859A1 (en)
WO (1) WO2001042205A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6358939B1 (en) * 1999-12-21 2002-03-19 Northern Lights Pharmaceuticals, Llc Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
US6989377B2 (en) * 1999-12-21 2006-01-24 Wisconsin Alumni Research Foundation Treating vitamin D responsive diseases
AU2012326485B2 (en) * 2011-10-21 2016-12-08 Wisconson Alumni Research Foundation 2-methylene-vitamin D analogs and their uses
JP6397695B2 (en) * 2014-08-25 2018-09-26 学校法人自治医科大学 Anti-pylori agent
EP3331533B1 (en) * 2015-08-05 2021-09-01 Wisconsin Alumni Research Foundation Synthesis and biological activity of 2-methylene analogs of calcitriol and related compounds
WO2021161312A1 (en) * 2020-02-11 2021-08-19 The E. Wolfson Medical Center A method effective for treating ulcerative colitis

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05294834A (en) * 1990-02-09 1993-11-09 Teijin Ltd Treating agent containing activated vitamin d
DE4405545A1 (en) * 1994-02-22 1995-08-31 Dietl Hans Oral vitamin compsn. with improved resorption
WO1996030326A1 (en) * 1995-03-30 1996-10-03 The Trustees Of The University Of Pennsylvania Differentiating agents for the treatment of inflammatory intestinal diseases
US5583125A (en) * 1992-10-06 1996-12-10 Schering Aktiengesellschaft 25-Carboxylic acid derivatives in the vitamin D series, process for their production, intermediate products for these processes, pharmaceutical preparations containing these derivatives as well as their use for the production of pharmaceutical agents
US5663157A (en) * 1992-06-30 1997-09-02 Schering Aktiengesellschaft 22-en-25-oxa derivatives in the vitamin D series, process for their production, pharmaceutical preparations containing these derivatives as well as their use as pharmaceutical agents
WO1998051678A1 (en) * 1997-05-16 1998-11-19 Women & Infants Hospital CYCLIC ETHER VITAMIN D3 COMPOUNDS, 1α (OH) 3-EPI-VITAMIN D3 COMPOUNDS AND USES THEREOF
WO1998051664A1 (en) * 1997-05-16 1998-11-19 Women & Infants Hospital 3-epi vitamin d2 compounds and uses thereof
WO1999003828A1 (en) * 1997-07-17 1999-01-28 F.Hoffmann-La Roche Ag Dihomo-seco-cholestanes with two unsaturated bones in the side chain

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6358939B1 (en) * 1999-12-21 2002-03-19 Northern Lights Pharmaceuticals, Llc Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05294834A (en) * 1990-02-09 1993-11-09 Teijin Ltd Treating agent containing activated vitamin d
US5663157A (en) * 1992-06-30 1997-09-02 Schering Aktiengesellschaft 22-en-25-oxa derivatives in the vitamin D series, process for their production, pharmaceutical preparations containing these derivatives as well as their use as pharmaceutical agents
US5583125A (en) * 1992-10-06 1996-12-10 Schering Aktiengesellschaft 25-Carboxylic acid derivatives in the vitamin D series, process for their production, intermediate products for these processes, pharmaceutical preparations containing these derivatives as well as their use for the production of pharmaceutical agents
DE4405545A1 (en) * 1994-02-22 1995-08-31 Dietl Hans Oral vitamin compsn. with improved resorption
WO1996030326A1 (en) * 1995-03-30 1996-10-03 The Trustees Of The University Of Pennsylvania Differentiating agents for the treatment of inflammatory intestinal diseases
WO1998051678A1 (en) * 1997-05-16 1998-11-19 Women & Infants Hospital CYCLIC ETHER VITAMIN D3 COMPOUNDS, 1α (OH) 3-EPI-VITAMIN D3 COMPOUNDS AND USES THEREOF
WO1998051664A1 (en) * 1997-05-16 1998-11-19 Women & Infants Hospital 3-epi vitamin d2 compounds and uses thereof
WO1999003828A1 (en) * 1997-07-17 1999-01-28 F.Hoffmann-La Roche Ag Dihomo-seco-cholestanes with two unsaturated bones in the side chain

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE CHEMABS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002167821 *
PATENT ABSTRACTS OF JAPAN vol. 018, no. 093 16 February 1994 (1994-02-16) *
See also references of EP1233942A2 *

Also Published As

Publication number Publication date
EP1233942A2 (en) 2002-08-28
CA2390859A1 (en) 2001-06-14
AU4510001A (en) 2001-06-18
WO2001042205A2 (en) 2001-06-14
JP2003516386A (en) 2003-05-13

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